Opto-mechanical design for sight windows under high loads

In this study, the design aspects of optically accessible pressure vessels are investigated via a case study of a High Pressure Combustor experimental rig. The rig was designed to take optical measurements of combustion, simulating the conditions found in internal combustion engines and turbines. Although, it is not new to equip chambers and reactors with sight windows, important aspects of design and relevant information regarding optical access is missing or are insufficiently explored or not readily accessible in the existing literature. A comprehensive review of requirements for optical access to such high-pressure, high-temperature systems has been conducted. It is shown in a readily-navigable format as function of application and precision, with data and technical correlations hitherto not found in a ‘user-friendly’ style. The material selection procedure is detailed and supported by a complete comparison of optical materials and relevant properties. The review revealed a significant inconsistency in mechanical properties claimed in the literature for optical materials. As a response to this, increased safety factor values are suggested as function of level of uncertainties and effects of failure, typically three to four times higher than the industrial standard. Moreover, newly developed equations are presented linking performance analysis to the design criteria

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Smart Fortified PHBV-CS Biopolymer with ZnO–Ag Nanocomposites for Enhanced Shelf Life of Food Packaging

Thymus vulgaris leaf extract was used as a stabilizer and reducing agent in the green, facile, and biomimetic hydrothermal decomposition reaction for the fabrication of zinc oxide silver nanocomposites (ZnO-Ag NCs). The nanocomposite (NC) as an active agent was integrated into poly(3-hydroxybutyrate-co-3-hydroxyvalerate)-chitosan (PHBV-CS) in a highly precise ratio of solvent mixture by ultrasonication without the aid of any coupling agent to fabricate the novel degradable biopolymer (BP) nanocomposite via solvent casting method to enhance the mechanical properties and antimicrobial activity and with the lowest immigration rate to improve the shelf life of poultry items. The ZnO-Ag NCs as a nanoactive agent in the food packaging preserved food safety by controlling its spoilage. The morphology, physical, mechanical, barrier, antibacterial, and migration properties of the nanocrystals were assessed via several characterization methods to show the enhancement of the prepared polymer in various aspects of properties. The NCs BP were used for potential sensory evaluation of chicken breast refrigerated over a period of 15 days. The data demonstrated that these bio-based nanocomposites show great antimicrobial activity that offers perspectives for the replacement of traditional petrochemical-based polymers currently used for food packaging of poultry items

SU086, an inhibitor of HSP90, impairs glycolysis and represents a treatment strategy for advanced prostate cancer.

Among men, prostate cancer is the second leading cause of cancer-associated mortality, with advanced disease remaining a major clinical challenge. We describe a small molecule, SU086, as a therapeutic strategy for advanced prostate cancer. We demonstrate that SU086 inhibits the growth of prostate cancer cells in vitro, cell-line and patient-derived xenografts in vivo, and ex vivo prostate cancer patient specimens. Furthermore, SU086 in combination with standard of care second-generation anti-androgen therapies displays increased impairment of prostate cancer cell and tumor growth in vitro and in vivo. Cellular thermal shift assay reveals that SU086 binds to heat shock protein 90 (HSP90) and leads to a decrease in HSP90 levels. Proteomic profiling demonstrates that SU086 binds to and decreases HSP90. Metabolomic profiling reveals that SU086 leads to perturbation of glycolysis. Our study identifies SU086 as a treatment for advanced prostate cancer as a single agent or when combined with second-generation anti-androgens