30 research outputs found
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
- Author
- Abecasis GR
- Abecasis GR
- Abecasis Goncalo R.
- Absher D
- Absher D
- Aherrahrou Z
- Ahmadi KR
- Alavere Helene
- Alizadeh Behrooz Z.
- Altshuler D
- Altshuler David
- Amin Najaf
- Andersen K
- Andrews JS
- Aragam J
- Arking DE
- Arnett DK
- Arora Pankaj
- Aspelund T
- Aspelund T
- Aspelund Thor
- Assime TL
- Assimes TL
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- Atkinson EJ
- Attwood T
- Aulchenko YS
- Aulchenko YS
- Aulchenko YS
- Aulchenko Yurii
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- Bakker SJ
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- Beckmann J
- Beckmann Jacques S.
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- Blankenberg S
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- Boehnke Michael
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- Chasman Daniel I.
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- Publication venue
- Nat Genet
- Publication date
- 01/01/2011
- Field of study
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Localization and broadband follow-up of the gravitational-wave transient GW150914
- Author
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- Abbott R
- Abbott TD
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- Abdalla FB
- Abe F
- Abernathy MR
- Acernese F
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- Yancey CC
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- Zhu XJ
- Zimmer S
- Zucker ME
- Zuntz J
- Zuraw SE
- Zweizig J
- Publication venue
- Astrophysical Journal Letters
- Publication date
- 01/01/2016
- Field of study
A gravitational-wave (GW) transient was identified in data recorded by the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) detectors on 2015 September 14. The event, initially designated G184098 and later given the name GW150914, is described in detail elsewhere. By prior arrangement, preliminary estimates of the time, significance, and sky location of the event were shared with 63 teams of observers covering radio, optical, near-infrared, X-ray, and gamma-ray wavelengths with ground- and space-based facilities. In this Letter we describe the low-latency analysis of the GW data and present the sky localization of the first observed compact binary merger. We summarize the follow-up observations reported by 25 teams via private Gamma-ray Coordinates Network circulars, giving an overview of the participating facilities, the GW sky localization coverage, the timeline, and depth of the observations. As this event turned out to be a binary black hole merger, there is little expectation of a detectable electromagnetic (EM) signature. Nevertheless, this first broadband campaign to search for a counterpart of an Advanced LIGO source represents a milestone and highlights the broad capabilities of the transient astronomy community and the observing strategies that have been developed to pursue neutron star binary merger events. Detailed investigations of the EM data and results of the EM follow-up campaign are being disseminated in papers by the individual teams
All-sky search for gravitational-wave bursts in the second joint LIGO-Virgo run
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
We present results from a search for gravitational-wave bursts in the data
collected by the LIGO and Virgo detectors between July 7, 2009 and October 20,
2010: data are analyzed when at least two of the three LIGO-Virgo detectors are
in coincident operation, with a total observation time of 207 days. The
analysis searches for transients of duration < 1 s over the frequency band
64-5000 Hz, without other assumptions on the signal waveform, polarization,
direction or occurrence time. All identified events are consistent with the
expected accidental background. We set frequentist upper limits on the rate of
gravitational-wave bursts by combining this search with the previous LIGO-Virgo
search on the data collected between November 2005 and October 2007. The upper
limit on the rate of strong gravitational-wave bursts at the Earth is 1.3
events per year at 90% confidence. We also present upper limits on source rate
density per year and Mpc^3 for sample populations of standard-candle sources.
As in the previous joint run, typical sensitivities of the search in terms of
the root-sum-squared strain amplitude for these waveforms lie in the range 5
10^-22 Hz^-1/2 to 1 10^-20 Hz^-1/2. The combination of the two joint runs
entails the most sensitive all-sky search for generic gravitational-wave bursts
and synthesizes the results achieved by the initial generation of
interferometric detectors.Comment: 15 pages, 7 figures: data for plots and archived public version at
https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=70814&version=19, see
also the public announcement at
http://www.ligo.org/science/Publication-S6BurstAllSky
Localization and broadband follow-up of the gravitational-wave transient GW150914
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- Zadko
- Zadrożny A
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- Ćwiek FTPESSTOCA
- Ćwiok M
- Żarnecki AF
- Publication venue
- IOP PUBLISHING LTD
- Publication date
- Field of study
A gravitational-wave transient was identified in data recorded by the Advanced LIGO detectors on 2015 September 14. The event candidate, initially designated G184098 and later given the name GW150914, is described in detail elsewhere. By prior arrangement, preliminary estimates of the time, significance, and sky location of the event were shared with 63 teams of observers covering radio, optical, near-infrared, X-ray, and gamma-ray wavelengths with ground- and space-based facilities. In this Letter we describe the low-latency analysis of the gravitational wave data and present the sky localization of the first observed compact binary merger. We summarize the follow-up observations reported by 25 teams via private Gamma-ray Coordinates Network Circulars, giving an overview of the participating facilities, the gravitational wave sky localization coverage, the timeline and depth of the observations. As this event turned out to be a binary black hole merger, there is little expectation of a detectable electromagnetic signature. Nevertheless, this first broadband campaign to search for a counterpart of an Advanced LIGO source represents a milestone and highlights the broad capabilities of the transient astronomy community and the observing strategies that have been developed to pursue neutron star binary merger events. Detailed investigations of the electromagnetic data and results of the electromagnetic follow-up campaign will be disseminated in the papers of the individual teams
Learning by doing? Prospective elementary teachers' developing understandings of scientific inquiry and science teaching and learning
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Emergency Neurological Life Support: Intracranial Hypertension and Herniation
- Author
- A Meyer
- A Monro
- A Qureshi
- A Raco
- A Taylor
- AD Mendelow
- AH Ropper
- B Schmidt
- BB Allen
- BM Eberle
- Brain Trauma F
- Brain Trauma F
- Brain Trauma Foundation
- C Battison
- C Ichai
- CF Contant
- DF Kelly
- DJ Cooper
- DW Marion
- DW Marion
- EM Bulger
- EM Kerr
- G Francony
- G Francony
- G Kellie
- GR Quartey
- H Cushing
- HI Chen
- HM Eisenberg
- I Ng
- J Edge
- J Hofmeijer
- J Jiang
- J Perez-Barcena
- JH Galicich
- JJ Chang
- JJ Fong
- JP Coles
- JP Muizelaar
- JW Kernohan
- JY Jiang
- K Brady
- K Vahedi
- L Longhi
- M Olivecrona
- MA Dubick
- MA Koenig
- MA Koenig
- MA Sperling
- Michael Shoykhet
- N Glaser
- P Kochanek
- P LeRoux
- RD Johnson
- Rhonda Cadena
- RJ Roberts
- Robert D. Stevens
- S Khoshyomn
- T Pfefferkorn
- T Shiozaki
- TS Skoglund
- W Qiu
- WG Liu
- Y Udomphorn
- Z Feldman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Sustained intracranial hypertension and acute brain herniation are “brain codes,” signifying catastrophic neurological events that require immediate recognition and treatment to prevent irreversible injury and death. As in cardiac arrest, a brain code mandates the organized implementation of a stepwise management algorithm. The goal of this emergency neurological life support protocol is to implement an evidence-based, standardized approach to the evaluation and management of patients with intracranial hypertension and/or herniation
Recent Police Recruits’ Existing Knowledge of the Police and Organisational Commitment
- Author
- A Macvean
- A Morris
- AM Richardsen
- B Bradford
- B Metcalfe
- B Metcalfe
- C Ostroff
- CL Adkins
- DM Truxillo
- EF Holton III
- F Jaramillo
- F Lievens
- Fran Boag-Munroe
- G Dokko
- GP Dick
- GP Huber
- H Cooper-Thomas
- HJ Klein
- I Pepper
- J Maanen Van
- JA Breaugh
- JC Carr
- JC McElroy
- JD Kammeyer-Mueller
- JJ Rodwell
- JM Beyer
- JM Phillips
- JP Meyer
- JP Meyer
- JP Meyer
- JP Meyer
- JP Wanous
- JP Wanous
- LT Eby
- LW Porter
- M Riketta
- MA Quinones
- MM Moon
- MR Barrick
- MS Crow
- MW Kramer
- N Marion
- P Currie
- R Heslop
- RJ Vandenberg
- RL Moreland
- RP Bagozzi
- RR Johnson
- S Christopher
- SI Tannenbaum
- SL Rynes
- SY Kuo
- TN Bauer
- TN Bauer
- WD Orrick
- Y Brunetto
- Y Brunetto
- Y Hur
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Bacterial siderophores : structure and NMR assignment of pyoverdins Pa, siderophores ofPseudomonas aeruginosa ATCC 15692
- Author
- A Bax
- A Bax
- AA Bothner-By
- CC Yang
- CD Cox
- CD Cox
- D Helm van der
- D Marion
- ED Weinberg
- ED Weinberg
- G Briskot
- G Döring
- GB Barlin
- GC Levy
- GP Bodey
- H Zähner
- HO Kalinowski
- JB Neilands
- JB Neilands
- JB Neilands
- JJ Bullen
- JM Meyer
- JS Buyer
- K Poppe
- K Wüthrich
- K Wüthrich
- KN Raymond
- L Braunschweiler
- M Teintze
- P Demange
- P Demange
- PE Hansen
- R Ankenbauer
- RC Hider
- S Itoh
- S Wendenbaum
- SB Philson
- SM Cramer
- T Kolasa
- TS Viswanathan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Open Nephrostomy
- Author
- A Boari
- AMK Rickwood
- AR Cato
- AU Khan
- B Fallon
- BK Dalley
- C Cope
- C Kim
- CE Carlton
- DFM Thomas
- DM Davis
- DM Davis
- DT Graham
- EN Brun
- F Schopf
- G Rose
- GC McLoughlin
- GC Tressidder
- GSM Harrison
- H Grabstald
- H Marion
- J Albarran
- J Wilksch
- JC Anderson
- JE Meyer
- JEA Wickham
- JF Jimenez
- JG Blaivas
- JI Gillenwater
- JJ Cunningham
- JM Parker
- JP Blandy
- JP Kohler
- JP Maddern
- JW Bovée
- JWA Ramsay
- L Persky
- LM Zinman
- M Iselin
- MG McLoughlin
- OA Rose
- P Reddy
- PA Androulakakis
- RE Stutzman
- RE Williams
- RG Weaver
- RL Vereecken
- RP Finney
- RTW Turner
- RTW Turner
- RTW Turner
- S Holden
- SA Ortlipp
- TA McNicholas
- TA Stamey
- TD Moore
- TE McNamara
- TP Stephenson
- TT Alagaratnam
- WM Drake
- WP Mulvaney
- WS Tunner
- WSC Hare
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1992
- Field of study