The Grizzly, April 15, 2010

Ursinus\u27 Relay for Life Brings in Over $43,000 • V-Day Celebrations Continue with The Vagina Monologues • Phi Kappa Sigma Runs Another Successful Bike-a-Thon • Enough is Enough Week Brings Awareness to Campus Violence • Title IX: A Female Athlete\u27s Freedom, or Her Health? • Bruno\u27s Restaurant: Cheeseburgers in Paradise? • Omega Chi and UCARE Team Up for Blood Drive • Opinion: Two Worlds of Ursinus\u27 Small Campus; Ursinus Dining Offers Less Than Healthy Optionshttps://digitalcommons.ursinus.edu/grizzlynews/1811/thumbnail.jp

The Grizzly, April 8, 2010

First Annual Backwards Beauty Pageant Held • Ursinus Senior to Travel Abroad for a Year with Watson • Kappa Alpha Psi and Seismic Step Emerge on Campus • UC Welcomes New Field Hockey Coach • Sex on Wheels Documentary Screening • Volunteering with St. Christopher\u27s Children\u27s Hospital • Feeling Good in The Skin We\u27re In • The Sacrifice Your Body Makes for [Better] Grades • Opinion: Kyleigh\u27s Law Profiles Drivers by Age in New Jersey • Upper Classmen Off-Campus Living • UC Gymnastics Closes Season with Successhttps://digitalcommons.ursinus.edu/grizzlynews/1810/thumbnail.jp

The Grizzly, March 25, 2010

27th Annual Airband Benefits Dignity House • Ursinus College Theater Presents The Elephant Man • Bank Robber Flees to Ursinus Campus Parking Lot • InterVarsity Group Travels to Camden Over Spring Break • Dangerous Risk to Multi-Tasking • Ursinus Field Hockey Intramurals are Open for Spring • UC Baseball Makes Best of Florida Trip • UC Alum Coaches Cornell to Sweet 16https://digitalcommons.ursinus.edu/grizzlynews/1809/thumbnail.jp

The Grizzly, February 25, 2010

Airband Date Auction Meets, Surpasses Goal • Drawing the Curtain Opens at the Berman Museum • Spread the Word to End the R Word Next Week • Student-Athlete Advisory Committee Takes UC Athletics Beyond the Fieldhouse • Snow Photos • Author Speaks on Campus About Bringing Nature Home • Skin We\u27re In Addresses Self-Esteem Issues • Cutting Down Waste by Recycling Kegs Instead of Canshttps://digitalcommons.ursinus.edu/grizzlynews/1807/thumbnail.jp

The Grizzly, March 4, 2010

Ursinus Theater presents The Crucible • Political Cartoonist, Author Discusses New Book • CoSA Application, Logo Submission Deadlines Extended • Interest in Bioethics in Medicine Rises at UC • American Heart Month • Ursinus Looks Into The Buried Life • Neshoba Highlights Civil Rights Corruption in Honor of Black History Month • Chat Roulette Gambles with the Issues of Social Networking • Ursinus Lacrosse Looks to Outwork Opposition • Indoor Track & Field Championshiphttps://digitalcommons.ursinus.edu/grizzlynews/1808/thumbnail.jp

Dendritic cells in cancer immunology and immunotherapy

Dendritic cells (DCs) are a diverse group of specialized antigen-presenting cells with key roles in the initiation and regulation of innate and adaptive immune responses. As such, there is currently much interest in modulating DC function to improve cancer immunotherapy. Many strategies have been developed to target DCs in cancer, such as the administration of antigens with immunomodulators that mobilize and activate endogenous DCs, as well as the generation of DC-based vaccines. A better understanding of the diversity and functions of DC subsets and of how these are shaped by the tumour microenvironment could lead to improved therapies for cancer. Here we will outline how different DC subsets influence immunity and tolerance in cancer settings and discuss the implications for both established cancer treatments and novel immunotherapy strategies.S.K.W. is supported by a European Molecular Biology Organization Long- Term Fellowship (grant ALTF 438– 2016) and a CNIC–International Postdoctoral Program Fellowship (grant 17230–2016). F.J.C. is the recipient of a PhD ‘La Caixa’ fellowship. Work in the D.S. laboratory is funded by the CNIC, by the European Research Council (ERC Consolidator Grant 2016 725091), by the European Commission (635122-PROCROP H2020), by the Ministerio de Ciencia, Innovación e Universidades (MCNU), Agencia Estatal de Investigación and Fondo Europeo de Desarrollo Regional (FEDER) (SAF2016-79040-R), by the Comunidad de Madrid (B2017/BMD-3733 Immunothercan- CM), by FIS- Instituto de Salud Carlos III, MCNU and FEDER (RD16/0015/0018-REEM), by Acteria Foundation, by Atresmedia (Constantes y Vitales prize) and by Fundació La Marató de TV3 (201723). The CNIC is supported by the Instituto de Salud Carlos III, the MCNU and the Pro CNIC Foundation, and is a Severo Ochoa Centre of Excellence (SEV-2015-0505).S

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe