The use of imaging systems to monitor shoreline dynamics

The development of imaging systems is nowadays established as one of the most powerful and reliable tools for monitoring beach morphodynamics. Two different techniques for shoreline detection are presented here and, in one case, applied to the study of beach width oscillations on a sandy beach (Pauanui Beach, New Zealand). Results indicate that images can provide datasets whose length and sample interval are accurate enough to resolve inter-annual and seasonal oscillations, and long-term trends. Similarly, imaging systems can be extremely useful in determining the statistics of rip current occurrence. Further improvements in accuracy and reliability are expected with the recent introduction of digital systems

Starting a 300-cow intensive rotational grazing dairy (2011)

This guide examines the financial feasibility of starting a 300-cow intensive rotational grazing dairy in Missouri. The model dairy described is designed to be a pasture-based dairy to use labor and capital as efficiently as possible. This dairy is designed to be located in an area where winter weather conditions and soil types allow cattle to be housed outside all year

Starting a 75-cow intensive rotational grazing dairy (2011)

This guide examines the financial feasibility of starting a 75-cow intensive rotational grazing dairy in Missouri. The model dairy described is designed to be a pasture-based dairy to use labor and capital as efficiently as possible. This dairy is designed to be located in an area where winter weather conditions and soil types allow cattle to be housed outside all year

Converting an existing dairy to the Missouri 75-cow grazing dairy model (2011)

This guide examines the financial feasibility of creating a new Missouri grass-based dairy by converting an existing conventional dairy to a 75-cow intensive rotational grazing dairy. The model for this conversion assumes the farm buyer is able to purchase a dairy without paying anything extra for the fact that it contains an obsolete double-4 herringbone parlor. Using a low-cost retrofit of the parlor, the new dairy producer is able to increase labor efficiency without committing a large amount of additional capital. This model allows the new dairy producer to overcome the capital threshold that is a barrier to entry for most new smaller dairies. This dairy is designed to be located in an area where winter weather conditions and soil types allow cattle to be housed outside all year

Starting a 150-cow intensive rotational grazing dairy (2011)

This guide examines the financial feasibility of starting a 150-cow intensive rotational grazing dairy in Missouri. The model dairy described is designed to be a pasture-based dairy to use labor and capital as efficiently as possible. This dairy is designed to be located in an area where winter weather conditions and soil types allow cattle to be housed outside all year

Introduction to the economics of pasture-based dairying (2011)

The following series of minimalist, pasture-based dairy model farms (75-cow, 150-cow, 300-cow and 600-cow) was developed to help dairy producers understand the economics of these dairy systems. Each model is customized to reflect an operational system typical of a dairy farm and herd of four different sizes. These models were developed using assumptions, costs and benchmarking information from existing Missouri pasture-based dairies and from experts in the dairy industry. Data presented here reflect costs and conditions as of October 2010. While these farms were customized specific to Missouri, they could be adapted to conditions elsewhere

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

A multimodal cell census and atlas of the mammalian primary motor cortex

ABSTRACT We report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex (MOp or M1) as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties, and cellular resolution input-output mapping, integrated through cross-modal computational analysis. Together, our results advance the collective knowledge and understanding of brain cell type organization: First, our study reveals a unified molecular genetic landscape of cortical cell types that congruently integrates their transcriptome, open chromatin and DNA methylation maps. Second, cross-species analysis achieves a unified taxonomy of transcriptomic types and their hierarchical organization that are conserved from mouse to marmoset and human. Third, cross-modal analysis provides compelling evidence for the epigenomic, transcriptomic, and gene regulatory basis of neuronal phenotypes such as their physiological and anatomical properties, demonstrating the biological validity and genomic underpinning of neuron types and subtypes. Fourth, in situ single-cell transcriptomics provides a spatially-resolved cell type atlas of the motor cortex. Fifth, integrated transcriptomic, epigenomic and anatomical analyses reveal the correspondence between neural circuits and transcriptomic cell types. We further present an extensive genetic toolset for targeting and fate mapping glutamatergic projection neuron types toward linking their developmental trajectory to their circuit function. Together, our results establish a unified and mechanistic framework of neuronal cell type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries