Traffic Classification over Gbit Speed with Commodity Hardware

This paper discusses necessary components of a GPU-assisted traffic classification method, which is capable ofmulti-Gbps speeds on commodity hardware. The majority of the traffic classification is pushed to the GPU to offload the CPU, which then may serve other processing intensive tasks, e.g., traffic capture. The paper presents two massively parallelizable algorithms suitable for GPUs. The first one performs signature search using a modification of Zobrist hashing. The second algorithm supports connection pattern-based analysis and aggregation of matches using a parallel-prefix-sum algorithm adapted to GPU.The performance tests of the proposed methods showed that traffic classification is possible up to approximately 6 Gbps with a commodity PC

Visualization of mucosal field in HPV positive and negative oropharyngeal squamous cell carcinomas: combined genomic and radiology based 3D model

The aim of this study was to visualize the tumor propagation and surrounding mucosal field in radiography-based 3D model for advanced stage HNSCC and combine it with HPV genotyping and miRNA expression characterization of the visualized area. 25 patients with T1-3 clinical stage HNSCC were enrolled in mapping biopsy sampling. Biopsy samples were evaluated for HPV positivity and miR-21-5p, miR-143, miR-155, miR-221-5p expression in Digital Droplet PCR system. Significant miRNA expression differences of HPV positive tumor tissue biopsies were found for miR-21-5p, miR-143 and miR-221-5p compared to the HPV negative tumor biopsy series. Peritumoral mucosa showed patchy pattern alterations of miR-21-5p and miR-155 in HPV positive cases, while gradual change of miR-21-5p and miR-221-5p was seen in HPV negative tumors. In our study we found differences of the miRNA expression patterns among the HPV positive and negative tumorous tissues as well as the surrounding mucosal fields. The CT based 3D models of the cancer field and surrounding mucosal surface can be utilized to improve proper preoperative planning. Complex evaluation of HNSCC tissue organization field can elucidate the clinical and molecular differentiation of HPV positive and negative cases, and enhance effective organ saving therapeutic strategies

Subspecialty training in Europe:a report by the European Network of Young Gynaecological Oncologists

Backgroun

A multi-targeted approach to suppress tumor-promoting inflammation

Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-κB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes

Distribution and ecology of Carex secalina in the Czech Republic and Slovakia

Current and historical occurrence as well as coenotic affinity and ecology of Carex secalina in the Czech Republic and Slovakia are presented. The study is based on revision of herbarium specimens from 25 herbaria, literature data excerption and a field survey carried out during 2004-2010. Altogether, 168 sites were documented in the Czech Republic divided to two separate areas. Stabile occurrence trend was found in last decades, because 45 localities were documented in period 1975-1999 (27% of sites) and recent occurrence was confirmed at 42 localities (24% of sites). On the basis of our current knowledge the species was included into the IUCN threat category VU (vulnerable). In Slovakia, 19 localities of the species were recorded in total, but only 4 sites were confirmed recently (21% of sites recorded). However, only a small number of individuals was recorded there (less than 50 individuals in total) and half of this sites is acutely threatened by destruction (ploughing, secondary succession). Therefore, the C. secalina status in the Slovak Red List was changed to the IUCN category "critically endangered" (CR). Results of the study are summarised in the maps of historical and current species distribution. C. secalina usually occurred in halophytic grassland communities, especially in association Agrostio stoloniferae-Juncetum ranarii Vicherek 1962. However, it may occur in many other communities which suggest that the species had not well-defined coenotic relationships. On the basis of our knowledge, we consider C. secalina as an obligate halophyte

Separation of antibody drug conjugate species by RPLC: A genericmethod development approach

This study reports the use of modelling software for the successful method development of IgG1 cysteineconjugated antibody drug conjugate (ADC) in RPLC. The goal of such a method is to be able to calculate theaverage drug to antibody ratio (DAR) of and ADC product. A generic method development strategy wasproposed including the optimization of mobile phase temperature, gradient profile and mobile phaseternary composition. For the first time, a 3D retention modelling was presented for large therapeuticprotein. Based on a limited number of preliminary experiments, a fast and efficient separation of theDAR species of a commercial ADC sample, namely brentuximab vedotin, was achieved. The predictionoffered by the retention model was found to be highly reliable, with an average error of retention timeprediction always lower than 0.5% using a 2D or 3D retention models. For routine purpose, four to six initialexperiments were required to build the 2D retention models, while 12 experiments were recommendedto create the 3D model. At the end, RPLC can therefore be considered as a good method for estimatingthe average DAR of an ADC, based on the observed peak area ratios of RPLC chromatogram of the reducedADC sample

Association of Restless Legs Syndrome With Incident Parkinson's Disease.

The association between restless legs syndrome (RLS) and Parkinson's disease (PD) has been extensively studied with inconclusive results; therefore, we prospectively examined the associations of the presence of RLS with development of incident PD. From a nationally representative prospective cohort of almost 3.5 million US veterans (age: 60 ± 14 years, 93% male, median follow-up time of 7.8 years [interquartile range: 6.4-8.4 years]), we created a propensity-matched cohort of 100882 PD-free patients and examined the association between prevalent RLS and incident PD. This association was also assessed in the entire cohort. Associations were examined using Cox models. There were 68 incident PD events (0.13%, incidence rate 1.87 [1.48-2.37]/10000 patient-years) in the RLS-negative group, and 185 incident PD events (0.37%, incidence rate 4.72 [4.09-5.45]/10000 patient-years) in the RLS-positive group in the propensity-matched cohort. Prevalent RLS was associated with more than twofold higher risk of incident PD (hazard ratio [HR]: 2.57, 95% confidence interval [CI]: 1.95-3.39) compared to RLS-negative patients. Qualitatively similar results were found when we examined the entire 3.5 million cohort: Prevalent RLS was associated with more than twofold higher risk of incident PD (multivariable adjusted HR: 2.81, 95%CI: 2.41-3.27). RLS and PD share common risk factors. In this large cohort of US veterans, we found that prevalent RLS is associated with higher risk of incident PD during 8 years of follow-up, suggesting that RLS could be an early clinical feature of incident PD