6 research outputs found
Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants
- Author
- Abbas Dehghan
- Abdonas Tamosiunas
- Abdullatif S Husseini
- Abhijit Sen
- Abla M Sibai
- Adela Chirita-Emandi
- Adolfo Rubinstein
- Afshin Ostovar
- Ahmad Ali Noorbala
- Ahmad Ali Zainuddin
- Ahmad Faudzi Yusoff
- Aicha Soumare
- Aida Pilav
- Akihiro Yoshihara
- Akram Pourshams
- Ala'a Alkerwi
- Alain Morejon
- Albert Hofman
- Albertino Damasceno
- Alberto Barceló
- Alejandro Diaz
- Aleksandar Džakula
- Aleksander Giwercman Wu
- Aleksandra Piwonska
- Alet H Wijga
- Aletta E Schutte
- Alexandre C Pereira
- Alicia Matijasevich
- Alina Kerimkulova
- Aline Meirhaeghe
- Aline Wagner
- Alireza Ahmadvand
- Alisha N Wade
- Alison J Hayes
- Allan Linneberg
- Altan Onat
- Aluisio J D Barros
- Alun Evans
- Ambady Ramachandran
- Amina Barkat
- Amir Kasaeian
- Amirabbas Momenan
- Ana Azevedo
- Ana B Crujeiras
- Ana Henriques
- Ana Jelaković
- Ana Maria B Menezes
- Ana Paula C Cândido
- Anders Grøntved
- Andre L Guimaraes
- Andre P Kengne
- Andre Pascal Kengne
- Andrea R V R Horimoto
- Andres Metspalu
- Andrzej Pajak
- Andrzej Wiecek
- Aneta Grajda
- Angela Chetrit
- Angela Döring
- Angelique W Chan
- Ann-Sofie Forslund
- Anna Bugge
- Anna G Iannone
- Annamari Lundqvist
- Anne Juolevi
- Anne Taylor
- Anne Tjonneland
- Anneke Blokstra
- Annette Peters
- Annika Rosengren
- Anoosheh Ghasemian
- Anselmo J Mc Donald Posso
- Anthony Kafatos
- Antoinette Amuzu
- Antonia Trichopoulou
- Antonio Bernabe-Ortiz
- Antonio Cabrera de León
- Antonis Zampelas
- Anup Ghimire
- Anwar M Batieha
- Arnaud Chiolero
- Aroor Bhagyalaxmi
- Aryeh D Stein
- Assembekov Batyrbek
- Astrid Petersmann
- Atul Trivedi
- Augusto F Di Castelnuovo
- Aung Soe Htet
- Avula Laxmaiah
- Avula Laxmaiah
- Axel C Carlsson
- Aya Mostafa
- Aye Aye Sein
- Aziz al-Safi Ismail
- Bagher Larijani
- Balkish M Naidu
- Baurzhan Zhussupov
- Beata Gurzkowska
- Belong Cho
- Ben Schöttker
- Benjamin Acosta-Cazares
- Benoit Salanave
- Bernardo L Horta
- Bernhard Föger
- Betina H Thuesen
- Bharathi Viswanathan
- Bihungum Bista
- Bill Stavreski
- Bin Zhou
- Blanca Sandra Ruiz-Betancourt
- Bogdan Wojtyniak
- Bojan Jelaković
- Bontha V Babu
- Breige A McNulty
- Carl Lachat
- Carlo M Barbagallo
- Carlos A Aguilar-Salinas
- Carlos P Boissonnet
- Carmelo A Caserta
- Carolina B Tarqui-Mamani
- Caroline H Fall
- Carsten O Schmidt
- Catherine Kyobutungi
- Catherine Leclercq
- Catterina Ferreccio
- Cecilia Björkelund
- Cesar G Victora
- Chao Qiang Jiang
- Charles Agyemang
- Charles K Mondo
- Charles Lugero
- Charles Sossa Jérome
- Charumathi Sabanayagam
- Chiara Donfrancesco
- Chien-An Sun
- Chien-Jen Chen
- Ching-Yu Cheng
- Chris Cowell
- Christa L Lilly
- Christa Meisinger
- Christina Howitt
- Christine Cameron
- Christophe Tzourio
- Chung T Nguyen
- Cihangir Erem
- Claudia M Hormiga
- Clive Osmond
- Cláudia S Minderico
- Con Burns
- Constance Schultsz
- Cora L Craig
- Cristina Padez
- Cristina Taddei
- Cynthia Robitaille
- Cyrus Cooper
- Daan Kromhout
- Dalia Luksiene
- Damaskini Valvi
- Damian K Francis
- Dan Zhu
- Daniel A Rangel Reina
- Daniel Ansong
- Daniel Fernández-Bergés
- Daniel Ferrante
- David Faeh
- Davide Noto
- Davood Khalili
- Deepa Weerasekera
- Deepak N Amarapurkar
- Delphine De Smedt
- Dermot O'Reilly
- Diana A Santos
- Diana Kuh
- Dianna J Magliano
- Dickman Gareta
- Diego Augusto Santos Silva
- Diego G Christofaro
- Diego Salmerón
- Diego Vanuzzo
- Dimitrios Papandreou
- Dimitrios Trichopoulos
- Dirk De Bacquer
- Dirk Vanderschueren
- Domenico Palli
- Dominique Arveiler
- Dominique Cottel
- Dong Wook Shin
- Dong Zhao
- Dongfeng Gu
- Dora Romaguera
- Doris Stöckl
- Dušan Grafnetter
- Dénes Molnár
- E Shyong Tai
- Eduardo Salazar Martinez
- Eero O Kajantie
- Ei Ei K Nang
- Eiji Oda
- Eira Viikari-Juntura
- Elena Pahomova
- Eleonora d'Orsi
- Elias F Gudmundsson
- Elin Kolle
- Elio Riboli
- Elisabete Ramos
- Eliza Cinteza
- Ellis Owusu-Dabo
- Ellisiv B Mathiesen
- Els Clays
- Elzbieta Dziankowska-Zaborszczyk
- Eman Aly
- Emily Sonestedt
- Emmanuel A Williams
- Emmanuella Magriplis
- Eng Joo Tan
- Enzo Manzato
- Erkin Mirrakhimov
- Espen Bjertness
- Esther Zimmermann
- Eugène Sobngwi
- Eunice E Ugel
- Eva Maria Navarrete-Muñoz
- Fabio Galvano
- Fangfang Chen
- Farshad Farzadfar
- Farzad Hadaegh
- Felipe F Casanueva
- Felix Gutzwiller
- Felix K Assah
- Fereidoun Azizi
- Fernando Rigo
- Fernando Rodríguez-Artalejo
- Fikru Tullu
- Flavio D Fuchs
- Flavio Nervi
- Francesco Branca
- Francesco Gianfagna
- Francesco Panza
- Francisco J Felix-Redondo
- Frank Claessens
- Frank Tanser
- Fred Michel Paccaud
- Freda Pitakaka
- Frederic Gottrand
- Frederick C Wu
- Gabriele Nagel
- Gabriella Gruden
- Gailute Bernotiene
- Garry Jennings
- Geetha R Menon
- Georg Lappas
- George L L Machado-Coelho
- George Moschonis
- George S Stergiou
- Giovanni de Gaetano
- Giovanni Veronesi
- Giselle Sarganas
- Giuseppe Grosso
- Glenn Oehlers
- Gonul Horasan Dinc
- Gonzalo Valdivia
- Goodarz Danaei
- Goodarz Danaei
- Graziella Bruno
- Graziella D'Arrigo
- Grazyna Jasienska
- Gregor Jurak
- Gregor Starc
- Gregor Starc
- Gretchen A Stevens
- Guang Ning
- Guansheng Ma
- Guillermo Frontera
- Gustavo Velasquez-Melendez
- Guy De Backer
- Gyulli Kazakbaeva
- Günay Can
- H B(as) Bueno-de-Mesquita
- Ha T P Do
- Haakon E Meyer
- Habiba Ben Romdhane
- Haiquan Xu
- Hajer Aounallah-Skhiri
- Han C G Kemper
- Hanna K Tolonen
- Hannelore K Neuhauser
- Hannelore K Neuhauser
- Hanno Ulmer
- Hannu M T Uusitalo
- Hans Concin
- Harshpal S Sachdev
- Harunobu Nakamura
- Hashem Jaddou
- Heba M Fouad
- Heiner Boeing
- Helen Gonçalves
- Heloisa Bettiol
- Herculina S Kruger
- Herman Schargrodsky
- Hermann Brenner
- Himanshu K Chaturvedi
- Hoang Van Minh
- Holger Theobald
- Honor Bixby
- Hossein Poustchi
- Hsien-Ho Lin
- Huashuai Chen
- Hui Cai
- Hung-Kwan So
- Hynek Pikhart
- Hélène Delisle
- Ian R Hambleton
- Ian R Hambleton
- Idowu O Senbanjo
- Idris Guessous
- Ilona Nenko
- Ilpo Tapani Hihtaniemi
- Imane Cherkaoui Dekkaki
- Imperia Brajkovich
- Imre Janszky
- Ina S Santos
- Indah S Widyahening
- Indrapal I Meshram
- Inge Huybrechts
- Inger Ariansen
- Iqbal Bata
- Iraj Nabipour
- Irene G M van Valkengoed
- Iris Pigeot
- Isabel O Oliveira
- Ivan Pecin
- Ivana Radic
- J Jaime Miranda
- Jaakko Mursu
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- Jacek Jóźwiak
- Jacqueline F Price
- Jakub Stokwiszewski
- Jalila El Ati
- James Bennett
- James Bentham
- Jan A Staessen
- Jana Námešná
- Janette Walton
- Janina Petkeviciene
- Janne S Tolstrup
- Japhet Killewo
- Jardena J Puder
- Jari J Jokelainen
- Jaume Marrugat
- Jean Claude N Mbanya
- Jean Dallongeville
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- Jean Woo
- Jean-Michel Gaspoz
- Jeannette Lee
- Jeonghee Lee
- Jeongseon Kim
- Jeremy M Jacobs
- Jerzy Chudek
- Jesus Vioque
- Jiang He
- Jie Mi
- Jim I Mann
- Jin Soo Moon
- Jing Liu
- Jing Liu
- Joana Araújo
- Joanne Katz
- Jochanan Stessman
- Jody C Miller
- Joel G R Roy
- Johan G Eriksson
- Johan Sundström
- Johan Sundström
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- Judith Simons
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- Kenji Shibuya
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- Krista Fischer
- Kumiko Ohara
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- Martin Neovius
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- Mohamed Bamoshmoosh
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- null null
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- Olli Raitakari
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- Orlando Landrove
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- Oscar H Franco
- Osman Ali
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- Ozren Polašek
- Paibul Suriyawongpaisal
- Panayiotis K Yiallouros
- Paolo Vineis
- Pascal Bovet
- Patrick Kolsteren
- Paul Elliott
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- Paul Korrovits
- Paula Duarte de Oliveira
- Paula Margozzini
- Paulo A Lotufo
- Pawel Kurjata
- Pedro Marques-Vidal
- Pedro Ordunez
- Pedro Plans-Rubió
- Per Lytsy
- Per Tynelius
- Peter Bjerregaard
- Peter H Whincup
- Peter Lund Kristensen
- Peter Stehle
- Peter Ueda
- Peter Vollenweider
- Peter Willeit
- Petra H Peeters
- Philippe Amouyel
- Pierre Traissac
- Pietro A Modesti
- Piotr Bandosz
- Prabhdeep Kaur
- Pradeep Joshi
- Prakash C Gupta
- Przemyslaw Slusarczyk
- Qian Wang
- Quang Ngoc Nguyen
- Quang V Nguyen
- Queenie Chan
- R Krishna Kumar
- Rachael M McLean
- Rachakulla Hari Kumar
- Rachel Cooper
- Rachel Dankner
- Radwan F Qasrawi
- Rahul Malhotra
- Rainford J Wilks
- Rajaa Al-Raddadi
- Rajeev Gupta
- Rajendra Pradeepa
- Rajiv T Erasmus
- Ramfis E Nieto-Martínez
- Ramin Heshmat
- Ramiro Guerrero
- Ranjit Mohan Anjana
- Raphael M Ritti-Dias
- Rebecca A Goldsmith
- Rebecca Hardy
- Renata Cifkova
- Renata Kuciene
- Renata Nunes dos Santos
- Reynaldo Martorell
- Reza Malekzadeh
- Reza Malekzadeh
- Ricardas Radisauskas
- Rildo S Wanderley
- Robert Beaglehole
- Robert Eggertsen
- Robert J Adams
- Roberto Elosua
- Roberto Lorbeer
- Robespierre Ribeiro
- Rod T Jackson
- Rod T Jackson
- Rodrigo M Carrillo-Larco
- Rody G Sy
- Roman Topór-Madry
- Romulo A Fernandes
- Ronald D Gregor
- Roosmarijn Verstraeten
- Rosalba Rojas-Martinez
- Rosalynn Siantar
- Rossana Borchini
- Roy A Wong-McClure
- Roya Kelishadi
- Rudolf Kaaks
- Rui Ornelas
- Rute Santos
- Ruzena Kubinova
- S Goya Wannamethee
- Sabina Zambon
- Sabine Schipf
- Sadaf G Sepanlou
- Sai Yin Ho
- Salim Mohanna
- Sameer Narake
- Sandra C Fuchs
- Sania Nishtar
- Sanjay Rampal
- Sanjib K Sharma
- Santosh K Bhargava
- Sarah P Garnett
- Sari Voutilainen
- Sauli Herrala
- Savvas Savva
- Scott B McLean
- Seppo Koskinen
- Sergej M Ostojic
- Sergio Viana Peixoto
- Seung-lyeal Jeong
- Shahab Khatibzadeh
- Shelly R McFarlane
- Shirin Djalalinia
- Shirin Djalalinia
- Shouling Wu
- Shu-Ti Chiou
- Shuohua Chen
- Sian M Robinson
- Sibel Sakarya
- Sidsel Graff-Iversen
- Sigmund A Anderssen
- Silvana P Donoso
- Simona Bo
- Simona Costanzo
- Simona Giampaoli
- Sine Skovbjerg
- Sirkka Keinänen-Kiukaanniemi
- Slawomir Koziel
- Snehalatha Chamukuttan
- Sofia Malyutina
- Sok King Ong
- Son Thai Pham
- Songhomitra Panda-Jonas
- Soon-Woo Park
- Sophie Visvikis-Siest
- Sounnia Mediene-Benchekor
- Stefaan De Henauw
- Stefan Kiechl
- Stefan Söderberg
- Stefania Maggi
- Steinar Krokstad
- Stela McLachlan
- Stephen T McGarvey
- Sudha Ramachandra Rao
- Sudhir Kowlessur
- Suhad Bahijri
- Suka Machi
- Sumit Bharadwaj
- Susana Sans
- Susi Kriemler
- Suzanne C Ho
- Tahir Aris
- Tai Hing Lam
- Takuro Furusawa
- Tandi E Matsha
- Tanja Stocks
- Tara C Coppinger
- Tazeen Jafar
- Teemu J Niiranen
- Teresa Norat
- Terho Lehtimäki
- Thein Thein Htay
- Thet Thet Mu
- Thomas M Dantoft
- Thor Aspelund
- Thorkild I A Sørensen
- Tien Yin Wong
- Tiffany K Gill
- Tiina Laatikainen
- Tiina Vlasoff
- Timothy Key
- Tobias F Rinke de Wit
- Tom Wilsgaard
- Tomas Vega
- Tomasz Grodzicki
- Tomasz Zdrojewski
- Tomi-Pekka Tuomainen
- Torben Jørgensen
- Toshiharu Ninomiya
- Tran Quoc Bao
- Trevor S Ferguson
- Tuyen D Le
- Ty T Dickerson
- Ulf Ekelund
- Ulrich Keil
- Urho M Kujala
- Ursula Kiechl-Kohlendorfer
- Valérie Deschamps
- Vanina Bongard
- Vanja Ivkovic
- Veikko Salomaa
- Ver Bilano
- Vera Grujic
- Vera Lanska
- Vera Musil
- Vesna Jureša
- Vilma E Irazola
- Vilmundur Gudnason
- Vilnis Dzerve
- Vinay B Nangia
- Vincenzo Capuano
- Vincenzo Solfrizzi
- Virginija Dulskiene
- Viswanathan Mohan
- Viviane C Cardoso
- W M Monique Verschuren
- Wan Mohamad Wan Bebakar
- Wan Nazaimoon Wan Mohamud
- Wan Zhu Zhang
- Wei Zheng
- Wei-Yen Lim
- Weili Yan
- Wen-Harn Pan
- Wenhua Zhao
- Wichai Aekplakorn
- William A Neal
- Winsome R Parnell
- Wojciech Drygas
- Wolfgang Ahrens
- Xenophon Theodoridis
- Xiaoguang Yang
- Xingwang Ye
- Xu Lin
- Xun Tang
- Ya Xing Wang
- Yadlapalli S Kusuma
- Yannis Manios
- Yanping Li
- Yeon-Yong Kim
- Yi Song
- Yi Zeng
- Ying-Wei Wang
- Yingfeng Zheng
- Yn-Tz Sung
- Yong Tao
- Yonghua Hu
- Youchan Shin
- Young-Ho Khang
- Young-Ho Khang
- Yousef Saleh Khader
- Yufang Bi
- Yuki Fujita
- Yumi Cho
- Yuna He
- Yvonne T van der Schouw
- Zbigniew Gaciong
- Zbigniew Kulaga
- Zhengming Chen
- Zhengming Chen
- Ziad A Abdeen
- Publication venue
- ZU Scholars
- Publication date
- 01/01/2018
- Field of study
© The Author(s) 2018. Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20-29 years to 70-79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probittransformed) prevalence of raised blood pressure and age-group- and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure. Results: In 2005-16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the highincome Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association. Conclusions: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups
Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)
- Author
- Abarca-Gómez Leandra
- Abdeen Ziad A
- Abdrakhmanova Shynar
- Abu-Rmeileh Niveen M
- Acosta-Cazares Benjamin
- Adams Robert J
- Aekplakorn Wichai
- Afsana Kaosar
- Afzal Shoaib
- Agdeppa Imelda A
- Aghazadeh-Attari Javad
- Aguilar-Salinas Carlos A
- Agyemang Charles
- Ahmad Mohamad Hasnan
- Ahmad Noor Ani
- Ahmadi Ali
- Ahmadi Naser
- Ahmed Soheir H
- Ahrens Wolfgang
- Aitmurzaeva Gulmira
- Ajlouni Kamel
- Al Nsour Mohannad
- Al-Hazzaa Hazzaa M
- Al-Lahou Badreya
- Al-Raddadi Rajaa
- Alarouj Monira
- AlBuhairan Fadia
- AlDhukair Shahla
- Ali Mohamed M
- Alkandari Abdullah
- Alkerwi Ala'a
- Allin Kristine
- Alvarez-Pedrerol Mar
- Aly Eman
- Amarapurkar Deepak N
- Amiri Parisa
- Amougou Norbert
- Amouyel Philippe
- Anderssen Sigmund A
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- Shengelia Lela
- Shi Zumin
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- Skodje Gry
- Slowikowska-Hilczer Jolanta
- Slusarczyk Przemyslaw
- Smeeth Liam
- So Hung-Kwan
- Soares Fernanda Cunha
- Sobek Grzegorz
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- Soekatri Moesijanti YE
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- Solomon Bethlehem D
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- Sorić Maroje
- Soto-Rojas Victoria E
- Soumaré Aïcha
- Sovic Slavica
- Sparboe-Nilsen Bente
- Sparrenberger Karen
- Spinelli Angela
- Spiroski Igor
- Staessen Jan A
- Stamm Hanspeter
- Starc Gregor
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- Staub Kaspar
- Stavreski Bill
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- Stergiou George S
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- Stevens Gretchen A
- Stieber Jutta
- Stocks Tanja
- Stokwiszewski Jakub
- Stoyanova Ekaterina
- Stratton Gareth
- Stronks Karien
- Strufaldi Maria Wany
- Sturua Lela
- Stöckl Doris
- Suka Machi
- Sun Chien-An
- Sundström Johan
- Sung Yn-Tz
- Sunyer Jordi
- Suriyawongpaisal Paibul
- Suárez-Medina Ramón
- Swinburn Boyd A
- Sy Rody G
- Syddall Holly E
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- Taddei Cristina
- Tai E Shyong
- Tammesoo Mari-Liis
- Tamosiunas Abdonas
- Tan Eng Joo
- Tang Xun
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- Trichopoulos Dimitrios
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- Trivedi Atul
- Tshepo Lechaba
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- Tullu Fikru
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- Ueda Peter
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- Unal Belgin
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- Velika Biruta
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- Vrkic Tajana Zeljkovic
- Völzke Henry
- Wade Alisha N
- Wagner Aline
- Waldhör Thomas
- Walton Janette
- Wambiya Elvis OA
- Wang Ming-Dong
- Wang Ningli
- Wang Qian
- Wang Xiangjun
- Wang Ya Xing
- Wang Ying-Wei
- Wannamethee S Goya
- Wareham Nicholas
- Weber Adelheid
- Wedderkopp Niels
- Weerasekera Deepa
- Weghuber Daniel
- Wei Wenbin
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- Werner Bo
- Whincup Peter H
- Widhalm Kurt
- Widyahening Indah S
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- Wilks Rainford J
- Willeit Johann
- Willeit Peter
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- Wong Andrew
- Wong Jyh Eiin
- Wong Norazizah Ibrahim
- Wong Tien Yin
- Wong-McClure Roy A
- Woo Jean
- Woodward Mark
- Wu Frederick C
- Wu Jianfeng
- Wu Li Juan
- Wu Shouling
- Xu Haiquan
- Xu Liang
- Yaacob Nor Azwany
- Yamborisut Uruwan
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yardim Nazan
- Yaseri Mehdi
- Yasuharu Tabara
- Ye Xingwang
- Yiallouros Panayiotis K
- Yoosefi Moein
- Yoshihara Akihiro
- You Qi Sheng
- You San-Lin
- Younger-Coleman Novie O
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zaccagni Luciana
- Zafiropulos Vassilis
- Zainuddin Ahmad A
- Zakavi Seyed Rasoul
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zamrazilová Hana
- Zapata Maria Elisa
- Zargar Abdul Hamid
- Zdrojewski Tomasz
- Zejglicova Kristyna
- Zeng Yi
- Zhang Luxia
- Zhang Zhen-Yu
- Zhao Dong
- Zhao Ming-Hui
- Zhao Wenhua
- Zhen Shiqi
- Zheng Wei
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhou Maigeng
- Zhu Dan
- Zins Marie
- Zitt Emanuel
- Zocalo Yanina
- Zuziak Monika
- Ängquist Lars
- Łuszczki Edyta
- Ševcíková Ludmila
- Publication venue
- eLife Sciences Publications
- Publication date
- 01/01/2021
- Field of study
From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions
Nuclear localization of TRK-A in liver cells
- Author
- Publication venue
- Murcia : F. Hernández
- Publication date
- 01/01/2008
- Field of study
The liver represents a site of expression of
neurotrophins and their receptors. We have characterized
the expression and intracellular localization of the nerve
growth factor (NGF) receptor, Trk-A, in liver cells in
vivo and in vitro. In both normal and fibrotic liver tissue,
Trk-A immunostaining was present in different cell
types, including parenchymal cells and cells of the
inflammatory infiltrate. In hepatocytes and activated
stellate cells (HSC), Trk-A showed a predominant
nuclear localization, both in the presence and absence of
injury. In cultured HSC, Trk-A was found to be
functional, because exposure of the cells to recombinant
NGF resulted in stimulation of cell migration and
activation of intracellular signaling pathways, including
Ras-ERK and PI3K/Akt. Remarkably, in cultured HSC,
Trk-A staining was found constitutively in the nucleus.
In these cells, Trk-A could be stained only by antibodies
directed against the intracellular domain but not by those
recognizing the extracellular portion of Trk-A
suggesting that the intracellular portion of the receptor is
the major determinant of nuclear Trk-A staining. In contrast to HSC, freshly isolated hepatocytes did not
show any nuclear localization of the intracellular portion
of Trk-A. In pheocromocytoma cells, nuclear staining
for Trk-A was not present in conditions of serum
deprivation, but could be induced by exposure to NGF or
to a mixture of soluble mediators. We conclude that
nuclear localization of the intracellular domain of Trk-A
is observed constitutively in liver cells such as HSC,
while in other cell types it could be induced in response
to soluble factors
Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants
- Author
- Abarca-Gómez Leandra
- Abdeen Ziad A
- Abu-Rmeileh Niveen M
- Acosta-Cazares Benjamin
- Adams Robert J
- Aekplakorn Wichai
- Afsana Kaosar
- Aguilar-Salinas Carlos A
- Agyemang Charles
- Ahmad Noor Ani
- Ahmadvand Alireza
- Ahrens Wolfgang
- Ajlouni Kamel
- Akhtaeva Nazgul
- Al Nsour Mohannad
- Al-Raddadi Rajaa
- al-Safi Ismail Aziz
- Ali Mohamed M
- Ali Osman
- Alkerwi Ala'a
- Aly Eman
- Amarapurkar Deepak N
- Amouyel Philippe
- Amuzu Antoinette
- Andersen Lars Bo
- Anderssen Sigmund Alfred
- Anjana Ranjit Mohan
- Ansong Daniel
- Aounallah-Skhiri Hajer
- Araujo Joana
- Ariansen Inger
- Aris Tahir
- Arlappa Nimmathota
- Arveiler Dominique
- Aryal Krishna K
- Aspelund Thor
- Assah Felix K
- Assunção Maria Cecília Formoso
- Avdicova Macria
- Azevedo Ana
- Azizi Fereidoun
- Babu Bontha V
- Bahijri Suhad
- Balakrishna Nagalla
- Bamoshmoosh Mohamed
- Banach Maciej
- Bandosz Piotr
- Banegas Jose R
- Bao Khanh Le Nguyen
- Bao Tran Quoc
- Barbagallo Carlo M
- Barceló Alberto
- Barkat Amina
- Barros Aluisio JD
- Barros Mauro V
- Bata Iqbal
- Batieha Anwar M
- Batyrbek Assembekov
- Baur Louise A
- Beaglehole Robert
- Benet Mikhail
- Bennett James
- Benson Lowell S
- Bentham James
- Bernabe-Ortiz Antonio
- Bernotiene Gailute
- Bettiol Heloisa
- Bhagyalaxmi Aroor
- Bharadwaj Sumit
- Bhargava Santosh K
- Bi Yufang
- Bikbov Mukharram
- Bilano Ver
- Bista Bihungum
- Bixby Honor
- Bjerregaard Peter
- Bjertness Espen
- Bjertness Marius Bergsmark
- Björkelund Cecilia
- Blokstra Anneke
- Bo Simona
- Bobak Martin
- Boeing Heiner
- Boggia Jose G
- Boissonnet Carlos P
- Boker Lital Keinan
- Bongard Vanina
- Borchini Rossana
- Bovet Pascal
- Braeckman Lutgart
- Brajkovich Imperia
- Branca Francesco
- Breckenkamp Juergen
- Brenner Hermann
- Brewster Lizzy M
- Bruno Graziella
- Bueno-De-Mesquita Hendrik Bastiaan
- Bugge Anna
- Burns Con
- Bursztyn Michael
- Cacciottolo Joseph
- Cadena Leticia Hernandez
- Cai Hui
- Cameron Christine
- Can Gunay
- Candido Ana Paula C
- Capuano Vincenzo
- Cardoso Viviane C
- Carlsson Axel C
- Carrillo-Larco Rodrigo M
- Carvalho Maria J
- Casanueva Felipe F
- Casas Juan-Pablo
- Caserta Carmelo A
- Chamukuttan Snehalatha
- Chan Angelique W
- Chan Queenie
- Chaturvedi Himanshu K
- Chaturvedi Nishi
- Chen Chien-Jen
- Chen Fangfang
- Chen Huashuai
- Chen Shuohua
- Chen Zhengming
- Cheng Ching-Yu
- Chetrit Angela
- Chiolero Arnaud
- Chiou Shu-Ti
- Chirita-Emandi Adela
- Chirlaque Maria-Dolores
- Cho Belong
- Cho Yumi
- Christofaro Diego G
- Chudek Jerzy
- Cifkova Renata
- Cinteza Eliza
- Cisneros Julio Zuñiga
- Claessens Frank
- Clays Els
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- Cooper Cyrus
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- Cottel Dominique
- Cowan Melanie J
- Cowell Chris
- Craig Cora L
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- Cruz Juan J
- D'Arrigo Graziella
- d'Orsi Eleonora
- Dallongeville Jean
- Damasceno Albertino
- Danaei Goodarz
- Dankner Rachel
- Dantoft Thomas M
- Dauchet Luc
- Davletov Kairat
- De Backer Guy
- De Bacquer Dirk
- de Gaetano Giovanni
- De Henauw Stefaan
- de Léon Antonio Cabrera
- de Oliveira Paula Duarte
- De Smedt Delphine
- Deepa Mohan
- Dehghan Abbas
- Dekkaki Imane Cherkaoui
- Delisle Helene
- Deschamps Valerie
- Dhana Klodian
- Di Castelnuovo Augusto F
- Di Cesare Mariachiara
- Dias-da-Costa Juvenal Soares
- Diaz Alejandro
- Dickerson Ty T
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- Djalalinia Shirin
- Do Ha TP
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- Donfrancesco Chiara
- Donoso Silvana P
- Doring Angela
- Dorobantu Maria
- Doua Kouamelan
- Drygas Wojciech
- Dulskiene Virginija
- Dzakula Aleksandar
- Dzerve Vilnis
- Dziankowska-Zaborszczyk Elzbieta
- Eggertsen Robert
- Ekelund Ulf
- El Ati Jalila
- Elliott Paul
- Elosua Roberto
- Erasmus Rajiv T
- Erem Cihangir
- Eriksen Louise
- Eriksson Johan G
- Escobedo-de la Peña Jorge
- Evans Alun
- Ezzati Majid
- Faeh David
- Fall Caroline H
- Farzadfar Farshad
- Felix-Redondo Francisco J
- Ferguson Trevor S
- Fernandes Romulo A
- Fernandez-Berges Daniel
- Ferrante Daniel
- Ferrari Marika
- Ferreccio Catterina
- Ferrieres Jean
- Finn Joseph D
- Fischer Krista
- Foger Bernhard
- Foo Leng Huat
- Forslund Ann-Sofie
- Forsner Maria
- Fouad Heba M
- Francis Damian K
- Franco Maria do Carmo
- Franco Oscar H
- Frontera Guillermo
- Fuchs Flavio D
- Fuchs Sandra C
- Fujita Yuki
- Furusawa Takuro
- Gaciong Zbigniew
- Galvano Fabio
- Garcia-de-la-Hera Manoli
- Gareta Dickman
- Garnett Sarah P
- Gaspoz Jean-Michel
- Gasull Magda
- Gates Louise
- Geleijnse Johanna M
- Ghasemian Anoosheh
- Ghimire Anup
- Giampaoli Simona
- Gianfagna Francesco
- Gill Tiffany K
- Giovannelli Jonathan
- Goldsmith Rebecca A
- Gonzalez-Gross Marcela
- González-Rivas Juan P
- Gonçalves Helen
- Gorbea Mariano Bonet
- Gottrand Frederic
- Graff-Iversen Sidsel
- Grafnetter Dusan
- Grajda Aneta
- Grammatikopoulou Maria G
- Gregor Ronald D
- Grodzicki Tomasz
- Grosso Giuseppe
- Gruden Gabriella
- Grujic Vera
- Grøntved Anders
- Gu Dongfeng
- Guan Ong Peng
- Gudmundsson Elias F
- Gudnason Vilmundur
- Guerrero Ramiro
- Guessous Idris
- Guimaraes Andre L
- Gulliford Martin C
- Gunnlaugsdóttir Johanna
- Gunter Marc
- Gupta Prakash C
- Gupta Rajeev
- Gureje Oye
- Gurzkowska Beata
- Gutierrez Laura
- Gutzwiller Felix
- Hadaegh Farzad
- Hajifathalian Kaveh
- Halkjær Jytte
- Hambleton Ian R
- Hardy Rebecca
- Hata Jun
- Hayes Alison J
- He Jiang
- He Yuna
- Hendriks Marleen Elisabeth
- Henriques Ana
- Herrala Sauli
- Heshmat Ramin
- Hihtaniemi Ilpo Tapani
- Ho Sai Yin
- Ho Suzanne C
- Hobbs Michael
- Hofman Albert
- Horimoto Andrea RVR
- Hormiga Claudia M
- Horta Bernardo L
- Houti Leila
- Howitt Christina
- Htay Thein Thein
- Htet Aung Soe
- Htike Maung Maung Than
- Hu Yonghua
- Huerta José María
- Huisman Martijn
- Husseini Abdullatif S
- Huybrechts Inge
- Hwalla Nahla
- Iacoviello Licia
- Iannone Anna G
- Ibrahim Mohsen M
- Ikeda Nayu
- Ikram M Arfan
- Irazola Vilma E
- Islam Muhammad
- Ivkovic Vanja
- Iwasaki Masanori
- Jackson Rod T
- Jacobs Jeremy M
- Jaddou Hashem
- Jafar Tazeen
- Jamrozik Konrad
- Janszky Imre
- Jasienska Grazyna
- Jelakovic Bojan
- Jennings Garry
- Jeong Seung-Lyeal
- Jiang Chao Qiang
- Joffres Michel
- Johansson Mattias
- Jokelainen Jari J
- Jonas Jost B
- Joshi Pradeep
- Juolevi Anne
- Jurak Gregor
- Juresa Vesna
- Jérome Charles Sossa
- Jóźwiak Ana
- Jóźwiak Jacek Jerzy
- Jørgensen Torben
- Kaaks Rudolf
- Kafatos Anthony
- Kajantie Eero O
- Kalter-Leibovici Ofra
- Kamaruddin Nor Azmi
- Karki Khem B
- Kasaeian Amir
- Katz Joanne
- Kauhanen Jussi
- Kaur Prabhdeep
- Kavousi Maryam
- Kazakbaeva Gyulli
- Keil Ulrich
- Keinänen-Kiukaanniemi Sirkka
- Kelishadi Roya
- Kemper Han CG
- Kengne Andre P
- Kengne Andre Pascal
- Kerimkulova Alina
- Kersting Mathilde
- Key Timothy
- Khader Yousef Saleh
- Khalili Davood
- Khang Young-Ho
- Khateeb Mohammad
- Khatibzadeh Shahab
- Khaw Kay-Tee
- Kiechl Stefan
- Kiechl-Kohlendorfer Ursula
- Killewo Japhet
- Kim Jeongseon
- Kim Yeon-Yong
- Klumbiene Jurate
- Knoflach Michael
- Kolle Elin
- Kolsteren Patrick
- Korrovits Paul
- Koskinen Seppo
- Kouda Katsuyasu
- Kowlessur Sudhir
- Koziel Slawomir
- Kriemler Susi
- Kristensen Peter Lund
- Krokstad Steinar
- Kromhout Daan
- Kruger Herculina S
- Kubinova Ruzena
- Kuciene Renata
- Kuh Diana
- Kujala Urho M
- Kulaga Zbigniew
- Kumar R Krishna
- Kumar Rachakulla Hari
- Kurjata Pawel
- Kusuma Yadlapalli S
- Kuulasmaa Kari
- Kyobutungi Catherine
- Laatikainen Tiina
- Lachat Carl
- Lam Tai Hing
- Landrove Orlando
- Lanska Vera
- Lappas Georg
- Larijani Bagher
- Laugsand Lars Erik
- Laxmaiah Avula
- Le Tuyen D
- Leclercq Catherine
- Lee Jeannette
- Lee Jeonghee
- Lehtimäki Terho
- Leon-Munoz Luz M
- Levitt Naomi S
- Li Yanping
- Lilly Christa L
- Lim Wei-Yen
- Lima-Costa M Fernanda
- Lin Hsien-Ho
- Lin Xu
- Lind Lars
- Linneberg Allan
- Lissner Lauren
- Litwin Mieczyslaw
- Liu Jing
- Lorbeer Roberto
- Lotufo Paulo A
- Lozano Jose Eugenio
- Lugero Charles
- Luksiene Dalia
- Lundqvist Annamari
- Lunet Nuno
- Lytsy Per
- Ma Guansheng
- Ma Jun
- Machado-Coelho George LL
- Machi Suka
- Maggi Stefania
- Magliano Dianna J
- Magriplis Emmanuella
- Majer Marjeta
- Makdisse Marcia
- Malekzadeh Reza
- Malhotra Rahul
- Malyutina Sofia
- Manios Yannis
- Mann Jim I
- Manzato Enzo
- Margozzini Paula
- Marques Larissa Pruner
- Marques-Vidal Pedro
- Marrugat Jaume
- Martinez Eduardo Salazar
- Martorell Reynaldo
- Mathiesen Ellisiv B.
- Matijasevich Alicia
- Matsha Tandi E
- Mbanya Jean Claude N
- McFarlane Shelly R
- McGarvey Stephen T
- McLachlan Stela
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- McLean Scott B
- McNulty Breige A
- Mediene-Benchekor Sounnia
- Medzioniene Jurate
- Meirhaeghe Aline
- Meisinger Christa
- Menezes Ana Maria B
- Menon Geetha R
- Meshram Indrapal I
- Metspalu Andres
- Meyer Haakon E
- Mi Jie
- Mikkel Kairit
- Miller Jody C
- Minderico Claudia S
- Miquel Juan Francisco
- Miranda J Jaime
- Mirrakhimov Erkin
- Misigoj-Durakovic Marjeta
- Modesti Pietro A
- Mohamed Mostafa K
- Mohammad Kazem
- Mohammadifard Noushin
- Mohan Viswanathan
- Mohanna Salim
- Molnar Denes
- Momenan Amirabbas
- Mondo Charles K
- Monyeki Kotsedi Daniel K
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- Tjønneland Anne
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- Topbas Murat
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- Trivedi Atul
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- Wan Bebakar Wan Mohamad
- Wan Mohamud Wan Nazaimoon
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- Wang Ming-Dong
- Wang Qian
- Wang Ya Xing
- Wang Ying-Wei
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- Whincup Peter H
- Widhalm Kurt
- Widyahening Indah S
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- Wijga Alet H
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- Willeit Johann
- Willeit Peter
- Williams Emmanuel A
- Wilsgaard Tom
- Wojtyniak Bogdan
- Wong Justin YY
- Wong Norazizah Ibrahim
- Wong Tien Yin
- Wong-McClure Roy A
- Woo Jean
- Woodward Mark
- Wu Aleksander Giwercman
- Wu Frederick C
- Wu Shouling
- Xu Haiquan
- Yan Weili
- Yang Xiaoguang
- Ye Xingwang
- Yiallouros Panayiotis K
- Yoshihara Akihiro
- Younger-Coleman Novie O
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zainuddin Ahmad Ali
- Zambon Sabina
- Zampelas Antonis
- Zdrojewski Tomasz
- Zeng Yi
- Zhang Wan Zhu
- Zhao Dong
- Zhao Wenhua
- Zheng Wei
- Zheng Yingfeng
- Zhou Bin
- Zhu Dan
- Zhussupov Baurzhan
- Zimmermann Esther
- Ängquist Lars H
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2018
- Field of study
Background
Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure.
Methods
We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20–29 years to 70–79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probit-transformed) prevalence of raised blood pressure and age-group- and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure.
Results
In 2005–16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the high-income Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association.
Conclusions
Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups
Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure : A pooled analysis of 1018 population-based measurement studies with 88.6 million participants
- Author
- Abarca-Gómez Leandra
- Abdeen Ziad A.
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adams Robert J.
- Aekplakorn Wichai
- Afsana Kaosar
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahmad Noor Ani
- Ahmadvand Alireza
- Ahrens Wolfgang
- Ajlouni Kamel
- Akhtaeva Nazgul
- Al Nsour Mohannad
- Al-Raddadi Rajaa
- al-Safi Ismail Aziz
- Ali Mohamed M.
- Ali Osman
- Alkerwi Ala'a
- Aly Eman
- Amarapurkar Deepak N.
- Amouyel Philippe
- Amuzu Antoinette
- Andersen Lars Bo
- Anderssen Sigmund Alfred
- Anjana Ranjit Mohan
- Ansong Daniel
- Aounallah-Skhiri Hajer
- Araujo Joana
- Ariansen Inger
- Aris Tahir
- Arlappa Nimmathota
- Arveiler Dominique
- Aryal Krishna K.
- Aspelund Thor
- Assah Felix K.
- Assunção Maria Cecília Formoso
- Avdicova Macria
- Azevedo Ana
- Azizi Fereidoun
- Babu Bontha V.
- Bahijri Suhad
- Balakrishna Nagalla
- Bamoshmoosh Mohamed
- Banach Maciej
- Bandosz Piotr
- Banegas Jose R.
- Bao Khanh Le Nguyen
- Bao Tran Quoc
- Barbagallo Carlo M.
- Barceló Alberto
- Barkat Amina
- Barros Aluisio J. D.
- Barros Mauro V.
- Bata Iqbal
- Batieha Anwar M.
- Batyrbek Assembekov
- Baur Louise A.
- Beaglehole Robert
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- Bernotiene Gailute
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- Bhagyalaxmi Aroor
- Bharadwaj Sumit
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- Bi Yufang
- Bikbov Mukharram
- Bilano Ver
- Bista Bihungum
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- Bjertness Espen
- Bjertness Marius Bergsmark
- Björkelund Cecilia
- Blokstra Anneke
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- Bobak Martin
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- Tarawneh Mohammed Rasoul
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- Taylor Anne
- Theobald Holger
- Theodoridis Xenophon
- ThetMu Thet
- Thijs Lutgarde
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- Tjønneland Anne
- Tolonen Hanna K.
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- Tormo Maria Jose
- Torrent Maties
- Traissac Pierre
- Trichopoulos Dimitrios
- Trichopoulou Antonia
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- van der Schouw Yvonne T.
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- Van Minh Hoang
- van Rossem Lenie
- Van Schoor Natasja M.
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- Voutilainen Sari
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- Wagner Aline
- Walton Janette
- Wan Bebakar Wan Mohamad
- Wan Mohamud Wan Nazaimoon
- Wanderley Rildo S.
- Wang Ming-Dong
- Wang Qian
- Wang Ya Xing
- Wang Ying-Wei
- Wannamethee S Goya
- Wareham Nicholas
- Wedderkopp Niels
- Weerasekera Deepa
- Whincup Peter H.
- Widhalm Kurt
- Widyahening Indah S.
- Wiecek Andrzej
- Wijga Alet H.
- Wilks Rainford J.
- Willeit Johann
- Willeit Peter
- Williams Emmanuel A.
- Wilsgaard Tom
- Wojtyniak Bogdan
- Wong Justin Y. Y.
- Wong Norazizah Ibrahim
- Wong Tien Yin
- Wong-McClure Roy A.
- Woo Jean
- Woodward Mark
- Wu Aleksander Giwercman
- Wu Frederick C.
- Wu Shouling
- Xu Haiquan
- Yan Weili
- Yang Xiaoguang
- Ye Xingwang
- Yiallouros Panayiotis K.
- Yoshihara Akihiro
- Younger-Coleman Novie O.
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zainuddin Ahmad Ali
- Zambon Sabina
- Zampelas Antonis
- Zdrojewski Tomasz
- Zeng Yi
- Zhang Wan Zhu
- Zhao Dong
- Zhao Wenhua
- Zheng Wei
- Zheng Yingfeng
- Zhou Bin
- Zhu Dan
- Zhussupov Baurzhan
- Zimmermann Esther
- Ängquist Lars H.
- Publication venue
- Publication date
- 01/01/2018
- Field of study
Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure.
Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20–29 years to 70–79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probit-transformed) prevalence of raised blood pressure and age-group- and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure.
Results: In 2005–16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the high-income Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association.
Conclusions: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups
Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight
- Author
- Abbas Dehghan (174878)
- Abbas Rezaianzadeh (4401220)
- Abdonas Tamosiunas (64549)
- Abdul Basit (174463)
- Abdul Hamid Zargar (10282958)
- Abdullah Alkandari (5327126)
- Abdullatif Husseini (506385)
- Abhijit Sen (47513)
- Abla M Sibai (9022573)
- Abu AM Hanif (10281725)
- Adela Chirita-Emandi (746896)
- Adelheid Weber (3587942)
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- Afshin Ostovar (8150169)
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- Agnès Le Port (111550)
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- Örn Olafsson (10282322)
- Publication venue
- Publication date
- 09/03/2021
- Field of study
From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions