Evolution of Anemone AR NOAA 10798 and the Related Geo-Effective Flares and CMEs

We present a detailed examination of the features of the Active Region (AR) NOAA 10798. This AR generated coronal mass ejections (CMEs) that caused a large geomagnetic storm on 24 August 2005 with the minimum Dst index of -216 nT. We examined the evolution of the AR and the features on/near the solar surface and in the interplanetary space. The AR emerged in the middle of a small coronal hole, and formed a {\it sea anemone} like configuration. H$\alpha$ filaments were formed in the AR, which have southward axial field. Three M-class flares were generated, and the first two that occurred on 22 August 2005 were followed by Halo-type CMEs. The speeds of the CMEs were fast, and recorded about 1200 and 2400 km s$^{-1}$, respectively. The second CME was especially fast, and caught up and interacted with the first (slower) CME during their travelings toward Earth. These acted synergically to generate an interplanetary disturbance with strong southward magnetic field of about -50 nT, which was followed by the large geomagnetic storm.Comment: 32 pages, 9 figures, JGR accepte

Analysis of reach-scale elevation distribution in braided rivers: Definition of a new morphologic indicator and estimation of mean quantities

This work has been carried out within the SMART Joint Doctorate (Science forthe MAnagement of Rivers and theirTidal systems) funded with the support of the Erasmus Mundus programme of the European Union. Data of the Rees River were derived as part of UKNatural Environment Research Council grant (NE/G005427/1) awarded to PI Brasington, along with further support from the NERC Geophysical Equipmen tFacility (Loan 892) and Leverhulme Trust IAF2014-03

A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms

We describe a genetic variation map for the chicken genome containing 2.8 million single-nucleotide polymorphisms ( SNPs). This map is based on a comparison of the sequences of three domestic chicken breeds ( a broiler, a layer and a Chinese silkie) with that of their wild ancestor, red jungle fowl. Subsequent experiments indicate that at least 90% of the variant sites are true SNPs, and at least 70% are common SNPs that segregate in many domestic breeds. Mean nucleotide diversity is about five SNPs per kilobase for almost every possible comparison between red jungle fowl and domestic lines, between two different domestic lines, and within domestic lines - in contrast to the notion that domestic animals are highly inbred relative to their wild ancestors. In fact, most of the SNPs originated before domestication, and there is little evidence of selective sweeps for adaptive alleles on length scales greater than 100 kilobases

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Recent advances quantifying the large wood dynamics in river basins: New methods and remaining challenges

Citation: Ruiz-Villanueva, V., Piégay, H., Gurnell, A. A., Marston, R. A., & Stoffel, M. (2016). Recent advances quantifying the large wood dynamics in river basins: New methods and remaining challenges. Reviews of Geophysics. doi:10.1002/2015RG000514Large wood is an important physical component of woodland rivers and significantly influences river morphology. It is also a key component of stream ecosystems. However, large wood is also a source of risk for human activities as it may damage infrastructure, block river channels, and induce flooding. Therefore, the analysis and quantification of large wood and its mobility are crucial for understanding and managing wood in rivers. As the amount of large-wood-related studies by researchers, river managers, and stakeholders increases, documentation of commonly used and newly available techniques and their effectiveness has also become increasingly relevant as well. Important data and knowledge have been obtained from the application of very different approaches and have generated a significant body of valuable information representative of different environments. This review brings a comprehensive qualitative and quantitative summary of recent advances regarding the different processes involved in large wood dynamics in fluvial systems including wood budgeting and wood mechanics. First, some key definitions and concepts are introduced. Second, advances in quantifying large wood dynamics are reviewed; in particular, how measurements and modeling can be combined to integrate our understanding of how large wood moves through and is retained within river systems. Throughout, we present a quantitative and integrated meta-analysis compiled from different studies and geographical regions. Finally, we conclude by highlighting areas of particular research importance and their likely future trajectories, and we consider a particularly underresearched area so as to stress the future challenges for large wood research. ©2016. American Geophysical Union

Sex-Specific Effects of Cacna1c Haploinsufficiency on Social Behavior, Ultrasonic Communication, and Cognition in Rats

The risk gene CACNA1C encodes for the α1C subunit of the L-type voltage-gated Ca2+ channel, known as Cav1.2. Genome wide association studies have implicated CACNA1C in neuropsychiatric disorders, such as major depression, bipolar disorder, schizophrenia, and autism spectrum disorder. Importantly, social behavior and communication deficits are persistent in each disorder with added cognitive impairments similarly being present. Several studies in humans and mouse models have indicated that Cav1.2 expression levels are associated with alterations in sociability and cognition. Rat models provide an ideal translational tool to determine underlying disease pathomechanisms, due in part to their highly gregarious nature emerging early in life, thus, creating a practical means to study the development of social behavior and communication. Using a newly developed Cacna1c rat model, this dissertation aimed at exploring the role Cacna1c plays in social behavior and communication in juvenile rats, as well as the association with cognitive impairments in adulthood. Detailed practical assessment for juvenile behavior and ultrasonic vocalizations (USV) outline social play (Review I) and USV playback (Review II) as pertinent paradigms to assess alterations in social behavior and communication with relevance to neuropsychiatric disorders. Results indicate that deficits in 50-kHz USV were evident in male haploinsufficient Cacna1c rats in the sender and receiver (Study I). Cacna1c haploinsufficiency in females resulted in abnormal social play behaviour and minor deficits in response to 50-kHz USV playback (Study II). Moreover, Cacna1c rats appear to show normal, and in some cases above normal, cognitive abilities, albeit with a slight reduction in cognitive flexibility in haploinsufficient Cacna1c males (Study III). Together, these findings further extend the notion that Cav1.2 expression levels may be associated with alterations in social behavior, communication, and cognitive abilities in a sex-dependent manner, with important bearings on neuropsychiatric disorders

Guidance for the prevention, testing, treatment and management of hepatitis C in primary care.

1. Hepatitis C infection is an under-diagnosed (five out of every six people infected are undiagnosed) and under-treated important cause of morbidity and mortality. 2. Hepatitis C is a common and potentially curable disease, but only 1 to 2% of infected people are currently receiving National Institute of Clinical Excellence (NICE) recommended therapy. 3. Every general practitioner is likely to have between 8 to 18 infected individuals per GP, based on an average list size of 1,800 and, partly depending upon local population demographics. Many of these patients may not be diagnosed and knowledge about HCV in population and primary care remains low but improving. 4. Prevalence of the hepatitis C virus (HCV) is estimated to be between 0.4 to 1% of the United Kingdom (UK) population, equating to be between 250,000 to 600,000 sufferers. Worldwide there are an estimated 170 million people, about 3% of the world’s population, who are chronically infected with HCV. 5. HCV is a blood-borne ribonucleic acid (RNA) virus that exists as a number of different strains (genotypes) and an important cause of liver disease. The effects of the infection vary from one individual to the next. Some people will remain symptom free, some will develop cirrhosis and others will develop liver failure or hepatocellular (primary liver) cancer