Direct origin of the right colic artery from the abdominal aorta

An isolated right colic artery originating directly from the abdominal aorta was incidentally observed during diagnostic spinal angiography. Variations in origin of the right colic artery are reviewed, and their embryology and potential clinical implications discussed

The JWST Galactic Center Survey -- A White Paper

The inner hundred parsecs of the Milky Way hosts the nearest supermassive black hole, largest reservoir of dense gas, greatest stellar density, hundreds of massive main and post main sequence stars, and the highest volume density of supernovae in the Galaxy. As the nearest environment in which it is possible to simultaneously observe many of the extreme processes shaping the Universe, it is one of the most well-studied regions in astrophysics. Due to its proximity, we can study the center of our Galaxy on scales down to a few hundred AU, a hundred times better than in similar Local Group galaxies and thousands of times better than in the nearest active galaxies. The Galactic Center (GC) is therefore of outstanding astrophysical interest. However, in spite of intense observational work over the past decades, there are still fundamental things unknown about the GC. JWST has the unique capability to provide us with the necessary, game-changing data. In this White Paper, we advocate for a JWST NIRCam survey that aims at solving central questions, that we have identified as a community: i) the 3D structure and kinematics of gas and stars; ii) ancient star formation and its relation with the overall history of the Milky Way, as well as recent star formation and its implications for the overall energetics of our galaxy's nucleus; and iii) the (non-)universality of star formation and the stellar initial mass function. We advocate for a large-area, multi-epoch, multi-wavelength NIRCam survey of the inner 100\,pc of the Galaxy in the form of a Treasury GO JWST Large Program that is open to the community. We describe how this survey will derive the physical and kinematic properties of ~10,000,000 stars, how this will solve the key unknowns and provide a valuable resource for the community with long-lasting legacy value.Comment: This White Paper will be updated when required (e.g. new authors joining, editing of content). Most recent update: 24 Oct 202

PESQUISAS DESENVOLVIDAS NO PROGRAMA DE PÓS-GRADUAÇÃO EM GERONTOLOGIA DA UNIVERSIDADE FEDERAL DE SÃO CARLOS E SUA IMPORTÂNCIA NO CONTEXTO DO ENVELHECIMENTO

Esta revisão narrativa tem como objetivo apresentar e discutir a relevância dos estudos desenvolvidos no Programa de Pós-Graduação em Gerontologia da Universidade Federal de São Carlos (PPGGero/UFSCar). Os dados foram coletados na disciplina “Seminários Avançados em Gerontologia”, em que os docentes autores apresentaram suas linhas de pesquisa, as quais foram compiladas pelos discentes autores. Os resultados desta revisão apresentam os estudos realizados em um programa interdisciplinar de mestrado acadêmico que possui duas linhas de pesquisa denominadas: 1) Saúde, Biologia e Envelhecimento; e 2) Gestão, Tecnologia e Inovação em Gerontologia. Os estudos se inserem em diversas temáticas da área do envelhecimento, que se articulam entre ambas as linhas de pesquisa do programa. Na linha 1 destacam-se estudos relacionados à cognição, à demência e suas consequências aos pacientes e cuidadores, bem como a pesquisas relacionadas ao seu diagnóstico e cuidado. Destacam-se também pesquisas epidemiológicas e aquelas relacionadas a condições ou doenças comuns no envelhecimento, como dor crônica, osteoartrite e, mais recentemente, a infecções em idosos, incluindo a COVID-19. Na linha 2 destacam-se pesquisas relacionadas a tecnologias assistivas voltadas aos idosos, bem como estratégias de marketing e políticas de atenção para esse público. É notório que a multidimensionalidade de abordagens das questões do envelhecimento exige enfoque multidisciplinar sobre um contexto de excelência acadêmica. Assim, conclui-se que as pesquisas do PPGGero/UFSCar, ao abrangerem várias áreas do conhecimento – as quais permeiam as ciências humanas, biológicas, sociais e exatas no contexto de tecnologia e inovação –, promovem a formação de mestres e pesquisadores que contribuem para a produção de conhecimento em Gerontologia no país

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial

Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort

First-Line Selective Internal Radiation Therapy in Patient With Uveal Melanoma Liver Metastases

Contexte Le mélanome de l'uvée est une maladie très rare mais constitue la tumeur maligne intraoculaire la plus fréquente chez l'adulte. La survie à 5 ans s'élève à 800/0. Néanmoins, entre 10 et 300/0 des patients vont développer des métastases dans les 5 ans, 45 0/0 dans les 15 ans, suivants le diagnostic. Le foie est atteint dans la grande majorité des cas (70-9096), cette tumeur présentant un tropisme particulier pour cet organe. La survie à long terme est fortement corrélée au contrôle de la maladie métastatique hépatique et n'est seulement que de 5 à 7 mois sans traitement. Malheureusement, cette tumeur se montre résistante aux thérapies systémiques et aucune standardisation n'existe concernant les traitements hépatiques locorégionaux. La thérapie par irradiation interne sélective, SIRT en anglais pour « Selective Internal Radiation Therapy », consiste en l'administration de microparticules contenant de l' Yttrium-90 dans le foie via un micro-cathéter positionné dans l'artère hépatique. Cette technique novatrice a déjà été testée chez les patients avec mélanome de l'uvée métastatique avec des résultats encourageants en thérapie dite de sauvetage lors de l'échec des autres méthodes de traitement. Le but de cette étude était de déterminer la sécurité et l'efficacité de la SIRT en première ligne de traitement chez les patients avec des métastases hépatiques du mélanome de l'uvée. Méthode Il s'agit d'une étude rétrospective basée sur les données collectées prospectivement de 22 patients traités par SIRT en première ligne. Les toxicités biologiques et cliniques ont été enregistrées. La réponse tumorale a été évaluée avec des critères reconnus, notamment à l'aide des critères EASL pour « European Association for the Study of Liver Disease ». Les facteurs prédictifs de survie ont été déterminés par analyses uni- et multivariées et la survie globale par analyse de Kaplan-Meier à l'aide du test de log-rank. Résultats Des signes de toxicité biologique ou clinique de grades 3 à 4 sont apparus chez 2496 des patients dans les deux cas. Selon les critères EASL, le contrôle de la maladie à 6 mois était atteint après 15 (5296) des 29 SIRT réalisées sur les 22 patients et s'est montré prédictif de survie. La survie générale médiane depuis la première SIRT était de 18 mois [intervalle de confiance à 95 0/0 (IC95%), 8-28]. Au moment de l'analyse, 5 patients (23 0/0) étaient encore en vie. Par analyse multivariée, la taille de la plus grande métastase hépatique [hazard ratio (HR) 1.22; IC95%, 0.98-1.53], le volume tumoral hépatique [HR 1.002; IC95%, 1.0004-1.003] ainsi que les thérapies ultérieures systémiques [HR 0.04; IC95%, 0.006-0.24] ou locorégionales [HR 0.204; IC95%, 0.04-0.94] se sont montrés prédictifs de survie. Conclusion La SIRT en première ligne de traitement chez les patients atteints de métastases hépatiques du mélanome de l'uvée est sûre et démontre des résultats encourageants. Les thérapies administrées ultérieurement, systémiques et locorégionales, sont corrélées à une augmentation de la survie suggérant un bénéfice accru par une approche combinée. Des études prospectives testant la SIRT en première ligne de traitement sont nécessaires afin de confirmer ces résultats

Anévrismes de l'aorte abdominale: connaissances actuelles et traitement endovasculaire

Abdominal aortic aneurysms are a common condition whose prognosis without treatment is poor because of the lethality in case of breakage. An early diagnosis is thus necessary by screening or symptoms recognition. Surgery is not the only option then, continuous monitoring and medical treatment being sometimes possible. If curative treatment is undertaken, endovascular technique is an alternative to open surgical repair but its indications are not yet fully established and endovascular grafts have not the same longevity as open surgery. A review of the indications for endovascular repair in patients operated at the Geneva University Hospital has been used to illustrate the importance of individualized care for each patient

Left sinus of Valsalva aneurysm as a cause of chronic stable angina

Sinus of Valsalva aneurysms are unusual, particularly when located on the left coronary sinus. They are mainly asymptomatic, however once ruptured, they are associated with high mortality. We present hereinafter an atypical case of a 71-year-old patient with an unruptured left sinus of Valsalva aneurysm causing myocardial ischaemia due to a compressed left main coronary artery. Surgical endoaneurysmorrhaphy was performed; however, a dehiscence of the suture line between the patch and the aortic wall required additional percutaneous implantation of a vascular occluder