Demanda de estacionamiento de bicicleta y espacios destinados a los mismos en la vía pública en el centro de la ciudad de Córdoba

Fil: Dapas, Oscar Milton. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Dapas, Oscar Milton. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Sanchez, Jose Daniel. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Sanchez, Jose Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Pinotti, Griselda. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Pinotti, Griselda. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Garrido, Guillermo. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Garrido, Guillermo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Cereda, Cristian A. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Cereda, Cristian A. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.En procura de mejorar el sistema de transporte en la ciudad de Córdoba, Argentina, se hace necesario implementar políticas que intenten brindar estacionamiento en la zona céntrica. Esto en virtud a las conclusiones extraídas de la investigación realizada por Baruzzi, Alejandro G. y otros (2013) (7). En la cual se determinan los atributos a optimizar para lograr la migración de los usuarios del transporte público al modo bicicleta, en los viajes que se generan con destino al centro desde una distancia de 4,5 km al mismo. Para la estimación de la demanda de estacionamiento al año 2020 de estos nuevos usuarios, fueron usadas proyecciones de matrices de origen destino de I.S.I.T. (2000) (1), PTUMA (2009) (2) y los valores de corte de boleto proporcionados por la Dirección de Transporte de la Ciudad de Córdoba (9). Para la estimación de la oferta de espacio para estacionamiento de bicicletas en la vía pública, tanto en calzada como fuera de la misma, se procedió a realizar relevamientos de campo, midiéndose dimensiones disponibles y registrándose hechos existentes que condicionan el estacionamiento, tal como ingresos a inmuebles, mobiliario urbano, arboles, entre otros. Se concluye que la oferta no es suficiente para soportar la demanda que se generaría a partir de la realización de la infraestructura requerida por los potenciales usuarios de la bicicleta, para viajar al centro de la ciudad desde los barrios periféricos al mismo.Fil: Dapas, Oscar Milton. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Dapas, Oscar Milton. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Sanchez, Jose Daniel. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Sanchez, Jose Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Pinotti, Griselda. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Pinotti, Griselda. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Garrido, Guillermo. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Garrido, Guillermo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Cereda, Cristian A. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Cereda, Cristian A. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Ingeniería del Transport

Tecnología del concreto. Capítulo 2: Materiales para el concreto

The following book chapter presents the essential components of concrete, being a material that can acquire any shape in the liquid state and is very resistant in the hardened state as well as being aesthetic to be used in a diversity of applications. References [1]A. Garófalo, “Evaluación físico-química de los cementos a partir de la correlación de sus propiedades asociadas con la producción de hormigón”, escuela superior politécnica del Litoral, Ecuador, 2015. [2]AFCP, “La industria del cemento y la sostenibilidad”, Argentina, 2014. [3]ASTM, “Especificación normalizada para cemento Portland C 150-07”, Estados unidos, 2007. [4]E. Riva, “Materiales para el concreto”, Ed. ICG, 3era edición, Lima, 2000. [5]Indecopi, “Norma Técnica Peruana NTP 334.001”, Lima, Perú ,2001. [6]P. Aching and W. Del Castillo, “Influencia del plastificante reductor de agua sika-cem en el concreto cemento arena-Iquitos, 2018”, tesis, Universidad científica del Perú, Loreto, Peru, 2018. [7]P. Valera, “Influencia de las propiedades físico –químicas del agua del río Shilcayo en la resistencia del concreto f´c= 210 kg/cm2, Tarapoto-2018”, tesis, Universidad Cesar Vallejo, Tarapoto, Perú. [8]R. Salamanca, “Aplicación del cemento portland y los cementos adicionados”, ciencia e ingeniería Neogranadina, no. 10, pp. 33-38, 2001. [9]S. Laura, “Diseño de mezclas de concreto”, Universidad Nacional del Altiplano, Puno, Perú, 2006.El siguiente capítulo de libro presenta los componentes esenciales del concreto, siendo este un material que puede adquirir cualquier forma en estado líquido y es muy resistente en estado endurecido además de ser estética para ser utilizadas en una diversidad de aplicaciones. Referencias [1]A. Garófalo, “Evaluación físico-química de los cementos a partir de la correlación de sus propiedades asociadas con la producción de hormigón”, escuela superior politécnica del Litoral, Ecuador, 2015. [2]AFCP, “La industria del cemento y la sostenibilidad”, Argentina, 2014. [3]ASTM, “Especificación normalizada para cemento Portland C 150-07”, Estados unidos, 2007. [4]E. Riva, “Materiales para el concreto”, Ed. ICG, 3era edición, Lima, 2000. [5]Indecopi, “Norma Técnica Peruana NTP 334.001”, Lima, Perú ,2001. [6]P. Aching y W. Del Castillo, “Influencia del plastificante reductor de agua sika-cem en el concreto cemento arena-Iquitos, 2018”, tesis, Universidad científica del Perú, Loreto, Peru, 2018. [7]P. Valera, “Influencia de las propiedades físico –químicas del agua del río Shilcayo en la resistencia del concreto f´c= 210 kg/cm2, Tarapoto-2018”, tesis, Universidad Cesar Vallejo, Tarapoto, Perú. [8]R. Salamanca, “Aplicación del cemento portland y los cementos adicionados”, ciencia e ingeniería Neogranadina, no. 10, pp. 33-38, 2001. [9]S. Laura, “Diseño de mezclas de concreto”, Universidad Nacional del Altiplano, Puno, Perú, 2006. &nbsp

Activating Transcription Factor 4 Modulates TGFβ-Induced Aggressiveness in Triple-Negative Breast Cancer via SMAD2/3/4 and mTORC2 Signaling

Purpose: On the basis of the identified stress-independent cellular functions of activating transcription factor 4 (ATF4), we reported enhanced ATF4 levels in MCF10A cells treated with TGFβ1. ATF4 is overexpressed in patients with triple-negative breast cancer (TNBC), but its impact on patient survival and the underlying mechanisms remain unknown. We aimed to determine ATF4 effects on patients with breast cancer survival and TNBC aggressiveness, and the relationships between TGFβ and ATF4. Defining the signaling pathways may help us identify a cell signaling-tailored gene signature.Experimental Design: Patient survival data were determined by Kaplan-Meier analysis. Relationship between TGFβ and ATF4, their effects on aggressiveness (tumor proliferation, metastasis, and stemness), and the underlying pathways were analyzed in three TNBC cell lines and in vivo using patient-derived xenografts (PDX).Results: ATF4 overexpression correlated with TNBC patient survival decrease and a SMAD-dependent crosstalk between ATF4 and TGFβ was identified. ATF4 expression inhibition reduced migration, invasiveness, mammosphere-forming efficiency, proliferation, epithelial-mesenchymal transition, and antiapoptotic and stemness marker levels. In PDX models, ATF4 silencing decreased metastases, tumor growth, and relapse after chemotherapy. ATF4 was shown to be active downstream of SMAD2/3/4 and mTORC2, regulating TGFβ/SMAD and mTOR/RAC1-RHOA pathways independently of stress. We defined an eight-gene signature with prognostic potential, altered in 45% of 2,509 patients with breast cancer.Conclusions: ATF4 may represent a valuable prognostic biomarker and therapeutic target in patients with TNBC, and we identified a cell signaling pathway-based gene signature that may contribute to the development of combinatorial targeted therapies for breast cancer

Standards in semen examination:publishing reproducible and reliable data based on high-quality methodology

Biomedical science is rapidly developing in terms of more transparency, openness and reproducibility of scientific publications. This is even more important for all studies that are based on results from basic semen examination. Recently two concordant documents have been published: the 6th edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen, and the International Standard ISO 23162:2021. With these tools, we propose that authors should be instructed to follow these laboratory methods in order to publish studies in peer-reviewed journals, preferable by using a checklist as suggested in an Appendix to this article.Peer reviewe

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI

Search for stop and higgsino production using diphoton Higgs boson decays

Results are presented of a search for a "natural" supersymmetry scenario with gauge mediated symmetry breaking. It is assumed that only the supersymmetric partners of the top-quark (stop) and the Higgs boson (higgsino) are accessible. Events are examined in which there are two photons forming a Higgs boson candidate, and at least two b-quark jets. In 19.7 inverse femtobarns of proton-proton collision data at sqrt(s) = 8 TeV, recorded in the CMS experiment, no evidence of a signal is found and lower limits at the 95% confidence level are set, excluding the stop mass below 360 to 410 GeV, depending on the higgsino mass

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Search for anomalous production of events with three or more leptons in pp collisions at √s = 8TeV

Published by the American Physical Society under the terms of the Creative Commons Attribution 3.0 License. Further distribution of this work must maintain attribution to the author(s) and the published articles title, journal citation, and DOI.A search for physics beyond the standard model in events with at least three leptons is presented. The data sample, corresponding to an integrated luminosity of 19.5fb-1 of proton-proton collisions with center-of-mass energy s=8TeV, was collected by the CMS experiment at the LHC during 2012. The data are divided into exclusive categories based on the number of leptons and their flavor, the presence or absence of an opposite-sign, same-flavor lepton pair (OSSF), the invariant mass of the OSSF pair, the presence or absence of a tagged bottom-quark jet, the number of identified hadronically decaying τ leptons, and the magnitude of the missing transverse energy and of the scalar sum of jet transverse momenta. The numbers of observed events are found to be consistent with the expected numbers from standard model processes, and limits are placed on new-physics scenarios that yield multilepton final states. In particular, scenarios that predict Higgs boson production in the context of supersymmetric decay chains are examined. We also place a 95% confidence level upper limit of 1.3% on the branching fraction for the decay of a top quark to a charm quark and a Higgs boson (t→cH), which translates to a bound on the left- and right-handed top-charm flavor-violating Higgs Yukawa couplings, λtcH and λctH, respectively, of |λtcH|2+|λctH|2<0.21