An Administrative Guide for Developing A TECH PREP Program for Horticulture Education at South Kitsap High School

The purpose of this study was to develop a Tech Prep Program for horticulture education. This program focused on career goals of students enrolled at South Kitsap High School and South Seattle Community College. To accomplish this purpose, current research and literature on Tech Prep models, career paths, and the horticulture industry were reviewed. Additionally, selected materials were obtained from model Tech Prep programs throughout the State of Washington

Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases

PURPOSE: Bone metastases secondary to solid tumors increase the risk of skeletal-related events (SREs), including the occurrence of pathological fracture (PF), radiation to bone (RB), surgery to bone (SB), and spinal cord compression (SCC). The aim of this study was to evaluate the impact of SREs on patients' pain, analgesic use, and pain interference with daily functioning. METHODS: Data were combined from patients with solid tumors and bone metastases who received denosumab or zoledronic acid across three identically designed phase 3 trials (N = 5543). Pain severity (worst pain) and pain interference were assessed using the Brief Pain Inventory at baseline and each monthly visit. Analgesic use was quantified using the Analgesic Quantification Algorithm. RESULTS: The proportion of patients with moderate/severe pain and strong opioid use generally increased in the 6 months preceding an SRE and remained elevated, while they remained relatively consistent over time in patients without an SRE. Regression analysis indicated that all SRE types were significantly associated with an increased risk of progression to moderate/severe pain and strong opioid use. PF, RB, and SCC were associated with significantly greater risk of pain interference overall. Results were similar for pain interference with emotional well-being. All SRE types were associated with significantly greater risk of pain interference with physical function. CONCLUSIONS: SREs are associated with increased pain and analgesic use in patients with bone metastases. Treatments that prevent SREs may decrease pain and the need for opioid analgesics and reduce the impact of pain on daily functioning

Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases

PURPOSE: Bone metastases secondary to solid tumors increase the risk of skeletal-related events (SREs), including the occurrence of pathological fracture (PF), radiation to bone (RB), surgery to bone (SB), and spinal cord compression (SCC). The aim of this study was to evaluate the impact of SREs on patients' pain, analgesic use, and pain interference with daily functioning. METHODS: Data were combined from patients with solid tumors and bone metastases who received denosumab or zoledronic acid across three identically designed phase 3 trials (N = 5543). Pain severity (worst pain) and pain interference were assessed using the Brief Pain Inventory at baseline and each monthly visit. Analgesic use was quantified using the Analgesic Quantification Algorithm. RESULTS: The proportion of patients with moderate/severe pain and strong opioid use generally increased in the 6 months preceding an SRE and remained elevated, while they remained relatively consistent over time in patients without an SRE. Regression analysis indicated that all SRE types were significantly associated with an increased risk of progression to moderate/severe pain and strong opioid use. PF, RB, and SCC were associated with significantly greater risk of pain interference overall. Results were similar for pain interference with emotional well-being. All SRE types were associated with significantly greater risk of pain interference with physical function. CONCLUSIONS: SREs are associated with increased pain and analgesic use in patients with bone metastases. Treatments that prevent SREs may decrease pain and the need for opioid analgesics and reduce the impact of pain on daily functioning

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Services Supporting Management of Distributed Applications and Systems

A distributed computing system consists of heterogeneous computing devices, communication networks, operating system services and applications. As organisations move toward distributed computing environments, there will be a corresponding growth in distributed applications central to the enterprise. The design, development, and management of distributed applications presents many difficult challenges. As these systems grow to hundreds or even thousands of devices and similar or greater magnitude of software components, it will become increasingly difficult to manage them without appropriate support tools and frameworks. Further, the design and deployment of additional applications and services will be, at best, ad hoc without modelling tools and timely data on which to base design and configuration decisions. This paper presents a framework for management of distributed applications and systems. The framework is based on a set of common management services which support management acti..

What we talk about when we talk about seasonality – A transdisciplinary review

The role of seasonality is indisputable in climate and ecosystem dynamics. Seasonal temperature and precipitation variability are of vital importance for the availability of food, water, shelter, migration routes, and raw materials. Thus, understanding past climatic and environmental changes at seasonal scale is equally important for unearthing the history and for predicting the future of human societies under global warming scenarios. Alas, in palaeoenvironmental research, the term ‘seasonality change’ is often used liberally without scrutiny or explanation as to which seasonal parameter has changed and how. Here we provide fundamentals of climate seasonality and break it down into external (insolation changes) and internal (atmospheric CO2 concentration) forcing, and regional and local and modulating factors (continentality, altitude, large-scale atmospheric circulation patterns). Further, we present a brief overview of the archives with potentially annual/seasonal resolution (historical and instrumental records, marine invertebrate growth increments, stalagmites, tree rings, lake sediments, permafrost, cave ice, and ice cores) and discuss archive-specific challenges and opportunities, and how these limit or foster the use of specific archives in archaeological research. Next, we address the need for adequate data-quality checks, involving both archive-specific nature (e.g., limited sampling resolution or seasonal sampling bias) and analytical uncertainties. To this end, we present a broad spectrum of carefully selected statistical methods which can be applied to analyze annually- and seasonally-resolved time series. We close the manuscript by proposing a framework for transparent communication of seasonality-related research across different communities