Prevalence, diagnosis and management of musculoskeletal disorders in elite athletes: A mini-review

[Abstract] Musculoskeletal injuries in elite sports are ones of the most impact issue because their remarkable impact on performance caused by drastic absence of training and competition and a progressive deterioration in physical health, emotional and social athletes’ dimen- sions. Also, the prevalence of epidemiologic research found an incidence of musculoskeletal disorders vary within sports and in elite athletes which is even higher as a consequence of higher demand physical performance. This way, the loss of physical performance due to an sport injury impacts not only the individual economic sphere of the professional but also that of sports entities, reaching, according to some studies, a loss estimated in the range of 74.7 million pounds. Thus, the purpose of this article is to review and to pro- vide an overview of the most common musculoskeletal injuries in elite sports precipitating factors, clinical presentation, evidence-based diagnostic evaluation, and treatment recom- mendations with a view to preventing medical conditions or musculoskeletal injuries that may alter performance and general health in the elite athletes

Pre and postoperative care for the outpatient fulguration in superficial bladder tumor. What should know the primary care physician?

Introducción: El objetivo de este trabajo es transmitir al médico de atención primaria los cuidados pre y postoperatorios en la fulguración con láser holmium de la recidiva del tumor vesical superficial. Material y Métodos: Estudio descriptivo de una cohorte de pacientes, llevado a cabo en el Hospital Universitario Morales Meseguer, Murcia (España). Se incluyen 37 pacientes con recidiva de tumor vesical superficial de bajo riesgo, sometidos a fulguración con láser de holmium. Se incluyen en el estudio pacientes con tumor papilar, tamaño ≤15 mm, menos de 5 tumores y sin alteraciones en la coagulación ni alergias a anestésicos locales. Se entregan recomendaciones pre y postoperatorias al paciente que debe conocer el médico de atención primaria, previa y tras la intervención (fulguración vesical ambulatoria con láser de holmium). Se miden complicaciones, dolor tras el procedimiento, satisfacción del paciente. Resultados: La edad media de los pacientes fue de 69.2 años, siendo el 86.5% hombres. El número de lesiones fue de 1.5 ± 0.8 y el tamaño global medio de 5.5 ± 2.7 mm. El tiempo medio de realización del procedimiento endoscópico fue de 12 ± 4.3 minutos. El 100% de los pacientes presentó puntuación en la escala visual analógica del dolor ≤ 3. Sólo 1 caso de hematuria que se resolvió de forma conservadora. Conclusión: El tratamiento con láser holmium de la recidiva tumoral vesical superficial de bajo riesgo de forma ambulatoria es seguro, precisa de profilaxis antibiótica, control del dolor y especial atención a efectos adversos que suelen ser leves.Introduction: The objective of this work is to inform to primary care the pre and postoperative care in holmium laser fulguration of superficial bladder tumor recurrence. Methods: A descriptive study of a cohort of patients, conducted at the University Hospital Morales Meseguer, Murcia (Spain). 37 patients with superficial bladder tumor recurrence undergoing holmium laser fulguration are included. Included in the study patients with papillary tumor size ≤ 15 mm, less than 5 tumors without coagulation disorders or allergies to local anesthetics. Pre and postoperative recommendations are given to the patient to know the family physician, after care and after surgery (outpatient bladder holmium laser fulguration). Complications, pain after the procedure and patient satisfaction were measured. Results: The mean age of the patients was 69.2 years, with 86.5% male. The number of lesions was 1.5 ± 0.8 and the overall average size of 5.5 ± 2.7 mm. The average time for completion of the endoscopic procedure was 12 ± 4.3 minutes. 100% of patients had scores on the visual analog pain scale ≤ 3. Only 1 case of hematuria that resolved conservatively. Conclusion: Holmium laser treatment of in low-risk superficial bladder tumor recurrence ambulatory safe, requires antibiotic prophylaxis, pain management and attention to side effects are usually mild

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Determination of the strong coupling constant αs from transverse energy–energy correlations in multijet events at s√=8 TeV using the ATLAS detector

Measurements of transverse energy–energy correlations and their associated asymmetries in multi-jet events using the ATLAS detector at the LHC are presented. The data used correspond to s√=8 TeV proton–proton collisions with an integrated luminosity of 20.2 fb−1 . The results are presented in bins of the scalar sum of the transverse momenta of the two leading jets, unfolded to the particle level and compared to the predictions from Monte Carlo simulations. A comparison with next-to-leading-order perturbative QCD is also performed, showing excellent agreement within the uncertainties. From this comparison, the value of the strong coupling constant is extracted for different energy regimes, thus testing the running of αs(μ) predicted in QCD up to scales over 1 TeV . A global fit to the transverse energy–energy correlation distributions yields αs(mZ)=0.1162±0.0011(exp.) +0.0084−0.0070(theo.) , while a global fit to the asymmetry distributions yields a value of αs(mZ)=0.1196±0.0013(exp.) +0.0075−0.0045(theo.)

Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)

From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions