Light Quark Simulations With FLIC Fermions

Hadron masses are calculated in quenched lattice QCD in order to probe the scaling behavior of a novel fat-link clover fermion action in which only the irrelevant operators of the fermion action are constructed using APE-smeared links. Light quark masses corresponding to an m_pi / m_rho ratio of 0.35 are considered to assess the exceptional configuration problem of clover-fermion actions. This Fat-Link Irrelevant Clover (FLIC) fermion action provides scaling which is superior to mean-field improvement and offers advantages over nonperturbative improvement, including reduced exceptional configurations.Comment: 3 pages, 2 figures, Lattice2002(QCD Spectrum and Quark Masses

Impact of psychiatric diagnoses on hospital length of stay in children with sickle cell anemia

Background Patients with sickle cell anemia (SCA) experience a broad range of psychiatric disorders, placing them at risk for more complicated and longer hospitalizations for vaso‐occlusive crises (VOC). The current study examined the frequency of psychiatric disorders in SCA patients (ages birth to 20 years) admitted for VOC in a nationally representative sample and the association between psychiatric disorders and hospital length of stay (LOS). Procedure Patients with a primary diagnosis of SCA with crisis identified through the nationally representative Kids' Inpatient Database (KID) 2006 from the Agency of Healthcare Research and Quality were included for analysis. Patients with psychiatric disorders listed as secondary diagnoses were categorized under specific psychiatric disorders (mood disorder, anxiety disorder, disruptive behavior disorder, substance use disorder). Non‐parametric and regression analyses were utilized for nationally weighted data, to determine the effect of psychiatric disorders on LOS, while controlling for significant covariates. Results For 21,255 hospital discharges for children with SCA with crisis in 2006, the mean LOS was 4.51 days. Approximately 6% of the patients discharged had a psychiatric disorder. After adjusting for significant covariates, mood disorders, anxiety disorders, and any psychiatric disorder were each associated with significantly longer LOS ( P  < 0.01). Substance and disruptive behavior disorders were not associated with LOS. Conclusions Pediatric patients diagnosed with a psychiatric disorder, specifically mood or anxiety disorders, have longer LOS for VOC. These findings suggest that future interventions aimed at managing VOC may need to consider adjunctive psychiatric assessment and intervention. Pediatr Blood Cancer 2012; 58: 239–243. © 2011 Wiley Periodicals, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/89515/1/23117_ftp.pd

Solid Supported Reagents in Multi-Step Flow Synthesis.

The frequently overlooked benefits that considerably simplify and enrich our standard of living are most often hinged upon chemical synthesis. From the development of drugs in the ongoing fight against disease to the more aesthetic aspects of society with the preparation of perfumes and cosmetics, synthetic chemistry is the pivotally involved science. Furthermore, the quality and quantity of our food supply relies heavily upon synthesised products, as do almost all aspects of our modern society ranging from paints, pigments and dyestuffs to plastics, polymers and other man-made materials. However, the demands being made on chemists are changing at an unprecedented pace and synthesis, or molecular assembly, must continue to evolve in response to the new challenges and opportunities that arise. Responding to this need for improved productivity and efficiency chemists have started to explore new approaches to compound synthesis. Flow-based synthesis incorporating solid supported reagents and scavengers has emerged as a powerful way of manipulating chemical entities and is envisaged to become a core laboratory technology of the future