An Expected Average Run Length (EARL) Performance Comparison of the SSGR and EWMA Control Charts

The acceleration use of control charts in industrial processes has led to the effectiveness in their evaluation by quality practitioners. This is crucial, as it influences their decisions on the choice of which control charts to employ. This study aims to explore and compare the performance of the side sensitive group runs (SSGR) and exponentially weighted moving average (EWMA) control charts. In general, the average run length (ARL) characteristics were used to evaluate the performance of these control charts. The ARL, which considers the exact shift size in the process, is restricted in the case when the practitioner cannot identify the process shift size (unknown shift size). In this situation, the expected average run length (EARL) is an alternative performance criterion. Upon comparison of the findings obtained, the EWMA chart has superior performance when (δmin, δmax) = (0.1, 0.4). In contrast, the SSGR chart overtakes the EWMA chart when (δmin, δmax) = (0.5, 0.8) and (δmin, δmax) = (0.9, 1.2), except when the sample size n = 3 for (δmin, δmax) = (0.5, 0.8). For this particular combination, the EWMA chart performs slightly better than the SSGR chart. The outcome of this study is expected to contribute to practitioners in identifying suitable control charts in process monitoring and implementation

An Expected Average Run Length (EARL) Performance Comparison of the SSGR and EWMA Control Charts

The acceleration use of control charts in industrial processes has led to the effectiveness in their evaluation by quality practitioners. This is crucial, as it influences their decisions on the choice of which control charts to employ. This study aims to explore and compare the performance of the side sensitive group runs (SSGR) and exponentially weighted moving average (EWMA) control charts. In general, the average run length (ARL) characteristics were used to evaluate the performance of these control charts. The ARL, which considers the exact shift size in the process, is restricted in the case when the practitioner cannot identify the process shift size (unknown shift size). In this situation, the expected average run length (EARL) is an alternative performance criterion. Upon comparison of the findings obtained, the EWMA chart has superior performance when (δmin, δmax) = (0.1, 0.4). In contrast, the SSGR chart overtakes the EWMA chart when (δmin, δmax) = (0.5, 0.8) and (δmin, δmax) = (0.9, 1.2), except when the sample size n = 3 for (δmin, δmax) = (0.5, 0.8). For this particular combination, the EWMA chart performs slightly better than the SSGR chart. The outcome of this study is expected to contribute to practitioners in identifying suitable control charts in process monitoring and implementation

Model study on the photoassociation of a pair of trapped atoms into an ultralong-range molecule

Using the method of quantum-defect theory, we calculate the ultralong-range molecular vibrational states near the dissociation threshold of a diatomic molecular potential which asymptotically varies as $-1/R^3$. The properties of these states are of considerable interest as they can be formed by photoassociation (PA) of two ground state atoms. The Franck-Condon overlap integrals between the harmonically trapped atom-pair states and the ultralong-range molecular vibrational states are estimated and compared with their values for a pair of untrapped free atoms in the low-energy scattering state. We find that the binding between a pair of ground-state atoms by a harmonic trap has significant effect on the Franck-Condon integrals and thus can be used to influence PA. Trap-induced binding between two ground-state atoms may facilitate coherent PA dynamics between the two atoms and the photoassociated diatomic molecule.Comment: 11 pages, 4 figures, to appear in Phys. Rev. A (September, 2003

Synchronous communication in PLM environments using annotated CAD models

The connection of resources, data, and knowledge through communication technology plays a vital role in current collaborative design methodologies and Product Lifecycle Management (PLM) systems, as these elements act as channels for information and meaning. Despite significant advances in the area of PLM, most communication tools are used as separate services that are disconnected from existing development environments. Consequently, during a communication session, the specific elements being discussed are usually not linked to the context of the discussion, which may result in important information getting lost or becoming difficult to access. In this paper, we present a method to add synchronous communication functionality to a PLM system based on annotated information embedded in the CAD model. 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Association of Immunosuppression and Human Immunodeficiency Virus (HIV) Viremia with Anal Cancer Risk in Persons Living with HIV in the United States and Canada

Background: People living with human immunodeficiency virus (HIV; PLWH) have a markedly elevated anal cancer risk, largely due to loss of immunoregulatory control of oncogenic human papillomavirus infection. To better understand anal cancer development and prevention, we determined whether recent, past, cumulative, or nadir/peak CD4+ T-cell count (CD4) and/or HIV-1 RNA level (HIV RNA) best predict anal cancer risk. Methods: We studied 102 777 PLWH during 1996-2014 from 21 cohorts participating in the North American AIDS Cohort Collaboration on Research and Design. Using demographics-adjusted, cohort-stratified Cox models, we assessed associations between anal cancer risk and various time-updated CD4 and HIV RNA measures, including cumulative and nadir/peak measures during prespecified moving time windows. We compared models using the Akaike information criterion. Results: Cumulative and nadir/peak CD4 or HIV RNA measures from approximately 8.5 to 4.5 years in the past were generally better predictors for anal cancer risk than their corresponding more recent measures. However, the best model included CD4 nadir (ie, the lowest CD4) from approximately 8.5 years to 6 months in the past (hazard ratio [HR] for <50 vs ≥500 cells/μL, 13.4; 95% confidence interval [CI], 3.5-51.0) and proportion of time CD4 <200 cells/μL from approximately 8.5 to 4.5 years in the past (a cumulative measure; HR for 100% vs 0%, 3.1; 95% CI, 1.5-6.6). Conclusions: Our results are consistent with anal cancer promotion by severe, prolonged HIV-induced immunosuppression. Nadir and cumulative CD4 may represent useful markers for identifying PLWH at higher anal cancer risk

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Indigowood root extract protects hematopoietic cells, reduces tissue damage and modulates inflammatory cytokines after total-body irradiation: Does Indirubin play a role in radioprotection?

Radix of Isatis indigotica (indigowood root, IR) has been used in traditional medicine for its potential anti-inflammatory effect. The purpose of this study is to investigate THE radioprotective effects of radiation caused damages in hematopoietic system and normal tissues in mice. A total of 57 BALB/c mice were randomized into six treatment groups control, IR treatment (0.195, 0 585 and 1170 g/kg, p o. daily), L-glutamine (0.520 g/kg) and sham group. All mice except the sham group were irradiated and then administered for one week. The radioprotective effect on hematopoietic system, serum cytokines. and intestinal toxicity was studied. Protective effects on spleen and thymus are found in IR-treated groups. IR assisted in restoration of leukocytopenia after whole mice irradiation with significant reduction of serum TNF-alpha, IL-1 beta and IL-6 These enhancements of hematopoietic effects are due to an increase in the serum G-CSF concentration in IR treated groups In histopathological assessment, significant improvement of intestine toxicity is observed in high-dose IR and L-glutamine group Evidences show that IR has potentials to be a radioprotector, especially in recovery of hematopoietic system, reduction of inflammatory cytokines and intestinal toxicity. Indirubin may play a crucial role, but the underlying mechanism is not very clear and warrants further studies. (C) 2009 Elsevier GmbH All rights reserve