288 research outputs found
Type III Secretion System Genes of Dickeya dadantii 3937 Are Induced by Plant Phenolic Acids
- Author
- A Brencic
- A Chatterjee
- A Chatterjee
- A Chatterjee
- CH Yang
- Ching-Hong Yang
- D Aldon
- D Buttner
- D Park
- DW Bauer
- DW Bauer
- E Lopez-Solanilla
- JE Galan
- JH Chang
- JH Ham
- JR Alfano
- LJ Mota
- M Alhenc-Gelas
- M Arlat
- M Fagard
- M Lindeberg
- M Montesano
- Michael San Francisco
- MN Yap
- MS Francis
- MW Pfaffl
- N Hugouvieux-Cotte-Pattat
- N Yalpani
- Niyaz Ahmed
- Q Peng
- Quan Peng
- Quan Zeng
- R Bouhenni
- RD Barabote
- RS Ravirala
- S Heeb
- S Vidal
- S Yang
- S Yang
- SH Yang
- Shihui Yang
- TF Mah
- W Nasser
- WG Miller
- WG Miller
- X Tang
- Y Cui
- Yongjun Wang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2008
- Field of study
Background: Dickeya dadantii is a broad-host range phytopathogen. D. dadantii 3937 (Ech3937) possesses a type III secretion system (T3SS), a major virulence factor secretion system in many Gram-negative pathogens of plants and animals. In Ech3937, the T3SS is regulated by two major regulatory pathways, HrpX/HrpY-HrpS-HrpL and GacS/GacA-rsmB-RsmA pathways. Although the plant apoplast environment, low pH, low temperature, and absence of complex nitrogen sources in media have been associated with the induction of T3SS genes of phytobacteria, no specific inducer has yet been identified. Methodology/Principal Findings: In this work, we identified two novel plant phenolic compounds, o-coumaric acid (OCA) and t-cinnamic acid (TCA), that induced the expression of T3SS genes dspE (a T3SS effector), hrpA (a structural protein of the T3SS pilus), and hrpN (a T3SS harpin) in vitro. Assays by qRT-PCR showed higher amounts of mRNA of hrpL (a T3SS alternative sigma factor) and rsmB (an untranslated regulatory RNA), but not hrpS (a s 54-enhancer binding protein) of Ech3937 when these two plant compounds were supplemented into minimal medium (MM). However, promoter activity assays using flow cytometry showed similar promoter activities of hrpN in rsmB mutant Ech148 grown in MM and MM supplemented with these phenolic compounds. Compared with MM alone, only slightly higher promoter activities of hrpL were observed in bacterial cells grown in MM supplemented with OCA/TCA. Conclusion/Significance: The induction of T3SS expression by OCA and TCA is moderated through the rsmB-Rsm
Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology.
- Author
- A Argiris
- A Lan
- A Marusyk
- A Sottoriva
- A Sottoriva
- AJ Levine
- AM Urvalek
- B Hu
- B Yuan
- C Greenman
- C Thirlwell
- Cancer Genome Atlas Network.
- CC Maley
- CJ Kemp
- CR Leemans
- CR Pickering
- D Jones
- D Sano
- DH Spencer
- DJ Downes
- F Blokzijl
- F de Chaumont
- G Tischler
- H Kosmehl
- H Liu
- I Martincorena
- I Martincorena
- I Sequeira
- J Ferlay
- J Wang
- J-P Foy
- JA Sikorsky
- JT Robinson
- K Osei-Sarfo
- K Wallenius
- K Ye
- KT Kim
- LB Alexandrov
- LB Alexandrov
- LF Yap
- M Ferreira
- M Gerlinger
- M Hofreiter
- M Janghorban
- M Vered
- MJ Williams
- MJ Williams
- ML Hedberg
- N Agrawal
- N Andor
- N Stransky
- O Meurette
- P Descargues
- R Feldman
- R Jackstadt
- S Demehri
- S Kim
- S Liu
- S Turajlic
- S-C Lin
- S-C Su
- SK Loganathan
- SQ Wong
- SX Ge
- TF Hayes
- TL Whiteside
- TM Keane
- W-L Chen
- X-H Tang
- X-H Tang
- XX Quan
- Y Osugi
- Y-T Kwak
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
To establish whether 4-nitroquinoline N-oxide-induced carcinogenesis mirrors the heterogeneity of human oral squamous cell carcinoma (OSCC), we have performed genomic analysis of mouse tongue lesions. The mutational signatures of human and mouse OSCC overlap extensively. Mutational burden is higher in moderate dysplasias and invasive SCCs than in hyperplasias and mild dysplasias, although mutations in p53, Notch1 and Fat1 occur in early lesions. Laminin-α3 mutations are associated with tumour invasiveness and Notch1 mutant tumours have an increased immune infiltrate. Computational modelling of clonal dynamics indicates that high genetic heterogeneity may be a feature of those mild dysplasias that are likely to progress to more aggressive tumours. These studies provide a foundation for exploring OSCC evolution, heterogeneity and progression
Cushing's syndrome: aftermath of the cure
- Author
- Annamaria Colao
- Antongiulio Faggiano
- Arnaldi G
- Atkinson AB
- Avgerinos PC
- Bateman A
- Boscaro M
- Bourdeau I
- Bourdeau I
- Candrina R
- Colao A
- Colao A
- Dal Bo Zanon R
- Di Somma C
- Di Somma C
- Di Somma C
- Dorn LD
- Dougherty TF
- Estrada J
- Etxabe J
- Faggiano A
- Faggiano A
- Faggiano A
- Faggiano A
- Faggiano A
- Fallo F
- Forget H
- Gaetano Lombardi
- Giustina A
- Gozzi TG
- Heald AH
- Heinz ER
- Hermus AR
- Hughes NR
- Jeffcoate WJ
- Kaltsas GA
- Kelly WF
- Kingsley GH
- Koch CA
- Kristo C
- Lado-Abeal J
- Libuse Tauchmanovà
- Lindholm J
- Lindsay JR
- Magiakou MA
- Mancini T
- Manning PJ
- Maria Cristina De Martino
- Mauri M
- Mazziotti G
- McCance DR
- Merke DP
- Minetto M
- Momose KJ
- Monica De Leo
- Morita H
- Naguchi Y
- Newell-Price J
- Newell-Price J.
- Niepomniszcze H
- Ohmori N
- Orth DN.
- Patrassi GM
- Pecori Giraldi F
- Pereira AM
- Phillips KA
- Pikkarainen L
- Pivonello R
- Pivonello R
- Rosario Pivonello
- Sacerdote A
- Sharon P
- Simmons NE
- Sonino N
- Starkman MN
- Starkman MN
- Starkman MN
- Steuer A
- Suzuki T
- Takada J
- Takasu N
- Takasu N
- Tauchmanovà L
- Trainer PJ
- Tzanela M
- Valéro R
- van Aken MO
- Wake DJ
- Walker BR.
- Wolkowitz OM
- Yakushiji F
- Yap LB
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
The non-coding transcriptome as a dynamic regulator of cancer metastasis.
- Author
- A Baraniskin
- A Congrains
- A Hall
- A Khanna
- A Lujambio
- A Mizrahi
- A O’Loghlen
- A Watahiki
- Abhijit Parolia
- AC Tahira
- AE Karnoub
- AJ Lay
- AM Khalil
- AP Bracken
- AV Tinker
- B Yu
- BE Lippitz
- BS Taylor
- C Ender
- C Vandewalle
- CA Davison
- Cheryl D. Helgason
- CI Brannan
- CI Michel
- CL Chaffer
- CM Rudin
- CP Ponting
- CP Ponting
- CY Darini
- D Amit
- D Barsyte-Lovejoy
- D Li
- D Silvera
- D Spano
- DA Petrov
- DL Lafontaine
- DS Hong
- E Birney
- E Cerami
- EA Gibb
- ES Martens-Uzunova
- F Aguilo
- F Bertucci
- F Crea
- F Crea
- F Crick
- F Lovat
- F Vumbaca
- F Yang
- Francesco Crea
- G Chen
- G Petrovics
- GT Williams
- GV Glazko
- H Cui
- H Royo
- H Sasaki
- HE Gee
- HJ Ferreira
- I Matouk
- I Matouk
- IJ Matouk
- IJ Matouk
- J Comijn
- J Feng
- J Gil
- J Tabernero
- JA Makarova
- JC Brase
- JC Brase
- JE Chaft
- JE Wilusz
- JF Huang
- JM Tang
- JN Hutchinson
- JP Bachellerie
- JR Prensner
- JW Catto
- K Mannoor
- K Tano
- KH Chang
- KL Yap
- KM Chisholm
- L Benetatos
- L Chu
- L Poliseno
- L Salmena
- L Yang
- L Ying
- LH Schmidt
- M Beltran
- M Brameier
- M Ciganda
- M Esteller
- M Huarte
- M Luo
- M Ono
- MC Tsai
- MC Tsai
- MG Mendez
- MH Yang
- ML Anko
- MS Scott
- MS Song
- MT Qiu
- N Berteaux
- N Brockdorff
- O Nyormoi
- P Carninci
- P Ji
- P Johnsson
- P Laneve
- P Mehlen
- P Tavassoli
- PD Cao
- Pier Luc Clermont
- PJ Batista
- PJ Volders
- R Bernards
- R Lin
- R Taulli
- R Zielinski
- RA Gupta
- S Chung
- S Guil
- S Jalali
- S Kalyana-Sundaram
- S Kishore
- S Turajlic
- SA Mani
- SB Cassidy
- SM Park
- SW Cheetham
- SX Yuan
- T Gutschner
- T Gutschner
- T Kiss
- T Moulton
- T Nakagawa
- TF Gajewski
- TR Mercer
- U Ala
- V Sorin
- V Tripathi
- WP Tsang
- X Cai
- X Tan
- X Zong
- XY Dong
- XY Dong
- Y Fellig
- Y Han
- Y Kanamori
- Y Kotake
- Y Kuwano
- Y Lu
- Y Mei
- Y Tay
- Y Zhang
- YP Mei
- Yuzhuo Wang
- Z Du
- Z Yang
- ZY Xu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
Since the discovery of microRNAs, non-coding RNAs (NC-RNAs) have increasingly attracted the attention of cancer investigators. Two classes of NC-RNAs are emerging as putative metastasis-related genes: long non-coding RNAs (lncRNAs) and small nucleolar RNAs (snoRNAs). LncRNAs orchestrate metastatic progression through several mechanisms, including the interaction with epigenetic effectors, splicing control and generation of microRNA-like molecules. In contrast, snoRNAs have been long considered "housekeeping" genes with no relevant function in cancer. However, recent evidence challenges this assumption, indicating that some snoRNAs are deregulated in cancer cells and may play a specific role in metastasis. Interestingly, snoRNAs and lncRNAs share several mechanisms of action, and might synergize with protein-coding genes to generate a specific cellular phenotype. This evidence suggests that the current paradigm of metastatic progression is incomplete. We propose that NC-RNAs are organized in complex interactive networks which orchestrate cellular phenotypic plasticity. Since plasticity is critical for cancer cell metastasis, we suggest that a molecular interactome composed by both NC-RNAs and proteins orchestrates cancer metastasis. Interestingly, expression of lncRNAs and snoRNAs can be detected in biological fluids, making them potentially useful biomarkers. NC-RNA expression profiles in human neoplasms have been associated with patients' prognosis. SnoRNA and lncRNA silencing in pre-clinical models leads to cancer cell death and/or metastasis prevention, suggesting they can be investigated as novel therapeutic targets. Based on the literature to date, we critically discuss how the NC-RNA interactome can be explored and manipulated to generate more effective diagnostic, prognostic, and therapeutic strategies for metastatic neoplasms
Phase 1 trial of the oral AKT inhibitor MK-2206 plus carboplatin/paclitaxel, docetaxel, or erlotinib in patients with advanced solid tumors
- Author
- A Biondo
- A Carnero
- Adriane M Zernhelt
- AJ Ten Tije
- Amita Patnaik
- Andrea Biondo
- Anthony W Tolcher
- AS Clark
- AW Tolcher
- C Mack
- D Sarker
- Daniel M Sullivan
- Eric Chen
- Ernestina Tetteh
- ES Kim
- G Perkins
- H Hirai
- HY Irie
- J Brognard
- JA Engelman
- JA Engelman
- Joanna Vitfell-Rasmussen
- Johann S de Bono
- JR Testa
- KA West
- KD Courtney
- Kyriakos P Papadopoulos
- L Rhoda Molife
- L Van Zuylen
- L Yan
- L Yan
- Li Yan
- Lillian L Siu
- LZ Liu
- MP Scheid
- P Therasse
- Philippe A Cassier
- SD Baker
- SE Winograd-Katz
- Susan Minton
- T Okuzumi
- TA Yap
- TA Yap
- TF Franke
- Y Ji
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Super-resolution:A comprehensive survey
- Author
- A Adler
- A Almansa
- A Chakrabarti
- A Corduneanu
- A Gholipour
- A Giachetti
- A Lorette
- A Marquina
- A Panagiotopoulou
- A Schatzberg
- A Zomet
- AJ Patti
- AJ Patti
- AJ Storkey
- AJ Tatem
- AK Katsaggelos
- ALD Martins
- AWMV Eekeren
- AWMV Eekeren
- B Choi
- B Cohen
- B Huhle
- B Li
- B Li
- B Narayanan
- B Wu
- BC Song
- BGV Kumar
- BK Gunturk
- BK Gunturk
- BK Gunturk
- BK Gunturk
- BR Hunt
- C Jung
- C Liu
- C Liu
- C Miravet
- C Miravet
- C Papathanassiou
- C Pohl
- C Su
- C Wang
- C Wang
- CA Segall
- CA Segall
- CA Segall
- CS Tong
- CV Jiji
- CV Jiji
- CV Jiji
- D Calle
- D Capel
- D Datsenko
- D Lin
- D Pastina
- D Rajan
- D Rajan
- D Rajan
- D Rajan
- D Rajan
- D Rajan
- D Robinson
- D Robinson
- D Yldrm
- D Zhang
- D Zhang
- DO Walsh
- DP Capel
- E Salari
- E Shechtman
- EM Hung
- F Champagnat
- F Humblot
- F Rousseau
- F Sroubek
- F Sroubek
- F Zhou
- FM Candocia
- G Dedeoglu
- G Gilboa
- G Ye
- GH Costa
- GH Costa
- GH Costa
- GK Chantas
- GM Callic
- GM Callico
- H Bouzari
- H Chang
- H Demirel
- H He
- H He
- H Huang
- H Huanga
- H Ji
- H Nasir
- H Shekarforoush
- H Shekarforoush
- H Shekarforoush
- H Stark
- H Su
- H Su
- H Takeda
- H Takeda
- H Yang
- H Zhang
- H Zhang
- H Zhao
- HF Shen
- HK Aghajan
- I Begin
- J Chen
- J Chung
- J Cui
- J Sun
- J Tian
- J Tian
- J Tian
- J Wang
- J Wang
- J Wu
- J Yang
- J Yang
- J Yu
- JA Kennedy
- JD Ouwerkerk van
- JJ Green
- JS Park
- K Aizawa
- K Choi
- K Donaldson
- K Jia
- K Jia
- K Jia
- K Kimura
- K Nasrollahi
- Kamal Nasrollahi
- KD Sauer
- KH Yap
- KI Kim
- KV Suresh
- L Ma
- L Zhang
- LC Pickup
- LC Pickup
- LC Pickup
- LJ Karam
- M Ben-Ezra
- M Ben-Ezra
- M Bertero
- M Carcenac
- M Chappalli
- M Elad
- M Elad
- M Elad
- M Elad
- M Elad
- M Elad
- M Gevrekci
- M Gevrekci
- M Gonzalez-Audcana
- M Irani
- M Irani
- M Jung
- M Protter
- M Protter
- M Shen
- M Shen
- M Shen
- M Singh
- MC Chiang
- MC Hong
- MC Pan
- MD Robinson
- ME Tipping
- ME Tipping
- MH Cheng
- MK Nema
- MK Ng
- MK Ng
- MK Ng
- MM Islam
- MV Joshi
- MV Joshi
- MVW Zibetti
- MVW Zibetti
- MVW Zibetti
- MVW Zibetti
- N Bose
- N Bose
- N Goldberg
- N Kulkarni
- N Nguyen
- N Nguyen
- NA Woods
- NA Yamany
- NK Bose
- NK Bose
- NK Bose
- OA Omer
- OA Omer
- P Chainais
- P Kramer
- P Milanfar
- P Purkait
- P Vandewalle
- P Vandewalle
- P Vandewalle
- PD Santis
- PE Eren
- PP Gajjar
- Q Pan
- Q Yuan
- Q Yuan
- R Fransens
- R He
- R Molina
- R Sasaharay
- R Tsai
- RC Hardie
- RC Hardie
- RC Hardie
- RR Schultz
- RR Schultz
- RR Schultz
- RS Prendergast
- RW Gerchberg
- S Baker
- S Chaudhuri
- S Dai
- S Farsiu
- S Farsiu
- S Farsiu
- S Farsiu
- S Farsiu
- S Kim
- S Liu
- S Lui
- S Mallat
- S Peleg
- S Pelletier
- S Peng
- S Rajaram
- S Yang
- S Zhang
- S Zhao
- SC Park
- SD Babacan
- SH Keller
- SP Belekos
- SW Park
- T Akgun
- T Gotoh
- T Katsuki
- T Komatsu
- T Szydzik
- TA Stephenson
- TC Ho
- TF Gee
- Thomas B. Moeslund
- V Patanavijit
- V Patanavijit
- V Patanavijit
- W Fan
- W Liu
- W Liu
- W Wu
- W Zhang
- W Zhao
- WT Freeman
- WT Freeman
- WWW Zou
- WZ Shao
- X Gao
- X Gao
- X Gao
- X Li
- X Li
- X Li
- X Ma
- X Maa
- X Wang
- X Zeng
- X Zhang
- Y Altunbasak
- Y He
- Y He
- Y Hu
- Y Hu
- Y Huang
- Y Mochizuki
- Y Zhuang
- Y-W Tai
- YJ Ma
- YR Li
- Z Arycan
- Z Bi
- Z Jiang
- Z Lin
- Z Lin
- Z Wang
- Z Wang
- Z Xiong
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 14/06/2014
- Field of study
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
- Anderson T
- Anderson WG
- Andrada B
- Andre M
- Andreoni I
- Andreoni I
- Andringa S
- Angelova SV
- Anghinolfi M
- Angner EO
- Angus CR
- Annis J
- Ansseau I
- Antier S
- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
- Ashton G
- Asorey H
- Assis P
- Ast M
- Aston SM
- Astone P
- Atallah DV
- ATLAS
- Atwood WB
- Aubert J-J
- Aubert P
- Aublin J
- Auffenberg J
- Aufmuth P
- Aulbert C
- AultONeal K
- Austin C
- Avgitas T
- Avila G
- Avila-Alvarez A
- Awad A Kuotb
- Axani S
- Baar S
- Babak S
- Bachetti M
- Backes M
- Bacon P
- Bader MKM
- Badescu AM
- Bae S
- Bagherpour H
- Bai X
- Bailes M
- Baker PT
- Balaceanu A
- Balanutsa PV
- Balasubramanian A
- Balbinot E
- Baldaccini F
- Baldini L
- Ballardin G
- Ballmer SW
- Bally J
- Balzer A
- Banagiri S
- Banerji M
- Bannister KW
- Barayoga JC
- Barbarino C
- Barbato F
- Barber AS
- Barbiellini G
- Barbiellini G
- Barclay SE
- Baret B
- Barish BC
- Barker D
- Barkett K
- Barnard M
- Barnes J
- Barone F
- Barr B
- Barrios-Marti J
- Barron JP
- Barsotti L
- Barsuglia M
- Barta D
- Barthelmy SD
- Bartlett J
- Bartos I
- Barway S
- Barway S
- Barwick SW
- Basa S
- Bassiri R
- Basti A
- Bastieri D
- Batch JC
- Bauer FE
- Bauer FE
- Baum V
- Bawaj M
- Bay R
- Bayley JC
- Bazzan M
- Bazzano A
- Bchele M
- Beardmore AP
- Beardsley A
- Beatty JJ
- Becerril A
- Becherini Y
- Bechtol K
- Becker KH
- Becsy B
- Beer C
- Bejger M
- Belahcene I
- Belhorma B
- Bell AS
- Bellazzini R
- Bellido JA
- Bellm E
- Belmont-Moreno E
- Benetti S
- Benkhali F Ait
- Benoit-Levy A
- BenZvi SY
- Berat C
- Berenji B
- Berge D
- Berger BK
- Berger E
- Bergmann G
- Berisso M Gomez
- Berley D
- Bernal A
- Bernardini E
- Bernardini MG
- Bernhard S
- Bernrhr K
- Bero JJ
- Beroiz M
- Berry CPL
- Bersanetti D
- Bertaina ME
- Bertin E
- Bertin V
- Bertolini A
- Berton M
- Bertou X
- Bessell MS
- Besson DZ
- Beswick R
- Betzwieser J
- Bhagwat S
- Bhalerao V
- Bhandare R
- Bhattacharya D
- Biagi S
- Biermann PL
- Bilenko IA
- Billingsley G
- Billman CR
- Binder G
- Bindig D
- Birch J
- Birney R
- Birnholtz O
- Biscans S
- Biscoveanu S
- Bisht A
- Bissaldi E
- Bissaldi E
- Biteau J
- Bitossi M
- Biwer C
- Bizouard MA
- Blackburn JK
- Blackburn L
- Blackman J
- Blackwell R
- Blaess SG
- Blagorodnova N
- Blair CD
- Blair DG
- Blair RM
- Blanchard P
- Blanco A
- Bland PA
- Blandford RD
- Blaufuss E
- Blazek J
- Bleve C
- Bloemen S
- Bloom ED
- Blot S
- Bock O
- Bode N
- Boer M
- Bogaert G
- Bohacova M
- Bohe A
- Bohm C
- Boisson C
- Bolmont J
- Bond IA
- Bondu F
- Bonifazi C
- Bonilla E
- Bonino R
- Bonnand R
- Bonnefoy S
- Bonoli S
- Booler T
- Boom BA
- Bordas P
- Bork R
- Bormuth R
- Borner M
- Borodai N
- Bos F
- Boschi V
- Bose D
- Bose S
- Boser S
- Bossie K
- Botner O
- Bottacini E
- Bottcher M
- Botti AM
- Botticella MT
- Bouffanais Y
- Bourbeau E
- Bourbeau J
- Bourret S
- Bouwhuis MC
- Bozzi A
- Bozzo E
- Brack J
- Bradaschia C
- Bradascio F
- Brady PR
- Branchesi M
- Brancus I
- Brandt S
- Brau JE
- Braun J
- Braun J
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Localization and broadband follow-up of the gravitational-wave transient GW150914
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- Mohapatra SRP
- Moiseev AA
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- Monzani ME
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- Moreno G
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- Mossavi K
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- Munoz VF
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- Nardecchia I
- Naticchioni L
- Nayak RK
- Necula V
- Nedkova K
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- Neilsen E
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- Network I
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- Nitz A
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- Onken CA
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- Oppermann P
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- Orienti M
- Orlando E
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- Paciesas WS
- Padilla N
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- Palashov O
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- Paneque D
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- Paoletti F
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- Passaquieti R
- Passuello D
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- Pedurand R
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- Pereyra NA
- Perez del Pulgar C
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- Perley D
- Perreca A
- Perri M
- Pesce-Rollins M
- Petravick D
- Phelps M
- Pian E
- Piascik AS
- Piccinni O
- Pichot M
- Piergiovanni F
- Pierro V
- Pillant G
- Pinard L
- Pinto IM
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- Plazas AA
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- Poleshuk V
- Pollacco D
- Popolizio P
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- Postigo ADU
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- Predoi V
- Preece RD
- Premachandra SS
- Prestegard T
- Price LR
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- Schofield RMS
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- Slagmolen BJJ
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- Steinmeyer D
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- Straniero N
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- Strigin S
- Stubbs CW
- Sturani R
- Stuver AL
- Suchyta E
- Summerscales TZ
- Sun L
- Surace J
- Survey LS-Q
- Suson DJ
- Sutton PJ
- Svinkin DS
- Swanson MEC
- Swinkels BL
- Szczepanczyk MJ
- Tacca M
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- Tajima H
- Talukder D
- Tanaka M
- Tanner DB
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- Thirugnanasambandam MP
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- Thorne KA
- Thorne KS
- Thrane E
- Tibaldo L
- Tingay SJ
- Tiwari S
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- Tokmakov KV
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- Troja E
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- Tsunemi H
- Tucker DL
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- Turpin D
- Tuyenbayev D
- Tyurina N
- Ubertini P
- Uchiyama Y
- Ueno S
- Ugolini D
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- van Heijningen JV
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- Vine DJ
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- Vitek S
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- von Kienlin A
- von Kienlin A
- Voronkov MA
- Vorvick C
- Voss D
- Vousden WD
- Vrech R
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- Wechsler RH
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- Westphal T
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- Willke B
- Willman M
- Wilson-Hodge CA
- Wimmer MH
- Winkler W
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- Wood M
- Worden J
- Wright DE
- Wright JL
- Wu G
- Yablon J
- Yam W
- Yamamoto H
- Yanagisawa K
- Yancey CC
- Yang S
- Yanny B
- Yap MJ
- Yock PC
- Yoshida M
- Young DR
- Yu H
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- Yuan F
- Yurkov V
- Yvert M
- Zadrozny A
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- Zanolin M
- Zaremba M
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- Zevin M
- Zhang B-B
- Zhang F
- Zhang L
- Zhang M
- Zhang X
- Zhang Y
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- Zhao C
- Zhou M
- Zhou Z
- Zhu S
- Zhu XJ
- Zimmer S
- Zucker ME
- Zuntz J
- Zuraw SE
- Zweizig J
- Publication venue
- Astrophysical Journal Letters
- Publication date
- 01/01/2016
- Field of study
A gravitational-wave (GW) transient was identified in data recorded by the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) detectors on 2015 September 14. The event, initially designated G184098 and later given the name GW150914, is described in detail elsewhere. By prior arrangement, preliminary estimates of the time, significance, and sky location of the event were shared with 63 teams of observers covering radio, optical, near-infrared, X-ray, and gamma-ray wavelengths with ground- and space-based facilities. In this Letter we describe the low-latency analysis of the GW data and present the sky localization of the first observed compact binary merger. We summarize the follow-up observations reported by 25 teams via private Gamma-ray Coordinates Network circulars, giving an overview of the participating facilities, the GW sky localization coverage, the timeline, and depth of the observations. As this event turned out to be a binary black hole merger, there is little expectation of a detectable electromagnetic (EM) signature. Nevertheless, this first broadband campaign to search for a counterpart of an Advanced LIGO source represents a milestone and highlights the broad capabilities of the transient astronomy community and the observing strategies that have been developed to pursue neutron star binary merger events. Detailed investigations of the EM data and results of the EM follow-up campaign are being disseminated in papers by the individual teams
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
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- Abbasy J
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- Elzowawi F
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman AC
- Acharya BS
- Adam Bourdarios C
- Adamczyk L
- Adamek L
- Addepalli SV
- Addison MJ
- Adelman J
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahuja S
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- Karentzos E
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- Zhemchugov A
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- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of √s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
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