Handoffs in User-Centric Cell-Free MIMO Networks: A POMDP Framework

We study the problem of managing handoffs (HOs) in user-centric cell-free massive MIMO (UC-mMIMO) networks. Motivated by the importance of controlling the number of HOs and by the correlation between efficient HO decisions and the temporal evolution of the channel conditions, we formulate a partially observable Markov decision process (POMDP) with the state space representing the discrete versions of the large-scale fading and the action space representing the association decisions of the user with the access points (APs). We develop a novel algorithm that employs this model to derive a HO policy for a mobile user based on current and future rewards. To alleviate the high complexity of our POMDP, we follow a divide-and-conquer approach by breaking down the POMDP formulation into sub-problems, each solved separately. Then, the policy and the candidate pool of APs for the sub-problem that produced the best total expected reward are used to perform HOs within a specific time horizon. We then introduce modifications to our algorithm to decrease the number of HOs. The results show that half of the number of HOs in the UC-mMIMO networks can be eliminated. Namely, our novel solution can control the number of HOs while maintaining a rate guarantee, where a 47%-70% reduction of the cumulative number of HOs is observed in networks with a density of 125 APs per km2. Most importantly, our results show that a POMDP-based HO scheme is promising to control HOs.Comment: Accepted in IEEE Transactions on Wireless Communications (TWC

Characterizing Long COVID: Deep Phenotype of a Complex Condition.

BACKGROUND: Numerous publications describe the clinical manifestations of post-acute sequelae of SARS-CoV-2 (PASC or long COVID ), but they are difficult to integrate because of heterogeneous methods and the lack of a standard for denoting the many phenotypic manifestations. Patient-led studies are of particular importance for understanding the natural history of COVID-19, but integration is hampered because they often use different terms to describe the same symptom or condition. This significant disparity in patient versus clinical characterization motivated the proposed ontological approach to specifying manifestations, which will improve capture and integration of future long COVID studies. METHODS: The Human Phenotype Ontology (HPO) is a widely used standard for exchange and analysis of phenotypic abnormalities in human disease but has not yet been applied to the analysis of COVID-19. FINDINGS: We identified 303 articles published before April 29, 2021, curated 59 relevant manuscripts that described clinical manifestations in 81 cohorts three weeks or more following acute COVID-19, and mapped 287 unique clinical findings to HPO terms. We present layperson synonyms and definitions that can be used to link patient self-report questionnaires to standard medical terminology. Long COVID clinical manifestations are not assessed consistently across studies, and most manifestations have been reported with a wide range of synonyms by different authors. Across at least 10 cohorts, authors reported 31 unique clinical features corresponding to HPO terms; the most commonly reported feature was Fatigue (median 45.1%) and the least commonly reported was Nausea (median 3.9%), but the reported percentages varied widely between studies. INTERPRETATION: Translating long COVID manifestations into computable HPO terms will improve analysis, data capture, and classification of long COVID patients. If researchers, clinicians, and patients share a common language, then studies can be compared/pooled more effectively. Furthermore, mapping lay terminology to HPO will help patients assist clinicians and researchers in creating phenotypic characterizations that are computationally accessible, thereby improving the stratification, diagnosis, and treatment of long COVID. FUNDING: U24TR002306; UL1TR001439; P30AG024832; GBMF4552; R01HG010067; UL1TR002535; K23HL128909; UL1TR002389; K99GM145411

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Simulation of Mobile Networks using Discrete Event System Specification Theory

The fourth generation (4G) of mobile telecommunication technology provides ultra-band internet access for mobile devices such as smartphones, tablets, and laptops. One of the challenges in the Long Term Evolution (LTE) 4G networks is the low data rate for cell-edge users as well as coverage gaps. In this paper, we define and evaluate models for analysis of performance of mobile networks architectures defined by 3GPP. We used the Discrete-Event System Specification (DEVS) formalism to model the mobile networks and implement the framework. The proposed model implements the deployment layout of the Base Station (BS) cellular antennas, and it manages the distribution and movement of the User Equipment (UE) devices. The model calculates the Propagation for each BS, as well as the pathloss in the links between BSs and the UEs in the range. It also computes the power received by the BS and the UE in each link. These results will be used in the design of models for Coordinated Multipoint approach in delivering faster data. 1