La cubierta como centralidad de proyecto

En el presente trabajo reflexionamos sobre un proyecto de renovación e inclusión social y laboral para un barrio carenciado de recursos tanto en infraestructura como en la situación particular de cada familia. Creemos que es la creación de OPORTUNIDADES para crecer, es darle la herramienta necesaria para satisfacer las necesidades que creemos oportunas en base al análisis que hicimos. El mercado del rio, como así lo llamamos, expresa a través de su escala y su forma un gran impacto visual. Alternando entre escalas humanas y edilicias de gran porte, estructuras en hormigón visto y la cubierta como una parte esencial del proyecto, generamos un nuevo núcleo de encuentro social y productivo de valor barrial y patrimonial para la ciudad de Pueblo Esther. Cabe destacar entonces su cubierta, sus texturas, sus transparencias, y sus espacios generados como potenciadores de un pequeño barrio productivo hacia una nueva centralidad de la zona.Universidad Nacional de Rosario. Facultad de Arquitectura, Planeamiento y Diseño. Rosario, Argentina

Protein C Inhibitor—A Novel Antimicrobial Agent

Protein C inhibitor (PCI) is a heparin-binding serine proteinase inhibitor belonging to the family of serpin proteins. Here we describe that PCI exerts broad antimicrobial activity against bacterial pathogens. This ability is mediated by the interaction of PCI with lipid membranes, which subsequently leads to their permeabilization. As shown by negative staining electron microscopy, treatment of Escherichia coli or Streptococcus pyogenes bacteria with PCI triggers membrane disruption followed by the efflux of bacterial cytosolic contents and bacterial killing. The antimicrobial activity of PCI is located to the heparin-binding site of the protein and a peptide spanning this region was found to mimic the antimicrobial activity of PCI, without causing lysis or membrane destruction of eukaryotic cells. Finally, we show that platelets can assemble PCI on their surface upon activation. As platelets are recruited to the site of a bacterial infection, these results may explain our finding that PCI levels are increased in tissue biopsies from patients suffering from necrotizing fasciitis caused by S. pyogenes. Taken together, our data describe a new function for PCI in innate immunity

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency–Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research

La cubierta como centralidad de proyecto

En el presente trabajo reflexionamos sobre un proyecto de renovación e inclusión social y laboral para un barrio carenciado de recursos tanto en infraestructura como en la situación particular de cada familia. Creemos que es la creación de OPORTUNIDADES para crecer, es darle la herramienta necesaria para satisfacer las necesidades que creemos oportunas en base al análisis que hicimos. El sitio en el cual se emplaza el proyecto se ubica en la ciudad de Pueblo Esther, mas precisamente en los limites norte y este de la ciudad teniendo como bordes físicos el Río Paraná y el Arroyo Frías. Frente a estas dificultades, se pretende que el proyecto permita la puesta en valor del entorno circundante, generando un sentido de pertenencia y arraigo con la gente del lugar, y permita desarrollar con normalidad las actividades productivas mas importantes de la zona como es la pesca. Por ello, en este mercado para pescadores se ha decidido por generar una gran cubierta, que acapare todas las necesidades del barrio y a su vez responda a lo programático. Tomamos la decisión de la utilización de materiales en su máxima expresión, sin la utilización de pinturas ni revoques, materiales en estados puros. En la investigación de cada material supimos generar distintas tramas con el fin de generar distintas opacidades para que el proyecto en si se mantuviera cerrado en cuyo casi así se lo desee pero que no estuviera totalmente cerrado al barrio NUNCA. De esta manera logramos una transparencia casi ininterrumpida en el cual se genera una fusión entre lo existente en el entorno en cual se emplaza y el nuevo proyecto, respetando así lo esencial del barrio. El mercado del rio, como así lo llamamos, expresa a través de su escala y su forma un gran impacto visual. Alternando entre escalas humanas y edilicias de gran porte, estructuras en hormigón visto y la cubierta como una parte esencial del proyecto, generamos un nuevo núcleo de encuentro social y productivo de valor barrial y patrimonial para la ciudad de Pueblo Esther. Cabe destacar entonces su cubierta, sus texturas, sus transparencias, y sus espacios generados como potenciadores de un pequeño barrio productivo hacia una nueva centralidad de la zona