60 research outputs found
Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand
- Author
- Alvarez S.
- Angulo R.
- Apilanez M.
- Back NKT.
- Badillo K.
- Badolato R.
- Bakker Y.
- Baldi F.
- Beceiro J.
- Belfrage E.
- Bergsma D.
- Berkhout B.
- Bernardi S.
- Bezemer DO.
- Bezemer M.
- Blazquez D.
- Bont LJ.
- Boucher CAB.
- Bruzzese E.
- Bustillo M.
- Calavia O.
- Cellini M.
- Colino E.
- Coll M.
- Collado P.
- Collins I.J.
- Consolini R.
- Cornelissen MTE.
- Couceiro JA.
- Coupland U.
- Crichton S.
- Cristiano L.
- de Boer CG.
- de Groot L.
- de Groot-de Jonge H.
- de Jong A.
- de Martino M.
- de Ory SJ.
- de Tejada BM.
- Decker L.
- Delforge M.
- Di Biagio A.
- Dodi I.
- Doerholt K.
- Dona D.
- Doroba M.
- Duenas J.
- El Berkaoui A.
- Ene L.
- Erba P.
- Escosa L.
- Esposito S.
- Falcon L.
- Faldella G.
- Fortuny C.
- Fraaij PLA.
- Frick MA.
- Gabiano C.
- Galli L.
- Gamell A.
- Garazzino S.
- Garcia L.
- Garrote E.
- Garzon M.
- Geelen SPM.
- Geerlinks J.
- Genovese O.
- Giacomet V.
- Giaquinto C.
- Gibb D.M.
- Goetghebuer T.
- Gonzalez-Tome MI.
- Goodall R.
- Grande A.
- Grivell S.
- Guerrero C.
- Guillen S.
- Hainaut M.
- Henriet SSV.
- Herranz M.
- Hillebregt M.
- Hortelano MG.
- Jourdain G.
- Judd A.
- Jurriaans S.
- Knoester M.
- Koopmans MPG.
- Koops J.
- Kruijne E.
- Kuekou HT.
- Labutina S.
- Larovere D.
- Le Coeur S.
- Lendinez F.
- Lillo M.
- Lipreri R.
- Lisi C.
- Lo Vecchio A.
- Lodewijk C.
- Lopez N.
- Losada B.
- Lucas E.
- Maccabruni A.
- Marczynska M.
- Martinez J.
- Mateo M.
- Mayol L.
- Mazza A.
- Mc Phee CF.
- Meijering R.
- Mellado MJ.
- Mendez M.
- Miloenko M.
- Montagnani C.
- Montesdeoca A.
- Moreno D.
- Munjishvili L.
- Munoz MA.
- Munoz MJ.
- Mur A.
- Nauta N.
- Navarro M.L.
- Neth O.
- Niesters HGM.
- Noguera A.
- Noguera-Julian A.
- Okhonskaia L.
- Oldakowska A.
- Olmeo P.
- Pajkrt D.
- Paling E.
- Pas SD.
- Patrizia O.
- Peeck B.
- Pellegatta A.
- Perez A.
- Perez C.
- Perez-Hoyos S.
- Pineda V.
- Pocheville I.
- Pokorska-Spiewak M.
- Popielska J.
- Prieto L.
- Raethke M.
- Rahamat-Langendoen J.
- Ramos J.T.
- Rampon O.
- Ree C.
- Regtop R.
- Reiss P.
- Rius N.
- Roa MA.
- Rojo P.
- Roman V.
- Romano A.
- Romero FJ.
- Rovira N.
- Ruggeri M.
- Ruijs Y.
- Ruiz B.
- Rutkens T.
- Saavedra J.
- Sainz T.
- Salvini F.
- Santa Ansone.
- Santos JL.
- Santos M.
- Scherpbier H.
- Scherpbier HJ.
- Schinkel CJ.
- Schnorr P.
- Scholvinck EH.
- Schoorl M.
- Schuurman R.
- Sirvent JG.
- Smit C.
- Smit C.
- Soler-Palacin P.
- Spoulou V.
- Stelma FF.
- Strik-Albers R.
- Tagliabue C.
- Taramasso L.
- Terol P.
- Thorne C.
- Tovo PA.
- Tuijn E.
- Tuk B.
- Vallmanya T.
- van Aerde K.
- van de Flier M.
- van de Sande L.
- van den Akker M.
- Van der Kelen E.
- van der Knaap LC.
- van der Meer R.
- van der Vliet S.
- van Kampen JJA.
- van Leer-Buter CC.
- van Rossum AMC.
- van Sighem AI.
- Veenenberg L.
- Venturini E.
- Verduyn-Lunel F.
- Vermont CL.
- Visser EG.
- Voronin E.
- Weijsenfeld AM.
- Wensing AMJ.
- Wisse A.
- Wit FWMN.
- Witte EC.
- Wolfs TFW.
- Wolthers KC.
- Woudstra T.
- Zaaijer HL.
- Zaheri S.
- Zawadka K.
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2019
- Field of study
Objective: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV.
Design: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand.
Methods: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1-10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters.
Results: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8, 9.0] years and -1.2 (IQR: -2.3 to -0.2), respectively. Median follow-up was 9.1 (IQR: 6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20-0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21-1.78) years later in those starting with HAZ less than -3 compared with HAZ at least -1. Later growth spurts in girls resulted in continued height growth into later adolescence. In boys starting ART with HAZ less than -1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least -1, there was no association with age. Girls and boys who initiated ART with HAZ at least -1 maintained a similar height to the WHO reference mean.
Conclusion: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least -1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
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- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
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- Agathos M
- Agatsuma K
- Aggarwal N
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- Agudo I
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- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
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- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
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- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
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- Array LWA Long Wavelength
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- Pant BC
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- Piro AL
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Measurement of the differential and double-differential Drell-Yan cross sections in proton-proton collisions at root s=7 TeV
- Author
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- Abbiendi G
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
Copyright @ 2013 CERN,
for the bene t of the CMS collaboration. This article is distributed under the terms of the Creative Commons
Attribution License which permits any use, distribution and reproduction in any medium,
provided the original author(s) and source are credited.Measurements of the differential and double-differential Drell-Yan cross sections are presented using an integrated luminosity of 4.5 (4.8) fb−1 in the dimuon (dielectron) channel of proton-proton collision data recorded with the CMS detector at the LHC at s√ = 7 TeV. The measured inclusive cross section in the Z-peak region (60–120 GeV) is σ(ℓℓ) = 986.4 ± 0.6 (stat.) ± 5.9 (exp. syst.) ± 21.7 (th. syst.) ± 21.7 (lum.) pb for the combination of the dimuon and dielectron channels. Differential cross sections dσ/dm for the dimuon, dielectron, and combined channels are measured in the mass range 15 to 1500 GeV and corrected to the full phase space. Results are also presented for the measurement of the double-differential cross section d2σ/dm d|y| in the dimuon channel over the mass range 20 to 1500 GeV and absolute dimuon rapidity from 0 to 2.4. These measurements are compared to the predictions of perturbative QCD calculations at next-to-leading and next-to-next-to-leading orders using various sets of parton distribution functions.The Austrian
Federal Ministry of Science and Research and the Austrian Science Fund; the Belgian Fonds
de la Recherche Scienti que, and Fonds voor Wetenschappelijk Onderzoek; the Brazilian
Funding Agencies (CNPq, CAPES, FAPERJ, and FAPESP); the Bulgarian Ministry of
Education and Science; CERN; the Chinese Academy of Sciences, Ministry of Science and
Technology, and National Natural Science Foundation of China; the Colombian Funding
Agency (COLCIENCIAS); the Croatian Ministry of Science, Education and Sport; the Research
Promotion Foundation, Cyprus; the Ministry of Education and Research, Recurrent
nancing contract SF0690030s09 and European Regional Development Fund, Estonia; the
Academy of Finland, Finnish Ministry of Education and Culture, and Helsinki Institute of
Physics; the Institut National de Physique Nucl eaire et de Physique des Particules / CNRS,
and Commissariat a l' Energie Atomique et aux Energies Alternatives / CEA, France; the
Bundesministerium f ur Bildung und Forschung, Deutsche Forschungsgemeinschaft, and
Helmholtz-Gemeinschaft Deutscher Forschungszentren, Germany; the General Secretariat
for Research and Technology, Greece; the National Scienti c Research Foundation, and National Innovation O ce, Hungary; the Department of Atomic Energy and the Department
of Science and Technology, India; the Institute for Studies in Theoretical Physics
and Mathematics, Iran; the Science Foundation, Ireland; the Istituto Nazionale di Fisica
Nucleare, Italy; the Korean Ministry of Education, Science and Technology and the World
Class University program of NRF, Republic of Korea; the Lithuanian Academy of Sciences;
the Mexican Funding Agencies (CINVESTAV, CONACYT, SEP, and UASLP-FAI);
the Ministry of Business, Innovation and Employment, New Zealand; the Pakistan Atomic
Energy Commission; the Ministry of Science and Higher Education and the National Science
Centre, Poland; the Funda c~ao para a Ci^encia e a Tecnologia, Portugal; JINR, Dubna;
the Ministry of Education and Science of the Russian Federation, the Federal Agency of
Atomic Energy of the Russian Federation, Russian Academy of Sciences, and the Russian
Foundation for Basic Research; the Ministry of Education, Science and Technological Development
of Serbia; the Secretar a de Estado de Investigaci on, Desarrollo e Innovaci on
and Programa Consolider-Ingenio 2010, Spain; the Swiss Funding Agencies (ETH Board,
ETH Zurich, PSI, SNF, UniZH, Canton Zurich, and SER); the National Science Council,
Taipei; the Thailand Center of Excellence in Physics, the Institute for the Promotion of
Teaching Science and Technology of Thailand, Special Task Force for Activating Research
and the National Science and Technology Development Agency of Thailand; the Scienti c
and Technical Research Council of Turkey, and Turkish Atomic Energy Authority; the
Science and Technology Facilities Council, UK; the US Department of Energy, and the US
National Science Foundation
Measurement of the ratio of the inclusive 3-jet cross section to the inclusive 2-jet cross section in pp collisions at root s=7 TeV and first determination of the strong coupling constant in the TeV range
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- Yelton J
- Yetkin T
- Yi K
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
- Yu SS
- Yucel M
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti A
- Zanetti M
- Zarubin A
- Zeinali M
- Zeise M
- Zenz SC
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang L
- Zheng Y
- Zhokin A
- Zhu RY
- Zhukov V
- Zhukova V
- Zielinski M
- Zito G
- Zotto P
- Zou W
- Zsigmond AJ
- Zuranski A
- Publication venue
- Publication date
- 26/11/2015
- Field of study
A measurement is presented of the ratio of the inclusive 3-jet cross section to the inclusive 2-jet cross section as a function of the average transverse momentum, , of the two leading jets in the event. The data sample was collected during 2011 at a proton-proton centre-of-mass energy of 7 TeV with the CMS detector at the LHC, corresponding to an integrated luminosity of 5.0 fb(-1). The strong coupling constant at the scale of the Z boson mass is determined to be alpha(S)(M-Z) = 0.1148 +/- 0.0014 (exp.) +/- 0.0018 (PDF) +/- 0.0050 (theory), by comparing the ratio in the range 0.42 < 1.39 TeV to the predictions of perturbative QCD at next-to-leading order. This is the first determination of alpha(S)(M-Z) from measurements at momentum scales beyond 0.6 TeV. The predicted ratio depends only indirectly on the evolution of the parton distribution functions of the proton such that this measurement also serves as a test of the evolution of the strong coupling constant. No deviation from the expected behaviour is observed
Search for the standard model Higgs boson in the diphoton decay channel with 4.9fb -1 of pp collision data at √s=7TeV with atlas
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdel Khalek S
- Abdelalim AA
- Abdesselam A
- Abdinov O
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- Åkesson TPA
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- Publication venue
- Publication date
- 01/01/2012
- Field of study
A search for the standard model Higgs boson is performed in the diphoton decay channel. The data used correspond to an integrated luminosity of 4.9 fb-1 collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of √s=7 TeV. In the diphoton mass range 110–150 GeV, the largest excess with respect to the background-only hypothesis is observed at 126.5 GeV, with a local significance of 2.8 standard deviations. Taking the look-elsewhere effect into account in the range 110–150 GeV, this significance becomes 1.5 standard deviations. The standard model Higgs boson is excluded at 95% confidence level in the mass ranges of 113–115 GeV and 134.5–136 GeV
Search for the standard model Higgs boson in the diphoton decay channel with 4.9fb -1 of pp collision data at √s=7TeV with atlas
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- Abdallah J
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- Publication venue
- Publication date
- 01/01/2012
- Field of study
A search for the standard model Higgs boson is performed in the diphoton decay channel. The data used correspond to an integrated luminosity of 4.9 fb-1 collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of √s=7 TeV. In the diphoton mass range 110–150 GeV, the largest excess with respect to the background-only hypothesis is observed at 126.5 GeV, with a local significance of 2.8 standard deviations. Taking the look-elsewhere effect into account in the range 110–150 GeV, this significance becomes 1.5 standard deviations. The standard model Higgs boson is excluded at 95% confidence level in the mass ranges of 113–115 GeV and 134.5–136 GeV
Obsolescence Management
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Obsolescence management for long-life contracts: State of the art and future trends
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/08/2009
- Field of study
This paper provides a comprehensive literature review on the problem of
obsolescence in “sustainment-dominated systems” that require support for many
decades. Research on this topic continues to grow as a result of the high impact
of obsolescence on the in-service phase of long-term projects. Research on
obsolescence also seeks to understand how it can be managed, mitigated and
resolved. The paper aims to clarify and classify the different activities that
may be included in an obsolescence management planning, taking into account not
only electronic components but also other aspects of the system such as
mechanical components, software, materials, skills and tooling. The literature
review shows that although there are many commercial tools available that
support the obsolescence management during the in-service phase of the life
cycle of a system, little research has been done to forecast the costs incu
Serum leptin and habitual fatty acid dietary intake in patients with type 1 diabetes mellitus
- Author
- Publication venue
- 'Bioscientifica'
- Publication date
- Field of study
The embryo as moral work object: PGD/IVF staff views and experiences
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- Publication venue
- 'Wiley'
- Publication date
- 01/01/2008
- Field of study
Copyright @ 2008 the authors. This article is available in accordance with the Creative Commons Deed, Attribution 2.5, see http://creativecommons.org/licenses/by-nc-nd/2.5/deed.en_CA.We report on one aspect of a study that explored the views and experiences of practitioners and scientists on social, ethical and clinical dilemmas encountered when working in the field of preimplantation genetic diagnosis (PGD) for serious genetic disorders. The study produced an ethnography based on observation, interviews and ethics discussion groups with staff from two PGD/IVF Units in the UK. We focus here on staff perceptions of work with embryos that entails disposing of ‘affected’ or ‘spare’ embryos or using them for research. A variety of views were expressed on the ‘embryo question’ in contrast to polarised media debates. We argue that the prevailing policy acceptance of destroying affected embryos, and allowing research on embryos up to 14 days leaves some staff with rarely reported, ambivalent feelings. Staff views are under-researched in this area and we focus on how they may reconcile their personal moral views with the ethical framework in their field. Staff construct embryos in a variety of ways as ‘moral work objects’. This allows them to shift attention between micro-level and overarching institutional work goals, building on Casper's concept of ‘work objects’ and focusing on negotiation of the social order in a morally contested field.The Wellcome Trust Biomedical Ethics Programme, who funded the projects‘Facilitating choice, framing choice: the experience of staff working in pre-implantation genetic diagnosis’ (no: 074935), and ‘Ethical Frameworks for Embryo Donation:the views and practices of IVF/PGD staff’ (no: 081414)
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