11 research outputs found
Direct Measurement of Pancreatic Enzymes After Stimulation With Secretin Versus Secretin Plus Cholecystokinin
- Author
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- Field of study
Phase I study of nelfinavir in liposarcoma
- Author
- A Carr
- AK Gupta
- AT Nguyen
- Bixin Xi
- C Flexner
- CDM Fletcher
- D Hoff Von
- Ernestine Hepner
- Frances Valdes
- GO Garza De La
- I Shimomura
- J Sakai
- Janet Pan
- JE Gallant
- JH Lillibridge
- JP Bastard
- K Brinkman
- Kristen Fousek
- M Caron
- M Guan
- Michelle Mott
- Min Guan
- MS Brown
- MS Brown
- P Pyrko
- P Therasse
- Paul Frankel
- Rachel Magnusson
- Raechelle Tinsley
- RL Jones
- SL Ettinger
- T Yang
- TB Brunner
- Timothy Synold
- V Martino Di
- WA Chow
- Warren A. Chow
- Y Yang
- Z Jiang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
PURPOSE: HIV protease inhibitors are associated with HIV protease inhibitorârelated lipodystrophy syndrome. We hypothesized that liposarcomas would be similarly susceptible to the apoptotic effects of an HIV protease inhibitor, nelfinavir. METHODS: We conducted a phase I trial of nelfinavir for liposarcomas. There was no limit to prior chemotherapy. The starting dose was 1,250 mg twice daily (Level 1). Doses were escalated in cohorts of three to a maximally evaluated dose of 4,250 mg (Level 5). One cycle was 28 days. Steady-state pharmacokinetics (PKs) for nelfinavir and its primary active metabolite, M8, were determined at Levels 4 (3,000 mg) and 5. RESULTS: Twenty subjects (13 males) were enrolled. Median (range) age was 64 years (37â81). One subject at Level 1 experienced reversible, grade 3 pancreatitis after 1 week and was replaced. No other dose-limiting toxicities were observed. Median (range) number of cycles was 3 (0.6â13.5). Overall best responses observed were 1 partial response, 1 minor response, 4 stable disease, and 13 progressive disease. Mean peak plasma levels and AUCs for nelfinavir were higher at Level 4 (7.3 mg/L; 60.9 mg/L Ă h) than 5 (6.3 mg/L; 37.7 mg/L Ă h). The mean ratio of M8:nelfinavir AUCs for both levels was ~1:3. CONCLUSIONS: PKs demonstrate auto-induction of nelfinavir clearance at the doses studied, although the mechanism remains unclear. Peak plasma concentrations were within range where anticancer activity was demonstrated in vitro. M8 metabolite is present at ~1/3 the level of nelfinavir and may also contribute to the anticancer activity observed
The effect of hospital safety-net burden on outcomes, cost, and reportable quality metrics after emergent clipping and coiling of ruptured cerebral aneurysms
- Author
- Agency for Healthcare Research and Quality
- Alexander A. Khalessi
- Arvin R. Wali
- Attenello
- Barker
- Brian R. Hirshman
- Christian Lopez Ramos
- Connolly
- David R. Santiago-Dieppa
- De la Garza Ramos
- Dupree
- Eslami
- Fargen
- Gilman
- Gilman
- Gilman
- Go
- Goldman
- Haider
- Herrel
- Hoehn
- Institute of Medicine
- Jeffrey A. Steinberg
- Jeffrey S. Pannell
- Kevin Porras
- Khera
- Lai
- Lai
- Leake
- McCutcheon
- McHugh
- Michael G. Brandel
- Mouch
- Neuhausen
- Pandey
- Peter Abraham
- Robert C. Rennert
- Romano
- Shahan
- Teufack
- Washington
- Wen
- Won
- Won
- Yazeed Almosa
- Zacharia
- Publication venue
- 'Journal of Neurosurgery Publishing Group (JNSPG)'
- Publication date
- Field of study
A guide to the effects of a large portion of the residues of triosephosphate isomerase on catalysis, stability, druggability, and human disease
- Author
- Aguirre
- Aguirre
- Aissa
- Alahuhta
- Alvarez
- Alvarez
- Arya
- Bandyopadhyay
- Banerjee
- Banerjee
- Banerjee
- Borchert
- Borchert
- Cabrera
- Cardinale
- Casteleijn
- Celotto
- Chandrayan
- Chanez-Cardenas
- Chang
- Chavez-Calvillo
- Chen
- Chu
- Crooks
- Daar
- Delboni
- Deng
- Deng
- Devenish
- Dhaunta
- Dumont
- Eaazhisai
- Eber
- Enriquez-Flores
- Enriquez-Flores
- Espinoza-Fonseca
- Espinoza-Fonseca
- Fermo
- Furuya
- Galland
- Gao
- Garcia-Torres
- Garcia-Torres
- Garza-Ramos
- Garza-Ramos
- Gayathri
- Gayosso-De-Lucio
- Gnerer
- Go
- Gokhale
- Gomez-Puyou
- Gonzalez-Mondragon
- Goodsell
- Guix
- Guzman-Luna
- Guzman-Luna
- Haley
- Hernandez-Alcantara
- Hernandez-Alcantara
- Hernandez-Alcantara
- Hipkiss
- Joseph-McCarthy
- Joubert
- Kohlhoff
- Komives
- Kursula
- Kursula
- Kusaka
- la Mora-de la Mora
- La Mora-De La Mora
- Lambeir
- Lara-Gonzalez
- Lopez-Castillo
- Lopez-Zavala
- Madej
- Maes
- Mainfroid
- Maithal
- Malabanan
- Malabanan
- Maldonado
- Mande
- Nagano
- Nickbarg
- Nolan
- Nolan
- Norledge
- Olah
- Olivares-Illana
- OlĂĄh
- Orosz
- Pareek
- Parthasarathy
- Pattanaik
- Peimbert
- Pereira
- Perez-Montfort
- Pretsch
- Quezada
- Ralser
- Reardon
- Reyes-Lopez
- Reyes-Vivas
- Reyes-Vivas
- Reyes-Vivas
- Reyes-Vivas
- Richard
- Richard
- Rodriguez-Almazan
- Rodriguez-Bolaños
- Roland
- Roland
- Saab-Rincon
- Saab-Rincon
- Samanta
- Sampson
- Sampson
- Schliebs
- Schneider
- Seigle
- Serdaroglu
- Shi
- Silverman
- Sun
- Sun
- Sun
- Sun
- Sun
- Sundberg
- Tajes
- Talent
- Tellez-Valencia
- Verlinde
- Wang
- Watanabe
- Wierenga
- Wierenga
- Williams
- Xiang
- Zhai
- Zhang
- Zhang
- Publication venue
- 'Wiley'
- Publication date
- Field of study
ESPGHAN and NASPGHAN Report on the Assessment of Exocrine Pancreatic Function and Pancreatitis in Children
- Author
- Amarri
- Bai
- Bertin
- Boocock
- Boyd
- Caras
- Carriere
- Carroccio
- Chowdhury
- Cleghorn
- Cohn
- Conwell
- Conwell
- Darge
- DiMagno
- Dominguez Munoz
- Dominguez-Munoz
- Dreiling
- Dror
- Dutta
- Elphick
- Etemad
- Farrell
- Fine
- Fischer
- Fomon
- Gaskin
- Glasgow
- Go
- Green
- Green
- Gupte
- Guy-Crotte
- Hegyi
- Hermon-Taylor
- Ishiguro
- Issa
- Jacob
- Jazrawi
- Kalivianakis
- Kalivianakis
- Kalivianakis
- Kaspar
- Koumantakis
- Kunitz
- LaRusch
- Lieb
- Lindkvist
- Lindkvist
- Lindquist
- Littlewood
- Loser
- Lucidi
- Madrazo-de la Garza
- Malfertheiner
- Manfredi
- Manfredi
- Mayerle
- Molinari
- Morinville
- Morinville
- Nakamura
- Neff
- Ng
- Noone
- Nydegger
- Ooi
- Paolini
- Paracchini
- Park
- Pelaez-Luna
- Phillips
- Phuapradit
- Ravi Kanth
- Rebours
- Rings
- Rotig
- Rustagi
- Scheele
- Schibli
- Sharer
- Shelton
- Sikkens
- Smanio
- Spanier
- Stein
- Stevens
- Sultan
- Sziegoleit
- Thompson
- Tipnis
- Tran
- Trout
- Van De Kamer
- van Dijk-van Aalst
- Varadarajulu
- Wali
- Walkowiak
- Walkowiak
- Walkowiak
- Weintraub
- Witt
- Yang
- Zenker
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- Field of study
Biotechnology Crop Adoption: Potential and Challenges of Genetically Improved Crops
- Author
- Abbadi
- Agarwal
- Agius
- Anai
- Anderson
- Asensi-Fabado
- Awad
- Bekaert
- Bennett
- Bino
- Bouhnik
- Brigelius-Flohe
- Brinch-Pedersen
- Brinch-Pedersen
- Brookes
- Brookes
- Bruce
- Buchanan
- Butelli
- Cahoon
- Caimi
- Carlson
- Carter
- Castiglioni
- Chakraborty
- Chapman
- Chen
- Chiang
- Choudhary
- Choudhary
- Christensen
- Connolly
- Cromwell
- da Silva
- Davidovich-Rikanati
- Davies
- Dehesh
- Del Vecchio
- DellaPenna
- DellaPenna
- Denbow
- Deng
- Diaz de la Garza
- Dinkins
- Diretto
- Dixelius
- Drakakaki
- Ducreux
- Eggeling
- Elmegaard
- Enfissi
- Falco
- Fraser
- Froman
- Galili
- German
- Giliberto
- Giovannucci
- Giovinazzo
- Go
- Gonzali
- Goto
- Green
- Hajirezaei
- Hall
- Harjes
- Hartwig
- Hellwege
- Hellwege
- Helm
- Herman
- Hipskind
- Hutchison
- Jalani
- James
- James
- Jung
- Katsube
- Keshavarz
- Kinney
- Kobayashi
- Kramer
- Lai
- Li
- Liu
- Long
- Lopez-Bucio
- Lucca
- Lukaszewicz
- Mathers
- Mazzatti
- McCue
- Mehta
- Muir
- Naqvi
- Newell-McGloughlin
- Nicholson
- Niggeweg
- Ogita
- OâQuinn
- Parveez
- Paul
- Pfeiffera
- Potrykus
- Potrykus
- Prakash
- Reddy
- Reiffel
- Rocheford
- Roesler
- Rosati
- Schauer
- Schirmer
- Schwall
- Scorza
- Shewmaker
- Shin
- Shintani
- Siritunga
- Smeekens
- Smuts
- Sottosanto
- Sprenger
- Stark-Lorenzen
- Stern
- Storozhenko
- Sun
- SĂ©venier
- Tang
- Trewavas
- Turnbaugh
- Uauy
- Ursin
- Wambugu
- Wehrspann
- Welsch
- White
- Yang
- Ye
- Yonekura-Sakakibara
- Young
- Yu
- Yu
- Yu
- Yuan
- Zeh
- Zhang
- Zou
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
Cytoprotective Systems Within the Kidneysâ
- Author
- Abbott
- Adachi
- Adams
- Adams
- Agarwal
- Alam
- Aleo
- Almeida
- Ambrose
- Anderson
- Anderson
- Anderson
- Andersson
- Andreoli
- Andrews
- Ansari
- Aposhian
- Aposhian
- Arany
- Arnér
- Ashkar
- Aw
- Baggett
- Baines
- Ballatori
- Barnes
- Barone
- Bathula
- Beisswenger
- Bellamy
- BeltrĂĄn
- Benipal
- Benipal
- Berryman
- Bhatt
- Bonventre
- Bonventre
- Borkan
- Borkan
- Borutaite
- Botta
- Braithwaite
- Bridges
- Bridges
- Bridges
- Bridges
- Bridges
- Bridges
- Brookes
- Brooks
- Brown
- Brownlee
- Bruschi
- Bruschi
- Burton
- Cai
- Calabrese
- Caudrado
- Chan
- Chander
- Chavez
- Chen
- Chen
- Chen
- Chen
- Chen
- Cherian
- Clare
- Clarkson
- Coimbra
- Coll
- Counts
- Coyle
- Cullinan
- Cummings
- Dalton
- Danial
- Dass
- de Ceaurriz
- de Graauw
- de la Torre
- Dickinson
- Dieguez-Acuña
- DiMari
- DiMari
- Dong
- Dong
- Dong
- Dong
- Drieman
- Drieman
- Eaton
- Evers
- Fernandez
- Fernandez-Checa
- Fernandez-Checa
- Fernandez-Checa
- Fine
- Fish
- Flagg
- Flagg
- Fonteles
- Formigari
- Gale
- Garcia-Ruiz
- Gardner
- Garrett
- Garrett
- Garrett
- Garza-Quintero
- George
- Gerk
- Ghafourifar
- Ghosh
- Girardi
- Girardi
- Giulivi
- Go
- Gonzalez-Ramirez
- Gopalakrishnan
- Gopalakrishnan
- Gregus
- Griffith
- Griffith
- Griffith
- Griffith
- Griffith
- Griffith
- Griffith
- Griffith
- Hagen
- Hagen
- Hagos
- Hamada
- Hammerman
- Han
- Hanigan
- Hansen
- Haq
- Harris
- Harrison
- Havasi
- He
- Heyman
- Hinchman
- Hoey
- Holmgren
- Houser
- Huang
- Huang
- Humes
- Humes
- Hung
- Hurd
- Hwang
- HĂ€berle
- HĂ€ussler
- Ikeda
- Inoue
- Inoue
- James
- Jeong
- Johnson
- Jones
- Jones
- Jones
- Jones
- Kanki
- Kays
- Kensler
- Keppler
- Kim
- Kim
- Klaassen
- Klingenberg
- Klotzbach
- Kurosawa
- Lager
- Laity
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Lash
- Laurent
- Leonard
- Li
- Li
- Li
- Li
- Li
- Li
- Liang
- Lieberman
- Liu
- Loguercio
- Lu
- Mandel
- Mao
- Mao
- Marathe
- Martensson
- McEneaney
- McIntyre
- McKernan
- Megyesi
- Megyesi
- Megyesi
- Meister
- Meredith
- Mididoddi
- Miller
- Miller
- Miller
- Miller
- Miller
- Mittur
- Moch
- Moinova
- Moldéus
- Moldéus
- Mollerup
- Morin
- Mulcahy
- Nath
- Nerland
- Nissim
- Nissim
- Nonn
- Nony
- Norman
- Nowak
- Nowak
- Nowak
- Nowak
- Nowak
- Nowak
- Nowak
- Nowak
- Oberly
- Obrosova
- Ookhtens
- Orellana
- Ormstad
- Ormstad
- Ormstad
- Ormstad
- Orrenius
- Paller
- Palmieri
- Palmieri
- Park
- Parks
- Patenaude
- Paulusma
- Peherstorfer
- Pompella
- Puri
- Putt
- Rall
- Ramachandiran
- Rankin
- Rankin
- Rasbach
- Rasbach
- Rebbeor
- Reed
- Riordan
- Rodeheaver
- Rohas
- Rolo
- Ruchalski
- Sakarcan
- Samiec
- Sarang
- Satoh
- Saunder
- Schena
- Schmelzer
- Schmelzer
- Schnellmann
- Schnellmann
- Scott
- Selivanov
- Shaikh
- Shanley
- Shelden
- Shelden
- Shimizu
- Shirley
- Sies
- Sinha
- Sochor
- Sogabe
- Soltoff
- Somji
- Spater
- Stewart
- Storz
- Storz
- Tanaka
- Tanaka
- Tang
- Tang
- Tapodi
- Tatoyan
- Terlouw
- Tian
- Toback
- Turrens
- Ueno
- van Aubel
- Van Why
- Venkatachalam
- Venkatachalam
- Verstrepen
- Visarius
- Wallin
- Wang
- Wang
- Wang
- Waters
- Watson
- Weinberg
- Weinberg
- Weinberg
- Weinberg
- Weinberg
- Weinberg
- Weinberg
- Weinberg
- Weinberg
- Weinberg
- Weinberg
- Wendel
- Winiarska
- Wispriyono
- Witzgall
- Wlodek
- Wolf
- Woods
- Xu
- Yamaji
- Yan
- Yang
- Yang
- Yang
- Yaqoob
- Yee
- Yu
- Zalups
- Zalups
- Zalups
- Zalups
- Zalups
- Zalups
- Zalups
- Zalups
- Zalups
- Zalups
- Zalups
- Zalups
- Zalups
- Zalups
- Zalups
- Zalups
- Zhang
- Zhang
- Zhang
- Zhong
- Zhong
- Zhong
- Zhong
- Zhuang
- Zhuang
- Zhuang
- Zhuang
- Zipper
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
Helicobacter pylori in Childhood
- Author
- Achyut
- Aebischer
- Agha
- Akhiani
- Alm
- Ando
- Annibale
- Apfelbacher
- Archambault
- Ashorn
- Ashorn
- Atherton
- Atherton
- Azem
- Azuma
- Backert
- Backert
- Backhed
- Baele
- Baggett
- Bahremand
- Bahu Mda
- Baldwin
- Bamford
- Banatvala
- Baron
- Basso
- Bauer
- Beales
- Beales
- Berg
- Bergman
- Bethel
- Bettelli
- Bisogno
- Bjorkholm
- Blackwood
- Blaser
- Blaser
- Blaser
- Blaser
- Blaser
- Blecker
- Boncristiano
- Borrelli
- Bourke
- Bourke
- Brandt
- Brenner
- Brenner
- Brodersen
- Bronte-Tinkew
- Broutet
- Bussiere
- Caruso
- Castillo
- Cellini
- Ceponis
- Chan
- Chen
- Chen
- Chen
- Cherian
- Chiba
- Chimonas
- Choe
- Choe
- Choe
- Choe
- Choe
- Chuang
- Clyne
- Couturier
- Crew
- Croxen
- Dale
- Daugule
- Daugule
- de Jonge
- Del Giudice
- Del Giudice
- Dondi
- Dong
- Dong
- Dooley
- Drazek
- Drumm
- Drumm
- Drumm
- Dubois
- Dupont
- DâElios
- DâElios
- Eaton
- Eaton
- Egbaria
- El-Omar
- El-Omar
- El-Omar
- El-Omar
- el-Omar
- Elitsur
- Elitsur
- Elitsur
- Elitsur
- Elitsur
- Emiroglu
- Ertem
- Eshun
- Faber
- Fagan
- Fallone
- Falsafi
- Falush
- Falush
- Fan
- Farrell
- Ferlay
- Feydt-Schmidt
- Feydt-Schmidt
- Figueiredo
- Fock
- Francavilla
- Francavilla
- Fujimoto
- Furuta
- Furuta
- Furuta
- Galmiche
- Ganga-Zandzou
- Garg
- Garza-Gonzalez
- Gasbarrini
- Gatta
- Gebert
- Geijtenbeek
- Genta
- Genta
- Gerhard
- Gerhard
- Gerrits
- Gerrits
- Gerrits
- Gessner
- Gillen
- Girardin
- Gisbert
- Gisbert
- Gisbert
- Gisbert
- Glupczynski
- Go
- Gobert
- Gobert
- Goel
- Gold
- Gold
- Gold
- Goldman
- Gonzalez
- Gonzalez
- Gonzalez
- Goodwin
- Gorbach
- Gormally
- Gotteland
- Gottrand
- Graham
- Graham
- Gringhuis
- Grove
- Guiney
- Haesebrouck
- Halitim
- Hampe
- Hansen
- Hansson
- Hardikar
- Hassall
- Henriksen
- Herold
- Higashi
- Hofreuter
- Hold
- Homan
- Hornsby
- Houghton
- Hu
- Huang
- Hurduc
- Hussey
- Iijima
- Ilver
- Innocenti
- Ito
- Jackson
- Jenks
- Jolley
- Jones
- Jones
- Kalach
- Kato
- Kato
- Kato
- Kawaguchi
- Kawakami
- Kawakami
- Kayhan
- Kersulyte
- Kim
- Kindermann
- Kindermann
- Kluge
- Ko
- Koletzko
- Koletzko
- Koletzko
- Koletzko
- Kuipers
- Kuipers
- Kuloglu
- Kumagai
- Kupcinskas
- Kurugoglu
- Kwok
- Kwon
- Labenz
- Laheij
- Laine
- Lee
- Lehmann
- Levine
- Liew
- Lin
- Lind
- Lindholm
- Linz
- Lionetti
- Liu
- Liu
- Lopes
- Lottspeich
- Lu
- Lundgren
- Luzza
- Luzza
- Luzza
- Machado
- Machado
- Machado
- Machado
- Maeda
- Magista
- Magnusson
- Mahalanabis
- Mahdavi
- Makristathis
- Malaty
- Malaty
- Malaty
- Malaty
- Malfertheiner
- Malfertheiner
- Malfertheiner
- Marignani
- Marshall
- Marshall
- Masoodpoor
- Mattapallil
- Mazzucchelli
- Medzhitov
- Medzhitov
- Medzhitov
- Menaker
- Mendez-Sanchez
- Mera
- Merrell
- Mitchell
- Mitchell
- Mitchell
- Mitchell
- Miwa
- Mizuno
- Moayyedi
- Mobley
- Mohammad
- Mohammadi
- Mohammadi
- Molinari
- Molinari
- Moodley
- Moura
- Mourad-Baars
- Muhsen
- Muhsen
- Muotiala
- Murphy
- Naito
- Naja
- Nakayama
- Ndip
- Necchi
- Nguyen
- NIH Consensus Conference
- Nijevitch
- Nilsson
- Nilsson
- Niv
- Nomura
- Nordenstedt
- Obonyo
- Odenbreit
- Odenbreit
- Oderda
- Oderda
- Ohkusa
- Oksanen
- Okuda
- Olbe
- Oleastro
- Owen
- Pacifico
- Palli
- Palli
- Parkin
- Parsonnet
- Pattis
- Peek
- Pflock
- Poddar
- Putsep
- Queiroz
- Queiroz
- Quiding-Jarbrink
- Rad
- Rad
- Ramarao
- Ramus
- Reeves
- Ren
- Richter
- Rioux
- Robinson
- Robinson
- Rodrigues
- Rohde
- Roosendaal
- Roovers
- Rothenbacher
- Rothenbacher
- Rotter
- Rowland
- Rowland
- Rowland
- Rowland
- Rowland
- Rowland
- Rudi
- Ruggiero
- Rupnow
- Rupnow
- Russmann
- Saadat
- Sabbi
- Sachdeva
- Salles
- Santos
- Sarker
- Schwarzer
- Schwizer
- Segal
- Selbach
- Seo
- Sgouras
- Shcherbakov
- Shiotani
- Siai
- Sisson
- Smeets
- Smith
- Solnick
- Sood
- Soylu
- Stasi
- Steinman
- Steinman
- Stone
- Suerbaum
- Suerbaum
- Suerbaum
- Sundrud
- Suoglu
- Sykora
- Szabo
- Szajewska
- Takahashi
- Take
- Talarico
- Tam
- Tanaka
- Tankovic
- Terebiznik
- Terebiznik
- Thakkar
- Thomas
- Tindberg
- Tkachenko
- Tomb
- Tomita
- Tong
- Tong
- Toulaymat
- Treepongkaruna
- Trejo-de la
- Tsutsumi
- Tu
- Tutar
- Uemura
- Utt
- Vaira
- Vaira
- Valle
- van Doorn
- Velayudhan
- Viala
- Vinette
- Voland
- Wang
- Wang
- Wang
- Wang
- Wang
- Weeks
- Weyermann
- Weyermann
- Willhite
- Wilschanski
- Wilson
- Wilson
- Wong
- Wotherspoon
- Wu
- Wu
- Wu
- Xia
- Xie
- Xu
- Yamanishi
- Yamaoka
- Yamaoka
- Yanez
- Yang
- Yang
- Yu
- Yucel
- Yuceyar
- Zeng
- Zheng
- Zullo
- Zullo
- Zullo
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone
- Author
- Abalos-Galito M
- Abboy C
- Abrahamian F
- Abreu E
- Ackerman If
- Acosta Ia
- Adams L
- Adaoag Aa
- Adiaz-Baui Tt
- Aggarwal Nk
- Aguilar Dominguez Pe
- Aguilar-Orozco Ra
- Aguirre Sosa I
- Ahmed M
- Aleksandrova E
- Alekseeva E
- Alexandrescu Ds
- Ali Mi
- Allen GG Jr
- Allen Dr
- Allison Dc
- Altieri Hh
- Alvey Jc
- Alwine Lk
- Amer L
- Anand S
- Andrasofszky Z
- Anspach Rb
- Antuni Jd
- Antépara Ercoreca I
- Anwar J
- Apaliski Sj
- Arastu Rs
- Aries Sp
- Arimah C
- Arnedillo Muñoz A
- Arora Cm
- Arthur Cp
- Asherova I
- Auerbach D
- Austri Investigators
- Azzam Sj
- Babyesiza A
- Backer V
- Badar FL 3rd
- Badat A
- Baker Jw
- Balakrishnan K
- Balthazar Y
- Banovcin P
- Barasch Jp
- Barbarash Ol
- Barbe Illa F
- Barber Ma
- Bardin Pg
- Bardinas-Rodriguez R
- Barnes Nc
- Barreiro LĂłpez B
- Barreiro Tj
- Barros Monge Mj
- Barth D
- Bartha A
- Bartuzi Z
- Bassa A
- Bauler A
- Baumbach Rr
- Baur Ce
- Baxter Bs
- Beach Jl
- Beasley Rl
- Beavins Je
- Beliveau Wj
- Benbow Mj
- Benedix A
- Bennett Nl
- Bennett Rl
- Berenfus Vi
- Berg P
- Bergna Ma
- Bergtholdt B
- Bernal H
- Bernan Ap
- Bernstein Di
- Besh L
- Bettig U
- Bielous-Wilk A
- bin Abdul Aziz Fa
- Bindig Hw
- Blaiss Ms
- Blanco Aparicio M
- Blumenthal Kw
- Boada Valmaseda A
- Boas Sr
- Bolivar Grimaldos F
- Bolliger Ct
- Bonavia M
- Borders Jl
- Boscia Ja
- Bosque GarcĂa M
- Botzen U
- Boulware Wn
- Bowling Bt
- BoĆŒek A
- Brabec Ba
- Braga M
- Bramlet Dg
- Brautigam Df
- Breedt J
- Brehler R
- Breyer Go
- Brown V
- Brownell Jm
- Bruce Tr
- Bruckhaus-Walter M
- Bruning A
- Brzostek J
- Buaron Ks
- Bugrova O
- Bukreeva Eb
- Buresova M
- Burhan H
- Bursova J
- Bustamante Ruiz A
- Butkovic-Tomljanovic R
- BĆaĆŒowski Ć
- Call Rs
- Calvo Gil Ma
- Campbell Ca
- Canaan Ya
- Cannon Df
- Carpio Jm
- Carretero Anibarro P
- Carroll Pa
- Castillo Hofer Cr
- Cathcart Ws
- Cerveri I
- Cevallos Jp
- Chapman Kr
- Chaudhuri R
- Chauhan Av
- Cheng Sl
- Chermenskiy A
- Chern Jh
- Chetta Aa
- Chevalier D
- Chiu Mh
- Chizhova O
- Choi I
- Chomiciene A
- Chorostowska-Wynimko J
- Christensen J
- Christensen Ta
- Christina Mo
- Chrzanowski Rr
- Chuang Rb
- Chung Cl
- Ciekalska K
- Cieslicki J
- Cirule I
- Cisneros Am
- Civitarese Fa
- Clark Jp
- Clements Bs
- Clifford Dp
- Coggi Ja
- Cohen Kr
- Collier D
- Collins Bg
- Collins H
- Comellas A
- Condit J
- Cordasco EM Jr
- Corder Cn
- Covar Ra
- Coverston Kd
- Crimi N
- Croce Sa
- Cruz H
- Csanadi Ma
- Cuadrado Ja
- Curtis Ct
- Cutrera R
- Daftary Pk
- Dalan D
- Dalawari Sp
- Daly Wc
- Dapper T
- Daud M
- Davies Ej
- Davis Kc
- Davoliene I
- Dawes Kw
- De Gennaro Ms
- De Rosa M
- De Valle Ol
- Decotiis Ba
- Del Campo Matias F
- Deluca Rf
- Demko I
- Desantis Dm
- Dhillon R
- Diaz Amor Pv
- Diaz Jd
- Diaz Jl
- Dice Jp
- Dimitrova R
- Dimova D
- Diogo Jj
- Dixon C
- Djajalaksana S
- Dobkin La
- Dobrusin Rs
- Dopudja Pantic V
- Dore Nd
- Dransfield Mt
- Dudnyk O
- Duka Kd
- Dupont Lj
- Ebbeling Wl
- Echave-Sustaet Jm
- Eckhard Jg
- Edwards Jd
- Eglite R
- Elacion Jm
- Elizalde A
- Elkayam D
- Ellery A
- Ellis Gc
- Ellison Wt
- Elsen Jr
- Emanuel S
- Emeryk A
- Emmett Ah
- Engel Lr
- Engelhard R
- Ensz Dj
- Ericksen Cl
- Ervin Je
- Espinosa de los Monteros Garde Mj
- Esposito S
- Estrella Viladegut Ra
- Evdokimova A
- Fang C
- Farkas M
- Farrah Vb
- Fazio Lizandrelo Cl
- Feldmeyer F
- Field Jd
- Figueroa Dp
- Fishman Hj
- Fissan H
- Fitzgerald Da
- Florea R
- Focauld F
- Focil A
- Folcik K
- Foresi A
- Forstner B
- Fouche Lf
- Franco MA Jr
- Frandsen Br
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- Fratrik J
- Frick Bs
- Fulat Ma
- Funck J
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- Gammeri E
- Gani M
- Ganti K
- Garcia Hernandez Gm
- Garcia Fl
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- Garscadden Ag
- Garza-Salinas S
- Gatti Ea
- Gattolin G
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- Gellady Am
- George Ar
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- Gibbon Gw
- Giejlo M
- Ginko T
- Giorgadze Ml
- Gleason Gp
- Godlevska O
- Goldberg P
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- Gonzalez Ge
- Gosn Am
- Gower Rg
- Grande Ja
- Gregory D
- Grigat Ce
- Grigoryev S
- Grimm-Sachs V
- Griskeviciene V
- Groth G
- Grubb Sd
- Guthrie Rp
- Guttlerova E
- Gömöri K
- Haas Ta
- Haft Ks
- Hajal R
- Hamelmann E
- Hammond Gd
- Hampf J
- Hanf G
- Hansel Nn
- Hansen Vr
- Harat R
- Harris Af
- Hartman An
- Hartman P
- Harvey Rr
- Havasi-Jost G
- Hazan-Steinberg S
- Headley Dm
- Hegedus-Jungvirth M
- Heigerick Gc
- Heinz Gu
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- Helm K
- Hendrix El
- Henein S
- Herrod Jn
- Hewitt Mj
- Hines Rl
- Hirdt Ap
- Hirschfield Ja
- Hoeltz S
- Hoffman Ks
- Hofman T
- Hofmann S
- Hogan Ad
- Horvathova H
- Hosler Mr
- Hospodarskyy I
- Howland Wc
- Hsu Cc
- Hsu Fj
- Hubbard Wm
- Hudson Jd
- Huffman C
- Hussain M
- Iashyna L
- Idrisova E
- Iemoli E
- Ioachimescu Oc
- Irkhina I
- Ismail Ai
- Ismail Ms
- Ismail Ym
- Ivkovic-Jurekovic I
- Jaffrani Na
- Jahnz-RĂłĆŒyk K
- Jander R
- Jandl M
- Jasch-Hoppe B
- Jedrzejczak M
- Jiang N
- Jirmanova I
- Johnsen Cr
- Jones Sw
- Jordan Rs
- Joshi Ke
- Jung T
- Junggeburth Jj
- Jurgens Jc
- Kaashmiri Mw
- Kachel T
- Kaik G
- Kaladze M
- Kalafer M
- Kalina P
- Kamdar Ba
- KamiĆski D
- Kanuga Jg
- Kao Nl
- Karako P Sr
- Kardos P
- Karetzky M
- Katsetos Jc
- Kay Js
- Kelly Aj
- Kelm Warchol A
- Khurkhurova Nv
- Khvelos Si
- Kim C
- Kim Js
- Kim Wj
- Kimmel Ma
- Kimura Sh
- Kingsley Jk
- Kirstein Jl
- Kis S
- Kissyova Ibrishimova G
- Kleerup Ec
- Klein Rm
- Knueppel W
- Koch T
- Koeberl Gh
- Koh Dw
- Koh Yy
- Kohli N
- Kolman P
- Kolorz C
- Kondyurina Eg
- Konieczny Z
- Korduan M
- Korth-Wiemann B
- Kostin Vi
- Kostromina Vp
- Koura Fa
- Kovacs Sp
- Krakhmalova O
- Kral Km
- Krasko Mp
- Kratzer J
- Kreit Ci
- Kreutter Fm
- Krezdorn Hg
- Kroker A
- Kruell M
- Kryuchko T
- Kubicki Tm
- Kucera M
- Kudelya L
- Kuehne P
- Kulynych Ov
- Kwasniewski A
- Kwok S
- Kwon Ss
- Labuda Jm
- Lai Rs
- Laleko Sl
- Lam As
- Lapidus Rj
- Lara Mm
- Larrateguy Ld
- Latorre Aj
- Lechin Ae
- Lee Jj
- Lee Md
- Lee S
- Lee Sh
- Lee Sk
- Lee Wm
- Legnani Dl
- Lenk U
- Lenney W
- Lenskaya L
- Lentnek Al
- Lenz Jj
- Lesh Kw
- LeszczyĆski W
- Levashov S
- Levchenko O
- Levins Pf
- Levinsky Dm
- Lezana Soya V
- Liefring E
- Liem Jj
- Lillestol Mj
- Lim H
- Lin Ck
- Litvinova T
- Liu Yc
- Livezey Md
- Lloyd-Turney Cw
- Loboshka Becheva M
- Lockey Rf
- Logvinenko N
- Long Ra
- Lores Obradors L
- Lougheed Md
- Lowe Dw
- Luengo Planas Mt
- Luisetti M
- Lynch Mj
- López Viña A
- Macgillivray Bk
- Machkovska M
- Madjarov S
- Mahadevan Kp
- Mahmood Sm
- Major K
- Makam Sk
- Maloney Mj
- Maltbaek N
- Mandazhieva Pepelanova M
- Mapel D
- Marcipar Am
- Margolis Bd
- Margulies J
- Martin Ee
- Martin Ef
- Martinot Jb
- Martynov A
- Mascolo M
- Maspero Jf
- Mataria H
- Mathur Rn
- Matsuno Fuchigami A
- Mattar Pn
- Maynard Km
- Maynard N
- Mccormick B
- Mcelya M
- Mcevoy Ce
- Mckenzie Wc
- Md Kassim Rm
- Medina Iv
- Medwedeff Le
- Mehta Kd
- Melamed Ir
- Meli Jv
- Merke J
- Merrick Bh
- Meyers Pj
- Mezei M
- Michetti G
- Micke L
- Miller Bt
- Mincewicz G
- Minton Sm
- Miranda Fg
- Mitic Milikic M
- Mitlehner W
- Mizernitski Y
- Mohar De
- Mohd Fadzli Fb
- MonsĂł Molas E
- Montenegro Ch
- Morris Fa
- Morrison Bs
- Moss Mh
- Mueller H
- Munoz F
- MĂ©szĂĄros I
- Nadaskic R
- Naidenova I
- Naini Gr
- Nakamura Ct
- Naseeruddin S
- Nassim C
- Naudts If
- Naudziunas A
- Naudziunas S
- Navarro Dourdil A
- Navazo Lj
- Nayyar S
- Neamtu Ml
- Nell H
- Nemtsov B
- Nestorovic B
- Neumann G
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- Nieuwoudt G
- Niezgoda K
- Ninane V
- Nissim Je
- Noleva K
- Noor F
- Nordstrom M
- Norman D
- Novozhenov Vg
- O'Connor Tm
- Oberoi Ms
- Offenberger J
- Oldenburg W
- Olszewska-ZiÄ ber A
- Onasz-Manitius M
- Onia Af
- Orr Rr
- Osea Ea
- Overlack A
- Paine Wj
- Palatnik M
- Pandya Hc
- Pangtay D
- Panina Ss
- Panuto Ja
- Panzer F
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- Parker Iw
- Pascoe Sj
- Pasiyeshvili Lm
- Pastorello Ea
- Patel M
- Pavlishchuk S
- Pawlukiewicz M
- Peché R
- Perera Ms
- Perez Chada Rd
- Perez A
- Perpina Tordera M
- Pesci A
- Peters PH Jr
- Petrova I
- Picado Valles C
- Pilette C
- Pimentel SM Jr
- Piotrowicz P
- Piotrowski W
- Pisarczyk-Bogacka E
- Piskorz P
- Pistolesi M
- Plutinsky J
- Pluto Tm
- Poga M
- Pollock Mt
- Popova Vv
- Posner Ls
- Povysilova L
- Pratt Se
- Pravda P
- Prazma Cm
- Pribulova E
- Pritchard Jc
- Prokop-Staszecka A
- Prystupa Ln
- Pudi Kk
- Puig Cm
- Puterman As
- Qaqundah Py
- Quilodran Silva Cn
- Radbill Mk
- Rahman St
- Rai Ib
- Raikhel M
- Raissy Hh
- Rajakulasingam K
- Rakvacs M
- Ramirez-Diaz Sp
- Ramstad Ds
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- Rangel Os
- Raphiou Ih
- Rapo Se
- Raschal Sp
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- Reddy Dg
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- Rihal Ps
- Riley ED 4th
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- Rizvi Q
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- Robinson Pj
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- Rodriguez Dh
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- Todea D
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- Trevino Me
- Tripodi S
- Trofimov Vi
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- TĆuczykont B
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- Updegrove Jd
- Upham Jw
- Urbonas G
- Urval Kr
- Uusinarkaus Kt
- Vaela R
- Vahed Ya
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- Valavicius A
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- Valiulis A
- Valyon E
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- van den Berg L
- Van Der Berg Bj
- Van der Linden M
- Van Zyl L
- Varano S
- Vebriene J
- Velarde-Mora Hj
- Vertkin Al
- Victorio Cf
- Villasante Fernandez-Montes C
- Visser Ss
- Vlasenko Ma
- Vo Qd
- von Mallinckrodt C
- Vorobeva E
- Vujic T
- Vukcevic M
- Vynnychenko Lb
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- Wakeling Ja
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- Wall Sj
- Wallner G
- Wan Mohamad Wh
- Wang Cc
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- Weber U
- Weberling F
- Wehgartner-Winkler S
- Wei Yf
- Weimer J
- Weinstein Dl
- Welker Ja
- Wellmon B 2nd
- Wells T
- Wenocur Hs
- White Mv
- Wiemer S
- Wijanarko P
- Williams Dl
- Williams Sl
- Win Ph
- Wingo Td
- Winkelmann Ej
- Wisman PP Jr
- Wojciechowska I
- Wyszomierski Da
- Yakushin S
- Yamada Hm
- Yarows S
- Yatsyshyn Ri
- Yeakey Am
- Yu Cy
- Yunger TM Jr
- Yunus F
- Zadionchenko V
- Zaitsev I
- Zakova L
- Zeisler Kh
- Zhebel V
- Zhiglinskaya O
- Zibotics H
- Zidel B
- Ziegner A
- Ziering Rw.
- Zimny Hh
- Ziora D
- Zlatos A
- Zubarenko O
- Zykov K
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND:
The safe and appropriate use of long-acting beta-agonists (LABAs) for the treatment of asthma has been widely debated. In two large clinical trials, investigators found a potential risk of serious asthma-related events associated with LABAs. This study was designed to evaluate the risk of administering the LABA salmeterol in combination with an inhaled glucocorticoid, fluticasone propionate.
METHODS:
In this multicenter, randomized, double-blind trial, adolescent and adult patients (age, â„12 years) with persistent asthma were assigned to receive either fluticasone with salmeterol or fluticasone alone for 26 weeks. All the patients had a history of a severe asthma exacerbation in the year before randomization but not during the previous month. Patients were excluded from the trial if they had a history of life-threatening or unstable asthma. The primary safety end point was the first serious asthma-related event (death, endotracheal intubation, or hospitalization). Noninferiority of fluticasone-salmeterol to fluticasone alone was defined as an upper boundary of the 95% confidence interval for the risk of the primary safety end point of less than 2.0. The efficacy end point was the first severe asthma exacerbation.
RESULTS:
Of 11,679 patients who were enrolled, 67 had 74 serious asthma-related events, with 36 events in 34 patients in the fluticasone-salmeterol group and 38 events in 33 patients in the fluticasone-only group. The hazard ratio for a serious asthma-related event in the fluticasone-salmeterol group was 1.03 (95% confidence interval [CI], 0.64 to 1.66), and noninferiority was achieved (P=0.003). There were no asthma-related deaths; 2 patients in the fluticasone-only group underwent asthma-related intubation. The risk of a severe asthma exacerbation was 21% lower in the fluticasone-salmeterol group than in the fluticasone-only group (hazard ratio, 0.79; 95% CI, 0.70 to 0.89), with at least one severe asthma exacerbation occurring in 480 of 5834 patients (8%) in the fluticasone-salmeterol group, as compared with 597 of 5845 patients (10%) in the fluticasone-only group (P<0.001).
CONCLUSIONS:
Patients who received salmeterol in a fixed-dose combination with fluticasone did not have a significantly higher risk of serious asthma-related events than did those who received fluticasone alone. Patients receiving fluticasone-salmeterol had fewer severe asthma exacerbations than did those in the fluticasone-only group
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Aawsaj Y
- Abadia M
- AbadâGurumeta A
- AbadâMotos A
- Abassy J
- Abate E
- Abbasov A
- Abbott D
- Abbott Tom EF
- Abdalla M
- Abdeldayem H
- Abdelkabir M
- Abdelkader Salama I
- Abdelkarim M
- Abdelsamed A
- Abdulfattah F
- Abdulwahed E
- AbdurâRahman LO
- Abel MK
- Abelevich A
- Abiyere H
- Aboelkassem Ibrahim A
- Aboharp Hasan Z
- Abou Chaar MK
- Abreu da Silva A
- Abubakar A
- Abukhalaf SA
- Abukhalaf Sadi
- Acebes GarcĂa F
- Achalandabaso Boira M
- Acher A
- Acosta MĂ©rida MA
- Acrich E
- Adam Essa Adam ME
- Adamina M
- Adamina Michel
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Aderombi A
- Adeyeye A
- Adeyeye A
- Adi H
- Adiamah A
- Adisa Adewale
- Afzal MF
- Agapov M
- Agarwal Arnav
- Aggarwal M
- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguado LĂłpez H
- Aguiar JĂșnior S
- Aguilar Gonzalez M
- Ahmed A
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- Ahmeidat A
- Ahn JH
- Aiken T
- Aimé A
- Akalin M
- Akaydin E
- Akbas A
- Akhtar MA
- Akhtar N
- Akhter Rahman MM
- Akin E
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al ahmad F
- Al Asadi T
- Al Awwad S
- Al Ayed A
- Al Habes H
- Al Riyami S
- AL Sayed M
- Alaa S
- AlAamer O
- Aladeojebi A
- Alagoa Joao A
- Alakaloko Felix
- Alam F
- Alameer Ehab
- Alamri Alex
- Alanazi F
- Alawneh F
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- Albertsmeier M
- Albertsmeier Markus
- Alcaide Matas F
- Alconchel F
- AlcĂĄzar JA
- Alderson Derek
- Aldokali N
- AleksiÄ L
- Alemanno G
- Alfaifi J
- Alfieri S
- Alfonso Garcia M
- Algallai M
- Alghamdi M
- Alghuliga A
- Alhamed A
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- Alhassan N
- Ali karar AA
- Ali Sani S
- Ali AA
- Ali M
- Ali S
- Alishi Y
- Aliyeva Z
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- Alkadiki Ghadah Z
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- Kayyal MY
- Kazachenko E
- Keatley James M
- Kebabçı E
- KecmanoviÄ D
- Keeler BD
- Keller Debby
- Keller Debby
- Kembuan G
- Kenic M
- Kennelly R
- Kent A
- Kerawala AA
- Khajuria A
- Khan A
- Khan AH
- Khan F
- Khan J
- Khan K
- Khan S
- Khan Tabassum
- Khatri Chetan
- Khaw Rachel A
- Khokhar MI
- Kiconco H
- Kilani AI
- Kilinc Tuncer G
- Killeen S
- Kim NJ
- Kirmizi Y
- Kjaer DW
- Klaristenfeld D
- Klatte Tobias
- Kleeff J
- Kler A
- Klimopoulos S
- Kloppers C
- KmeziÄ S
- Knezevic D
- Knight Andrew
- Knights E
- Knowles C
- Knowles J
- Kocatas A
- Koh A
- Kokkinos G
- Kokobelyan AK
- Kokoropoulos P
- Koleva Radica M
- Kolias Angelos
- Kolias Angelos
- Kolla C
- Kollengode VV
- Kolli VS
- Konney Thomas
- Konstadoulakis M
- Konstantinou C
- Konsten J
- Kontovounisios C
- Kornblith LZ
- Kottayasamy Seenivasagam R
- Koukoulis G
- Kourdouli A
- Kovacevic B
- Kowalewski P
- Krarup P
- Krdzic I
- Kredan A
- Kretzmer L
- Krishnan E
- Kristensen HĂ
- Krivokapic Z
- Kroon HM
- Kruijff Schelto
- KrĆĄul D
- Kubiliute E
- Kubyshkin V
- Kucuk GO
- Kudchadkar S
- Kuiper S
- Kulkarni N
- Kulkarni R
- Kulle CB
- Kumar A
- Kumar L
- Kumar S
- Kumar V
- KutkeviÄius J
- Kuttanchettiyar KG
- KwanâFeinberg R
- Kwiatkowski A
- Kyriacou H
- KÀlviÀinen H
- Königsrainer A
- KĂŒĂ§ĂŒk IF
- La Regina D
- La Torre F
- Labib PL
- Lacy AM
- Ladd MR
- Laface L
- Laforest A
- Laharwal A
- Lakkis Z
- Lala AK
- Lalou L
- Lamb Benjamin
- Landaluceâolavarria A
- Lapolla P
- Laporte G
- Larentzakis A
- Larkin J
- Laskar N
- Lasses MartĂnez B
- LatinÄiÄ S
- Lauretta A
- Lauscher J
- Lavy R
- Law J
- Lawani Ismail
- Lawday S
- Lawday Samuel
- Lawday Samuel
- Layton Georgia R
- Le Roy B
- Lecolle K
- Lederhuber Hans
- Lederhuber Hans
- Ledesma FS
- Lee M
- Lee N
- Leede E
- Lenzi E
- Leon R
- Leung Elaine YL
- Leventoglu Sezai
- Leventoglu Sezai
- LewisâLloyd C
- Li Elizabeth
- Li Elizabeth
- Li M
- Li Z
- Liakakos T
- Liao CCL
- Lieske B
- Lim M
- Lim RZM
- Lima Buarque I
- Lima da Cruz L
- Lima da Silva C
- Lima MJ
- Linari C
- Lippa Laura
- Lira dos Santos Leite A
- Litta F
- Litvin A
- Litvin Andrey
- Litvina Y
- Liu J
- Liu T
- Lizzi V
- Locatelli A
- Loch FN
- Loehrer A
- Loehrer Andrew
- Loncar Z
- Long C
- Longhi M
- Longhini A
- Longstaff L
- Lopes L
- Lopez Abad A
- LoraâCumplido P
- Lorena Maria Aguilera
- Lorenzon L
- Losada M
- Lott N
- Loubani M
- Loutzidou L
- Lowery A
- Lozano Lominchar P
- Lucchini SM
- Luglio G
- Lule H
- Lun EWY
- Lunevicius R
- Lunghi EG
- Lynch N
- Lyons A
- LĂĄzaro A
- López Antoñanzas L
- Löffler Markus W
- Löffler MW
- Löfgren N
- M. elghazaly S
- Maa Albared S
- Maccabe TA
- MacDonald L
- Machado D
- Machado N
- Macina S
- Madani Kia T
- Madani R
- Madonini M
- Maffioli A
- Magee C
- Maghrebi H
- Magowan D
- Mahajan A
- Mahendran V
- Mahmood M
- Mahmoud Ali F
- Mahvi D
- Maida P
- Maiga A
- Maimbo Mayaba
- Majbar AM
- Majkowska A
- Major P
- Major Piotr
- Majrashi S
- Majumdar KS
- Mak TWC
- Malapati H
- Malcolm FL
- Malgras B
- Malibary N
- Mall JW
- Maltinti G
- Manatakis DK
- Manfredelli S
- Manku B
- Mann Harvinder S
- Manrique E
- Manso I
- Manson J
- Mantoglu B
- Manu N
- Maqueda GonzĂĄlez R
- Marafante C
- Marano A
- Marchbank Adrian
- MarcosâSantos P
- Marcus Hani J
- Mardare M
- Margalit A
- Mari G
- Marialva J
- Mariani NM
- MarieâMacron L
- Marinello P
- Marino Cosentino L
- Marino M
- Marino MV
- Markaryan D
- Markovic I
- Markovic V
- Marques R
- Marques T
- Marqueta De Salas M
- Marra AA
- Marra E
- Marreiro A
- Marson Ella J
- Marte G
- Martel A
- Martin E
- Martin E
- Martin Janet
- Martin ST
- Martinek L
- Martinez German A
- Martins dos Santos G
- Martins JordĂŁo D
- Martins A
- Martins D
- Martins R
- MartinâPerez B
- MartinâPerez E
- MartĂn Anoro LF
- MartĂn L
- MartĂnez Chicote C
- MartĂnezâHurtado E
- MartĂnezâPinedo C
- MartĂnezâPĂ©rez P
- MartĂnâArĂ©valo J
- Marx W
- Marzi F
- Marçal A
- MarĂn H
- Masciandaro A
- Mashat A
- Mashbari Hassan N
- Massey LH
- Massie E
- Massobrio A
- Mastoridis S
- Math S
- Mathew S
- MatiÄ S
- Matos Costa P
- Matute M
- Maté Mate P
- MatĂasâGarcĂa B
- Maw A
- Mazingi Dennis
- Mazzotta E
- Mazzotti F
- McAleer J
- McAree B
- McCanny A
- Mccluney S
- Mccormick P
- McDermott FD
- McElhinney K
- McEwen R
- McGivern K
- McGrath John S
- McIlmunn C
- McIntosh S
- McIntyre J
- McKay Siobhan
- Mckay Siobhan C
- McKevitt K
- McLean Kenneth A
- McNaught C
- McNeill Alan
- McNicol F
- MdRazali. I null
- Mehigan BJ
- Mehraj A
- Meimaâvan Praag EM
- Mekhael M
- MelchorâRuan J
- Melenhorst J
- Melhem S
- Memon AS
- Memos N
- Mendes F
- Mendes JR
- MendozaâMoreno F
- Meneghini S
- Mercado MĂ
- Merdrignac A
- Merh R
- Meriç S
- Messner F
- Metallidis Symeon
- Metwalli M
- Metzger J
- Michalopoulos N
- Michalski C
- Michel M
- Micic D
- Migliore M
- Mignot G
- Miguel T
- Mihanovic J
- Mihmanli M
- Miladinov M
- MilanoviÄ M
- Milic LJ
- Mills Emily C
- Mills SJ
- Milne K
- Minaya Bravo AM
- MinayaâBravo Ana
- MinayaâBravo Ana
- MinayaâBravo Ana
- Mingoli A
- Minicozzi A
- Minto G
- Mir I
- Mirabella A
- Miranda P
- Mirica RM
- Mirnezami R
- Mishra N
- Mishra S
- Mishra T
- Misra S
- Mitchell D
- Mitchell S
- Mithany R
- Mitra JK
- Mitrofan C
- Mittal R
- Mittal Rohin
- Miu V
- Mochet S
- Modolo Maria Marta
- Modolo Maria Marta
- Moftah M
- Moggia E
- Mohamed Sidek AS
- Mohammad Z
- Mohammed MM
- MohammedJibreel M
- Mohan H
- Mohan Helen M
- Mohan Helen M
- Mohd Azman ZA
- Mohd Yunus MF
- Mohsine R
- Mongelli F
- Montauban P
- Montelatici M
- Monteleone M
- Montella MT
- Montori G
- Montuori M
- Moore Rachel
- Moorthy M
- Morais H
- Moras L
- MoraâGuzmĂĄn I
- Morelli L
- Moretto G
- Morgan R
- Moritani K
- MoroâValdezate D
- Morris A
- Morsi A
- Mosley F
- Moss J
- Moszkowicz David
- Moug S
- Moug Susan
- Moug Susan
- Moura F
- Mourad M
- Mshelbwala P
- Msherghi A
- Mudawi I
- Muduly D
- Muguerza JM
- Muiesan P
- Mukherjee S
- Muller B
- Mulligan CS
- Mungo S
- Muratore A
- Murawa D
- Murgese A
- Murphy C
- Musetti S
- Mustafa A
- Mutter D
- Muzamil J
- Muñoz Camarena JM
- MuñozâAtienza V
- MuñozâBellvis L
- Naar L
- Nacif L
- Nafees Ahmed R
- Nageh MA
- Nahm C
- Najarian M
- Nally D
- Namazov Ä°
- Nankivell Paul
- Narahari Krishna
- Nassa H
- Nassif M
- Natale J
- Naumann D
- Navaratne L
- Nazir S
- Neary P
- Neary PM
- Neely D
- Negoi I
- Negoi Ionut
- Negoita VM
- Nel D
- Nelli T
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Neri J
- Nespoli LC
- Nessim C
- Neville Iuri
- Newman S
- Newman T
- Newton C
- Newton K
- Ng HJ
- Ng Joe
- Ng S
- Ng V
- Ng V
- Ngo CW
- NgâKamstra Joshua S
- NicolĂĄsâLĂłpez T
- Nikaj H
- Nikolaou S
- Nikolic S
- Niquen Milagros
- Nisar P
- Nitschke C
- Nogueira O
- Nogueiro J
- Nogués A
- Noiret B
- Nolan GJ
- Norcini C
- Nordberg M
- Notte F
- Nouh T
- Novello S
- Novikova A
- Nowak K
- Ntirenganya Faustin
- Nugent E
- Nunes Coelho M
- Nunes R
- NunezâGarcia B
- NunooâMensah JW
- Nuñez Del Barrio H
- Nwabuoku SE
- NĂșñez J
- Obeidat K
- Ocaña J
- OchagavĂa S
- Oguttu B
- Okafor B
- Okunlola A
- Olaogun J
- Olasehinde O
- Oldfield F
- Oliva Mompean F
- Oliveira A
- Olivier J
- Olivieri M
- Olivos Maricarmen
- Olori S
- Olson KA
- Olute A
- Omar W
- Omeroglu S
- Ong SL
- Onos L
- Oosterlinck W
- Oosterling S
- Opocher E
- Ortega VĂĄzquez I
- Ortiz de SolĂłrzano Aurusa FJ
- Ortiz LĂłpez D
- Osagie O
- Oseira A
- Osman N
- Osorio Ramos A
- Otero A
- Otoniel LR
- Oussama Kacimi
- Outani Oumaima
- Ovejero Merino E
- Owen H
- Owens P
- Oyende O
- Ozben V
- Ozcelık MF
- Ozgediz D
- Ozmen BB
- OâBrien H
- OâBrien S
- OâDonnell S
- OâMalley S
- OâRiordan J
- OâShea M
- P Delrio
- Pacheco SĂĄnchez D
- PadillaâValverde D
- Padmore G
- Pagano G
- Pajan H
- Palagi S
- Palma P
- Palmeri M
- Panahi P
- Pandey D
- Paniagua GarcĂa Señorans M
- Papaconstantinou I
- Papadopoulos V
- Papagni V
- Papatheodorou P
- Paquette N
- Parasyris S
- Pareek P
- Pareja Rene
- Parello A
- Parente A
- Parini S
- Parise P
- Park J
- Parkin E
- Parkins K
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- Parmar C
- Parra Baños PA
- Parray FQ
- Parreira R
- ParreñoâSacdalan Marie Dione
- ParreñoâSacdalan Marie Dione
- Parseliunas A
- Parwaiz I
- Pasini F
- Paspaliari D
- Pata Francesco
- Pata Francesco
- Pata Francesco
- Patel Akshay
- Patel K
- Patel M
- Patel P
- Patil S
- Patrone R
- PatrĂcio B
- Pattyn P
- Pattyn P
- Pavlov M
- Pedrazzani C
- Pedro J
- Pedro V
- Peirce C
- Pejnovic L
- Pejovic I
- Pellegrino L
- Pellino G
- Pellino Gianluca
- Peluso C
- Penumadu P
- Pera R
- Peralta Ferreira M
- Pereca J
- Pereira Rodrigues A
- Pereira A
- Pereira C
- Pereira I
- Pereira R
- Perez Gonzalez M
- Perez D
- Pergolini I
- Perivoliotis K
- Peros G
- Perotto LO
- Perra T
- Perrone G
- Persad A
- Persiani R
- Pertile D
- Peteja M
- Petrillo A
- Peyroteo M
- Pezzuto AP
- Peña Ros E
- Peña Soria MJ
- Pham H
- Phan D
- Phang PT
- Phillips E
- Picardo AL
- Picciariello A
- Picciochi Maria
- Pickett L
- PicĂłn RodrĂguez R
- Pieniowski E
- Piessen G
- Pina S
- Pinilla Morales RE
- Pinkney Thomas D
- Pinotti E
- Pinto J
- Pipara A
- Piper Rory J
- Pipitone Federico NS
- Pirozzolo G
- Pirzada A
- Pisani Ceretti A
- Pisanu A
- Pius Ogolekwu I
- PlaâMarti V
- Pockney P
- Pockney Peter
- Pockney Peter
- Pockney Peter
- Podda M
- Poeze M
- Poggioli G
- Police A
- Polydorou A
- PolâFachin L
- Ponchietti L
- Popoola AA
- Porcu A
- Portinari M
- PosadasâTrujillo OE
- PosmaâBouman L
- Potter R
- Pourcher G
- Powell S
- Pozotou I
- Praetorius C
- Pramesh CS
- Prando D
- Presl J
- Price C
- Price Stephen J
- Prieto Calvo M
- Prieto Nieto MI
- Pronk AJM
- Prosperi P
- Provozina A
- Pruvot FR
- Pujari R
- Pujol Cano N
- PĂ©rez SĂĄnchez MA
- PĂ©rezâSaborido B
- Qadan M
- Qasem A
- Qatora MS
- Quante M
- Quintana Martinic M
- QuirogaâValcĂĄrcel A
- Qureshi Ahmad
- Qureshi AU
- RabyâSmith W
- Radenkovic Dejan
- Raggio E
- Rai L
- Rajan S
- Rajaretnam N
- Rakvin I
- Ramachandran A
- Ramalho de Almeida F
- Ramamoorthy R
- Ramasamy S
- Ramcharan S
- Ramesh P
- Ramirez Faraco M
- Ramirez Romero P
- Ramos Bonilla A
- Ramos D
- RamosâDe la Medina Antonio
- RamosâMartĂn P
- Ramwell A
- Rao S
- Rapaport S
- Rashid A
- Rashid MM
- Rasoaherinomenjanahary F
- Rattizzato S
- Ratto C
- Raval M
- Ravindrakumar S
- Ravindran S
- Rayamajhi S
- Raymond T
- Razafindrahita JB
- Recordare A
- Reddy P
- Redfern J
- Refky B
- Rega D
- Rega D
- Regina de Sampaio L
- Reilly J
- Reim D
- Reinhard T
- Revez T
- Rey Ferro M
- Rey Valcarcel C
- Reynolds IS
- Ribeiro A
- Ribeiro CG
- Ribeiro R
- Ribolla M
- Rice D
- Richards S
- Richards T
- Richards Toby
- Riddell A
- Ridgway PF
- Righini E
- Riley C
- Rimonda R
- Ringressi MN
- RipollĂ©sâMelchor J
- Riquoir Altamirano C
- Risaliti M
- Riva C
- Rivas R
- Rivera Carlos Jose Perez
- RiveraâAlonso D
- Rizk M
- Rizzi A
- Roberts Keith
- Roberts Keith
- Robertson Faith
- Robinson A
- Roca Calvo MJ
- Rodrigo VSD
- Rodrigues K
- Rodriguez Artigas JM
- Rodriguez JL
- RodrĂguez GĂłmez L
- Rodwell H
- Rogers LJ
- Rogers M
- Rojo LĂłpez JA
- RoldĂłn Golet M
- Romano M
- Romero Bañuelos E
- Romero de Diego A
- Ronellenfitsch U
- Rooney SM
- Rosa F
- Rose J
- Roslani AC
- Roslani April C
- Rosseau Gail
- Rossi S
- Roszkowski R
- Rottoli M
- Roux A
- Roxo V
- Roy Mahapatra S
- Royle T
- RubioâPerez I
- Ruivo A
- Ruiz Esquide M
- Ruiz Manzanera JJ
- Ruiz Soriano M
- RuizâEscobar A
- RuizâMarĂn M
- Russ J
- Russo IS
- RutegÄrd M
- RutegÄrd Martin
- RutegÄrd Martin
- Rutherford D
- Ruzgar NM
- Ruzzenente A
- Ryan M
- Ryan ĂJ
- Ryska O
- RĂo Lafuente FD
- S RRR
- Saad MM
- Saafan T
- Saavedra J
- Sabry A
- Saeed S
- Saez Carlin P
- Sagar J
- Sagnotta A
- Sahid Nik Amin
- Sahin I
- Sahnan K
- Saklani A
- Sakr A
- Saksena AR
- Salazar A
- Saleem A
- Saleem A
- Saleh M
- Salem H
- Salem H
- Salem M
- Salerno G
- Sales Mallafré R
- SalgadoâNesme N
- Salim A
- SalimoÄlu S
- Salindera S
- Sallam I
- Samadov E
- Samih A
- Samir Abdelaal A
- Samison LH
- Samkari A
- Sammarco G
- Sammour T
- Sampaio da NĂłvoa Gomes Miguel II
- Sampaio Soares A
- Sampietro GM
- San Miguel C
- Sanchez Cabezudo Noguera F
- Sanchez Gonzalez J
- Sanchez Jimenez R
- SanchezâCasado AB
- SanchezâPelaez D
- Sanchon L
- SanchoâMuriel J
- Sanli AN
- Santanach C
- Santarrufina Martinez S
- SanteroâRamirez MS
- Santos Bezerra T
- Santos IrĂšne
- Santos PMDD
- Santos R
- SantosâSousa H
- Sanz Larrainzar A
- Sanz Ortega G
- SanzâLĂłpez R
- Sapienza P
- Sapre D
- Saraiva P
- Sarantitis I
- Sarigul M
- Sarin A
- Sarjanoja E
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- Sarpel U
- Sarre C
- Sartarelli L
- Sarveswaran J
- Sasapu K
- Sasia D
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- Satoi Sohei
- SaudĂ S
- Sauvain M
- Sauvat F
- Saverio Salomone Di
- Saverio Salomone Di
- SavkoviÄ N
- Sayyed R
- Sayyed Raza
- Scabini S
- Scalabre A
- Scanu AM
- Schache Andrew
- Schache Andrew G
- Schaller Karl
- Scheiwiller A
- Schiavo M
- Schiergens T
- Schineis C
- Schizas D
- Schlesinger N
- Schnitzbauer Andreas A
- Schwartz PB
- Scott L
- Scotton G
- Scrima O
- Sebai A
- Seebah K
- Seeliger B
- Seenivasagam Rajkumar Kottayasamy
- Seguinâgivelet A
- SeguraâSampedro JJ
- SeguraâSampedro Juan JosĂ©
- Sehgal T
- Sehouli Jalid
- Seleim A
- Selmani J
- Semina E
- Sena G
- Senossi O
- Serevina OL
- Serralta de Colsa D
- Serrano GonzĂĄlez J
- SerranoâNavidad M
- Sert Ä°
- Servadei Franco
- SeyiâOlajide Justina O.
- Seymour Z
- Sganga G
- SgrĂČ A
- Shah J
- Shah S
- Shah ZA
- Shaikh I
- Shaikh S
- Shakoor Z
- Shanthakunalan K
- Sharabiany S
- Sharma Neil
- Sharma P
- Shaw Catherine A
- Shaw Richard
- Shaw Richard
- Sheel A
- Shehata S
- Shenit K
- Sheridan K
- Sherief M
- Sherif A
- Sherif Ahmed Elshawadfy
- Sherif G
- Shokuhi P
- Sholadoye TT
- Shortland T
- Shream S
- Shrestha A
- Shu Sebastian
- Shylasree TS
- Sian T
- SiawâAcheampong Kwabena
- Sibilla MG
- Siddiqui MT
- Sidiropoulos T
- Silva A
- Silva M
- Silva N
- Silva R
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- Silvestre D
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- Singh AA
- Singh Jagdeep K
- Singh MP
- Singh R
- Singh S
- Singh S
- Sion M
- Skrovina M
- Smart Neil
- Smart Neil J
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- Smith H
- Smith J
- Smith L
- Soh JY
- Sohrabi C
- Sokolov M
- Solari F
- Soldevila Verdeguer C
- Soliman H
- Soltan H
- Soreide Kjetil
- Soriano AI
- Soriero D
- Sorrentino L
- Sorribas Grifell M
- Sosa Duran EE
- SosaâRodrĂguez MV
- Soto Montesinos C
- Souadka A
- SoulĂ© MartĂnez CE
- Sousa Fernandes M
- Sousa R
- Sousa S
- Spagni G
- Spampinato MG
- Spanu A
- Spartalis E
- Spencer N
- Spiezio G
- Spinelli A
- Spinelli Antonino
- Spolini A
- Sreedharan L
- Srikumar B
- Sriram RK
- Srishankar S
- SroczyĆski P
- St John S
- Stafford J
- Stavrinidou O
- Stebbing J
- Steele C
- Steidle C
- Steinke J
- Stevens K
- Stevenson J
- Stevic D
- Stewart Grant D
- Stewart Grant D
- Stewart KE
- Stockdale T
- Stoica B
- Strate T
- Stylianides N
- Stylianidis G
- Subhi MT
- Subocius A
- Subramaniam S
- Sud A
- Sund Malin
- Sundar Sudha
- Sundar Sudha
- Sundaram Venkatesan G
- Sundhu M
- SusztĂĄk N
- Sutherland A
- Swinson B
- Syed WAS
- Syllaios A
- Szatmary P
- Szubota I
- SĂĄnchez del Pueblo C
- SĂĄnchez Fuentes N
- SĂĄnchez Tocino JM
- SĂĄnchezâGarcĂa S
- SĂĄnchezâGuillĂ©n L
- Tabiri Stephen
- Tactuk N
- Taddei A
- Tadic B
- Taibi A
- Talaat M
- Talal ElâAbur I
- Talukder S
- Talwar R
- Tamini N
- Tammaro P
- Tan JA
- Tan KHM
- Tan XS
- Tanal M
- Tang AM
- Tanzanu M
- Tartaglia D
- Tasis N
- Tatar OC
- Tavares F
- Tawheed A
- Tayeh S
- Taylor Elliott H
- Tebala GD
- Teh C
- Teixeira J
- Teixeira M
- TejeroâPintor FJ
- Telma K
- Testa V
- Tewari N
- Tezas S
- Thaha MA
- Thalgaspitiya SPB
- Thanapal MR
- Thekinkattil Dinesh
- Theodosopoulos T
- Theophilidou E
- Thian A
- Thomas A
- Thompson D
- Thrumurthy S
- Thulasiraman SV
- Timbrell S
- Tirloni L
- Tirotta Fabio
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- Tiwari Abhinav
- Tojal A
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- Tolani MA
- Tom K
- Tonini V
- Tooulias A
- Torres Arcos C
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- Townend D
- Townend Philip
- Townend Philip
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- Tsoulfas G
- Tsoulfas Georgios
- Tsui G
- Tucci R
- Tufo A
- Tugmen C
- Tulina I
- Tuncer K
- Turina M
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- Turnbull A
- TurradoâRodriguez V
- Turri G
- Tweedle E
- Tzedakis S
- Tzovaras G
- TĂ©bar Zamora A
- UgarteâSierra B
- Ugolini G
- Ullrich S
- UludaÄ SS
- Umair M
- Umar A
- Uras C
- Urbani A
- Urbieta A
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- Utkan NZ
- Utrilla Fornals A
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- van der Plas Willemijn
- Van Heinsbergen M
- Van Nieuwenhove Y
- Van Ramshorst G
- van Ramshorst Gabrielle H
- Vanker R
- Varcada M
- Varghese Chris
- Varma MG
- Vartanoglu T
- Vasconcelos M
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- Vera Mansilla C
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- Vervoort D
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- Vezakis A
- Veziant J
- Videira JF
- Vidya Raghavan
- Vidya Raghavan
- Vieira Barros A
- Vieira Caroço T
- Vieira Paiva Lopes AC
- Vieira A
- Vieira B
- Vignali A
- Vignotto C
- Vigorita V
- Vijayan D
- VilarâCompte D
- Villalabeitia Ateca I
- Villalonga B
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- Vimalachandran Dale
- Vimalchandran Dale
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- Vishnoi JR
- Viswanath Y
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- Y J
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- Yanar H
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- Yesantharao P
- Yetkin G
- Yezzaji H
- YeĆilyurt D
- Yiallourou A
- Yigitbas H
- Yildirim A
- Yildiz A
- Yildiz A
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- Yousof EA
- Youssef M
- Yurttas C
- YĂĄnez C
- YĂŒksel E
- Zafar SN
- Zakaria AD
- Zakaria Z
- Zakharenko A
- Zambon M
- ZamfirâChiruâAnton M
- Zanus G
- Zegarac M
- ZeliÄ M
- Zengin AK
- Zerbib P
- Zervas K
- Zese M
- Zhang H
- Zizzo M
- Zmora O
- Zografos C
- Zonta S
- Zorrilla OrtĂșzar J
- Zourntou S
- Zubaidi A
- Ăngelo M
- ĂlgĂ„ A
- Ăelebi F
- Ăolak E
- Ăfner D
- Ăhlberger L
- Ăzant A
- Ăzçay N
- ĂÄĂŒcĂŒ H
- ĂberrĂŒck L
- Äoza I
- Ćawnicka A
- ĆœateckĂœ J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2022
- Field of study
AimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4âweeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4âweeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, PÂ =Â 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, PâConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease