Ventilation and air-conditioning systems in dental clinics and COVID-19 : how much do we know?

This study evaluated the association between knowledge and management of ventilation and air-conditioning systems (VAC) to avoid the spread of the SARS-CoV-2 virus in health facilities by dentists and demographic variables. A cross-sectional digital me

Spanish cohort of VEXAS syndrome : clinical manifestations, outcome of treatments and novel evidences about UBA1 mosaicism

The vacuoles, E1-enzyme, X linked, autoinflammatory and somatic (VEXAS) syndrome is an adult-onset autoinflammatory disease (AID) due to postzygotic UBA1 variants. To investigate the presence of VEXAS syndrome among patients with adult-onset undiagnosed AID. Additional studies evaluated the mosaicism distribution and the circulating cytokines. Gene analyses were performed by both Sanger and amplicon-based deep sequencing. Patients' data were collected from their medical charts. Cytokines were quantified by Luminex. Genetic analyses of enrolled patients (n=42) identified 30 patients carrying UBA1 pathogenic variants, with frequencies compatible for postzygotic variants. All patients were male individuals who presented with a late-onset disease (mean 67.5 years; median 67.0 years) characterised by cutaneous lesions (90%), fever (66.7%), pulmonary manifestations (66.7%) and arthritis (53.3%). Macrocytic anaemia and increased erythrocyte sedimentation rate and ferritin were the most relevant analytical abnormalities. Glucocorticoids ameliorated the inflammatory manifestations, but most patients became glucocorticoid-dependent. Positive responses were obtained when targeting the haematopoietic component of the disease with either decitabine or allogeneic haematopoietic stem cell transplantation. Additional analyses detected the UBA1 variants in both haematopoietic and non-haematopoietic tissues. Finally, analysis of circulating cytokines did not identify inflammatory mediators of the disease. Thirty patients with adult-onset AID were definitively diagnosed with VEXAS syndrome through genetic analyses. Despite minor interindividual differences, their main characteristics were in concordance with previous reports. We detected for the first time the UBA1 mosaicism in non-haematopoietic tissue, which questions the previous concept of myeloid-restricted mosaicism and may have conceptual consequences for the disease mechanisms

A pan-European epidemiological study reveals honey bee colony survival depends on beekeeper education and disease control

Reports of honey bee population decline has spurred many national efforts to understand the extent of the problem and to identify causative or associated factors. However, our collective understanding of the factors has been hampered by a lack of joined up trans-national effort. Moreover, the impacts of beekeeper knowledge and beekeeping management practices have often been overlooked, despite honey bees being a managed pollinator. Here, we established a standardised active monitoring network for 5 798 apiaries over two consecutive years to quantify honey bee colony mortality across 17 European countries. Our data demonstrate that overwinter losses ranged between 2% and 32%, and that high summer losses were likely to follow high winter losses. Multivariate Poisson regression models revealed that hobbyist beekeepers with small apiaries and little experience in beekeeping had double the winter mortality rate when compared to professional beekeepers. Furthermore, honey bees kept by professional beekeepers never showed signs of disease, unlike apiaries from hobbyist beekeepers that had symptoms of bacterial infection and heavy Varroa infestation. Our data highlight beekeeper background and apicultural practices as major drivers of honey bee colony losses. The benefits of conducting trans-national monitoring schemes and improving beekeeper training are discussed

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Fatores relacionados à Duração do Tratamento Ortodôntico no Programa de Graduação em Ortodontia

Introduction: To establish the relationship between orthodontic treatment time with educational/administrative/clinical factors, in patients treated and finished, at the orthodontics program clinic of an University. Methods: Data were obtained from clinical records, panoramic radiographs and final dental cast from 40 treated patients (21 women and 19 men), 15.97 ± 5.79 years old. The administrative variables included:  number of accomplished appointments, number of appointments per year of treatment, total number of missed appointments, total months of treatment, number of effective months of treatment, number of residents and instructors attending the patients and percentage of treatment planning for next appointment. Clinical variables included: malocclusion complexity, quality of finalization, teeth extractions, age and number of orthodontic appliance issues/breakages. Results: The average ± SD treatment duration was 55.5 ± 22.2 months. In patients with dental extractions, treatment time was significantly higher (p=0.0231). A model of multiple linear regression explained 59% of the variability, identifying four significant variables, two related to administration (number of missed appointments and number of instructors) and two clinical variables (number of orthodontic appliance issues/breakages and quality of finalization). Conclusion: Significant clinical and administrative issues were detected and it was observed that excessive time for treatment may deteriorate the static clinical results achieved.Introducción: Este estudio observacional de corte transversal fue  realizado con el fin de determinar el tiempo de tratamiento y los factores que pueden afectarlo en los pacientes finalizados en el programa de posgrado de ortodoncia de la Universidad de Antioquia. Métodos: Los datos fueron obtenidos de las historias clínicas, radiografías panorámicas y modelos finales de 40 pacientes (21 mujeres y 19 hombres) con edad promedio de  15.97 años (± 5.79), que cumplieron los criterios de selección. Se estudiaron variables administrativas como  número de citas cumplidas en total, numero de citas cumplidas por año de tratamiento, numero de citas incumplidas en total,  numero de meses  totales de tratamiento, numero de meses efectivos de tratamiento, número de docentes, número de residentes que atendieron a los pacientes y porcentaje de planeación de cita y variables clínicas como edad, complejidad de la maloclusión, calidad de la finalización del tratamiento, exodoncias y numero de reparaciones. Resultados: Se encontró un  tiempo promedio de tratamiento de 55.5 meses (± 22.2). El tiempo de tratamiento en los pacientes con exodoncias fue significativamente mayor (p=0.0231) comparado con los que no se les realizaron exodoncias. Un modelo de regresión lineal múltiple explico el 59% de la variabilidad e identifico cuatro variables significativas, dos administrativas (número de citas incumplidas y número de docentes) y dos clínicas (número de reparaciones y calidad de finalización). Conclusiones: Algunos factores administrativos y clínicos afectan el tiempo de tratamiento de manera significativa y el alargar excesivamente el tiempo de tratamiento, puede empeorar los resultados clínicos estáticos obtenidos.Introdução: Estabelecer a relação entre a duração do tratamento ortodôntico e osfatores educacionais/administrativos/clínicos em pacientes tratados e finalizados na clínicade ortodontia da universidade. Métodos: Dados foram obtidos a partir de registros clínicos,radiografias panorâmicas e modelagens dentárias finais de 40 pacientes tratados (21mulheres e 19 homens), de 15,97 ± 5,79 anos. Variáveis administrativas incluíram númerode consultas atendidas, número de consultas por ano de tratamento, número total de consultas perdidas, total de meses de tratamento, número de meses efetivos de tratamento, número de residentes e instrutores atendendo aos pacientes e percentual de planejamento de tratamento para a próxima consulta. Variáveis clínicas incluíram a complexidade da maloclusão, a qualidade da finalização, extrações dentárias, idade e número de problemas e quebras de aplicações ortodônticas. Resultados: A média de duração do tratamento era de 55,5 ± 22,2 meses. Em pacientes com extrações dentárias, a duração do tratamento era significativamente mais longa (p=0,0231). Um modelo de regressão linear múltipla explicou 59% da variabilidade, identificando quatro variáveis significativas, duas relacionadas à administração (número de consultas perdidas e números de instrutores) e duas variáveis clínicas (número de problemas e quebras de aplicações ortodônticas e qualidade da finalização). Conclusão: Questões clínicas e administrativas significativas foram detectadas efoi observado que o tempo excessivo de tratamento pode deteriorar os resultados clínicosestáticos alcançados

Fatores relacionados à Duração do Tratamento Ortodôntico no Programa de Graduação em Ortodontia

Introduction: To establish the relationship between orthodontic treatment time with educational/administrative/clinical factors, in patients treated and finished, at the orthodontics program clinic of an University. Methods: Data were obtained from clinical records, panoramic radiographs and final dental cast from 40 treated patients (21 women and 19 men), 15.97 ± 5.79 years old. The administrative variables included:  number of accomplished appointments, number of appointments per year of treatment, total number of missed appointments, total months of treatment, number of effective months of treatment, number of residents and instructors attending the patients and percentage of treatment planning for next appointment. Clinical variables included: malocclusion complexity, quality of finalization, teeth extractions, age and number of orthodontic appliance issues/breakages. Results: The average ± SD treatment duration was 55.5 ± 22.2 months. In patients with dental extractions, treatment time was significantly higher (p=0.0231). A model of multiple linear regression explained 59% of the variability, identifying four significant variables, two related to administration (number of missed appointments and number of instructors) and two clinical variables (number of orthodontic appliance issues/breakages and quality of finalization). Conclusion: Significant clinical and administrative issues were detected and it was observed that excessive time for treatment may deteriorate the static clinical results achieved.Introducción: Este estudio observacional de corte transversal fue  realizado con el fin de determinar el tiempo de tratamiento y los factores que pueden afectarlo en los pacientes finalizados en el programa de posgrado de ortodoncia de la Universidad de Antioquia. Métodos: Los datos fueron obtenidos de las historias clínicas, radiografías panorámicas y modelos finales de 40 pacientes (21 mujeres y 19 hombres) con edad promedio de  15.97 años (± 5.79), que cumplieron los criterios de selección. Se estudiaron variables administrativas como  número de citas cumplidas en total, numero de citas cumplidas por año de tratamiento, numero de citas incumplidas en total,  numero de meses  totales de tratamiento, numero de meses efectivos de tratamiento, número de docentes, número de residentes que atendieron a los pacientes y porcentaje de planeación de cita y variables clínicas como edad, complejidad de la maloclusión, calidad de la finalización del tratamiento, exodoncias y numero de reparaciones. Resultados: Se encontró un  tiempo promedio de tratamiento de 55.5 meses (± 22.2). El tiempo de tratamiento en los pacientes con exodoncias fue significativamente mayor (p=0.0231) comparado con los que no se les realizaron exodoncias. Un modelo de regresión lineal múltiple explico el 59% de la variabilidad e identifico cuatro variables significativas, dos administrativas (número de citas incumplidas y número de docentes) y dos clínicas (número de reparaciones y calidad de finalización). Conclusiones: Algunos factores administrativos y clínicos afectan el tiempo de tratamiento de manera significativa y el alargar excesivamente el tiempo de tratamiento, puede empeorar los resultados clínicos estáticos obtenidos.Introdução: Estabelecer a relação entre a duração do tratamento ortodôntico e osfatores educacionais/administrativos/clínicos em pacientes tratados e finalizados na clínicade ortodontia da universidade. Métodos: Dados foram obtidos a partir de registros clínicos,radiografias panorâmicas e modelagens dentárias finais de 40 pacientes tratados (21mulheres e 19 homens), de 15,97 ± 5,79 anos. Variáveis administrativas incluíram númerode consultas atendidas, número de consultas por ano de tratamento, número total de consultas perdidas, total de meses de tratamento, número de meses efetivos de tratamento, número de residentes e instrutores atendendo aos pacientes e percentual de planejamento de tratamento para a próxima consulta. Variáveis clínicas incluíram a complexidade da maloclusão, a qualidade da finalização, extrações dentárias, idade e número de problemas e quebras de aplicações ortodônticas. Resultados: A média de duração do tratamento era de 55,5 ± 22,2 meses. Em pacientes com extrações dentárias, a duração do tratamento era significativamente mais longa (p=0,0231). Um modelo de regressão linear múltipla explicou 59% da variabilidade, identificando quatro variáveis significativas, duas relacionadas à administração (número de consultas perdidas e números de instrutores) e duas variáveis clínicas (número de problemas e quebras de aplicações ortodônticas e qualidade da finalização). Conclusão: Questões clínicas e administrativas significativas foram detectadas efoi observado que o tempo excessivo de tratamento pode deteriorar os resultados clínicosestáticos alcançados

Implantación de los estudios de conservación y restauración del arte contemporáneos en el EEES. Desarrollo de recursos didácticos innovadores en el seno de las asignaturas pertenecientes al grado en conservación y restauración del patrimonio cultural.

Depto. de Pintura y Conservación-RestauraciónFac. de Bellas ArtesFALSEsubmitte