127 research outputs found
Minimal information for studies of extracellular vesicles 2018 (MISEV2018):a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
- Author
- Afd Pharmaceutics
- Afd Pharmacology
- Aikawa Elena
- Alcaraz Maria Jose
- Anderson Johnathon D
- Andriantsitohaina Ramaroson
- Antoniou Anna
- Arab Tanina
- Archer Fabienne
- Atkin-Smith Georgia K
- Ayre D Craig
- Bach Jean-Marie
- Bachurski Daniel
- Baharvand Hossein
- Balaj Leonora
- Baldacchino Shawn
- Bauer Natalie N
- Baxter Amy A
- Bebawy Mary
- Beckham Carla
- Bedina Zavec Apolonija
- Benmoussa Abderrahim
- Berardi Anna C
- Bergese Paolo
- Bielska Ewa
- Blenkiron Cherie
- Bobis-Wozowicz Sylwia
- Boilard Eric
- Boireau Wilfrid
- Bongiovanni Antonella
- BorrĂ s Francesc E
- Bosch Steffi
- Boulanger Chantal M
- Breakefield Xandra
- Breglio Andrew M
- Brennan Meadhbh Ă
- Brigstock David R
- Brisson Alain
- Broekman Marike Ld
- Bromberg Jacqueline F
- Bryl-GĂłrecka Paulina
- Buch Shilpa
- Buck Amy H
- Burger Dylan
- Busatto Sara
- Buschmann Dominik
- Bussolati Benedetta
- BuzĂĄs Edit I
- Byrd James Bryan
- Camussi Giovanni
- Carter David Rf
- Caruso Sarah
- Celbiologie
- Chamley Lawrence W
- Chang Yu-Ting
- Chen Chihchen
- Chen Shuai
- Cheng Lesley
- Chin Andrew R
- Clayton Aled
- Clerici Stefano P
- Cocks Alex
- Cocucci Emanuele
- Coffey Robert J
- Cordeiro-da-Silva Anabela
- Couch Yvonne
- Coumans Frank Aw
- Coyle Beth
- Crescitelli Rossella
- Criado Miria Ferreira
- D'Souza-Schorey Crislyn
- Das Saumya
- Datta Chaudhuri Amrita
- dB&C I&I
- de Candia Paola
- De Santana Eliezer F
- De Wever Olivier
- Del Portillo Hernando A
- Demaret Tanguy
- Deville Sarah
- Devitt Andrew
- Dhondt Bert
- Di Vizio Dolores
- Dieterich Lothar C
- Dolo Vincenza
- Dominguez Rubio Ana Paula
- Dominici Massimo
- Dourado Mauricio R
- Driedonks Tom Ap
- Duarte Filipe V
- Duncan Heather M
- Eichenberger Ramon M
- Ekström Karin
- El Andaloussi Samir
- Elie-Caille Celine
- ErdbrĂŒgger Uta
- FalcĂłn-PĂ©rez Juan M
- Fatima Farah
- Fish Jason E
- Flores-Bellver Miguel
- Frelet-Barrand Annie
- Fricke Fabia
- Fuhrmann Gregor
- Försönits Andrås
- Gabrielsson Susanne
- Gardiner Chris
- Gaudin Raphael
- Gho Yong Song
- Giebel Bernd
- Gilbert Caroline
- Gimona Mario
- Giusti Ilaria
- Goberdhan Deborah Ci
- Gorski Sharon M
- Greening David W
- Gross Julia Christina
- Gualerzi Alice
- Gupta Gopal N
- Gustafson Dakota
- GĂĄmez-Valero Ana
- GĂ€rtner Kathrin
- Görgens André
- Handberg Aase
- Haraszti Reka A
- Harrison Paul
- Hegyesi Hargita
- Hendrix An
- Hill Andrew F
- Hochberg Fred H
- Hoffmann Karl F
- Holder Beth
- Holthofer Harry
- Hosseinkhani Baharak
- Hu Guoku
- Huang Yiyao
- Huber Veronica
- Hunt Stuart
- Ibrahim Ahmed Gamal-Eldin
- Ikezu Tsuneya
- Inal Jameel M
- Isin Mustafa
- Ivanova Alena
- Jackson Hannah K
- Jacobsen Soren
- Jay Steven M
- Jayachandran Muthuvel
- Jenster Guido
- Jiang Lanzhou
- Johnson Suzanne M
- Jones Jennifer C
- Jong Ambrose
- Jovanovic-Talisman Tijana
- Jung Stephanie
- Kalluri Raghu
- Kano Shin-Ichi
- Kaur Sukhbir
- Kawamura Yumi
- Keller Evan T
- Khamari Delaram
- Khomyakova Elena
- Khvorova Anastasia
- Kierulf Peter
- Kim Kwang Pyo
- Kislinger Thomas
- Klingeborn Mikael
- Klinke David J
- Kornek Miroslaw
- KosanoviÄ Maja M
- KovĂĄcs ĂrpĂĄd Ferenc
- Krasemann Susanne
- Krause Mirja
- KrÀmer-Albers Eva-Maria
- Kurochkin Igor V
- Kusuma Gina D
- Kuypers Sören
- Laitinen Saara
- Langevin Scott M
- Languino Lucia R
- Lannigan Joanne
- Laurent Louise C
- Lavieu Gregory
- Le Lay Soazig
- Lee Myung-Shin
- Lee Yi Xin Fiona
- Lemos Debora S
- Lenassi Metka
- Leszczynska Aleksandra
- Li Isaac Ts
- Liao Ke
- Libregts Sten F
- Ligeti Erzsebet
- Lim Rebecca
- Lim Sai Kiang
- Linnemannstöns Karen
- LinÄ Aija
- Llorente Alicia
- Lombard Catherine A
- Lorenowicz Magdalena J
- Lovett Jason
- Lowry Michelle C
- Loyer Xavier
- LS Celbiologie-Algemeen
- Lu Quan
- Lukomska Barbara
- Lunavat Taral R
- Låzaro-Ibåñez Elisa
- LĂ€sser Cecilia
- Lörincz Ăkos M
- Lötvall Jan
- Maas Sybren Ln
- Malhi Harmeet
- Marcilla Antonio
- Mariani Jacopo
- Mariscal Javier
- Martens-Uzunova Elena S
- Martin-Jaular Lorena
- Martinez M Carmen
- Martins Vilma Regina
- Mathieu Mathilde
- Mathivanan Suresh
- Maugeri Marco
- McGinnis Lynda K
- McVey Mark J
- Meckes David G
- Meehan Katie L
- Mertens Inge
- Minciacchi Valentina R
- Morales-Kastresana Aizea
- Morhayim Jess
- Mullier François
- Muraca Maurizio
- Musante Luca
- Mussack Veronika
- Muth Dillon C
- Myburgh Kathryn H
- Möller Andreas
- MĂžller JĂžrgensen Malene
- Najrana Tanbir
- Nawaz Muhammad
- Nazarenko Irina
- Nejsum Peter
- Neri Christian
- Neri Tommaso
- Nieuwland Rienk
- Nimrichter Leonardo
- Nolan John P
- Nolte-'t Hoen Esther NM
- Noren Hooten Nicole
- O'Driscoll Lorraine
- O'Grady Tina
- O'Loghlen Ana
- Ochiya Takahiro
- Olivier Martin
- Ortiz Alberto
- Ortiz Luis A
- Osteikoetxea Xabier
- Ostrowski Matias
- Park Jaesung
- Pegtel D Michiel
- Peinado Hector
- Perut Francesca
- Pfaffl Michael W
- Phinney Donald G
- Pieters Bartijn Ch
- Pink Ryan C
- Pisetsky David S
- Pogge von Strandmann Elke
- Polakovicova Iva
- Poon Ivan Kh
- Powell Bonita H
- Prada Ilaria
- Pulliam Lynn
- Quesenberry Peter
- Radeghieri Annalisa
- Raffai Robert L
- Raimondo Stefania
- Rak Janusz
- Ramirez Marcel I
- Raposo Graça
- Rayyan Morsi S
- Regev-Rudzki Neta
- Ricklefs Franz L
- Robbins Paul D
- Roberts David D
- Rodrigues Silvia C
- Rohde Eva
- Rome Sophie
- Rouschop Kasper Ma
- Rughetti Aurelia
- Russell Ashley E
- Sahoo Susmita
- Salas-Huenuleo Edison
- Saugstad Julie A
- Saul Meike J
- SaĂĄ Paula
- Schiffelers Raymond M
- Schneider Raphael
- SchĂžyen Tine Hiorth
- Scott Aaron
- Shahaj Eriomina
- Sharma Shivani
- Shatnyeva Olga
- Shekari Faezeh
- Shelke Ganesh Vilas
- Shetty Ashok K
- Shiba Kiyotaka
- Siljander Pia R-M
- Silva Andreia M
- Skowronek Agata
- Snyder Orman L
- Soares Rodrigo Pedro
- Soekmadji Carolina
- Sotillo Javier
- Stahl Philip D
- Stoorvogel Willem
- Stott Shannon L
- Strasser Erwin F
- Sub Biomol.Mass Spect. and Proteomics
- Sub General Pharmaceutics
- Swift Simon
- SĂĄnchez Catherine
- SĂłdar Barbara W
- Tahara Hidetoshi
- Tewari Muneesh
- Théry Clotilde
- Timms Kate
- Tiwari Swasti
- Tixeira Rochelle
- Tkach Mercedes
- Toh Wei Seong
- Tomasini Richard
- Torrecilhas Ana Claudia
- Tosar Juan Pablo
- Toxavidis Vasilis
- Urbanelli Lorena
- Vader Pieter
- van Balkom Bas Wm
- van der Grein Susanne G
- Van Deun Jan
- van Herwijnen Martijn Jc
- Van Keuren-Jensen Kendall
- van Niel Guillaume
- van Royen Martin E
- van Wijnen Andre J
- Vasconcelos M Helena
- Vechetti Ivan J
- Veit Tiago D
- Vella Laura J
- Velot Ămilie
- Verweij Frederik J
- Vestad Beate
- Visnovitz TamĂĄs
- Viñas Jose L
- Vukman Krisztina V
- Wahlgren Jessica
- Watson Dionysios C
- Wauben Marca Hm
- Weaver Alissa
- Webber Jason P
- Weber Viktoria
- Wehman Ann M
- Weiss Daniel J
- Welsh Joshua A
- Wendt Sebastian
- Wheelock Asa M
- Wiener ZoltĂĄn
- Witte Leonie
- Witwer Kenneth W
- Wolfram Joy
- Xagorari Angeliki
- Xander Patricia
- Xu Jing
- Yan Xiaomei
- Yin Hang
- Yuana Yuana
- Yåñez-MĂł MarĂa
- Zappulli Valentina
- Zarubova Jana
- Zhang Jian-Ye
- Zhao Zezhou
- Zheng Lei
- Zheutlin Alexander R
- Zickler Antje M
- Zimmermann Pascale
- Zivkovic Angela M
- Zocco Davide
- Zuba-Surma Ewa K
- Ăstergaard Ole
- ĆœÄkas Vytautas
- Publication venue
- Publication date
- 01/01/2018
- Field of study
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (âMISEVâ) guidelines for the field in 2014. We now update these âMISEV2014â guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- AbellĂĄn AN
- AbellĂĄn AN
- AbellĂĄn AN
- Abrams ST
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- Agarossi A
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- Ageeva T
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- Aguayo-DeHoyos E
- Aguilar AL
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- Ahmadnia E
- Ahn C
- Ahn JY
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- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
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- Albaladejo P
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- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
- Erdogan M
- Eroles AA
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- EscĂłrcio S
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- Espinasse F
- Espinel E
- Estagnasie P
- Esteban A
- Estella A
- Estenssoro E
- Evelein-Brugman S
- Facchin F
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- Fang M
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- Farias P
- Faulds MC
- Fave G
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- Feijoo AM
- Feliot E
- Ferez MA
- Fernandes MJ
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- Ferraz AB
- Ferrero-Calleja J
- Ferri F
- Ferry A
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- Fiks T
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- FilekoviÄ S
- Filho CA
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- FINNRESUSCI Study Group
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- Frithiof R
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- Fromentin M
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- Garrido BB
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- Garrouste M
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- Hou DS
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- Hozhabri K
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- Hwang GS
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- Ibañes PG
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- Idei M
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- Idone FA
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- Jang BH
- Janotka M
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- Jansen D
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- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
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- Jensen AE
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- Jeong IY
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- Jibaja M
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- Jiménez GJ
- Jo YH
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- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
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- Juez A
- Juliarena A
- Jun IG
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- Jung K
- Jung KW
- Junior JM
- Kaczirek K
- Kaese S
- Kalani N
- Kalenka A
- Kalfon P
- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
- Kang M
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- Kang Y
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- Kappler F
- Kara A
- Karachi F
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- Karbing DS
- Karsten E
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- Kashiya S
- Kashyap R
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- Katabami K
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- Kawano S
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- Kayaaslan B
- Kayambu G
- Kazutoshi F
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- Kezyte G
- Khadjibaev A
- Khaliq W
- Khine H
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- Kirwan CJ
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- Kleinpell R
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- Kobayashi A
- Koco E
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- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
- Kostalas M
- Kosuk ME
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- Kou PS
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- Kox M
- Kraegpoeth A
- Krenn CG
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- Kristof J
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- Kubota K
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- Kunze-Szikszay N
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- Kurtz P
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- Lacerda P
- Laerkner E
- Lafaurie M
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- Lahmer T
- Lai CC
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- Latorre J
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- Lauretta MP
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- MacPhee I
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- Maghsoudi B
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- Okamoto H
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- Olaechea P
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- Ong C
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- Orden VA
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- Phongpagdi P
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- Pifferi S
- Pinsky M
- Pinto JL
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- Yılmaz G
- Yilmazer F
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- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
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- Yoshida T
- Yoshihiro S
- Yoshitake E
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- Youn AM
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- Zani D
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- ZĂœkovĂĄ I
- Ălvarez JT
- Ălvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study
- Author
- Abad RD
- Abe T
- Abroug F
- Adams JC
- Adamsson RO
- Adolfsson A
- Aguilar RZ
- Aguirre JS
- Aguirre-Bermeo H
- Aisa TM
- Aisiku I
- Ajetunmobi OO
- Aker M
- Akyol OO
- Al Dorzi HM
- Al Jabbary AS
- Albaiceta GM
- Albarrak MM
- Albiero D
- Alda RS
- Alejandro RV
- Alexander P
- Algaba Ă
- Aliaga FA
- Alisasis AU
- Allan RM
- Allue RM
- Almekhlaf G
- Alonso JG
- Altaf W
- Alvarez AM
- Alvarez J
- Amin P
- Amir F
- Amor M
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- Andersen FH
- Andoh K
- Andruszkiewicz P
- Aneman A
- Antonelli MM
- AntĂŽnio ACP
- Aoki N
- Appelberg H
- Arabi Y
- Arabi YM
- Araujo AM
- Arizmendi A
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- Artiga MJD
- Artigas A
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- Battle CE
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- Beegle SH
- Beitler JR
- Bellani G
- Bellani G.
- Beloncle F
- Ben Souissi A
- Benslama A
- Beraldo DO
- Berghe C
- Berkelmans F
- Besset SL
- Bettini LR
- Beuret P
- Bezzi MG
- Bhardwaj VK
- Bhowmick K
- Biehler J
- Bigot C
- Bihari S
- Biondi RS
- Biscione RR
- Bisso MC
- Black CS
- Blakeman TC
- Blanco J
- Bolon S
- Borello SA
- Borotto EE
- Botteri M
- Bouchoucha S
- Boukhazna M
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- Braschi A
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- Brochard L.
- Broman LM
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- Bumbasirevic V
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- BĂ©duneau G
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- Castro AG
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- Cazorla-Barranquero FG
- Ceniceros-Barros A
- Cereijo E
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- Cesar PS
- Ceunen H
- Ceylan I
- Chabanne R
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- Chau SK
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- Chen K
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- Choudry S
- Christiansen A
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- CitalĂĄn JE
- Claraco-Vega LM
- Clarkson K
- Clarkson KP
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- Cole JM
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- Combaux DM
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- Corneci DE
- Cortegiani A
- Cortez CA
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- Cranshaw JH
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- Dector DM
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- Eugenio Luis PS
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- Hou PC
- Hou SK
- Hraiech S
- Hua MX
- Huang QQ
- Huang XB
- Huerta FP
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- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2019
- Field of study
OBJECTIVES: To describe the characteristics and outcomes of patients with acute respiratory distress syndrome with or without spontaneous breathing and to investigate whether the effects of spontaneous breathing on outcome depend on acute respiratory distress syndrome severity. DESIGN: Planned secondary analysis of a prospective, observational, multicentre cohort study. SETTING: International sample of 459 ICUs from 50 countries. PATIENTS: Patients with acute respiratory distress syndrome and at least 2 days of invasive mechanical ventilation and available data for the mode of mechanical ventilation and respiratory rate for the 2 first days. INTERVENTIONS: Analysis of patients with and without spontaneous breathing, defined by the mode of mechanical ventilation and by actual respiratory rate compared with set respiratory rate during the first 48 hours of mechanical ventilation. MEASUREMENTS AND MAIN RESULTS: Spontaneous breathing was present in 67% of patients with mild acute respiratory distress syndrome, 58% of patients with moderate acute respiratory distress syndrome, and 46% of patients with severe acute respiratory distress syndrome. Patients with spontaneous breathing were older and had lower acute respiratory distress syndrome severity, Sequential Organ Failure Assessment scores, ICU and hospital mortality, and were less likely to be diagnosed with acute respiratory distress syndrome by clinicians. In adjusted analysis, spontaneous breathing during the first 2 days was not associated with an effect on ICU or hospital mortality (33% vs 37%; odds ratio, 1.18 [0.92-1.51]; p = 0.19 and 37% vs 41%; odds ratio, 1.18 [0.93-1.50]; p = 0.196, respectively ). Spontaneous breathing was associated with increased ventilator-free days (13 [0-22] vs 8 [0-20]; p = 0.014) and shorter duration of ICU stay (11 [6-20] vs 12 [7-22]; p = 0.04). CONCLUSIONS: Spontaneous breathing is common in patients with acute respiratory distress syndrome during the first 48 hours of mechanical ventilation. Spontaneous breathing is not associated with worse outcomes and may hasten liberation from the ventilator and from ICU. Although these results support the use of spontaneous breathing in patients with acute respiratory distress syndrome independent of acute respiratory distress syndrome severity, the use of controlled ventilation indicates a bias toward use in patients with higher disease severity. In addition, because the lack of reliable data on inspiratory effort in our study, prospective studies incorporating the magnitude of inspiratory effort and adjusting for all potential severity confounders are required
Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database
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- Zogheib Eh
- Ăamendys-Silva Sa
- Ănal N
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF fully explained by cardiac failure were excluded. Important clinical characteristics were included in a stepwise selection approach (forward and backward selection combined with a significance level of 0.05) to identify a set of independent variables associated with having ARDS at any time, developing ARDS (defined as ARDS occurring after day 2 from meeting AHRF criteria) and with hospital mortality. Furthermore, propensity score analysis was undertaken to account for the differences in baseline characteristics between patients with and without diabetes mellitus, and the association between diabetes mellitus and outcomes of interest was assessed on matched samples. Results: Of the 4107 patients with AHRF included in this study, 3022 (73.6%) patients fulfilled ARDS criteria at admission or developed ARDS during their ICU stay. Diabetes mellitus was a pre-existing co-morbidity in 913 patients (22.2% of patients with AHRF). In multivariable analysis, there was no association between diabetes mellitus and having ARDS (OR 0.93 (0.78-1.11); p = 0.39), developing ARDS late (OR 0.79 (0.54-1.15); p = 0.22), or hospital mortality in patients with ARDS (1.15 (0.93-1.42); p = 0.19). In a matched sample of patients, there was no association between diabetes mellitus and outcomes of interest. Conclusions: In a large, global observational study of patients with AHRF, no association was found between diabetes mellitus and having ARDS, developing ARDS, or outcomes from ARDS. Trial registration: NCT02010073. Registered on 12 December 2013
Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries
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- Abad RD
- Abe T
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- Adams JC
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- Albaiceta GM
- Albarrak MM
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- Alda RS
- Alejandro RV
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- van Haren F
- Van Wezel HM
- Vargas MP
- Vascotto ER
- Vasquez DN
- Vega LD
- Veljovic M.
- Venti A
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- Zhu BH
- Zhu WH
- Zogheib EH
- Ăamendys-Silva SA
- Ănal N
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: To better understand the epidemiology and patterns of tracheostomy practice for patients with acute respiratory distress syndrome (ARDS), we investigated the current usage of tracheostomy in patients with ARDS recruited into the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG-SAFE) study. Methods: This is a secondary analysis of LUNG-SAFE, an international, multicenter, prospective cohort study of patients receiving invasive or noninvasive ventilation in 50 countries spanning 5 continents. The study was carried out over 4 weeks consecutively in the winter of 2014, and 459 ICUs participated. We evaluated the clinical characteristics, management and outcomes of patients that received tracheostomy, in the cohort of patients that developed ARDS on day 1-2 of acute hypoxemic respiratory failure, and in a subsequent propensity-matched cohort. Results: Of the 2377 patients with ARDS that fulfilled the inclusion criteria, 309 (13.0%) underwent tracheostomy during their ICU stay. Patients from high-income European countries (n = 198/1263) more frequently underwent tracheostomy compared to patients from non-European high-income countries (n = 63/649) or patients from middle-income countries (n = 48/465). Only 86/309 (27.8%) underwent tracheostomy on or before day 7, while the median timing of tracheostomy was 14 (Q1-Q3, 7-21) days after onset of ARDS. In the subsample matched by propensity score, ICU and hospital stay were longer in patients with tracheostomy. While patients with tracheostomy had the highest survival probability, there was no difference in 60-day or 90-day mortality in either the patient subgroup that survived for at least 5 days in ICU, or in the propensity-matched subsample. Conclusions: Most patients that receive tracheostomy do so after the first week of critical illness. Tracheostomy may prolong patient survival but does not reduce 60-day or 90-day mortality. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
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- Author
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- Aad G
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- Abdinov O
- Abeloos B
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- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zou R
- zur Nedden M
- Zwalinski L
- Ălvarez Piqueras D
- Ă kesson TPA
- Ć filigoj T
- ĆœeniĆĄ T
- ĆœivkoviÄ L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2018
- Field of study
Results from a search for supersymmetry in events with four or more charged leptons (electrons, muons and taus) are presented. The analysis uses a data sample corresponding to 36.1 fb â1 of proton-proton collisions delivered by the Large Hadron Collider at s â =13 TeV and recorded by the ATLAS detector. Four-lepton signal regions with up to two hadronically decaying taus are designed to target a range of supersymmetric scenarios that can be either enriched in or depleted of events involving the production and decay of a Z boson. Data yields are consistent with Standard Model expectations and results are used to set upper limits on the event yields from processes beyond the Standard Model. Exclusion limits are set at the 95% confidence level in simplified models of General Gauge Mediated supersymmetry, where higgsino masses are excluded up to 295 GeV. In R -parity-violating simplified models with decays of the lightest supersymmetric particle to charged leptons, lower limits of 1.46 TeV, 1.06 TeV, and 2.25 TeV are placed on wino, slepton and gluino masses, respectively
Recommended from our members
Search for Dark Matter Produced in Association with a Higgs Boson Decaying to bb[over ÂŻ] Using 36ââfb^{-1} of pp Collisions at sqrt[s]=13ââTeV with the ATLAS Detector.
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adye T
- Affolder AA
- Agatonovic-Jovin T
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt SC
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Gonzalez B
- Alviggi MG
- Amadio BT
- Amaral Coutinho Y
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
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- Annovi A
- Antel C
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- Antrim DJ
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- Arabidze G
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- ATLAS Collaboration
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- Calfayan P
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- Capeans Garrido MDM
- Caprini I
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- Capua M
- Carbone RM
- Cardarelli R
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- Carli I
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- Carlino G
- Carlson BT
- Carminati L
- Carney RMD
- Caron S
- Carquin E
- Carrillo-Montoya GD
- CarrĂĄ S
- Carvalho J
- Casadei D
- Casado MP
- Casolino M
- Casper DW
- Castelijn R
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- Castro NF
- Catinaccio A
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- Caudron J
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- Cetin SA
- Chafaq A
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- Charlton DG
- Chau CC
- Chavez Barajas CA
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- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chelstowska MA
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- Zhemchugov A
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- Zinser M
- Ziolkowski M
- Zobernig G
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- Zwalinski L
- Ălvarez Piqueras D
- Ă kesson TPA
- ĆœeniĆĄ T
- ĆœivkoviÄ L
- Publication venue
- Phys Rev Lett
- Publication date
- 03/11/2017
- Field of study
Several extensions of the standard model predict associated production of dark-matter particles with a Higgs boson. Such processes are searched for in final states with missing transverse momentum and a Higgs boson decaying to a bb[over ÂŻ] pair with the ATLAS detector using 36.1ââfb^{-1} of pp collisions at a center-of-mass energy of 13Â TeV at the LHC. The observed data are in agreement with the standard model predictions and limits are placed on the associated production of dark-matter particles and a Higgs boson
Search for flavour-changing neutral current top-quark decays t â qZ in proton-proton collisions at \sqrt{s} = 13 TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adam ER
- Adamczyk L
- Adelman J
- Adersberger M
- Adye T
- Affolder AA
- Afik Y
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
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- ĆœeniĆĄ T
- ĆœivkoviÄ L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/07/2018
- Field of study
A search for flavour-changing neutral-current processes in top-quark decays is presented. Data collected with the ATLAS detector from proton-proton collisions at the Large Hadron Collider at a centre-of-mass energy of sâ=13 TeV, corresponding to an integrated luminosity of 36.1 fbâ1, are analysed. The search is performed using top-quark pair events, with one top quark decaying through the t â qZ (q = u, c) flavour-changing neutral-current channel, and the other through the dominant Standard Model mode t â bW. Only Z boson decays into charged leptons and leptonic W boson decays are considered as signal. Consequently, the final-state topology is characterized by the presence of three isolated charged leptons (electrons or muons), at least two jets, one of the jets originating from a b-quark, and missing transverse momentum from the undetected neutrino. The data are consistent with Standard Model background contributions, and at 95% confidence level the search sets observed (expected) upper limits of 1.7 Ă 10â4 (2.4 Ă 10â4) on the t â uZ branching ratio and 2.4 Ă 10â4 (3.2 Ă 10â4) on the t â cZ branching ratio, constituting the most stringent limits to date.
Open image in new windo
Performance of the ATLAS muon trigger in pp collisions at [Formula: see text] TeV
- Author
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- Abdallah J
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- Zinonos Z
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- Publication venue
- Publication date
- 01/03/2015
- Field of study
The performance of the ATLAS muon trigger system is evaluated with proton-proton collision data collected in 2012 at the Large Hadron Collider at a centre-of-mass energy of 8Â TeV. It is primarily evaluated using events containing a pair of muons from the decay of [Formula: see text] bosons. The efficiency of the single-muon trigger is measured for muons with transverse momentum [Formula: see text]Â GeV, with a statistical uncertainty of less than 0.01Â % and a systematic uncertainty of 0.6Â %. The [Formula: see text] range for efficiency determination is extended by using muons from decays of [Formula: see text] mesons, [Formula: see text] bosons, and top quarks. The muon trigger shows highly uniform and stable performance. The performance is compared to the prediction of a detailed simulation
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-GĂłmez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
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- Alonso GD
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- Altieri DC
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- Alzaharna MM
- Amadio M
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- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
- Andrade-Silva M
- Andres AM
- Angelini S
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- Anozie UC
- Ansari MY
- Antas P
- Antebi A
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- Anwar T
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- Vitale I
- Vocadlo DJ
- Voitsekhovskaja OV
- Volonté C
- Volta M
- Vomero M
- Von Haefen C
- Vooijs MA
- Voos W
- Vucicevic L
- Wade-Martins R
- Waguri S
- Waite KA
- Wakatsuki S
- Walker DW
- Walker MJ
- Walker SA
- Walter J
- Wandosell FG
- Wang B
- Wang C
- Wang C
- Wang C
- Wang C-Y
- Wang C-Y
- Wang D
- Wang F
- Wang F
- Wang F
- Wang G
- Wang H
- Wang H
- Wang H
- Wang H-G
- Wang J
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- Wang J
- Wang K
- Wang L
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- Wang Q
- Wang QA
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- Wang QK
- Wang W
- Wang W-T
- Wang X
- Wang X
- Wang Y
- Wang Y
- Wang Y
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- Wang Y
- Wang Y
- Wang Y
- Wang Y-Y
- Wang Z
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- Warnes G
- Warnsmann V
- Watada H
- Watanabe E
- Watchon M
- WawrzyĆska A
- Weaver TE
- Wegrzyn G
- Wehman AM
- Wei H
- Wei L
- Wei T
- Wei Y
- WeiergrÀber OH
- Weihl CC
- Weindl G
- Weiskirchen R
- Wells A
- Wen RH
- Wen X
- Werner A
- Weykopf B
- Wheatley SP
- Whitton JL
- Whitworth AJ
- Wiktorska K
- Wildenberg ME
- Wileman T
- Wilkinson S
- Willbold D
- Williams B
- Williams RL
- Williams RSB
- Williamson PR
- Wilson RA
- Winner B
- Winsor NJ
- Witkin SS
- Wodrich H
- Woehlbier U
- Wollert T
- Wong E
- Wong JH
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- Wu A-G
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- Wu S
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- Wu S-Y
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- Wu WKK
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- Wu Y-W
- Xavier RJ
- Xia H
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- Xiang G
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- Xiang W
- Xiao B
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- Xiao H-T
- Xiao J
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- Yakhine-Diop SMS
- Yamaguchi M
- Yamaguchi O
- Yamamoto A
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- Zeitlin SO
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- Zhivotovsky B
- Zhong Q
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- Zhou Y
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- Zhou Z
- Zhou Z-Y
- Zhu B
- Zhu C
- Zhu G-Q
- Zhu H
- Zhu H
- Zhu H
- Zhu W-G
- Zhu Y
- Zhu Y
- Zhuang H
- Zhuang X
- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Ălvarez ĂMC
- Ăvalos Y
- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
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