423 research outputs found
Difficulties in assessing cytomegalovirus-associated gastric perforation in an HIV-infected patient
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2005
- Field of study
BACKGROUND: Active Cytomegalovirus (CMV) infection is a common complication in advanced symptomatic Human Immunodeficiency Virus (HIV) infection. CMV-induced intestinal perforations are hard to diagnose and may be observed throughout the gastrointestinal tract. Isolated stomach perforation is exceptional. CASE PRESENTATION: A 47-year-old man was admitted to our intensive care unit with multiorgan failure. Gastrointestinal endoscopic examination showed erythematous gastritis but normal duodenum and colon. CMV blood culture was positive. Histologic examination of a gastric biopsy showed inflammatory infiltrate and immunostaining typical intranuclear CMV inclusion bodies. Concomitant abdominal CT scan disclosed large peripancreatic hypodensities without pneumoperitoneum. The patient died despite supportive therapies and ganciclovir infusion. Postmortem examination showed a 4-cm gastric perforation adhering to the transverse colon and liver, with a thick necrotic inflammatory coating around the pancreas. The whole GI tract, except the stomach, was normal. As other causes, especially Helicobacter pylori infection could be ruled out, a causal relationship between CMV and gastric disease was assumed. CONCLUSION: CMV may be responsible for gastric perforations, with difficulties in assessing the diagnosis. Early diagnosis based on cautious endoscopy and histopathologic examination is needed to make a favorable outcome possible
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- Valenti G
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- van Dierendonck D
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- Wu SL
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- Wunsch M
- Wyatt TR
- Wynhoff S
- Xia L
- Xie Y
- Xu R
- Xu ZZ
- Xue S
- Yamamoto J
- Yamashita S
- Yang BZ
- Yang CG
- Yang HJ
- Yang M
- Yeh SC
- Yuan C
- Yushchenko O
- Zachariadou K
- Zalewska A
- Zalewski P
- Zalite A
- Zalite Y
- Zavrtanik D
- Zeitnitz C
- Zer-Zion D
- Zhang J
- Zhang L
- Zhang ZP
- Zhao J
- Zhao W
- Zhu GY
- Zhu RY
- Zhuang HL
- Zhuravlov V
- Zichichi A
- Ziegler T
- Zilizi G
- Zimin NI
- Zimmermann B
- Zintchenko A
- Zito G
- Zivkovic L
- Zobernig G
- Zoller M
- Zupan M
- Publication venue
- ELSEVIER SCIENCE BV
- Publication date
- 17/07/2003
- Field of study
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at √s = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abulaitia Y
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Alpigiani C
- Altheimer A
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
- Amundsen G
- Anastopoulos C
- Ancu LS
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- Anh TV
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- Anulli F
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- Arabidze G
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- Argyropoulos S
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- Carrillo-Montoya GD
- Carter JR
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- Casadei D
- Casado MP
- Castaneda-Miranda E
- Castanheira MTD
- Castelli A
- Castillo Gimenez V
- Castillo IS
- Castillo LRF
- Castillo LRF
- Castro NF
- Catastini P
- Catinaccio A
- Catmore JR
- Cattai A
- Cattani G
- Caughron S
- Cavaliere V
- Cavalli D
- Cavalli-Sforza M
- Cavasinni V
- Ceradini F
- Cerio B
- Cerny K
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cerv M
- Cervelli A
- Cetin SA
- Chafaq A
- Chakraborty D
- Chalupkova I
- Chan K
- Chang P
- Chapleau B
- Chapman JD
- Charfeddine D
- Charlton DG
- Cheatham S
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chelstowska MA
- Chen C
- Chen H
- Chen K
- Chen L
- Chen S
- Chen X
- Chen Y
- Cheng HC
- Cheng Y
- Cheplakov A
- Chernyatin V
- Cheu E
- Chevalier L
- Chiarella V
- Chiefari G
- Childers JT
- Chilingarov A
- Chiodini G
- Chisholm AS
- Chislett RT
- Chitan A
- Chizhov MV
- Chouridou S
- Chow BKB
- Christidi IA
- Chromek-Burckhart D
- Chu ML
- Chudoba J
- Ciapetti G
- Ciftci AK
- Ciftci R
- Cinca D
- Cindro V
- Ciocio A
- Cirkovic P
- Citron ZH
- Citterio M
- Ciubancan M
- Clark A
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- Cleland W
- Clemens JC
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- Coccaro A
- Cochran J
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- Coffey L
- Cogan JG
- Coggeshall J
- Cole B
- Cole S
- Colijn AP
- Collaboration ATLAS
- Collins-Tooth C
- Collot J
- Colombo T
- Colon G
- Compostella G
- Conde Muino P
- Coniavitis E
- Conidi MC
- Connelly IA
- Consonni SM
- Consorti V
- Constantinescu S
- Conta C
- Conti G
- Conventi F
- Cooke M
- Cooper BD
- Cooper-Sarkar AM
- Cooper-Smith NJ
- Copic K
- Cornelissen T
- Corradi M
- Correia AMH
- Corriveau F
- Corso-Radu A
- Cortes-Gonzalez A
- Cortiana G
- Costa G
- Costa MJ
- Costanzo D
- Cote D
- Cottin G
- Coutinho YA
- Cowan G
- Cox BE
- Cranmer K
- Cree G
- Crepe-Renaudin S
- Crescioli F
- Cristinziani M
- Crosetti G
- Cuciuc C-M
- Cummings J
- Curatolo M
- Cuthbert C
- Czirr H
- Czodrowski P
- Czyczula Z
- D'Auria S
- D'Onofrio M
- Da Costa JBG
- Da Costa JGPF
- Da Costa JGPF
- Da Cunha Sargedas De Sousa MJ
- Da Via C
- Dabrowski W
- Dafinca A
- Dai T
- Dale O
- Dallaire F
- Dallapiccola C
- Dam M
- Damazio DO
- Daniells AC
- Dao V
- Darbo G
- Darlea GL
- Darmora S
- Dassoulas JA
- Davey W
- David C
- Davidek T
- Davies E
- Davies M
- Davignon O
- Davison AR
- Davison P
- Davygora Y
- Dawe E
- Dawson I
- Daya-Ishmukhametova RK
- de Asmundis R
- De Bruin PHS
- De Castro S
- De Cecco S
- de Graat J
- De Groot N
- de Jong P
- De la Taille C
- De la Torre H
- de Lima DEF
- de Lima DEF
- De Lorenzi F
- De Mendizabal JB
- De Nooij L
- De Pedis D
- De Regie JBDV
- de Renstrom PAB
- De Salvo A
- De Sanctis U
- De Santo A
- De Zorzi G
- De K
- Dearnaley WJ
- Debbe R
- Debenedetti C
- Dechenaux B
- Dedovich DV
- Degenhardt J
- Deigaard I
- Del Peso J
- Del Prete T
- Delemontex T
- Deliot F
- Deliyergiyev M
- Dell'Acqua A
- Dell'Asta L
- Della Pietra M
- della Porta GZ
- della Volpe D
- Delmastro M
- Delsart PA
- Deluca C
- Demers S
- Demichev M
- Demilly A
- Demirkoz B
- Denisov SP
- Derendarz D
- Derkaoui JE
- Derue F
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- Deviveiros PO
- Dewhurst A
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- Di Ciaccio A
- Di Ciaccio L
- Di Domenico A
- Di Donato C
- Di Girolamo A
- Di Girolamo B
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- Diaz MA
- Diehl EB
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- Diglio S
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- Zhemchugov A
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of √s = 7 TeV;{\rm Te}{\rm V}andcorrespondtoanintegratedluminosityof4.6\;{\rm f}{{{\rm b}}^{-1}}.ThemeasurementisperformedbyreconstructingtheboostedWorZbosonsinsinglejets.ThereconstructedjetmassisusedtoidentifytheWandZbosons,andajetsubstructuremethodbasedonenergyclusterinformationinthejetcentre−of−massframeisusedtosuppressthelargemulti−jetbackground.Thecross−sectionforeventswithahadronicallydecayingWorZboson,withtransversemomentum{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}andpseudorapidity|\eta |\lt 1.9,ismeasuredtobe{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at s√=8 TeV with the ATLAS detector
- Author
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- Abbott B
- Abdallah J
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- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
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- Zhao Z
- Zhemchugov A
- Zhong J
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- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
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- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fb−1 of proton–proton collision data at √s = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via t˜→tχ˜01 or t˜→ bχ˜±1 →bW(∗)χ˜01 , where χ˜01 (χ˜±1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of t˜ → tχ˜01 . For a branching fraction of 100%, top squark masses in the range 270–645 GeV are excluded for χ˜01 masses below 30 GeV. For a branching fraction of 50% to either t˜ → tχ˜01 or t˜ → bχ˜±1 , and assuming the χ˜±1 mass to be twice the χ˜01 mass, top squark masses in the range 250–550 GeV are excluded for χ˜01 masses below 60 GeV
Search for pair-produced long-lived neutral particles decaying to jets in the ATLAS hadronic calorimeter in ppcollisions at √s=8TeV
- Author
- Aad G
- Abbott B
- Abdallah J
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- Sedov G
- Sedykh E
- Seidel SC
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- Seixas JM
- Sekhniaidze G
- Sekula SJ
- Selbach KE
- Seliverstov DM
- Sellers G
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- Shabalina E
- Shamim M
- Shan LY
- Shang R
- Shank JT
- Shapiro M
- Shatalov PB
- Shaw K
- Shehu CY
- Sherwood P
- Shi L
- Shimizu S
- Shimmin CO
- Shimojima M
- Shiyakova M
- Shmeleva A
- Shochet MJ
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- Sipica V
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- Sisakyan AN
- Sivoklokov SY
- Sjoelin J
- Sjursen TB
- Skottowe HP
- Skovpen KY
- Skubic P
- Slater M
- Slavicek T
- Sliwa K
- Smakhtin V
- Smart BH
- Smestad L
- Smirnov SY
- Smirnov Y
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- Smirnova O
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- Smizanska M
- Smolek K
- Snesarev AA
- Snidero G
- Snyder S
- Sobie R
- Socher F
- Soffer A
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- Solans CA
- Solar M
- Solc J
- Soldatov EY
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- Solodkov AA
- Soloshenko A
- Solovyanov OV
- Solovyev V
- Sommer P
- Song HY
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- Sundermann JE
- Suruliz K
- Susinno G
- Sutton MR
- Suzuki Y
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- Swedish S
- Swiatlowski M
- Sykora I
- Sykora T
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- Taenzer J
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- Takeshita T
- Takubo Y
- Talby M
- Talyshev AA
- Tam JYC
- Tan KG
- Tanaka J
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- Tannenwald BB
- Tannoury N
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- Teuscher RJ
- Therhaag J
- Theveneaux-Pelzer T
- Thomas JP
- Thomas-Wilsker J
- Thompson AS
- Thompson EN
- Thompson PD
- Thompson PD
- Thompson RJ
- Thomsen LA
- Thomson E
- Thomson M
- Thong WM
- Thun RP
- Tian F
- Tibbetts MJ
- Tikhomirov VO
- Tikhonov YA
- Timoshenko S
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- Tipton P
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- Todorov T
- Todorova-Nova S
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- Tojo J
- Tokar S
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- Tolley E
- Tomlinson L
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- Trigger IM
- Trincaz-Duvoid S
- Tripiana MF
- Trischuk W
- Trocme B
- Troncon C
- Trottier-McDonald M
- Trovatelli M
- True P
- Trzebinski M
- Trzupek A
- Tsarouchas C
- Tseng JC-L
- Tsiareshka PV
- Tsionou D
- Tsipolitis G
- Tsirintanis N
- Tsiskaridze S
- Tsiskaridze V
- Tskhadadze EG
- Tsukerman I
- Tsulaia V
- Tsuno S
- Tsybychev D
- Tudorache A
- Tudorache V
- Tuna AN
- Tupputi SA
- Turchikhin S
- Turecek D
- Turra R
- Tuts PM
- Tykhonov A
- Tylmad M
- Tyndel M
- Uchida K
- Ueda I
- Ueno R
- Ughetto M
- Ugland M
- Uhlenbrock M
- Ukegawa F
- Unal G
- Undrus A
- Unel G
- Ungaro FC
- Unno Y
- Unverdorben C
- Urbaniec D
- Urquijo P
- Usai G
- Usanova A
- Vacavant L
- Vacek V
- Vachon B
- Valencic N
- Valentinetti S
- Valero A
- Valery L
- Valkar S
- Vallecorsa S
- Van Den Wollenberg W
- Van Der Deijl PC
- van der Geer R
- van der Graaf H
- Van Der Leeuw R
- van der Ster D
- Van Eldik N
- Van Gemmeren P
- van Huysduynen LH
- Van Nieuwkoop J
- van Vulpen I
- Van Woerden MC
- Vanadia M
- Vandelli W
- Vanguri R
- Vaniachine A
- Vankov P
- Vannucci F
- Vaque FV
- Vardanyan G
- Vari R
- Varnes EW
- Varol T
- Varouchas D
- Vartapetian A
- Varvell KE
- Vazeille F
- Vazquez JGP
- Veatch J
- Veloso F
- Velz T
- Veneziano S
- Ventura A
- Ventura D
- Venturi M
- Venturi N
- Venturini A
- Vercesi V
- Verducci M
- Verkerke W
- Vermeulen JC
- Verzini MJA
- Vest A
- Vetterli MC
- Viazlo O
- Vichou I
- Vickey T
- Viehhauser GHA
- Viel S
- Vigne R
- Villa M
- Vilucchi E
- Vincter MG
- Vinogradov VB
- Virzi J
- Vivarelli I
- Vlachos S
- Vladoiu D
- Vlasak M
- Vogel A
- Vokac P
- Volpi G
- Volpi M
- von der Schmitt H
- von Radziewski H
- von Toerne E
- Vorobel V
- Vorobev K
- Vos M
- Voss R
- Vossebeld JH
- Vranjes N
- Vrba V
- Vreeswijk M
- Vuanh T
- Vuillermet R
- Vukotic I
- Vykydal Z
- Wagner P
- Wagner W
- Wahlberg H
- Wahrmund S
- Wakabayashi J
- Walder J
- Walker R
- Walkowiak W
- Wall R
- Waller P
- Walls FMG
- Walsh B
- Wang C
- Wang C
- Wang F
- Wang H
- Wang H
- Wang J
- Wang J
- Wang K
- Wang R
- Wang SM
- Wang T
- Wang X
- Wanotayaroj C
- Warburton A
- Ward CP
- Wardrope DR
- Warsinsky M
- Washbrook A
- Wasicki C
- Watkins PM
- Watson AT
- Watson IJ
- Watson MF
- Watts G
- Watts S
- Waugh BM
- Webb S
- Weber MS
- Weber SW
- Webster JS
- Weidberg AR
- Weigell P
- Weinert B
- Weingarten J
- Weiser C
- Weits H
- Wells PS
- Wemans ADV
- Wenaus T
- Wendland D
- Weng Z
- Wengler T
- Wenig S
- Wermes N
- Werner M
- Werner P
- Wessels M
- Wetter J
- Whalen K
- White A
- White MJ
- White R
- White S
- Whiteson D
- Wicke D
- Wickens FJ
- Wiedenmann W
- Wielers M
- Wienemann P
- Wiglesworth C
- Wiik-Fuchs LAM
- Wijeratne PA
- Wildauer A
- Wildt MA
- Wilkens HG
- Will JZ
- Williams HH
- Williams S
- Willis C
- Willocq S
- Wilson A
- Wilson JA
- Wingerter-Seez I
- Winklmeier F
- Winter BT
- Wittgen M
- Wittig T
- Wittkowski J
- Wollstadt SJ
- Wolter MW
- Wolters H
- Wong KHY
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wright M
- Wu M
- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wyatt TR
- Wynne BM
- Xella S
- Xiao M
- Xu D
- Xu L
- Yabsley B
- Yacoob S
- Yakabe R
- Yamada M
- Yamaguchi H
- Yamaguchi Y
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamauchi K
- Yamazaki Y
- Yan Z
- Yang H
- Yang H
- Yang UK
- Yang Y
- Yanush S
- Yao L
- Yao W-M
- Yasu Y
- Yatsenko E
- Ye J
- Ye S
- Yeletskikh I
- Yen AL
- Yildirim E
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJS
- Youssef S
- Yu DR
- Yu J
- Yu J
- Yu JM
- Yuan L
- Yurkewicz A
- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang X
- Zhang Z
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou L
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
The ATLAS detector at the Large Hadron Collider at CERN is used to search for the decay of a scalar boson to a pair of long-lived particles, neutral under the Standard Model gauge group, in 20.3fb−1of data collected in proton–proton collisions at √s=8TeV. This search is sensitive to long-lived particles that decay to Standard Model particles producing jets at the outer edge of the ATLAS electromagnetic calorimeter or inside the hadronic calorimeter. No significant excess of events is observed. Limits are reported on the product of the scalar boson production cross section times branching ratio into long-lived neutral particles as a function of the proper lifetime of the particles. Limits are reported for boson masses from 100 GeVto 900 GeV, and a long-lived neutral particle mass from 10 GeVto 150 GeV
Breast density and mode of detection in relation to breast cancer specific survival: a cohort study
- Author
- A Olsson
- AH Olsen
- BS Wiseman
- CH van Gils
- CK Chow
- CM Vachon
- CW Elston
- DS Buist
- G Berglund
- G Maskarinec
- GA Greendale
- GC Wishart
- GJ Porter
- GL Gierach
- H Joensuu
- Hanna Sartor
- J Brisson
- J Manjer
- JA Harvey
- Jonas Manjer
- JS Varghese
- L Eriksson
- L Ma
- LA Johansson
- LJ Martin
- LSGBI Freedman
- MJ Yaffe
- MT Mandelson
- NA Bhowmick
- NF Boyd
- NF Boyd
- PA Carney
- PB Lam
- PM Vacek
- RM Tamimi
- S Alowami
- S Borgquist
- S Zackrisson
- Signe Borgquist
- SJ Dawson
- Sophia Zackrisson
- SY Chiu
- T Li
- VA McCormack
- W Demark-Wahnefried
- World Health Organization
- YP Guo
- Åsa Olsson
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Identification of Brain Nuclei Implicated in Cocaine-Primed Reinstatement of Conditioned Place Preference: A Behaviour Dissociable from Sensitization
- Author
- A Bilbao
- A Childress
- A Markou
- AJ Lawrence
- AM Graybiel
- Andrew John Lawrence
- AR Zavala
- AR Zavala
- AS Hamlin
- B Boutrel
- B Hope
- C O'Brien
- CA Crawford
- CA Dackis
- CJ Sanchez
- CJ Sanchez
- CP O'Brien
- CS McPherson
- CV Dayas
- D Mueller
- DB Adams
- DG Herrera
- DH Epstein
- E Hrabovszky
- EE Brown
- F Leri
- F Zhang
- FA Wagner
- FC Cruz
- G Biala
- GC Harris
- GJ Quirk
- Huibert D. Mansvelder
- J Peters
- Jennifer Lynn Short
- JI Morgan
- JL Neisewander
- JL Rogers
- JM Bossert
- K McFarland
- K McFarland
- K Touzani
- KB Franklin
- L Font
- L Lu
- LA Parker
- M Dragunow
- M Gossop
- M Matsumoto
- M Takagishi
- MA Aguilar
- MA Hebert
- MC Morissette
- MP Vachon
- NS Floyd
- O Hikosaka
- PR Kufahl
- PW Kalivas
- R Ciccocioppo
- R Sinha
- R Spanagel
- RE Harlan
- RE Watson Jr
- RG Paredes
- RJ Blanchard
- RJ Sutherland
- RM Brown
- RM Brown
- Robyn Mary Brown
- S Erb
- S Erb
- S Geisler
- S Grant
- SA Brown
- SD Comer
- SE Rhodes
- SE Rhodes
- SJ McDougall
- ST Young
- TE Robinson
- TE Robinson
- TJ De Vries
- TM Tzschentke
- TR Franklin
- W DeJong
- Y Shaham
- Y Shaham
- Publication venue
- Public Library of Science
- Publication date
- 29/12/2010
- Field of study
Relapse prevention represents the primary therapeutic challenge in the treatment of drug addiction. As with humans, drug-seeking behaviour can be precipitated in laboratory animals by exposure to a small dose of the drug (prime). The aim of this study was to identify brain nuclei implicated in the cocaine-primed reinstatement of a conditioned place preference (CPP). Thus, a group of mice were conditioned to cocaine, had this place preference extinguished and were then tested for primed reinstatement of the original place preference. There was no correlation between the extent of drug-seeking upon reinstatement and the extent of behavioural sensitization, the extent of original CPP or the extinction profile of mice, suggesting a dissociation of these components of addictive behaviour with a drug-primed reinstatement. Expression of the protein product of the neuronal activity marker c-fos was assessed in a number of brain regions of mice that exhibited reinstatement (R mice) versus those which did not (NR mice). Reinstatement generally conferred greater Fos expression in cortical and limbic structures previously implicated in drug-seeking behaviour, though a number of regions not typically associated with drug-seeking were also activated. In addition, positive correlations were found between neural activation of a number of brain regions and reinstatement behaviour. The most significant result was the activation of the lateral habenula and its positive correlation with reinstatement behaviour. The findings of this study question the relationship between primed reinstatement of a previously extinguished place preference for cocaine and behavioural sensitization. They also implicate activation patterns of discrete brain nuclei as differentiators between reinstating and non-reinstating mice
A likelihood ratio approach for utilizing case-control data in the clinical classification of rare sequence variants:Application to BRCA1 and BRCA2
- Author
- Aittomäkkiki Kristiina
- Andrulis Irene L
- Anton-Culver Hoda
- Aronson Kristan J
- Augustinsson Annelie
- Becher Heiko
- Bojesen Stig E
- Bolla Manjeet K
- Brenner Hermann
- Brown Melissa A
- Buys Saundra S
- Canzian Federico
- Caputo Sandrine M
- Castelao Jose E
- Chang-Claude Jenny
- Couch Fergus J
- Czene Kamila
- Daly Mary B
- De Nicolo Arcangela
- Dennis Joe
- Devilee Peter
- Dunning Alison M
- Dwek Miriam
- Dörk Thilo
- Easton Douglas F
- Eccles Diana M
- Engel Christoph
- Evans D Gareth
- Fasching Peter A
- Feng Bingjian
- Gago-Dominguez Manuela
- García-Closas Montserrat
- García-Sáenz José A
- Gentry-Maharaj Aleksandra
- Geurts - Giele Willemina RR
- Giles Graham G
- Glendon Gord
- Goldberg Mark S
- Goldgar David E
- Guénel Pascal
- Gómez Garcia Encarna B
- Güendert Melanie
- Hahnen Eric
- Haiman Christopher A
- Hall Per
- Hamann Ute
- Harkness Elaine F
- Hogervorst Frans BL
- Hollestelle Antoinette
- Hoppe Reiner
- Hopper John L
- Houdayer Claude
- Houlston Richard S
- Howell Anthony
- Investigators ABCTB
- Jakimovska Milena
- Jakubowska Anna
- James Paul
- Jernström Helena
- John Esther M
- Kaaks Rudolf
- Kitahara Cari M
- Koutros Stella
- Kraft Peter
- Kristensen Vessela N
- Lacey James V
- Lambrechts Diether
- Li Hongyan
- Lindblom Annika
- Lubiński Jan
- Lush Michael
- Léoné Melanie
- Mannermaa Arto
- Manoochehri Mehdi
- Manoukian Siranoush
- Margolin Sara
- Martinez Maria Elena
- Menon Usha
- Michailidou Kyriaki
- Milne Roger L
- Monteiro Alvaro N
- Murphy Rachel A
- Neuhausen Susan L
- Nevanlinna Heli
- Newman William G
- O'Mahony Denise G
- Offit Kenneth
- Park Sue K
- Parsons Michael T
- Peterlongo Paolo
- Peto Julian
- Plaseska-Karanfilska Dijana
- Punie Kevin
- Radice Paolo
- Rashid Muhammad U
- Rennert Gad
- Romero Atocha
- Rosenberg Efraim H
- Saloustros Emmanouil
- Sandler Dale P
- Schmidt Marjanka K
- Schmutzler Rita K
- Shu Xiao-Ou
- Simard Jacques
- Southey Melissa C
- Spurdle Amanda B
- Stone Jennifer
- Stoppa-Lyonnet Dominique
- Study Collaborators GC-HBOC
- Tamimi Rulla M
- Tapper William J
- Taylor Jack A
- Teo Soo Hwang
- Teras Lauren R
- Terry Mary Beth
- Thomassen Mads
- Troester Melissa A
- Vachon Celine M
- Vega Ana
- Vreeswijk Maaike PG
- Wang Qin
- Wappenschmidt Barbara
- Weinberg Clarice R
- Wolk Alicja
- Zanti Maria
- Zheng Wei
- Publication venue
- Publication date
- 01/01/2023
- Field of study
A large number of variants identified through clinical genetic testing in disease susceptibility genes are of uncertain significance (VUS). Following the recommendations of the American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP), the frequency in case-control datasets (PS4 criterion) can inform their interpretation. We present a novel case-control likelihood ratio-based method that incorporates gene-specific age-related penetrance. We demonstrate the utility of this method in the analysis of simulated and real datasets. In the analysis of simulated data, the likelihood ratio method was more powerful compared to other methods. Likelihood ratios were calculated for a case-control dataset of BRCA1 and BRCA2 variants from the Breast Cancer Association Consortium (BCAC) and compared with logistic regression results. A larger number of variants reached evidence in favor of pathogenicity, and a substantial number of variants had evidence against pathogenicity findings that would not have been reached using other case-control analysis methods. Our novel method provides greater power to classify rare variants compared with classical case-control methods. As an initiative from the ENIGMA Analytical Working Group, we provide user-friendly scripts and preformatted Excel calculators for implementation of the method for rare variants in BRCA1, BRCA2, and other high-risk genes with known penetrance.</p
Transcriptome-wide association study of breast cancer risk by estrogen-receptor status
- Author
- ABCTB Investigators
- ABCTB Investigators
- Abu-Full Zomoroda
- Aittomäki Kristiina
- Andrulis Irene L
- Anton-Culver Hoda
- Antoniou Antonis C
- Arason Adalgeir
- Arndt Volker
- Aronson Kristan J
- Arun Banu K
- Asseryanis Ella
- Auer Paul L
- Azzollini Jacopo
- Balmaña Judith
- Barkardottir Rosa B
- Barnes Daniel R
- Barrowdale Daniel
- BCFR Investigators
- BCFR Investigators
- Beckmann Matthias W
- Behrens Sabine
- Benitez Javier
- Bermisheva Marina
- Białkowska Katarzyna
- Blanco Ana
- Blomqvist Carl
- Boeckx Bram
- Bogdanova Natalia V
- Bojesen Stig E
- Bolla Manjeet K
- Bonanni Bernardo
- Borg Ake
- Brauch Hiltrud
- Brenner Hermann
- Briceno Ignacio
- Broeks Annegien
- Brüning Thomas
- Burwinkel Barbara
- Cai Qiuyin
- Caldés Trinidad
- Caligo Maria A
- Campa Daniele
- Campbell Ian
- Canisius Sander
- Carter Brian D
- Carter Jonathan
- Castelao Jose E
- Chang-Claude Jenny
- Chanock Stephen J
- Chenevix-Trench Georgia
- Christiansen Hans
- Chung Wendy K
- Claes Kathleen BM
- Clarke Christine L
- Couch Fergus J
- Cox Angela
- Cross Simon S
- Cybulski Cezary
- Czene Kamila
- Daly Mary B
- de la Hoya Miguel
- De Leeneer Kim
- Dennis Joe
- Devilee Peter
- Diez Orland
- Domchek Susan M
- Dos-Santos-Silva Isabel
- Dunning Alison M
- Dwek Miriam
- Dörk Thilo
- Easton Douglas F
- Eccles Diana M
- Ejlertsen Bent
- Ellberg Carolina
- EMBRACE Collaborators
- EMBRACE Collaborators
- Engel Christoph
- Eriksson Mikael
- Fasching Peter A
- Feng Helian
- Fletcher Olivia
- Flyger Henrik
- Fostira Florentia
- Friedman Eitan
- Fritschi Lin
- Frost Debra
- Gabrielson Marike
- Ganz Patricia A
- Gapstur Susan M
- Garber Judy
- García-Closas Montserrat
- García-Sáenz José A
- Gaudet Mia M
- GC-HBOC study Collaborators
- GC-HBOC study Collaborators
- GEMO Study Collaborators
- GEMO Study Collaborators
- Giles Graham G
- Glendon Gord
- Godwin Andrew K
- Goldberg Mark S
- Goldgar David E
- González-Neira Anna
- Greene Mark H
- Gronwald Jacek
- Gusev Alexander
- Guénel Pascal
- Haiman Christopher A
- Hake Christopher
- Hall Per
- Hamann Ute
- He Wei
- HEBON Investigators
- Heyworth Jane
- Hogervorst Frans BL
- Hollestelle Antoinette
- Hooning Maartje J
- Hoover Robert N
- Hopper John L
- Huang Guanmengqian
- Hulick Peter J
- Humphreys Keith
- Imyanitov Evgeny N
- Isaacs Claudine
- Jakimovska Milena
- Jakubowska Anna
- James Paul
- Janavicius Ramunas
- Jankowitz Rachel C
- Jiang Xia
- John Esther M
- Johnson Nichola
- Joseph Vijai
- Jung Audrey
- Kapoor Pooja M
- Karlan Beth Y
- Khusnutdinova Elza
- Kiiski Johanna I
- Konstantopoulou Irene
- Kraft Peter
- Kristensen Vessela N
- Laitman Yael
- Lambrechts Diether
- Lazaro Conxi
- Leroux Dominique
- Leslie Goska
- Lester Jenny
- Lesueur Fabienne
- Lindor Noralane
- Lindström Sara
- Lo Wing-Yee
- Long Jirong
- Loud Jennifer T
- Lubiński Jan
- Makalic Enes
- Mannermaa Arto
- Manoochehri Mehdi
- Manoukian Siranoush
- Margolin Sara
- Martens John WM
- Martinez Maria E
- Matricardi Laura
- Maurer Tabea
- Mavroudis Dimitrios
- McGuffog Lesley
- Meindl Alfons
- Menon Usha
- Michailidou Kyriaki
- Miller Austin
- Milne Roger L
- Montagna Marco
- Moreno Fernando
- Moserle Lidia
- Mulligan Anna M
- Muranen Taru A
- Nathanson Katherine L
- Neuhausen Susan L
- Nevanlinna Heli
- Nevelsteen Ines
- Nielsen Finn C
- Nikitina-Zake Liene
- OCGN Investigators
- OCGN Investigators
- Offit Kenneth
- Olah Edith
- Olopade Olufunmilayo I
- Olsson Håkan
- Osorio Ana
- Papp Janos
- Park-Simon Tjoung-Won
- Parsons Michael T
- Pasaniuc Bogdan
- Pedersen Inge S
- Peixoto Ana
- Peterlongo Paolo
- Peto Julian
- Pharoah Paul DP
- Phillips Kelly-Anne
- Plaseska-Karanfilska Dijana
- Poppe Bruce
- Pradhan Nisha
- Prajzendanc Karolina
- Presneau Nadege
- Punie Kevin
- Pylkäs Katri
- Radice Paolo
- Rantala Johanna
- Rashid Muhammad Usman
- Rennert Gad
- Risch Harvey A
- Robson Mark
- Romero Atocha
- Saloustros Emmanouil
- Sandler Dale P
- Santos Catarina
- Sawyer Elinor J
- Schmidt Daniel F
- Schmidt Marjanka K
- Schmutzler Rita K
- Schoemaker Minouk J
- Scott Rodney J
- Sharma Priyanka
- Shu Xiao-Ou
- Simard Jacques
- Singer Christian F
- Skytte Anne-Bine
- Soucy Penny
- Southey Melissa C
- Spinelli John J
- Spurdle Amanda B
- Stone Jennifer
- Swerdlow Anthony J
- Tapper William J
- Taylor Jack A
- Teixeira Manuel R
- Terry Mary Beth
- Teulé Alex
- Thomassen Mads
- Thull Darcy L
- Thöne Kathrin
- Tischkowitz Marc
- Toland Amanda E
- Tollenaar Rob AEM
- Torres Diana
- Truong Thérèse
- Tung Nadine
- Vachon Celine M
- van Asperen Christi J
- van den Ouweland Ans MW
- van Rensburg Elizabeth J
- Vega Ana
- Vieiro-Balo Paula
- Viel Alessandra
- Wang Qin
- Wappenschmidt Barbara
- Weinberg Clarice R
- Weitzel Jeffrey N
- Wendt Camilla
- Winqvist Robert
- Wu Lang
- Yang Xiaohong R
- Yannoukakos Drakoulis
- Zheng Wei
- Ziogas Argyrios
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome-wide association studies (GWAS), but analyses of breast cancer subtype-specific associations have been limited. In this study, we conducted a TWAS using gene expression data from GTEx and summary statistics from the hitherto largest GWAS meta-analysis conducted for breast cancer overall, and by estrogen receptor subtypes (ER+ and ER-). We further compared associations with ER+ and ER- subtypes, using a case-only TWAS approach. We also conducted multigene conditional analyses in regions with multiple TWAS associations. Two genes, STXBP4 and HIST2H2BA, were specifically associated with ER+ but not with ER- breast cancer. We further identified 30 TWAS-significant genes associated with overall breast cancer risk, including four that were not identified in previous studies. Conditional analyses identified single independent breast-cancer gene in three of six regions harboring multiple TWAS-significant genes. Our study provides new information on breast cancer genetics and biology, particularly about genomic differences between ER+ and ER- breast cancer.Peer reviewe
Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer
- Author
- Adlard J
- Ahmed M
- Aittomaki K
- Al-Ejeh F
- Andrulis IL
- Anton-Culver H
- Antoniou AC
- Arason A
- Arndt V
- Arnold N
- Aronson KJ
- Arun BK
- Asseryanis E
- Auber B
- Azzollini J
- Balleine R
- Balmana J
- Bane A
- Barnes DR
- Barrowdale D
- Barwell J
- Baxter R
- Beckmann MW
- Beesley J
- Behrens S
- Benitez J
- Bermisheva M
- Bialkowska K
- Blomqvist C
- Bogdanova NV
- Bogdanova-Markov N
- Bojesen SE
- Bolla MK
- Borde J
- Borg A
- Brady A
- Brauch H
- Braye S
- Brenner H
- Brewer C
- Broeks A
- Burwinkel B
- Buys SS
- Caldes T
- Caliebe A
- Caligo MA
- Campa D
- Campbell I
- Canzian F
- Carpenter J
- Carter BD
- Carter J
- Castelao JE
- Chang-Claude J
- Chanock SJ
- Chenevix-Trench G
- Christiansen H
- Chung WK
- Claes KBM
- Clarke CL
- Collaborators EMBRACE
- Collaborators GC-HBOCS
- Collaborators GEMOS
- Conner TA
- Cook J
- Couch FJ
- Cox A
- Cross SS
- Czene K
- Dahlstrom J
- Daly MB
- Davidson R
- de la Hoya M
- Dennis J
- Devilee P
- Diez O
- Ditsch N
- Doerk T
- Donaldson A
- Dunning AM
- Dwek M
- Dworniczak B
- Eason J
- Easton DF
- Eccles DM
- Eeles R
- Ejlertsen B
- Ellberg C
- Engel C
- Engert S
- Eriksson M
- Evans DG
- Fasching PA
- Faust U
- Ferreira MA
- Fletcher O
- Flyger H
- Forbes J
- Friedman E
- Frost D
- Gabrielson M
- Gago-Dominguez M
- Gamazon ER
- Ganz PA
- Gapstur SM
- Garber J
- Garcia-Closas M
- Garcia-Saenz JA
- Gaudet MM
- Gehrig A
- Giles GG
- Glendon G
- Godwin AK
- Goldberg MS
- Goldgar DE
- Gonzalez-Neira A
- Greene MH
- Gregory H
- Gronwald J
- Guenel P
- Hahnen E
- Haiman CA
- Hall P
- Hamann U
- Hanson H
- Harrington PA
- Hauke J
- He W
- Heemskerk-Gerritsen BAM
- Henderson A
- Hentschel J
- Herold N
- Heyworth J
- Hodgson S
- Hogervorst FBL
- Hollestelle A
- Honisch E
- Hoover RN
- Hopper JL
- Hulick PJ
- Humphreys K
- Imyanitov EN
- Investigators ABCTB
- Investigators BCFR
- Investigators HEBON
- Isaacs C
- Izatt L
- Jakimovska M
- Jakubowska A
- James PA
- Janavicius R
- Jankowitz RC
- John EM
- Johnson N
- Jones ME
- Joseph V
- Just W
- Kapuscinski M
- Karlan BY
- Kast K
- Kennedy MJ
- Khusnutdinova E
- Kiiski JI
- Ko Y-D
- Konstantopoulou I
- Kraft P
- Kristensen VN
- Laitman Y
- Lalloo F
- Lambrechts D
- Larsen M
- Lazaro C
- Lee SC
- Lemke J
- Leslie G
- Lester J
- Lesueur F
- Lindstrom S
- Long J
- Loud JT
- Lubinski J
- Makalic E
- Mannermaa A
- Manoochehri M
- Margolin S
- Marsh D
- Maurer T
- Mavroudis D
- McGuffog L
- Meindl A
- Menon U
- Michailidou K
- Miller A
- Miller C
- Milne RL
- Miron A
- Montagna M
- Moreno F
- Morey A
- Morrison PJ
- Moserle L
- Mulligan AM
- Nathanson KL
- Neuhausen SL
- Nevanlinna H
- Nevelsteen I
- Nguyen HP
- Niederacher D
- Nielsen FC
- Nikitina-Zake L
- Nussbaum RL
- Offit K
- Olah E
- Olopade OI
- Olsson H
- Ong K-R
- Osorio A
- Ott C-E
- Papp J
- Park-Simon T-W
- Parsons MT
- Pathmanathan N
- Pedersen IS
- Peixoto A
- Perkins J
- Peterlongo P
- Pharoah PDP
- Plaseska-Karanfilska D
- Platzer K
- Pohl-Rescigno E
- Poppe B
- Porteous ME
- Presneau N
- Prieur F
- Pujol P
- Radice P
- Ramser J
- Rantala J
- Rennert G
- Rhiem K
- Risch HA
- Rogers MT
- Rookus MA
- Ross E
- Sagne C
- Saloustros E
- Sanden K
- Sawyer EJ
- Schmidt MK
- Schmutzler RK
- Sevenet N
- Seynaeve CM
- Sharma P
- Shu X-O
- Side LE
- Simard J
- Simpson P
- Singer CF
- Snape K
- Sobol H
- Sokolowska J
- Soucy P
- Southey MC
- Spigelman A
- Spinelli JJ
- Spurdle AB
- Steinemann D
- Stone J
- Stoppa-Lyonnet D
- Sutter C
- Swerdlow AJ
- Tapper WJ
- Taylor JA
- Teixeira MR
- Terry MB
- Teule A
- Thoene K
- Thomassen M
- Thull DL
- Tischkowitz M
- Toland AE
- Torres D
- Truong T
- Tung N
- Vachon CM
- van Asperen CJ
- van den Ouweland AMW
- van der Baan FH
- van der Hout AH
- van der Kolk LE
- van der Luijt RB
- van Deurzen CHM
- van Doorn HC
- van Engelen K
- van Hest L
- van Os TAM
- van Rensburg EJ
- Varon-Mateeva R
- Vega A
- Venat-Bouvet L
- Verhoef S
- Viel A
- Vogel MJ
- Walker L
- Wang Q
- Wang-Gohrke S
- Wappenschmidt B
- Weber BHF
- Weitzel JN
- Wendt C
- Wijnen JT
- Wilcken N
- Winqvist R
- Yang XR
- Yannoukakos D
- Yip D
- Zheng W
- Ziogas A
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. We determine the directional effect of gene expression on disease risk measured based on single and multiple eQTL. In addition, using a gene-based test of association that considers eQTL from multiple tissues, we identify seven (and four) regions with variants associated with overall (and ER-negative) breast cancer risk, which were not reported in previous GWAS. Further investigation of the function of the implicated genes in breast and immune cells may provide insights into the etiology of breast cancer.Peer reviewe
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