The effect of targeting tolerance of children's negative emotions among anxious parents of children with anxiety disorders: a pilot randomised controlled trial

Following cognitive behavioural therapy for child anxiety a significant minority of children fail to lose their diagnosis status. One potential barrier is high parental anxiety. We designed a pilot RCT to test claims that parental intolerance of the child’s negative emotions may impact treatment outcomes. Parents of 60 children with an anxiety disorder, who were themselves highly anxious, received either brief parent-delivered treatment for child anxiety or the same treatment with strategies specifically targeting parental tolerance of their child’s negative emotions. Consistent with predictions, parental tolerance of the child’s negative emotions significantly improved from pre- to post-treatment. However, there was no evidence to inform the direction of this association as improvements were substantial in both groups. Moreover, while there were significant improvements in child anxiety in both conditions, there was little evidence that this was associated with the improvement in parental tolerance. Nevertheless, findings provide important clinical insight, including that parent-led treatments are appropriate even when the parent is highly anxious and that it may not be necessary to adjust interventions for many families

The role of experiential avoidance and parental control in the association between parent and child anxiety

Parenting behavior and practices contribute to the intergenerational relationship between parent and child anxiety, with parental control being a consistent predictor of child anxiety. Parental experiential avoidance refers to how a parent copes with their internal world in the context of parenting. Little is known about how this relatively new parenting concept relates to child anxiety. The current study tested the indirect effect of parent anxiety on child anxiety through parental control and parental experiential avoidance; the indirect effect of parent anxiety on parental control through parental experiential avoidance; and the moderating effect of parental experiential avoidance on the relationship between parental control and child anxiety. Using a cross-sectional design, parents (N = 85) from a community sample of 8–12-year-old children self-reported on a survey measuring parent anxiety, child anxiety, parental control, and parental experiential avoidance. A hierarchical regression indicated that parental experiential avoidance significantly predicted child anxiety and accounted for further variance in child anxiety, over, and above parental control. There was an indirect effect of parent anxiety on child anxiety through parental control and parental experiential avoidance. Parental experiential avoidance moderated the relationship between parental control and child anxiety, such that the relationship was only significant at high levels of parental experiential avoidance. The current study provides support for the role of parental experiential avoidance in an intergenerational understanding of anxiety. Future research should replicate the study with a clinical sample. Theoretical and practice implications are considered

A Review of Non-Invasive Techniques to Detect and Predict Localised Muscle Fatigue

Muscle fatigue is an established area of research and various types of muscle fatigue have been investigated in order to fully understand the condition. This paper gives an overview of the various non-invasive techniques available for use in automated fatigue detection, such as mechanomyography, electromyography, near-infrared spectroscopy and ultrasound for both isometric and non-isometric contractions. Various signal analysis methods are compared by illustrating their applicability in real-time settings. This paper will be of interest to researchers who wish to select the most appropriate methodology for research on muscle fatigue detection or prediction, or for the development of devices that can be used in, e.g., sports scenarios to improve performance or prevent injury. To date, research on localised muscle fatigue focuses mainly on the clinical side. There is very little research carried out on the implementation of detecting/predicting fatigue using an autonomous system, although recent research on automating the process of localised muscle fatigue detection/prediction shows promising results

Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma

[Excerpt] Multiple myeloma (MM) is the third most common hematological malignancy, after Non-Hodgkin Lymphoma and Leukemia. MM is generally preceded by Monoclonal Gammopathy of Undetermined Significance (MGUS) [1], and epidemiological studies have identified older age, male gender, family history, and MGUS as risk factors for developing MM [2]. The somatic mutational landscape of sporadic MM has been increasingly investigated, aiming to identify recurrent genetic events involved in myelomagenesis. Whole exome and whole genome sequencing studies have shown that MM is a genetically heterogeneous disease that evolves through accumulation of both clonal and subclonal driver mutations [3] and identified recurrently somatically mutated genes, including KRAS, NRAS, FAM46C, TP53, DIS3, BRAF, TRAF3, CYLD, RB1 and PRDM1 [3,4,5]. Despite the fact that family-based studies have provided data consistent with an inherited genetic susceptibility to MM compatible with Mendelian transmission [6], the molecular basis of inherited MM predisposition is only partly understood. Genome-Wide Association (GWAS) studies have identified and validated 23 loci significantly associated with an increased risk of developing MM that explain ~16% of heritability [7] and only a subset of familial cases are thought to have a polygenic background [8]. Recent studies have identified rare germline variants predisposing to MM in KDM1A [9], ARID1A and USP45 [10], and the implementation of next-generation sequencing technology will allow the characterization of more such rare variants. [...]French National Cancer Institute (INCA) and the Fondation Française pour la Recherche contre le Myélome et les Gammapathies (FFMRG), the Intergroupe Francophone du Myélome (IFM), NCI R01 NCI CA167824 and a generous donation from Matthew Bell. This work was supported in part through the computational resources and staff expertise provided by Scientific Computing at the Icahn School of Medicine at Mount Sinai. Research reported in this paper was supported by the Office of Research Infrastructure of the National Institutes of Health under award number S10OD018522. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors thank the Association des Malades du Myélome Multiple (AF3M) for their continued support and participation. Where authors are identified as personnel of the International Agency for Research on Cancer / World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy or views of the International Agency for Research on Cancer / World Health Organizatio

A Review on Research and Evaluation Methods for Investigating Self-Transcendence

Self-transcendence has been characterized as a decrease in self-saliency (ego disillusionment) and increased connection, and has been growing in research interest in the past decade. Several measures have been developed and published with some degree of psychometric validity and reliability. However, to date, there has been no review systematically describing, contrasting, and evaluating the different methodological approaches toward measuring self-transcendence including questionnaires, neurological and physiological measures, and qualitative methods. To address this gap, we conducted a review to describe existing methods of measuring self-transcendence, evaluate the strengths and weaknesses of these methods, and discuss research avenues to advance assessment of self-transcendence, including recommendations for suitability of methods given research contexts

Rapport II.4 Études de phénomènes à partir de bassins expérimentaux : exemples en hydrologie urbaine

Utilisation of "experimental bassins" method in urban hydrology. The methodology of "Experimental Drainage Basins" has been used in urban hydrology for the characterization of the connection between rain and flow, and for the characterization of the urban run-off pollution. The justifications for the use of this method are pointed out. The choice of the drainage basins and of the measurement method is described, close interactions existing between the choice of the objectives, the characterization of the drainage basins (topography and urbanization) and the nature of the observations, are analysed.La méthode des bassins versants expérimentaux a été utilisée en hydrologie urbaine aussi bien pour caractériser la relation pluie-débit, que la pollution des eaux de ruissellement. Les motivations pour l'emploi de cette méthode sont montrées. Le choix des bassins versants et du matériel de mesure est décrit, les interactions étroites qui existent entre le choix des objectifs, la nature propre des bassins versants (topographie, urbanisation) et la nature des observations qui ont été faites, sont analysées.Cheron James, Deutsch Jean-Claude. Rapport II.4 Études de phénomènes à partir de bassins expérimentaux : exemples en hydrologie urbaine. In: L'assainissement de demain. L'hydraulique des eaux pluviales et usées. Compte-rendu des XVIIes journées de l'hydraulique. Nantes,14-16 septembre 1982. Tome 1, 1982

Rapport IV.6 Problèmes divers d'exploitation des réseaux d'assainissement

Various problems arising in the operation of sewage systems. Three aspects of the operation of sewage systems are dealt with : extraneous water, fouling of main sewers, and fluidity of flow. After defining the types of extraneous water and their effects, a methodology of analysis and detection is described, on the basis of actual cases. With regard to the fouling of sewers, emphasis is laid on the need to properly understand the phenomena involved. Some methods of remedying this situation are set forth, and a technico-economic approach is presented. Lastly, among research carried out on conditions of flow, the injection of polymers into the fluid is described, and two types of utilization are proposed .Trois aspects liés à l'exploitation des réseaux d'assainissement sont évoqués : eaux parasites, encrassement des collecteurs, fluidité de l'écoulement. Après avoir défini les types d'eaux parasites et leurs impacts, une méthodologie d'analyse et de détection est décrite à partir de cas concrets. L'encrassement des réseaux est traité en insistant sur la nécessité d'en bien comprendre les phénomènes. Certaines méthodes à mettre en oeuvre pour y remédier sont exposées et une approche technico-économique est présentée. Enfin, parmi les recherches entreprises sur les conditions d'écoulement celle consistant à injecter des polymères dans le fluide est présentée en proposant deux type d'utilisation.Vicq André, Petry Martin, Cheron James, Vignolles Christian, Hélary Jean-Louis, Renard Daniel. Rapport IV.6 Problèmes divers d'exploitation des réseaux d'assainissement. In: L'assainissement de demain. L'hydraulique des eaux pluviales et usées. Compte-rendu des XVIIes journées de l'hydraulique. Nantes,14-16 septembre 1982. Tome 2, 1982

Migrer dans les Amériques

Numéro coordonné par Virginie Baby Collin, Françoise Lestage, Paul Schor et Isabelle Vagnoux Ont également contribué à l’élaboration de ce numéro pour le comité de rédaction : Hélène Aji, Christian Azaïs, Mokhtar Ben Barka, Laurence Cros, Alvar de La LIosa, Vincent Dubreuil, Jean Kempf, Donna Kesselman, Frédéric Leriche, Delphine Mercier, Claire Parfait, Modesta Suárez Secrétariat de rédaction : Claire Bouffar