54 research outputs found
Traumatic Brain Injury in Precariously Housed Persons: Incidence and Risks
- Author
- Askew Julia
- Barr Alasdair M.
- Buchanan Tari4
- Feldman Samantha J.
- Gicas Kristina M.
- Heran Manraj K.
- Honer William G.
- Hu X. Joan
- Lang Donna J.
- Livingston Emily M.
- Loken Thornton Wendy
- MacEwan G. William
- O'
- Panenk William J.
- Sahota Charanveer S.
- Stubbs Jacob L.
- Su Wayne
- Thornton Allen E.
- Vertinsky Alexandra T.
- Woodward Melissa L.
- Xu Linwan
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/02/2022
- Field of study
Background Homeless and precarious housed persons are particularly prone to traumatic brain injuries (TBIs), but existent incidence rates are hampered by poor case acquisition. We rigorously documented TBIs in precariously housed persons transitioning in and out of homelessness.
Methods Between December 2016 and May 2018, 326 precariously housed participants enrolled in a longitudinal study in Vancouver, Canada were assessed monthly for TBI occurrences after education on sequelae. Over one participant-year, 2433 TBI screenings were acquired for 326 person-years and variables associated with odds of incident TBI were evaluated.
Findings One hundred participants acquired 175 TBIs, yielding an observed incidence proportion of 30¢7% and event proportion of 53¢7%. Of the injured, 61% reported one TBI and 39% reported multiple injuries. Acute intoxication was present for more than half of the TBI events assessed. Additionally, 9¢7% of TBI events occurred in the context of a drug overdose. Common injury mechanisms were falls (45¢1%), assaults (25¢1%), and hitting one’s head on an object (13¢1%). In this community-based but non-randomly recruited sample, exploratory analyses identified factors associated with odds of an incident TBI over one year of follow-up, including: schizophrenia disorders (odds ratio (OR) = 0¢43, 95% confidence interval (CI) 0¢19, 0¢94), role functioning (OR = 0¢69, 95% CI 0¢52, 0¢91), opioid dependence (OR = 2¢17, 95% CI 1¢27, 3¢72) and those reporting past TBIs (OR = 1¢99, 95% CI 1¢13, 3¢52).
Interpretation Given the ubiquity of TBIs revealed in this precariously housed sample, we identify an underappreciated and urgent healthcare priority. Several factors modified the odds of incident TBI, which can facilitate investigations into targeted prevention efforts
Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement
- Author
- Alkio M. (Milla)
- Anttila K. (Katja)
- Beer V.J. (Vincent Jacob) de
- Blonden L. (Lau)
- Dalen B.M. (Bas) van
- Duin R.W.B. (Richard) van
- Duncker D.J.G.M. (Dirk)
- Heinonen I.H.A. (Ilkka)
- Hoogstrate Y. (Youri)
- Merkus D. (Daphne)
- Octavia Y. (Yanti)
- Sorop O. (Oana)
- Stubbs A.P. (Andrew)
- Velden J. (Jolanda) van der
- Wouw J. (Jens) van de
- Wüst R.C.I. (Rob C. I.)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
The prevalence of diabetic metabolic derangement (DMetD) has increased dramatically over the last decades. Although there is increasing evidence that DMetD is associated with cardiac dysfunction, the early DMetD-induced myocardial alterations remain incompletely understood. Here, we studied early DMetD-related cardiac changes in a clinically relevant large animal model. DMetD was established in adult male Göttingen miniswine by streptozotocin injections and a high-fat, high-sugar diet, while control animals remained on normal pig chow. Five months later left ventricular (LV) function was assessed by echocardiography and hemodynamic measurements, followed by comprehensive biochemical, molecular and histological analyses. Robust DMetD developed, evidenced by hyperglycemia, hypercholesterolemia and hypertriglyceridemia. DMetD resulted in altered LV nitroso-redox balance
Science Opportunities offered by Mercury's Ice-Bearing Polar Deposits
- Author
- A. K. Virkki
- Abhisek Maiti
- Adrienn Luspay-Kuti
- Alice Lucchetti
- Anthony Colaprete
- Ariel N. Deutsch
- Audrey Vorburger
- B. A. Anzures
- Ben Byron
- Brant M. Jones
- Bryan J. Butler
- Carl Schmidt
- Carolyn M. Ernst
- Cesare Grava
- Christian Klimczak
- Chuanfei Dong
- Colin D. Hamill
- Craig Hardgrove
- D. C. Hickson
- David J. Lawrence
- David T. Blewett
- E. S. Costello
- Edgard G. Rivera-Valentín
- Erwan Mazarico
- Gianrico Filacchione
- Giovanni Bacon
- Gregory A. Neumann
- Hannah C.M. Susorney
- Holly Brown
- Indhu Varatharajan
- Jacob L. Kloos
- James W. Head
- Jamey Szalay
- John Wilson
- Jordan K. Steckloff
- K. M. Cannon
- Kelly E. Miller
- Kristen M. Luchsinger
- L. O. Magana
- Lior Rubanenko
- Margaret E. Landis
- Maria Gritsevich
- Mark A. Schneegurt
- Martin A. Slade
- Matthew A. Siegler
- Maurizio Pajola
- Menelaos Sarantos
- Michael J. Poston
- Mike Sori
- Mona Delitsky
- Nancy L. Chabot
- Noemi Pinilla-Alonso
- Norbert Schorghofer
- Parvathy Prem
- Paul G. Lucey
- Paul K. Byrne
- Paul O. Hayne
- Peter B. James
- Petr Pokorny
- Ronald J. Vervack
- Rosemary M. Killen
- Ross W. K. Potter
- S. S. Bhiravarasu
- Sean C. Solomon
- Shashwat Shukla
- Steven A. Hauck
- Thomas M. Orlando
- Timothy J. Stubbs
- Valentin Tertius Bickel
- Vincent R. Eke
- William M. Farrell
- Ákos Kereszturi
- Publication venue
- Publication date
- 18/03/2021
- Field of study
n/
Multi-messenger observations of a binary neutron star merger
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- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
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- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
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- Anderson WG
- Andrada B
- Andre M
- Andreoni I
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- Andringa S
- Angelova SV
- Anghinolfi M
- Angner EO
- Angus CR
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- Ansseau I
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- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
- Ashton G
- Asorey H
- Assis P
- Ast M
- Aston SM
- Astone P
- Atallah DV
- ATLAS
- Atwood WB
- Aubert J-J
- Aubert P
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- Auffenberg J
- Aufmuth P
- Aulbert C
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- Austin C
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- Avila G
- Avila-Alvarez A
- Awad A Kuotb
- Axani S
- Baar S
- Babak S
- Bachetti M
- Backes M
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- Bader MKM
- Badescu AM
- Bae S
- Bagherpour H
- Bai X
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- Baker PT
- Balaceanu A
- Balanutsa PV
- Balasubramanian A
- Balbinot E
- Baldaccini F
- Baldini L
- Ballardin G
- Ballmer SW
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- Balzer A
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- Bannister KW
- Barayoga JC
- Barbarino C
- Barbato F
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- Barbiellini G
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- Barclay SE
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- Barish BC
- Barker D
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- Barta D
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- Basti A
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- Bauer FE
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- Beardmore AP
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- Bellido JA
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- Belmont-Moreno E
- Benetti S
- Benkhali F Ait
- Benoit-Levy A
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- Broderick JW
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- Collette CG
- Collica L
- Collin GH
- Colmenero E Romero
- Coluccia MR
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- Cominsky LR
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
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- Gálvez V
- Géri G
- Gómez LC
- Gómez-Jiménez C
- Gómez-Jiménez C
- Güven G
- Ha JK
- Hadley JS
- Haghbin S
- Haines R
- Hala P
- Hall D
- Hallows G
- Hallows G
- Hamilton A
- Han HS
- Han SH
- Han SH
- Handler E
- Hanekom S
- Haniffa R
- Hanna AA
- Haritydi T
- Harm S
- Harridge SD
- Harrison D
- Harrison M
- Hart N
- Hart R
- Hartmann J
- Hashimoto Y
- Hassanin H
- Hatakeyama J
- Hatib F
- Hawkins K
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- Hayakawa M
- Hayakawa M
- Hayakawa M
- Hayakawa M
- Hayashi K
- He X
- Healey AJ
- Hebert P
- Hegazy S
- Hellevuo H
- Helmy TA
- Helyar S
- Helyar S
- Hempel D
- Henderson MA
- Hendra H
- Henschel B
- Heras G
- Hernandis V
- Hernández A
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández AA
- Hernández G
- Hernández-Tejedor A
- Herpain A
- Herrera AN
- Herrera AN
- Herrera AN
- Herrera AN
- Herrera AN
- Herrera AN
- Herruzo-Aviles A
- Heunks LM
- Hewitt H
- Heyne T
- Hickey S
- Hidalgo C
- Hikasa Y
- Hillier SD
- Himmel Y
- Himpe D
- Hinojosa-Perez R
- Hirata A
- Hirayama T
- Hirohata S
- Hodgson LE
- Hodgson LE
- Hofmeijer J
- Hollands S
- Hom H
- Hopkins PA
- Hopkins PA
- Hoppu S
- Hoppu S
- Horkan CM
- Horstmann C
- Horton A
- Horvat A
- Hou DS
- Houzé S
- Houzé S
- Howes D
- Hozhabri K
- Hrachovina M
- Hraiech S
- Hravnak M
- Hu HC
- Hua Y
- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
- Hualde JB
- Huang CH
- Huang WC
- Huang WC
- Huang WC
- Huang WC
- Hubbard A
- Huber W
- Huddart S
- Hull AM
- Hung CY
- Hung WT
- Hung WT
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- Huot B
- Husheer SL
- Hutchings S
- Hutchison R
- Hwang GS
- Hwang GS
- Ibañes PG
- Ibsen M
- Idei M
- Idei M
- Idone FA
- Iesu E
- Iesu E
- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
- Ilan R
- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
- Iotti GA
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- IPREA Study Group
- Irazabal JM
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- Itenov TS
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- Jacobs FM
- Jacques T
- Jaffal K
- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
- Jeon YD
- Jeon YD
- Jeong IY
- Jeong IY
- Jeong WY
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- Jian Z
- Jiao LR
- Jibaja M
- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
- Jun IG
- Jun IG
- Jung K
- Jung KW
- Junior JM
- Kaczirek K
- Kaese S
- Kalani N
- Kalenka A
- Kalfon P
- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
- Kang M
- Kang PL
- Kang PL
- Kang PL
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- Kang Y
- Kao KC
- Kappler F
- Kara A
- Karachi F
- Karanjia N
- Karbing DS
- Karsten E
- Kasdan H
- Kashiya S
- Kashyap R
- Katabami K
- Katabami K
- Katabami K
- Katabami K
- Katira BH
- Kavanagh BP
- Kawamura N
- Kawano S
- Kay FU
- Kayaaslan B
- Kayambu G
- Kazutoshi F
- Ke MW
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- Keep J
- Keep J
- Keller E
- Kellner F
- Kelly JM
- Kenardy J
- Keough E
- Kerhuel L
- Kerr C
- Kezyte G
- Khadjibaev A
- Khaliq W
- Khine H
- Kim DJ
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- Kim KS
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- Kim MH
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- Kim W
- Kimmoun A
- King HS
- Kinnear J
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- Kirakli C
- Kirca H
- Kirman M
- Kirwan CJ
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- Klapsing P
- Klaus DA
- Kleinpell R
- Kluge S
- Knafelj R
- Knight LD
- Ko JI
- Ko SB
- Kobayashi A
- Koco E
- Kodate A
- Kodate A
- Kodate A
- Kokkini S
- Kolnikova I
- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
- Kostalas M
- Kosuk ME
- Kotsopoulos A
- Kou PS
- Kouatchet A
- Kovacikova L
- Kox M
- Kraegpoeth A
- Krenn CG
- Krishna B
- Kristof J
- Kruger A
- Kruger A
- Krüger A
- Ku NS
- Ku NS
- Kubik M
- Kubota K
- Kuebler WM
- Kulaga EV
- Kulkarni AP
- Kumari BK
- Kumbamu A
- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
- Kurtz P
- Kurtz P
- Kwon HM
- Kwon HM
- Kwon WY
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- Kye YC
- Kyle UG
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- Labaune MA
- Labra C
- Lacerda P
- Laerkner E
- Lafaurie M
- Lafuente E
- Lagonidis D
- Lagos R
- Lahmer T
- Lai CC
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- Larsson JS
- Latini R
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- Latini R
- Latorre J
- Lattuada M
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- Lauretta MP
- Laureys S
- Lavrentieva A
- Lawrence N
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- Le Brocque R
- Lebherz-Eichinger D
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- Lee EY
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- Legrand M
- Legrand M
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- Leitao AL
- Leite RT
- Leonard H
- Leone M
- Leone M
- Lerma FA
- Lesmes SP
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- Letizia T
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- León JP
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- Li SH
- Liao X
- Lichtenstein D
- Lim TH
- Limuti R
- Lin KC
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- Lin WC
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- Lischinsky A
- Lissonde F
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- Litchfield K
- Liu CP
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- Liu D
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- Llorente B
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- Lobato MS
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- Loizou C
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- Longani N
- Longhi L
- Lopes JA
- Lopez GD
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- Lopez-Caler C
- Lopez-Gude MJ
- Lorini L
- Lortat-Jacob B
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- Lotay R
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- Louf-Durier A
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- Louis B
- Lourido CM
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- Luciani A
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- Luini M
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- Lukaszewicz AC
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- MacPhee I
- Macrì M
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- Maekawa K
- Maekawa K
- Maekawa K
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- Magnoni S
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- Maistry N
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- Martínez F
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- Melo N
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- Mengelle C
- Mercat A
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- Mergulhão PJ
- Merino-Vega D
- Messenger D
- Mezidi M
- Mezidi M
- Michel L
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- Mignot T
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- Mukherjee DN
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- Okayama Research Investigation Organizing Network (ORION)investigators
- Olaechea P
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- Rodríguez FG
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- Rogero S
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- Romero DG
- Romero I
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- Romeu JD
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- Rosstalnaya A
- Rota L
- Roth GA
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- Sabetian G
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- Salgado DR
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- Santos F
- Sanui M
- Sanz ER
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- Savin I
- Savvidou S
- Sawamura A
- Sawamura A
- Sawamura A
- Sawamura A
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
- Adam M.
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- Adams C.
- Adams D.
- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
- Ahmad S.
- Ahmed A.
- Ahmed I.
- Ahmed M.
- Ahmed R.
- Ahmed R.
- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
- Alexander A.
- Alexander P.
- Alhabsha O.
- Ali M.
- Ali M.
- Aliberti E.
- Alin J.
- Aliyuda F.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati Cristiana
- Abbas Kaja M.
- Abbasi Mohammad
- Abbasi-Kangevari Mohsen
- Abbasifard Mitra
- Abbastabar Hedayat
- Abd El Razek Hassan Magdy
- Abd El Razek Muhammed Magdy
- Abd-Allah Foad
- Abdelalim Ahmed
- Abdollahi Mohammad
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abdullah Kanaan Hamagharib
- Abedi Aidin
- Abedi Parisa
- Abegaz Kedir Hussein
- Abolhassani Hassan
- Abosetugn Akine Eshete
- Aboyans Victor
- Abrams Elissa M.
- Abreu Lucas Guimaraes
- Abrigo Michael R. M.
- Abu Haimed Abdulaziz Khalid
- Abu-Gharbieh Eman
- Abu-Raddad Laith Jamal
- Abualhasan Ahmed
- Abushouk Abdelrahman I.
- Acebedo Alyssa
- Ackerman Ilana N.
- Adabi Maryam
- Adair Tim
- Adamu Abdu A.
- Adebayo Oladimeji M.
- Adedeji Isaac Akinkunmi
- Adekanmbi Victor
- Adelson Jaimie D.
- Adeoye Abiodun Moshood
- Adetokunboh Olatunji O.
- Adham Davoud
- Advani Shailesh M.
- Afarideh Mohsen
- Afshari Mahdi
- Afshin Ashkan
- Agardh Emilie E.
- Agarwal Gina
- Agasthi Pradyumna
- Agesa Kareha M.
- Aghaali Mohammad
- Aghamir Seyed Mohammad Kazem
- Agrawal Anurag
- Ahmad Tauseef
- Ahmadi Alireza
- Ahmadi Keivan
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmadpour Ehsan
- Ahmed Muktar Beshir
- Aji Budi
- Akalu Temesgen Yihunie
- Akinyemi Rufus Olusola
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- Akombi Blessing
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- Yousefi Zabihollah
- Yousefifard Mahmoud
- Yousefinezhadi Taraneh
- Yousuf Abdilahi Yousuf
- Yu Chuanhua
- Yu Yong
- Yuan Chun-Wei
- Yuce Deniz
- Yusefzadeh Hasan
- Zadey Siddhesh
- Zahabi Saleh Salehi
- Zaidi Syed Saoud
- Zaki Leila
- Zaki Maysaa El Sayed
- Zakzuk Josefina
- Zamani Mohammad
- Zamanian Maryam
- Zandian Hamed
- Zangeneh Alireza
- Zarafshan Hadi
- Zastrozhin Mikhail Sergeevich
- Zewdie Kaleab Alemayehu
- Zhang Jianrong
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhao Jeff T.
- Zhao Xiu-Ju George
- Zhao Yingxi
- Zheleva Bistra
- Zheng Peng
- Zhou Maigeng
- Zhu Cong
- Ziapour Arash
- Zimsen Stephanie R. M.
- Zlavog Bianca S.
- Zodpey Sanjay
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
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- Watt Nicola
- Webb Anthony
- Webb Jeannette
- Webber Caleb
- Weber Ryan J.
- Wehri Edward
- Wei Shulin
- Wei Xuehong
- Weidenbach Richard
- Weinstock George
- Weinstock Keith
- Weir John
- Weissenbach Jean
- Wells Alan
- Wells Sarah
- Welton Robert
- Wen Gaiping
- Wendi Mike
- Weng Li
- Wenning Sarah
- Wentz Sara
- Werler Daniela
- Wesley Mary Melissa
- West Paul
- West Tony
- Wetterstrand Kris
- Wheatley Angela
- Wheatley Carl
- Wheeler David A.
- Wheeler Gideon
- Wheeler Jeremy
- Whitaker Hayley
- White Adam
- White Amelia
- White Brian
- White Catherine
- White Flower
- White Jennifer
- White Johnathon
- White P. Scott
- White Scott P.
- White Simon
- Whitehead Sally
- Whiteley Matthew
- Whitmore Scott
- Whittaker Adam
- Whittaker Charles
- Whittaker Pamela
- Wickremasinghe Manosha I.
- Widaa Sara
- Wiegel Sarah
- Wild Anna
- Wilkinson Jane
- Wilkinson Jane
- Wilkinson Paul
- Willey David
- Williams Albert L.
- Williams Andy
- Williams Bill
- Williams Gabrielle A.
- Williams Leanne
- Williamson Angela L.
- Williamson Helen
- Wills Patricia L.
- Wills Richard
- Wilmer Tamsin
- Wilming Laurens
- Wilson Brian
- Wilson Gareth
- Wilson Margaret
- Wilson Nyree
- Wilson Piers
- Wilson Richard K.
- Wilson Siobhan
- Wilson Steve
- Wilson Wendy
- Wincker Patrick
- Window Philip
- Winster Jenny
- Winzar Claire
- Witt James
- Wleczyk Regina
- Wobus Fred
- Woessner Jeffrey
- Wohldmann Patty
- Wollard Jessica
- Womack Andrew W.
- Wong Benjamin
- Wong Gane K-S
- Wood Diane
- Wood Emma
- Wood Joe
- Wooden Hailey S.
- Wooden Steven H.
- Woodeson Sharon
- Woodfine Kathryn
- Woodmansey Rebecca
- Woods Eric
- Woodwark Cara
- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
- Wright Charmain
- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
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