DEVELOPMENT OF INTERACTIVE MULTIMEDIA-BASED GYMNASTICS FLOOR TECHNIQUES LEARNING MODEL FOR JUNIOR HIGH SCHOOL STUDENTS

Abstract Based on preliminary observations conducted on teachers and students of SMP Negeri in Malang Regency: (1) students can not and do not like the material gymnastics floor, and tend to like the material of big ball game (92%); (2) students state that educators have never done teaching with media in the form of interactive multimedia, 100%; and (3) students agree when done an development of interactive multimedia media for learning basic technique of gymnastic floor 100%. The purpose of this research and development is to develop an effective model of basic techniques of floor gymnastics for junior high school students using interactive multimedia. In this study is using development research methods from Borg and Gall (1983: 775), and researchers did not use the whole but only using 7 steps. The 7 steps chosen by the researchers are as follows: (1) collecting information, (2) initial product design, (3) expert evaluation, (4) trial in phase I , (5) product revision (6) trials in phase II, (7) revisions and final products. Based on the result of data analysis of the evaluation of the learning expert is very valid, the evaluation of expert gymnastics is very valid, the evaluation of media expert is very valid. From the data analysis result of small group trial is valid enough (73,1% ), while large group trial is very valid (85,75%), thus it can be concluded that the development of interactive multimedia-based floor gymnastic basic technique for junior high school student can be used. Keywords: development, learning, gymnastics floor, interactive multimedi

DEVELOPMENT OF INTERACTIVE MULTIMEDIA-BASED GYMNASTICS FLOOR TECHNIQUES LEARNING MODEL FOR JUNIOR HIGH SCHOOL STUDENTS

Based on preliminary observations conducted on teachers and students of SMP Negeri in Malang Regency: (1) students can not and do not like the material gymnastics floor, and tend to like the material of big ball game (92%); (2) students state that educators have never done teaching with media in the form of interactive multimedia, 100%; and (3) students agree when done an development of interactive multimedia media for learning basic technique of gymnastic floor 100%. The purpose of this research and development is to develop an effective model of basic techniques of floor gymnastics for junior high school students using interactive multimedia. In this study is using development research methods from Borg and Gall (1983: 775), and researchers did not use the whole but only using 7 steps. The 7 steps chosen by the researchers are as follows: (1) collecting information, (2) initial product design, (3) expert evaluation, (4) trial in phase I , (5) product revision (6) trials in phase II, (7) revisions and final products. Based on the result of data analysis of the evaluation of the learning expert is very valid, the evaluation of expert gymnastics is very valid, the evaluation of media expert is very valid. From the data analysis result of small group trial is valid enough (73,1% ), while large group trial is very valid (85,75%), thus it can be concluded that the development of interactive multimedia-based floor gymnastic basic technique for junior high school student can be used.. Keywords: Development, learning, gymnastics floor, interactive multimedi

The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo

Human lymphatic filariasis is a major tropical disease transmitted through mosquito vectors which take up microfilarial larvae from the blood of infected subjects. Microfilariae are produced by long-lived adult parasites, which also release a suite of excretory-secretory products that have recently been subject to in-depth proteomic analysis. Surprisingly, the most abundant secreted protein of adult Brugia malayi is triose phosphate isomerase (TPI), a glycolytic enzyme usually associated with the cytosol. We now show that while TPI is a prominent target of the antibody response to infection, there is little antibody-mediated inhibition of catalytic activity by polyclonal sera. We generated a panel of twenty-three anti-TPI monoclonal antibodies and found only two were able to block TPI enzymatic activity. Immunisation of jirds with B. malayi TPI, or mice with the homologous protein from the rodent filaria Litomosoides sigmodontis, failed to induce neutralising antibodies or protective immunity. In contrast, passive transfer of neutralising monoclonal antibody to mice prior to implantation with adult B. malayi resulted in 60–70% reductions in microfilarial levels in vivo and both oocyte and microfilarial production by individual adult females. The loss of fecundity was accompanied by reduced IFNγ expression by CD4+ T cells and a higher proportion of macrophages at the site of infection. Thus, enzymatically active TPI plays an important role in the transmission cycle of B. malayi filarial parasites and is identified as a potential target for immunological and pharmacological intervention against filarial infections

Mapping recent shoreline changes spanning the lateral collapse of Anak Krakatau Volcano, Indonesia

We use satellite imagery to investigate the shoreline changes associated with volcanic activity in 2018–2019 at Anak Krakatau, Indonesia, spanning a major lateral collapse and period of regrowth through explosive activity. The shoreline changes have been analyzed and validated through the adaptation of an existing methodology based on Sentinel-2 multispectral imagery and developed on Google Earth Engine. This work tests the results of this method in a highly dynamic volcanic environment and validates them with manually digitized shorelines. The analysis shows that the size of the Anak Krakatau Island increased from 2.84 km2 to 3.19 km2 during 15 May 2018–1 November 2019 despite the loss of area in the 22 December 2018 lateral collapse. The lateral collapse reduced the island area to ~1.5 km2 but this was followed by a rapid increase in area in the first two months of 2019, reaching up to 3.27 km2. This was followed by a period of little change as volcanic activity declined and then by a net decrease from May 2019 to 1 November 2019 that resulted from erosion on the SW side of the island. This history of post-collapse eruptive regrowth and coastal erosion derived from the shoreline changes illuminates the potential for satellite-based automated shoreline mapping to provide databases for monitoring remote island volcanoes

Interaction forces and membrane charge tunability: Oleic acid containing membranes in different pH conditions

Oleic acid is known to interact with saturated lipid molecules and increase the fluidity of gel phase lipid membranes. In this work, the thermodynamic properties of mixed monolayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and oleic acid at the air-water interface were determined using Langmuir isotherms. The isotherm study revealed an attractive interaction between oleic acid and DPPC. The incorporation of oleic acid also monotonically decreased the elastic modulus of the monolayer indicative of higher fluidity with increasing oleic acid content. Using the surface force apparatus, intermembrane force-distance profiles were obtained for substrate supported DPPC membranes containing 30mol% oleic acid at pH5.8 and 7.4. Three different preparation conditions resulted in distinct force profiles. Membranes prepared in pH5.8 subphase had a low number of nanoscopic defects ≤1% and an adhesion magnitude of ~0.6mN/m. A slightly higher defect density of 1-4% was found for membranes prepared in a physiological pH7.4 subphase. The presence of the exposed hydrophobic moieties resulted in a higher adhesion magnitude of 2.9mN/m. Importantly, at pH7.4, some oleic acid deprotonates resulting in a long-range electrostatic repulsion. Even though oleic acid increased the DPPC bilayer fluidity and the number of defects, no membrane restructuring was observed indicating that the system maintained a stable configuration

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Perancangan ui/ux pada game tower defense berjudul “rakshati”

Salah satu komponen dari game digital adalah user interface, untuk membantu pemain dengan memberikan informasi dari dunia game kepada pemain atau sebaliknya. Pengalaman pemain saat bermain game digital ini disebut juga dengan user experience. Pada game modern, visual user interface lebih bervariasi dibanding dengan game jaman dulu. Hal ini dilakukan sehingga user interface tidak hanya berfungsi sebagai penyampai informasi tetapi juga untuk menambahkan nilai estetika dari game. Dalam penelitian ini akan dirancang user interface untuk game mobile dengan genre tower defense yang sesuai dengan kebutuhan dan keinginan user bertema visual Bali dan Candi Gunung Kawi. Metode mendesain user interface akan berdasarkan studi literatur dari Paul Schuytema dan Jesse Schell. Sedangkan untuk analisa user experience akan menggunakan teori evaluasi menurut Wright dan teori usability dari Nielsen. Pengumpulan data dilakukan dengan cara observasi perbandingan user interface game mobile genre tower defense, wawancara dengan ahli, dan focus group discussion. Untuk referensi visual, akan mengambil ciri khas dari pemandangan Candi Gunung Kawi dan budaya Bali sehingga user interface dapat membaur dengan tema game. Hasil akhir dari penelitian ini merupakan sebuah game yang akan disebarkan melalui Google Play Store. Game ini diharapkan akan memperkenalkan dan meningkatkan ketenaran Candi Gunung Kawi