Catherine of Siena’s crusade letters: Spirituality and political context

Catherine of Siena has been credited with original views regarding the crusade as political policy and with influencing Gregory XI to carry this out. In this article, I argued that while Catherine of Siena did not succeed in furthering the crusade – nor did she initiate this policy – her crusade correspondence leaves us a legacy that reveals significant aspects of her spirituality. Over 40 letters to ecclesiastical authorities, Kings, Queens, leaders of city states, knights and her own followers reveal a religious intent, although addressing a policy with both religious and political consequences. The latter were important to Catherine because she considered political-cultural context vital for salvation and transformation; she advocated for the crusade because she considered that the crusade pilgrimage and holy war to recover the Holy Land would be critical for the salvation of many. Her epistles further witness to the prophetic, missionary nature of Catherine’s spirituality, and we see how she crafted her own version of crusade spirituality out of the wisdom on transformation learned through her union with God, fused with early Christian martyr spirituality and early crusade spirituality preached in medieval Europe. This thematisation of Catherine’s crusade letters is based on textual analysis of all crusade related letters in the 2002 critical text, on the most complete dating of Catherine’s letters (finished in 2008); and in dialogue with literary and other historical advances, making it an innovative study. Contribution: Catherine of Siena’s crusade letters reveal significant aspects of her spirituality rather than contributions to crusade politics. The letters evidence her prophetic-missionary spirituality and her conviction that socio-political context is significant for a journey of transformation; as well, this analysis details the importance of early Christian martyr spirituality for Catherine’s crusade spirituality

Catherine of Siena’s wisdom on discernment and her reception of scripture

Catherine of Siena’s wisdom on discernment represents a significant development in the history of this essential Christian theme. Her teaching is the fruit of personal wisdom rather than formal study as she was an uneducated lay woman in fourteenth century Italy. In this article I show how Scripture was central to Catherine’s wisdom. First I show that she was exposed to Scripture primarily orally and that she assimilated what she heard through her life of prayer and relationship with God. I describe the central biblical themes at the heart of her teaching on discernment, namely growth in charity and capacity for truth, and I show how these are related to her wisdom on discernment. I then examine how Catherine applied her teaching through an analysis of a letter to Pope Gregory XI. In this article I will show that central New Testament themes are at the heart of Catherine of Siena’s teaching on discernment and I will describe how the knowledge of Scripture that suffused her teaching was not internalized as a result of formal study, but rather as a result of her experience of God in prayer and of her personal reflection. Her oral reception of Scripture became transformed through her mystical experience into wisdom that has become a major Christian classic; indeed Catherine is one of only three women named Doctor of the Church in the Catholic tradition.peer-reviewe

Spirituality and belief: Implications for study and practice of Christian spirituality

The aim of this article is to show the inherent connection between spirituality and belief and the significance of this for the study and practice of Christian spirituality. John Hick, a scholar of religion, argues that religions arose in human culture in order to offer beliefs and practices that respond to the human quest for meaning and transcendence. Assuming spirituality refers to consciously living life in terms of such beliefs and rituals, then religion’s function in culture is to provide a spirituality. Based on the latter theory, I argue for the importance of theological or confessional reflection regarding contemporary belief, given that theology reflects on the beliefs of a religion and at its best helps persons understand and integrate their beliefs into the living of life at a particular historical-cultural moment. In our contemporary globalised, pluralistic culture the influence on spiritual practice of multiple sources of wisdom is common, as shown by sociological studies discussed in this study. This cultural context calls for identification, understanding and interpretation of the beliefs of Christians, as well as study regarding how these beliefs fulfil the purpose of religion in human culture, namely offering ways of living with suffering, evil and questions about the meaning of life. I argue such study fulfils both practical and theoretical functio

Continuous prayer in Catherine of Siena

Catherine of Siena offers considerable wisdom regarding continuous prayer. However, this wisdom in not well known because it is scattered among her texts, including over 373 letters, and is expressed in images and metaphors, the product of oral communication by a 14th-century woman with no formal education. Through a literary analysis of original texts, I will show the interconnection among the meanings of her symbolic communications, offering a narrative about continuous prayer. I will explore the meaning of inner cell and time spent in this cell for knowledge of self and God. I will show how this dual knowledge results in transformation of the deepest motivation at the core of the person. Living consciously and for God’s kingdom out of this transformed core of the self constitutes continuous prayer

Continuous prayer in Catherine of Siena

Catherine of Siena offers considerable wisdom regarding continuous prayer. However, this wisdom in not well known because it is scattered among her texts, including over 373 letters, and is expressed in images and metaphors, the product of oral communication by a 14th-century woman with no formal education. Through a literary analysis of original texts, I will show the interconnection among the meanings of her symbolic communications, offering a narrative about continuous prayer. I will explore the meaning of inner cell and time spent in this cell for knowledge of self and God. I will show how this dual knowledge results in transformation of the deepest motivation at the core of the person. Living consciously and for God’s kingdom out of this transformed core of the self constitutes continuous prayer

A neurodegenerative disease landscape of rare mutations in Colombia due to founder effects

Background The Colombian population, as well as those in other Latin American regions, arose from a recent tri-continental admixture among Native Americans, Spanish invaders, and enslaved Africans, all of whom passed through a population bottleneck due to widespread infectious diseases that left small isolated local settlements. As a result, the current population reflects multiple founder effects derived from diverse ancestries. Methods We characterized the role of admixture and founder effects on the origination of the mutational landscape that led to neurodegenerative disorders under these historical circumstances. Genomes from 900 Colombian individuals with Alzheimer’s disease (AD) [n = 376], frontotemporal lobar degeneration-motor neuron disease continuum (FTLD-MND) [n = 197], early-onset dementia not otherwise specified (EOD) [n = 73], and healthy participants [n = 254] were analyzed. We examined their global and local ancestry proportions and screened this cohort for deleterious variants in disease-causing and risk-conferring genes. Results We identified 21 pathogenic variants in AD-FTLD related genes, and PSEN1 harbored the majority (11 pathogenic variants). Variants were identified from all three continental ancestries. TREM2 heterozygous and homozygous variants were the most common among AD risk genes (102 carriers), a point of interest because the disease risk conferred by these variants differed according to ancestry. Several gene variants that have a known association with MND in European populations had FTLD phenotypes on a Native American haplotype. Consistent with founder effects, identity by descent among carriers of the same variant was frequent. Conclusions Colombian demography with multiple mini-bottlenecks probably enhanced the detection of founder events and left a proportionally higher frequency of rare variants derived from the ancestral populations. These findings demonstrate the role of genomically defined ancestry in phenotypic disease expression, a phenotypic range of different rare mutations in the same gene, and further emphasize the importance of inclusiveness in genetic studies.Q2Q2Antecedentes La población colombiana, así como la de otras regiones latinoamericanas, surgió de una mezcla tricontinental reciente entre los nativos americanos, los invasores españoles y los africanos esclavizados, todos los cuales pasaron por un cuello de botella poblacional debido a enfermedades infecciosas generalizadas que dejaron a pequeños aislados. asentamientos locales. Como resultado, la población actual refleja múltiples efectos fundadores derivados de diversas ascendencias. Métodos Caracterizamos el papel de la mezcla y los efectos fundadores en el origen del paisaje mutacional que condujo a trastornos neurodegenerativos en estas circunstancias históricas. Genomas de 900 individuos colombianos con enfermedad de Alzheimer (EA) [n = 376], continuo degeneración lobar frontotemporal-enfermedad de la motoneurona (FTLD-MND) [n = 197], demencia de inicio temprano no especificada (EOD) [n = 73 ], y participantes sanos [n = 254] fueron analizados. Examinamos sus proporciones de ascendencia global y local y examinamos esta cohorte en busca de variantes nocivas en los genes que causan enfermedades y confieren riesgos. Resultados Identificamos 21 variantes patogénicas en genes relacionados con AD-FTLD, y PSEN1 albergaba la mayoría (11 variantes patogénicas). Se identificaron variantes de las tres ascendencias continentales. Las variantes heterocigotas y homocigotas de TREM2 fueron las más comunes entre los genes de riesgo de EA (102 portadores), un punto de interés porque el riesgo de enfermedad conferido por estas variantes difería según la ascendencia. Varias variantes genéticas que tienen una asociación conocida con MND en poblaciones europeas tenían fenotipos FTLD en un haplotipo nativo americano. De acuerdo con los efectos del fundador, la identidad por descendencia entre portadores de la misma variante fue frecuente. Conclusiones La demografía colombiana con múltiples mini-cuellos de botella probablemente mejoró la detección de eventos fundadores y dejó una frecuencia proporcionalmente más alta de variantes raras derivadas de las poblaciones ancestrales. Estos hallazgos demuestran el papel de la ascendencia definida genómicamente en la expresión fenotípica de la enfermedad, un rango fenotípico de diferentes mutaciones raras en el mismo gen, y enfatizan aún más la importancia de la inclusión en los estudios genéticos.https://orcid.org/0000-0001-6529-7077https://scholar.google.com/citations?hl=es&user=kaGongoAAAAJ&view_op=list_works&sortby=pubdatehttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000055000&lang=esRevista Internacional - Indexad

A neurodegenerative disease landscape of rare mutations in Colombia due to founder effects.

Background: The Colombian population, as well as those in other Latin American regions, arose from a recent tri-continental admixture among Native Americans, Spanish invaders, and enslaved Africans, all of whom passed through a population bottleneck due to widespread infectious diseases that left small isolated local settlements. As a result, the current population reflects multiple founder effects derived from diverse ancestries. Methods: We characterized the role of admixture and founder effects on the origination of the mutational landscape that led to neurodegenerative disorders under these historical circumstances. Genomes from 900 Colombian individuals with Alzheimer's disease (AD) [n = 376], frontotemporal lobar degeneration-motor neuron disease continuum (FTLD-MND) [n = 197], early-onset dementia not otherwise specified (EOD) [n = 73], and healthy participants [n = 254] were analyzed. We examined their global and local ancestry proportions and screened this cohort for deleterious variants in disease-causing and risk-conferring genes. Results: We identified 21 pathogenic variants in AD-FTLD related genes, and PSEN1 harbored the majority (11 pathogenic variants). Variants were identified from all three continental ancestries. TREM2 heterozygous and homozygous variants were the most common among AD risk genes (102 carriers), a point of interest because the disease risk conferred by these variants differed according to ancestry. Several gene variants that have a known association with MND in European populations had FTLD phenotypes on a Native American haplotype. Consistent with founder effects, identity by descent among carriers of the same variant was frequent. Conclusions: Colombian demography with multiple mini-bottlenecks probably enhanced the detection of founder events and left a proportionally higher frequency of rare variants derived from the ancestral populations. These findings demonstrate the role of genomically defined ancestry in phenotypic disease expression, a phenotypic range of different rare mutations in the same gene, and further emphasize the importance of inclusiveness in genetic studies

Effect of mivacurium 200 and 250 μg/kg in infants during isoflurane anesthesia: a randomized controlled trial [ISRCTN07742712]

BACKGROUND: Infants usually respond differently to a neuromuscular relaxant compared to children or adults. Isoflurane is commonly used as an anesthetic gas in infants. In an RCT design, we investigated whether a dose of mivacurium 250 μg/kg results in faster onset of action than 200 μg/kg in infants under isoflurane anesthesia. Spontaneous recovery times and cardiovascular response were also evaluated. METHODS: Twenty-four low surgical risk children, aged 6–24 months, undergoing an elective surgery and requiring tracheal intubation were selected. After anesthetic induction, patients randomly received an iv bolus dose of mivacurium 200 or 250 μg/kg. After maximal relaxation, the patient was intubated. Isoflurane was administered to maintain anesthetic level during the surgical procedure. Neuromuscular function was monitored by accelerometry (TOF-Guard) at the adductor pollicies. The first twitch (T) of the TOF and the T4/T1 were measured. The time-course of heart rate and systolic and diastolic blood pressure were analysed by transforming them into their respective areas under the curve. RESULTS: Mivacurium 250 μg/kg produced a maximal T block faster than 200 μg/kg, i.e. 2.4 ± 1.1 vs. 3.5 ± 1.4 min (p < 0.05). Spontaneous recovery times were similar in both groups. Heart rate was similar between doses while systolic and diastolic blood pressures were lower with the higher dose (p < 0.05). Flushing was observed in two cases, one in each group. CONCLUSIONS: The maximal effect of mivacurium 250 μg/kg, in infants under isoflurane anesthesia, was present one minute faster than 200 μg/kg. However, it produced a significant cardiovascular response

Factores de riesgo psicosociales y ambientales asociados a trastornos mentales

In Colombia, there are few studies on the association of psychosocial and environmental factors with the most prevalent mental disorders; such studies are important due to the context of violence, social insecurity, and job and economic instability in the country. The objective of this study was to identify the psychosocial and environmental risk factors for mental disorders, in users of psychological services in Colombia. The Mini International Neuropsychiatric Interview and a Questionnaire to evaluate the Axis-IV of the DSM-IV-TR were applied to 490 participants. The analysis comprised descriptive statistics and risk factors. As risk factors for depression, there were identified housing problems, access to health care services, problems related to the primary group, economics, problems of the social environment, and labor. For generalized anxiety, there were identified economic and education issues. For panic disorders, the risk factors were related to social environment, and for social phobia, the risk factors were problems in education, work and social environment.En Colombia, son escasos los estudios sobre la asociaci&oacute;n de los factores psicosociales y medioambientales con trastornos mentales de mayor prevalencia; tales estudios son necesarios debido al contexto de violencia, inseguridad social e inestabilidad laboral y econ&oacute;mica del pa&iacute;s. El objetivo de este estudio fue identificar los factores de riesgo psicosociales y ambientales de los trastornos mentales, en los usuarios de servicios de psicolog&iacute;a de Colombia. Para ello, se aplicaron el MiniInternational Neuropsychiatric Interview y un cuestionario de evaluaci&oacute;n del Eje IV del DSM-IV-TR, a 490 participantes. Se utilizaron an&aacute;lisis descriptivos y de factores de riesgo. Como factor de riesgo para la depresi&oacute;n, se identificaron los problemas de vivienda, acceso a los servicios de asistencia sanitaria, los relativos al grupo primario, los econ&oacute;micos, del ambiente social y los problemas laborales. Para la ansiedad generalizada se identificaron los problemas econ&oacute;micos y los relativos a la ense&ntilde;anza. Para los trastornos de p&aacute;nico, fueron relevantes los problemas relacionados con el ambiente social, y para la fobia social, los problemas de ense&ntilde;anza, los laborales y el ambiente social

A multi-targeted approach to suppress tumor-promoting inflammation

Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-κB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes