Intermediate (S=1) spin state in five-coordinate cobalt(III): Magnetic properties of N-o-hydroxy-benzamido-meso-tetraphenylporphyrin cobalt(III), Co(N-NCO(o-O)C6H4-tpp)

The crystal structures of paramagnetic N-o-oxido-benzimido-meso-tetraphenylporphyrinato (-kappa(4),N-1,N-2,N-3,N-5,kappa O-2) cobalt(III) [Co(N-NCO(o-O)C6H4-tpp); 2] (S = 1) and diamagnetic N-o-oxido-benzimido-meso-tetraphenylporphyrinato (-kappa(4), N-1, N-2, N-3, N-5, kappa O-2) gallium( III) chloroform center dot methanol solvate [Ga(N-NCO(o-O)C6H4-tpp)center dot 0.5CHCl(3)center dot MeOH; 3 center dot 0.5CHCl(3) center dot MeOH] (S = 0) were determined. The coordination sphere around Co(III) in 2 [or Ga(III) in 3 center dot 0.5CHCl(3)center dot MeOH] is described as five-coordinate distorted trigonal bipyramid (DTBP) with O(1), N(1)and N(3) [or O(2), N(1), N(3)] lying in the equatorial plane for 2 [or 3 center dot 0.5CHCl(3)center dot MeOH]. The magnitude of axial (D) zero-field splitting (ZFS) for the Co(III) (S = 1) in 2 was determined as approximately 107 cm(-1) by paramagnetic susceptibility measurements. The compound (2) reacts in donor solvent such as pyridine to form six-coordinate diamagnetic species of the type Co(N-NCO(o-O) C6H4-tpp)(py) (4), whose H-1 NMR spectra can be interpreted as for Co(III) in an octahedral environment

Efeitos da aplicação de retardador (CCC) e acelerador (GA) de crescimento na morfologia e produtividade do feijoeiro (Phaseolus vulgaris L. cv. Carioca)

Verificou-se os efeitos de CCC e GA quando aplicados sob a forma de pulverização das plântulas, na morfologia, florescimento e produtividade do feijoeiro cultivar Carioca, em condições de casa de vegetação. Estudou-se as concentrações de 500, 2000 e 4000 ppm de CCC juntamente com 50 pprn de GA; sendo que CCC 500 + GA 50 ppm promoveu aceleração no crescimento da haste principal e CCC 4000 + GA 50 ppm retardou esse crescimento em relação ao controle. Aplicação de CCC 500 + GA 50 ppm aumentou o número de folhas do feijoeiro. Num período de 2 semanas após o tratamento com CCC 500 + GA 50 ppm ocorreu aumento no comprimento dos meritalos, sendo que 30 dias após a aplicação de CCC 4000 + GA 50 ppm verificou-se diminuição no comprimento dos mesmos. Observou-se aumento no comprimento do limbo foliar 5 dias após os tratamentos com CCC 500 + GA 50 ppm ou CCC 2000 + GA 50 ppm. Ocorreu aumento no número médio de flores com aplicação de CCC 500 + GA 50 ppm. Não ocorreram diferenças significativas entre a produtividade das plantas tratadas com relação ao controle.In this paper the autors tested the effects of (2 - chloroethyl) trimethylammonium chloride (CCC) and gibberellic acid (GA) on the cultivar Carioca of bean, in three different concentrations (500, 2000, and 4000 ppm) of CCC and one concentration of GA (50 ppm). Treatment with CCC 500 ppm + GA 50 ppm increased the height of bean plant and CCC 4000 ppm + GA 50 ppm reduced the height of Phaseolus vulgaris. Application of CCC 500 ppm + GA 50 ppm or CCC 2000 ppm + GA 50 ppm increased the leaf number of bean plant. CCC 500 ppm + GA 50 ppm promoted a increase in the internode length and CCC 4000 ppm + GA 50 ppm reduced the length of internodcs. Application of CCC 500 ppm + GA 50 ppm or CCC 2000 ppm + GA 50 ppm increased the leaf length 5 days after the treatment. CCC 500 ppm + GA 50 ppm promoted higher flowering in relation to the check.

Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.

BACKGROUND: Multiple recent genome-wide association studies (GWAS) have identified a single nucleotide polymorphism (SNP), rs10771399, at 12p11 that is associated with breast cancer risk. METHOD: We performed a fine-scale mapping study of a 700 kb region including 441 genotyped and more than 1300 imputed genetic variants in 48,155 cases and 43,612 controls of European descent, 6269 cases and 6624 controls of East Asian descent and 1116 cases and 932 controls of African descent in the Breast Cancer Association Consortium (BCAC; http://bcac.ccge.medschl.cam.ac.uk/ ), and in 15,252 BRCA1 mutation carriers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Stepwise regression analyses were performed to identify independent association signals. Data from the Encyclopedia of DNA Elements project (ENCODE) and the Cancer Genome Atlas (TCGA) were used for functional annotation. RESULTS: Analysis of data from European descendants found evidence for four independent association signals at 12p11, represented by rs7297051 (odds ratio (OR) = 1.09, 95 % confidence interval (CI) = 1.06-1.12; P = 3 × 10(-9)), rs805510 (OR = 1.08, 95 % CI = 1.04-1.12, P = 2 × 10(-5)), and rs1871152 (OR = 1.04, 95 % CI = 1.02-1.06; P = 2 × 10(-4)) identified in the general populations, and rs113824616 (P = 7 × 10(-5)) identified in the meta-analysis of BCAC ER-negative cases and BRCA1 mutation carriers. SNPs rs7297051, rs805510 and rs113824616 were also associated with breast cancer risk at P < 0.05 in East Asians, but none of the associations were statistically significant in African descendants. Multiple candidate functional variants are located in putative enhancer sequences. Chromatin interaction data suggested that PTHLH was the likely target gene of these enhancers. Of the six variants with the strongest evidence of potential functionality, rs11049453 was statistically significantly associated with the expression of PTHLH and its nearby gene CCDC91 at P < 0.05. CONCLUSION: This study identified four independent association signals at 12p11 and revealed potentially functional variants, providing additional insights into the underlying biological mechanism(s) for the association observed between variants at 12p11 and breast cancer risk.UK funding includes Cancer Research UK and NIH.This is the final version of the article. It first appeared from BioMed Central via http://dx.doi.org/10.1186/s13058-016-0718-

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Improvement of the horizontal directional drilling method by using an autonomous land vehicle with a radio direction finding system

This article discusses the improvement in the horizontal directional drilling method (HDD) by using an autonomous land vehicle (ALV) with a radio directional finding (RDF) system. The ALV with an RDF system carrying a receiver can locate a moving or static underground drill head and track it. Not limited to a pre-determined track or path, the ALV system utilizes its on board RDF system instantaneously to seek and to track a moving or static drill head. Compared to conventional systems, the system reduces the number of operators, minimizes labor costs, prevents accidents, and enhances the degree of automation.  The design of the RDF system and how to locate a target are considered in this article. To overcome the difficulty in obtaining the precise dynamic model of the ALV with the RDF system, a “fuzzy logic controller” is designed to control such a system and make the system capable of tracking a target. Experimental results verify that such an RDF ALV system can track a moving or static target.

The Manufacture of High Permeability Mn-Zn Ferrites by Atmospherical Protect

For the manufacture of high permeability Mn-Zn ferrite cores, the zinc loss from the surface of sintering cores causes poor yield rate of final products. This experiment uses the atmospherical protection to reduce the evaporation of zinc. The control of the oxygen partial pressure and flow rate precisely can reduce the zinc loss about 20% to 35%, but it is not enough to get a good distribution of permeability of products, i.e. the distribution of initial permeability from 12000 to 15000 per products about 14% before atmospherical control and 25% after atmospherical control, respectively. Combination with precise control and zinc vapor compensation can increase the yield rate 9% to 15%. Another experiment to manufacture high permeability Mn-Zn ferrite cores for 15000±30% in a batch type furnace (about 13 Kg / batch), is to use a new engineering method to protect sintering core to avoid vaporizing zinc vapor, the yield rate can be rapidly increased from 25% to 75% and the effective capacity of furnace can be at least twofold. It is successful to manufacture homogeneous and high permeability of Mn-Zn ferrites both increasing the quality of products and decreasing the operating costs

The Effect of Grain Boundary Impedance on the Power Loss of Mn-Zn Ferrites over 1 MHz

Recently, the operating frequency of switching mode power supplies has been increased from 25 kHz to several MHz to enhance their efficiency in a smaller size. Although, it was reported that Mn-Zn ferrites can also be used at 1 MHz, only few papers have discussed the possibility of using Mn-Zn ferrites at the frequency higher than 1 MHz. Our early paper reported that the core loss of low loss grade Mn-Zn ferrites is strongly dependent upon the capacitance of grain boundaries of sintered cores. In frequency region between 1 MHz to 3 MHz, the dielectric loss dominates the core loss, while eddy current loss is the major factor of the core loss in 3 MHz to 10 MHz. It is suggested that decreasing the grain boundary capacitance at middle high frequency or increasing the grain resistivity at high frequency region are the appropriate ways for Mn-Zn ferrites to be used at the frequency between 1 MHz and 10 MHz. This paper investigated the core loss of Mn-Zn ferrites in the frequency range between 1 MHz and 10 MHz in order to improve the properties of the Mn-Zn ferrite cores for their potential applications in this frequency region. The powders containing Fe2O3, MnO and ZnO in a molar ratio of 54.2:37.3:8.5 with the addition of CaO and SiO2 from 150 ppm to 450 ppm were prepared by a conventional ceramic process. Samples were sintered at 1150°C to 1250°C for 2 hrs then annealed at various condition. The results show that the sintering temperature and annealing condition altered the grain boundary impedance. For example, the grain boundary capacitance changes from 13 pF to 7 pF, meanwhile, the dielectric loss factor is lowered from 0.28x10-9 to 0.17x10-9, and consequently the power loss decreases from 253 KW/m3 to 145 KW/m3 at 2.5 MHz

Hybrid film of chemically modified graphene and vapor-phase-polymerized PEDOT for electronic nose applications

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Graphene quantum resistive sensing skin for the detection of alteration biomarkers

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