97 research outputs found
Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis
- Author
- Aahlin Eirik Kjus
- Aamer Ahmed
- Aaniana Kenneth
- Ababneh Ali
- Abaliksta Tomas
- Abantanga Francis
- Abbas Athar
- Abbasy Jibran
- Abbo Olivier
- Abbott Tom
- Abbouch Meryem
- Abd El-Latif Nadia Khalid
- Abd Elkhalek Esraa
- Abd-Elmawla Manar
- Abdallah Emad
- Abdel-Aty Abdulrahman
- Abdel-Hameed Noran
- Abdel-Kader Sara Mahmoud
- Abdelaal Abdelaziz
- Abdelaty Mohamed
- Abdelazeam Anan Rady
- Abdelazim Galaleldin
- Abdelaziz Mohamed A.
- Abdelbadeai Kholoud
- Abdelfatah Afnan
- Abdelhady Samar
- Abdelhamed Rasha
- Abdelhamid Amina
- Abdelhaq Aram
- Abdelkader Mostafa
- Abdelkader Omar
- Abdelkhalek Mohamed
- Abdelmageed Eman
- Abdelmotaleb Ibrahem
- Abdelraouf Ahmed Mahmoud
- Abdelrouf Doaa Maher
- Abdelshakour Mahmoud
- Abdrabou Abdulshafi Khaled
- Abdul-Latif Saiba
- Abdulaziz Hager
- Abdulaziz Mustafa
- Abdulbagi Omar
- Abdulhakeem Eman Mahmoud
- Abdullah Mohamed Abozed
- Abdullah Nik Azim Nik
- Abdullah Noha
- Abdullahi Lawal
- Abdurrazzaaq Abdussemiu
- Abem Owusu Emmanuel
- Abiola Olajide
- Aboelella Majed
- Aboelmagd Omnia
- Aboelsoud Moustafa R.
- Aboul-Naga Mariam Saad
- Abouzaid Arwa
- Abu Qumbos Amjad
- Abu-toyour Maram
- Abubakr Marwan
- Abuowda Yousef
- Abuqwaider Eman
- Abusalem Lana
- Abushamleh Soha
- Ackom Eric
- Acquah Emmanuel
- Adam Ali
- Adam Nourhan
- Adamu Ahmed
- Adawi Ihdaa
- Adawi Mohammad
- Adebanjo Ademola
- Adebola Oluwaseyi
- Adedeji Adesina
- Adel Badr Eldin
- Adel Israa
- Adella Fidelis Jacklyn
- Adelshone Abdelrahman
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O.
- Ademuyiwa Adesoji O.
- Adenekan Babajide
- Adeniran James
- Adeniyi Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adeyeye Ademola
- Adeyeye Ademola
- Adhitama Novia
- Adil Muhammad
- Adisa Adewale O.
- Adiyaman Can
- Adu-Aryee Niiarmah
- Afana Samah
- Agalianos Christos
- Agarwal Arnav
- Agarwal Arnav
- Agbedinu Kwabena
- Aglan Amro
- Aguado Suarez Nuria
- Aguilera Maria Lorena
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlonsou Germain
- Ahlqvist Sandra
- Ahlqvist Sandra
- Ahmed Asdaq
- Ahmed Ataa
- Ahmed Hayam
- Ahmed Hussien
- Ahmed Lopna Ahmed Mohamed
- Ahmed Sara
- Ahmed Saraibrahim
- Ahounou Ernest Yemalin Stephane
- Ajah Jonathan
- Ajai Olalekan
- Ajao Akinlabi
- Ajiboye Anthony
- Akoto Elliot
- Akpenyi Onyinye
- Al Amin Shadid
- Al Attar Samaa Mahmoud
- Al Barraw Fayez Elian
- Al Bastawis Fatema
- Al Meligy Amgad
- Al Rafati Ahmad Abdel Razaq
- Al Raouf Eman Abd
- Al Saied Ghiath
- Al Subaie Norah
- Al-Bahrani Ahmed
- Al-Buhaisi Alaa
- Al-Dakka Emad
- Al-faqawi Maha
- Al-farram Hadeel
- Al-khatib Ahmed
- Al-Marakby Dina
- Al-saqqa Sara
- Al-Saqqa Sara W.
- Al-Slaibi Ibrahim
- Al-taher Taher
- AlaaelDein Shahinaz
- Alada Muslimat
- Alakaloko Felix
- Alaloul Enas
- Alamin Shadid
- Alamoudi Mohammed
- Albiety Adel
- Alcca Ticona Willy
- Alejos Bermudez Ysabel Esthefany
- Alexander Philip
- Alexander Philip
- Alexandre Challine
- Alghamdi Ahmed
- Alghamdi Mohammed Saleh A.
- Alhady Khaled
- Alhammali Tariq
- Alhassan Basmah
- Alhazmi Wedyan
- Alherz Mohammad
- Ali Ahmed
- Ali Citra Dewi Mohd
- Ali Elsayed
- Ali Safia
- Ali Syed Abdul Wahhab Eusoffee Wan
- Ali Tebian Hassanein Ahmed
- Ali Wadah
- Alihonou Thierry
- Alis Halil
- Aliyu Halima
- Aliyu Mohammad
- Aliyu Shamsudeen
- Aljboor Khaled
- Aljiffry Murad
- Alkaaki Aroub
- Alkelani Muhammad
- Allam Meran
- Allam Yomna
- Alnaby Mohamed Hassab
- Alnusairat Aseel
- Alqahtani Saleh
- Alsaggaf Mohammed Ubaid
- Alser Osaid H.
- Alshareef Reham
- Altaf Abdulmalik
- Altamimi Abdullah
- Altamimi Afnan
- Altamini Afnan
- Altarayra Marwa
- Altibi Ahmed
- Altinel Yuksel
- Altinel Yuksel
- Altwijri Abdulaziz
- Alvi Abdul Rehman
- Aly Mohammed Yahia Mohamed
- Alyacoubi Said
- Alyahya Reem
- Alzahrani Ahmed
- Aman Nowrin F.
- Amandito Radhian
- Amandito Radhian
- Ambrona-Zafra David
- Amin Hager Abdul Aziz
- Amjad Mohammadasim
- Amoah Michael
- Amoako Joachim
- Amoako Philip Taah
- Amoako-Boateng Mabel
- Amole Isaac
- Amreia Mahmoud
- Anderson Frank
- Andika Ferry Fitriya Ayu
- Andreotti Dario
- Andress Cedar
- Andriola Valeria
- Ang Yun Lin
- Angelieri Daniele
- Anis Echaieb
- Ansaloni Luca
- Ansaloni Luca
- Ansaloni Luca
- Antezana Diego
- Anthoulakis Christos
- Antoniozzi Angelo
- Anwar Nourhan
- Anyanwu Lofty-John
- Aonzo Paolo
- Appeadu-Mensah William
- Appiah Eric Kofi
- Aquilino Fabrizio
- Arafa Omar
- Arafa Sara
- Arango Maria Clara Mendoza
- Arcudi Claudio
- Armellini Andrea
- Arnaud Alexis
- Arnaud Alexis Pierre
- Arshad Mohammad Mohsin
- Arslan Ekin
- Arsyad Hasbi Maulana
- Arthur Tom
- Aruldas Neerav
- Asar Yomna Hosny
- Asare-Bediako Kwasi
- Ashour Ahmad
- Ashour Ahmad
- Ashour Khlood
- Ashtari Morvarid
- Asi Fatema
- Asilah Siti Mohd Desa
- Assal Abdelrahman
- Asturias Sabrina
- Asumah Hamza
- Ata Ahmed
- Ata Aya Yehia
- Atiyeh Anwar
- Atkins Ebenezer Takyi
- Attia Attia
- Augestad Knut Magne
- Aviles Susan
- Avoka Anthony
- Awad Israa
- Awad Sawsan Adel
- Awadallah Salwa
- Ayandipo Omobolaji
- Aydin Mehmet Can
- Aziz Dayang Nita Abdul
- Aziz Mohamed Rezal Abdul
- Aziz Nora Abdul
- Azizeldine Mohammed G.
- Azzie Georges
- Azzis Olivier
- Baba Suleiman
- Bachri Houda
- Badawy Mahmoud
- Badenjki Mohamed Adel
- Badicel Maria
- Badr Mohamed Fawzy Mahrous
- Badwi Nermin Mohamed
- Bahar Suraya
- Baillie Katie
- Baki Bahadir Emre
- Bakr Ahmad
- Bakry Hesham Mohammed
- Bala Miklosh
- Balalis Dimitrios
- Balducci Genoveffa
- Ballouhey Quentin
- Balmaceda Ruben
- Balmaceda Ruben
- Balogun Fatai
- Baltrunas Robertas
- Baluch Fatima
- Bamford Rebecca
- Bamicha Athanasia
- Banaitis Vincas Jonas
- Bandi Ashwath
- Bandoh Dickson
- Bani-Sadar Ahmad
- Banipal Gurpreet Singh
- Baquero Suarez Alibeth Andres
- Baraka Heba
- Barendegere Venerand
- Barkolias Christos
- Barmayehvar Behrad
- Barnabas Gandau Naa
- Barrios Emmanuel
- Basilico Silvia
- Basir Elissa Rifhan Mohd
- Bassem Monica
- Bassit Khalil Abdul
- Basso Stefano M. M.
- Bayram Sefa
- Beamon Mieshia
- Bedada Alemayehu Ginbo
- BediakoBowan Antoinette
- Bekhet Amira Hassan
- Bekhet Nada Mohamed
- Beleno Alvaro Enrique Mendoza
- Belkouchi Abdelkader
- Belli Andrea
- Bello Bashir
- Benammi Sarah
- Benevento Angelo
- Bennai Redouane Mammar
- Bentounsi Zineb
- Benyaiche Chaymae
- Berti Stefano
- Bertuello Isaac
- Beuran Mircea
- Bhangu Aneel
- Bhangu Aneel
- Bhangu Anna
- Bhatnagar Ankur
- Bhopal Kamran Faisal
- Bianco Federica
- Bigaran Annamaria
- Billy Matthew
- Bin Adnan Ahmad
- Bin Hasnan Muhammad
- Bin Ismail Mohamad Jeffrey
- Birindelli Arianna
- Bisset Carly
- Bjorklund Ida
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- Blackwell James
- Blanco Ruth
- Blanco-Colino Ruth
- Blencowe Natalie
- Bliksoen Marte
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- Bode Chris
- Bodur Selim
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- Bond-Smith Giles
- Bondin John
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- Chan Luke
- Chan Tsz-Yan Katie
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- Cheong Yih Jeng
- Chetta Nicola
- Cheung Yuk Hong Eric
- Chibuye Chali
- Chiesa Deborah
- Chilton Gareth
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- Conlon Kevin C.
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- Cox Michael
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- Cullen Fraser
- Curletti Gianluca
- Currow Chelise
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- D'Souza Michelle S.
- Dabboor Majd
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- Dahy Ahmed
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- Darwish Abdelrhman K. Z.
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- Drake Thomas M.
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- Jaber Sahar
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- Jaich Robert
- Jama Guled M.
- Jamal Luai
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- Khafagy Toqa
- Khalifah Eyad
- Khallaf Salwa
- Khamajeet Arvin
- Khan Maryam Ali
- Khan Roaa
- Khan Zain Ali
- Khatri Chetan
- Khoja Ahmad
- Khokha Dzianis
- Khokha Vladimir
- Khosla Shivun
- Khreishi Reem
- Khreishi Rose
- Khulu Lawrence Bongani
- Kidd Thomas
- Kinandu Kamau
- King Sebastian
- Kiran Ravi P.
- Kirby Andrew
- Kiudelis Mindaugas
- Klappenbach Roberto
- Knight Stephen
- Koay Kean Leong
- Kobal Berna Buse
- Koh Pei Ying
- Koh Sharon
- Kojo Anyomih Theophilus Teddy
- Kojo Anyomih Theophilus Teddy
- Kondrotas Paulius
- Kong Chia
- Kong Shu Ning
- Kong Victor
- Konstantina Kolonia
- Kordorwu Hope Edem Kofi
- Korkolis Dimitrios
- Kosai Nik Ritza
- Kose Emin
- Koskenvuo Laura
- Koto Modise Zacharia
- Kotobi Henri
- Kourdouli Amar
- Kourdouli Amar
- Kufeji Dorothy
- Kuliavas Justas
- Kumar Basant
- Kumar Basant
- Kumar Basant
- Kumar Sandip
- Kumar Sunil
- Kumar Sunil
- Kumwenda Dayson
- Kushwaha Sameer
- Kusi Kwasi
- Kutkevicius Juozas
- Kwakyeafriyie Prince
- Kwatiwani Chimwemwe
- Kwizera Sandrine
- Kwok Stephanie Hiu-wai
- Kyereh Martin
- Kyriazanos Ioannis
- Kyrou Georgios
- Kyziridis Dimitrios
- L'Heveder Ariadne
- La Brocca Antonella
- Ladukas Adomas
- Lagunavicius Karolis
- Lai Anthony Chuk-Him
- Lam Justin Chak Yiu
- Lam Wai Him
- Lanau Maria Isabel Villegas
- Lando Justus
- Landolfo Giovanni
- Lapitan Marie Carmela
- Larsen Johannes Wiik
- Lasek Anna
- Latif Aliang
- Laugzemys Erikas
- Laurie Kirsten
- Lauzikas Giedrius
- Law Jia Hao
- Lawal Abdulrazzaq
- Lawal Taiwo
- Lazzari Giovanni
- Lazzari Veronica
- Le Vu Thanh Hien
- Leanne Almanon Christel
- Lecompte Jean-Francois
- Lee Eu Xian
- Lee Felix
- Lee Kai Yin
- Lee Kathryn
- Lee Kuok Chung
- Lee Tien Seng Bryan
- Leone Nicoletta
- Leong Faith Qi Hui
- Leppaniemi Ari
- Leroux Julien
- Leung Ka Wai
- Leusink Astrid
- Li Ka Hin Gabriel
- Licari Leo
- Lieske Bettina
- Lieske Bettina
- Liew Ignatius
- Lilford Richard
- Lilford Richard
- Lim Hui
- Lim Jieqi
- Lim Shujing Jane
- Lim Shyang Yee
- Limoges Bernard
- Lipnickas Vytautas
- Litvin Andrey
- Liu Qinyang
- Liu Qinyang
- Ljuhar Damir
- lo Conte Annalisa
- loaloa Mohamed Reda
- Lokman Muhammad Amsyar Auni
- Longstaff Lydia
- Lopez Manuel
- Lopez Manuel
- Lorenzon Laura
- Low Xinwei
- Luc Alberto Realis
- Lucia Contreras-Vergara Ana
- Luck Joshua
- Luglio Gaetano
- Lund Jonathan
- Lytras Dimitrios
- Mabitsela Matlou Ernest
- Mabrouk Mohamed
- Macchitella Yuri
- Machain Vega Gustavo Miguel
- Maciejec Laura
- Madiba Thandinkosi
- Madkor Mona Hamdy
- Madrid Barrientos Linda Alvi
- Maffioli Anna
- Magdy Ahmed
- Magdy Eman
- Magdy Hesham
- Magdy Mohamed
- Magdy Salma
- Maghrabi Ashraf
- Magri Daniela
- Mahanty Silke
- Mahdi Shareef
- Maher Mahmoud Elkhadragy
- Mahmoud Basma
- Mahmoud Farah
- Mahmoud Hend
- Mahmoud Mohamed Ali
- Mahmoud Moustafa Ibrahim
- Mahmoud Sabry Mohy Eldeen
- Mahmoud Shady
- Maillot Betty
- Maimbo Mayaba
- Maimbo Mayaba
- Mairs Nora Grace
- Maison Kwame
- Maistry Niveshni
- Majauskyte Dovile
- Majbar Anass
- Majid Aminah Hanum Haji Abdul
- Majid Kiran
- Major Piotr
- Major Piotr
- Mak T. W. C.
- Makama Jerry
- Makupe Alex
- Malaga Barbara
- Malavenda Mariastella
- Mamdouh Rana
- Manatakis Dimitrios K.
- Manfreda Serena
- Mangiapane Mirko
- Mann Thomas
- Mano Maria Jesusa B.
- Manrique Sila George Christian
- Manriquez-Reyes Marisol
- Mansor Eman Yahya
- Mansour Salma
- Mansuri Anahita
- Mao Patrizio
- Maraie Noha
- Margaritis Michail
- Maria Garcia-Perez Jose
- Mariani Aurora
- Marret Jean-Baptiste
- Mas Robinson
- Mat Tuan Nur'Azmah Tuan
- Mata Lusi Padma Sulistianingsih
- Matheu Alejandro
- Mathew Susan Wndy
- Matos-Puig Roel
- Mattar Omar
- Matter Sara Mamdouh
- Mazelyte Ruta
- Mazrimas Povilas
- Mazzella Angela
- McGarvie Susan
- McIntosh Kirsten
- Mclean Kenneth
- Mehdi Aia
- Melo Cardozo Ramon Augusto
- Melo Renato
- Mendel Henry
- Mensah Ekow
- Meqbil Jehad
- Mericliler Meric
- Merlini David
- Mesbah Nourhan
- Migliore Marco
- Mihaljevic Andre L.
- Mihanovic Jakov
- Mikalauskas Saulius
- Mikuckyte Deimante
- Mingrone Pietro
- Minguez Garcia Javier
- Minocha Ashish
- Miranda Cesar
- Mircea Hogea
- Mironescu Aurel
- Mironescu Aurel
- Mironescu Aurel Sandu
- Mirza Shahrukh
- Mitroudi Magdalini
- Mitul Ashrarur Rahman
- Miyar de Leon Alberto
- Miyasato Hector Shibao
- Mizzi Christine
- Mizzi Sean
- Moaty Mohamed
- Mochet Sylvie
- Modolo Maria Marta
- Modolo Maria Marta
- Moe Thomas Tetens
- Moghazy Mahmoud Elsayed
- Mohamed Ahmed Rabie
- Mohamed Amna
- Mohamed Amna Mamdouh
- Mohamed Arwa
- Mohamed Bakeer
- Mohamed Fawzy
- Mohamed Mazed
- Mohamed Mohamed Abdelaty
- Mohamed Shaza Rabie
- Mohammad Aminu
- Mohammed Ahmed Rabeih
- Mohammed Amany Eldosouky
- Mohammed Hussein
- Mohammed Mustafa Mohammed
- Mohammed Sara
- Mohan Midhun
- Mok Yi Ting
- Monaghan Eimear
- Monrad-Hansen Peter Wiel
- Monteleone Michela
- Monterroso Cohen David
- Montes Irene
- Montrimaite Margarita
- Moodley Yoshan
- Moore Rachel
- Mora John Jemuel V.
- Morandi Eugenio
- Morgan Catrin
- Morshedy Eman Mohamed
- Morton Dion
- Mostafa Merna
- Mostafa Mohamed
- Moussa Omar
- Moustafa Ahmed
- Mowafy Bassant
- Mshelbwala Philip
- Msiska Nelson
- Msosa Vanessa
- Msosa Vanessa
- Muddebihal Uday
- Mueller Julia
- Mukin Annisa Dewi Fitriana
- Muktar Umar
- Mukuzunga Cornelius
- Muller Cecile
- Muntean Liviu
- Murray Alice
- Murutoglu Busra
- Musleh Aseel
- Musowoya Joseph
- Mussad Ali
- Mustafa Mousa
- Musyoka Caroluce K.
- Mutabazi Alphonse Zeta
- Mutabazi Alphonse Zeta
- Mutlu Deniz
- Mutlu Vahit
- Muzio Elena
- Myers Jonathan
- Mykoniatis Ioannis
- Nadeem Najwa
- Naess Pal Aksel
- Nagy Ghada Saied
- Nahar Sayeda Nazmum
- Najjar Mohammed
- Nanthakumaran Shayanthan
- Napolitano Lena
- Narayanan Ragavan
- Narayanan Ragavan
- Nashat Mohamed
- Nashidengo Puyearashid
- Nasir Abdulrasheed
- Nasir Wan Nurul Ain Wan Mohd
- Nasr Maha
- Nassif Dima
- Natalie Hani
- Nataraja Ram
- Natili Andrea
- Navarro Andre
- Nawawi Abrar
- Nazir Mohamed
- Ndajiwo Aliyu
- Ndajiwo Aliyu
- Ndegwa Wairimu
- Ndlovu Sibongile Ruth
- Ndwambi Phumudzo
- Negoi Ionut
- Neo Ya Theng
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Nessa Ashrafun
- Nestorovic Milica
- Nevieraite Viktorija
- Ng James Chean Khun
- Ng Yung Kok
- Ng Zhan Herr
- Niazi Ali Khan
- Nicholson Luke
- Nikberg Maziar
- Nikoloudis Nikolaos
- Niranjan Nithya
- Nirumal Milaksh Kumar
- Niska Karoliina
- Nita Gabriela Elisa
- Nita Gabriela Elisa
- Njokanma Iloba
- Nocito Antonio
- Noor Fazlin
- Notarnicola Margherita
- Notarnicola Margherita
- Nouh Thamer
- Noukpozounkou Bruno
- Nsengiyumva Carlos
- Ntirenganya Faustin
- Nurqistan Hazmi Dwinanda
- Nwabuoku Emeka
- Nwinee Victor
- O'Connor Donal B.
- O'Higgins Roche Marcelo
- O'Neill Stephen
- O'Shea Margaret
- Occhionorelli Savino
- Odeyemi Babatunde
- Odutola Oluwatomi
- Ogunsua Oluseyi
- Ohene-Yeboah Micheal
- Okenabirhie Ogheneochuko
- Olajide Thomas Olagboyega
- Olaolorun Akin
- Olivier James
- Olori Samson
- Oludara Mobolaji
- Olugbemi Mojolaoluwa
- Omar Mohammad Elsayed
- Omar Muhammad Fathi Waleed
- Omer Omer Abdelbagi
- Onuoha Clement
- Opoku-Agyeman Richard
- Oram Shaun
- Ortega Irene
- Ortega Irene
- Ortiz Nadia
- Orton Peter
- Osagie Olabisi
- Osei-Nketiah Samuel
- Oshati Oyindamola
- Osinowo Adedapo
- Osuoji Roland
- Oswald Dennis
- Otero-Diez Jorge L.
- Ots Riinu
- Otten Kars
- Owen Christopher
- Owusu Frank
- Ozben Volkan
- Ozkan Bahar Busra
- Ozmen Berk Baris
- Padmore Greg
- Paez Lopez Larissa Ines
- Pagano Gianluca
- Pagnozz Janet
- Palayan Kandasami
- Palliyil Madanmohan
- Palma Adrian
- Paludi Miguel Angel
- Panteli Christina
- Papageorgiou Dimitrios
- Papailia Aspasia
- Papandrea Matteo
- Papaskarlatos IasonAntonios
- Pape James
- Parakh Jehangirshaw
- Paramasivan Arjun
- Parasyris Stavros
- Pardo Gabriel
- Park Esther H. G.
- Park Jay
- Parker Robert
- Parmentier Benoit
- Parpoudi Styliani
- Parseliunas Audrius
- Pascale Giovanni
- Pascale Marco Maria
- Pasquali Sandro
- Pastora Javier
- Pata Domenica
- Pata Francesco
- Pata Francesco
- Pata Francesco
- Pata Francesco
- Pata Francesco
- Pata Giacomo
- Patel Khyati
- Patel Priya
- Patel Sanjay
- Paterson-Brown Simon
- Patoulias Ioannis
- Paul Marie
- Paulouski Dzmitry
- Paz Galvez Carlos
- Pazuskis Matas
- Pektas Ahmet Murat
- Pellino Gianluca
- Peltrini Roberto
- Pena Lenin
- Perenyei Miklos
- Perera James
- Perera James
- Perez Rojas Angel David
- Perino Martina
- Peros Georgios
- Perrotta Gerardo
- Pertersen Servin Gustavo Rodolfo
- Pesenti Giovanni
- Petrikenas Steponas
- Peycelon Matthieu
- Pezas Theodore
- Picardo Antonio
- Picardo Antonio
- Picciariello Arcangelo
- Pineno-Flores Cristina
- Pinkney Thomas
- Pinkney Thomas
- Pinnagoda Kalitha
- Ploski Jennifer
- Pluke Kent
- Podevin Guillaume
- Poh Keat-Seong
- Popa Mariuca
- Popoola Ademola
- Poskus Tomas
- Poskus Tomas
- Poskus Tomas
- Post Nathan
- Prins Marloes
- Pronin Savva
- Prudhomme Thomas
- Psarianos Kyriakos
- Pugliesi Thays Brunelli
- Pujol-Cano Natalia
- Purwaningsih Nurlaila Ayu
- Puyana Juan
- Qaissieh Ahmad
- Qawasmi Israa
- Qenawy Mostafa
- Quek Roy
- Qureshi Ahmad Uzair
- Qureshi Ahmad Uzair
- Qureshi Mobeen
- Qurie Khalid
- Rackauskas Rokas
- Radkowiak Dorota
- Radojkovic Milan
- Rahantasoa Finaritra Casimir Fleur Prudence
- Rahmah Dina Faizatur
- Rajan Reynu
- Rajmohan Shivanchan
- Rakha Ibrahim
- Ramadan Menna Tallah
- Ramos Perez Virginia
- Ramos-De la Medina Antonio
- Ramos-De la Medina Antonio
- Ramos-De la Medina Antonio
- Raptis Dimitri Aristotle
- Raptis Dmitri
- Rashad Eman
- Rashed Ahmed M.
- Rasoaherinomenjanahary Fanjandrainy
- Rath Max
- Ravishankar Ramanish
- Rayne Sarah
- Rayne Sarah
- Rayne Sarah
- Rayne Sarah
- Raza Ahmed
- Raza Awais
- Raza Ibrahim
- Razuri Cesar
- Razzaque Joyeta
- Reali Claudia
- Recinos Gustavo
- Recinos Gustavo
- Reda Amira
- Reda Aya
- Redgrave Natalie
- Redota Menold Archee P.
- Reece-Smith Alex
- Reinisch Katharina
- Reinsoo Arvo
- Rekhis Syrine
- Renaux-Petel Mariette
- Restrepo Ivan Mendoza
- Reunis Elke
- Rezq Asmaa
- Riauka Romualdas
- Riaz Muhammed Masood
- Ribaldi Sergio
- Rickard Jennifer
- Rida Ahmed Hossam Eldin Fouad
- Riente Francesco
- Rinaldi Anna
- Ringressi Maria Novella
- Ripa Matteo
- Riswan Nur Zulaika
- Rob Zakaria
- Robert Elsa
- Robledo-Rabanal Alina
- Rocke Alistair
- Rod Julien
- Rod Julien
- Rodicio Joseluis
- Rodriguez Xianelle
- Roman Velasquez Armando Jose
- Romani Diego
- Romani Diego
- Rommaneh Muna
- Roodt Liana
- Rosales Javier
- Rosello Olivier
- Roslani April Camilla
- Rossi Davide
- Roszkowski Rafal
- Rotunno Giuseppe
- Rouse Tyler
- Roy Chloe
- Roy Swapnil
- Rubinkiewicz Mateusz
- Ruiz Panez Walter
- Ruiz-Tova Jaime
- Rulie Anthonius Santoso
- Runigamugabo Emmy
- Russo Alfio Alessandro
- Rutkowski Wiktor
- Ruzzenente Andrea
- Saad Abdalla Gamal
- Saad Hala
- Saad Hanan Adel
- Saad Mahmoud M.
- Saad Reham
- Saadeh Rana
- Saami Mahmoud
- Saar Sten
- Sabe Ahmad
- Sabe Ahmad Khaled
- Sabour Fahd Abdel
- Sacco Michele
- Sacco Rosario
- Saeed Manar
- Sahbaz Nuri Alper
- Sahel Sarah
- Saidbadr Ahmed
- Sakr Ahmad
- Salah Asmaa
- Salah Maram
- Salah Mohamed
- Salah Osama Mohamed
- Salama Mahmoud
- Salama Yahya
- Salamone Giuseppe
- Salcedo Jannin
- Sale Danjuma
- Saleh Amr Ahmed
- Salem Hosni Khairy
- Salem Hosni Khairy
- Salem Hosni Khairy
- Salem Menatalla
- Salem Mohammed Mousa
- Sallam Abd Elkhalek
- Salleh Afizah
- Sallinen Ville
- Salma Mahmoud
- Salma Umme
- Salman Ayman
- Salusso Paola
- Sam Zi Hao
- Samalavicius Narimantas E.
- Samison Luc Herve
- Sammarco Giuseppe
- Sammut Keith
- Samson Garba
- Samuel Sani Ali
- Samy Mostada
- Samy Mostafa
- Sanad Aly
- Sanchez Rosenberg Guillermo
- Sanchez Samaniego Camila
- Sanchez Belen
- Sanchez Diana
- Sander Anthony
- Sandler Simone
- Sandoval Barrantes Ana Maria
- Sanni Hakeem Ayomi
- Sanz Sandra
- Sapci Ipek
- Saqlain Muhammad
- Sarafilovic Hannah
- Saraste Deborah
- Saravia Fridiz
- Sasia Diego
- Saw Jian Er
- Sayed Farrag
- Sayed Marwa
- Scalabre Aurelien
- Scalabre Aurelien
- Schadde Erik
- Schiavone Roberto
- Schmid Roger
- Schmitt Francoise
- Schuetz Tobias
- Schultz Johannes Kurt
- Scicluna Ruth
- Segovia Lohse Helmut Alfredo
- Seisay Sam
- Selvaggi Francesco
- Selvaggi Lucio
- Semeda Nourhan
- Semiz Anil
- Sena-Ruiz Fatima
- Senanayake Kithsiri J.
- Setiawan Jonny
- Seto Djifid Morel
- Seyoum Nebyou
- Sfougaris Dimitrios
- Shachykava Tatsiana
- Shaharuddin Shahadatul
- Shahbaz Aized Raza
- Shaheen Alaa
- Shahine Ahmed
- Shahzad Noman
- Shaikh Nihaal
- Shakshouk Hend Adel Gawad
- Shalabi Ahmad
- Shalaby Mahmoud
- Shalaby Mostafa
- Shamasneh Ala
- Shamsedine Ahmed W.
- Sharma Abhishek
- Sharpin Claire
- Shatkar Veeranna
- Shaw Catherine A.
- Shaw Catherine A.
- Shawky Martina Yusuf
- Shawqi Muhammad
- Sheshe Abdurrahaman
- Sheta Ahmed
- Shillito Sam
- Shiwani Haaris A.
- Sholadoye Tunde
- Shrimanker Nikhita
- Shu Sebastian
- Shu Sebastian
- Shu Sebestian
- Shubianok Maryna
- Shwky Ayman
- Siaw Jia Yng
- Sierra Sebastian
- Sigurdadottir Johanna
- Sii Samuel S. Y.
- Sileri Pierpaolo
- Silvestri Vania
- Simioni Andrea
- Simutis Gintaras
- Skerritt Clare
- Slapelyte Evelina
- Sleem Ahmad Saber
- Sleem Mohamed
- Smart Neil
- Smart Neil
- Smedley Alexander
- Smith Christopher
- Sobnach Sanju
- Sokratous Arestis
- Solaini Leonardo
- Solar Garcia Lorena
- Soldevila-Verdeguer Carla
- Soledad Merlo Maria
- Soley Rafael
- Soliman Abdelrahman
- Soliman Ahmed
- Soliman Noha Abdullah
- Soliman Nourhan
- Soliman Samar
- Soliman Yasmin
- Sollazzo Viviana
- Soon Wai Cheong
- Soreide Jon Arne
- Soreide Kjetil
- Soreide Kjetil
- Souaibou Yacoubou Imorou
- Soulou Vasiliki
- Spence Richard
- Spence Richard
- Spence Richard
- Spence Richard
- Sproule Lorraine
- Srinivasan Ravi
- Sroor Fathy
- Sruogiene Elena Zdanyte
- Steccanella Francesca
- Stefanopoulos Anastasios
- Stock Simon
- Stoddart Michael
- Stoddart Michael
- Stourton Frederick
- Strupas Kestutis
- Stuva Jessica
- Styles Kristian
- Suarez Aida
- Subocius Andrejus
- Sund Malin
- Suresh Sukrit
- Sutandi Nathania
- Suyadi Arlindawati
- Swaroop Mamta
- Syibrah Khuzaimah Zahid
- Tabiri Stephen
- Tabiri Stephen
- Tabiri Stephen
- Tabiri Stephen
- Tackie Enoch
- Taddei Antonio
- Tahboub Haya
- Taher Ayman
- Taher Mustafa Mohammed
- Taieb Chouikh
- Taiwo Agboola
- Taiwo Ogechukwu
- Talaat Muhammed
- Tale Luis
- Talving Peep
- Talving Peep
- Tan Charlene
- Tan Choy Ling
- Tan Joel Kin
- Tan Keith Say Kwang
- Tan Ryan Choon Kiat
- Tan Yee Wen
- Tan Yi Koon
- Tang Lingshan
- Tani Sobhana Iftekhar
- Tansoker Ilkan
- Tarek Adham
- Tarek Dina
- Targa Simone
- Tariq Sherif
- Tata Mahadevan Deva
- Tawfik Badreldin Adel
- Tawfik Gehad
- Teasdale Ella
- Teasdale Ella
- Teasdale Ella
- Tedeschi Umberto
- Tembo Thelma
- Tennakoon Athula
- Teo Shuang Yi
- Ter Eunice Zuling
- Tew Yong Yong
- Tew Yong Yong
- Thabet Waleed
- Thalgaspitiya S. P. B.
- Theodosopoulos Theodosios
- Thollot Aurore
- Thorarinsdottir Hildur
- Thorell Anders
- Timothy Oyediran Kehinde
- Ting Jesse Ron Swire
- To Kathleen
- Tolonen Matti
- Tolotra Todisoa Emmanuella Christina
- Tomas Kadir
- Tori Sayeeda Aktar
- Toribio Orbegozo Pedro Angel
- Torrance Hew D.
- Torres Cardozo Jorge
- Torres Rodriguez Servio Tulio
- Toto Omer Faruk
- Townsend Dominic
- Trompetto Mario
- Tselos Angelos
- Tshisola Serge Kapenda
- Tugnoli Gregorio
- Tun Myint
- Turati Luca
- Turkustani Sondos
- Turpo Espinoza Kenny
- Turpo Espinoza Kevin
- Tutino Roberta
- Tverskis Zygimantas
- Tyler Robert
- Tze R. Goh Ern
- Tzikos Georgios
- Ubiali Paolo
- Ukwenya Yahaya
- ul Razi Syed Asaat
- Ulusahin Mehmet
- Upadhyaya Vijaid
- Urbonas Tomas
- Urniezius Zigmantas
- Uscinas Laimonas
- Uzabumwana Norbert
- Vaicius Arturas
- Valcarcel-Saldana Maria
- Valioulis Ioannis
- Van Der Naald Niels
- Van Niekerk Michael
- Van Straten Stephanie
- Vargas Marvin
- Vartanoglu Talar
- Vartic Mihaela
- Vasquez Giorgio
- Vasquez Idelso
- Veen Torhild
- Velasquez Ricardo
- Venclauskas Linas
- Vendramin Elena
- Venskutonis Donatas
- Venskutonis Donatas
- Verbeek Anna
- Vergara Mejia Angelica Genoveva
- Verjee Azmina
- Vermaas Maarten
- Vicario Erika
- Vicenta Collado Maria
- Vida Lucian Corneliu
- Vilcinskas Mantas
- Villalobos Santiago
- Violi Paola
- Visinskas Petras
- Voulgaris Evangelos
- Wael Noha
- Wakefield Rebecca
- Waledziak Maciej
- Walker Michael
- Walker Nathan
- Walls Luke
- Walsh Michael
- Waqar Muhammad
- Warren Oliver
- Waterman Ade
- Werder Gabriela
- Whitaker John
- White Rebecca
- Whitehurst Katharine
- Wiborg Joachim
- Widiastini T. Ariani
- Widmer Lukas Werner
- Wijayarathna L. S.
- Williams Omolara
- Wilson Ling
- Wilson Michael
- Wilson Michael
- Wimalge P. M. S. N.
- Wogensen Fredrik
- Wolf Bernhard
- Wondoh Paul
- Wondoh Paul
- Wong Chui Yee
- Wong Francisca
- Wong Hong Yee
- Wood Greta
- Worku Mengistu
- Worku Tewodros
- Wright Naomi
- Yahaya Muhammad Taqiyuddin
- Yakubu Musah
- Yam Sir Young
- Yang James
- Yap Suhhuey
- Yau Jih Dar
- Ye Joselyn
- Yeang Li Jing
- Yeung Man Hon Andrew
- Yifieyeh Abiboye
- Yildirim Reyyan
- Yip Chingwan
- Ymeri Shpetim
- Yoganathan Pigeneswaren
- Yolcu Sinem
- Yong Guo Liang
- Younis Abobaker
- Youssef Mohamed
- Yuksek Mahmut Arif
- Yusufali Taha
- Zaa'treh Rula
- Zadoroznas Antanas
- Zahran Diaaaldin
- Zakaria Esraay
- Zakaria Mahmoud
- Zakaria Yehia
- Zaki Ahmed
- Zammit Stefan
- Zampitis Nikolaos
- Zani Augusto
- Zani Augusto
- Zanini Nicola
- Zapata Felipe
- Zarb Ciskje
- Zeta Solis Ludwing Alexander
- Zielinski Martin
- Zilinskas Justas
- Zilinskas Justas
- Zilinskas Justas
- Zilinskiene Reda
- Ziubryte Greta
- Zohair Ahmed
- Zuber Markus
- Zuk Grzegorz
- Zulkifli Athirah
- Zumbuhl Lucius
- Publication venue
- Elsevier
- Publication date
- 01/06/2003
- Field of study
BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London
Paced-Mating Increases the Number of Adult New Born Cells in the Internal Cellular (Granular) Layer of the Accessory Olfactory Bulb
- Author
- A Alvarez-Buylla
- AI Danilov
- B Leuner
- C Lois
- CA Dudley
- CA Dudley
- DF Hardy
- DR Kornack
- E Gould
- EB Keverne
- EK Polston
- F Doetsch
- F Xu
- FS Corotto
- FS Corotto
- G Gheusi
- GD Das
- GD Das
- GK Mak
- GL Ming
- HA Hurtazo
- Hiroaki Matsunami
- HM Schellinck
- I Martinez
- J Larriva-Sahd
- Jorge Larriva-Sahd
- KL Martel
- L Huang
- L Oboti
- L Petreanu
- LA Shapiro
- M Alonso
- M Matsuoka
- M Matsuoka
- M Yamaguchi
- MK McClintock
- MK McClintock
- MS Erskine
- MS Erskine
- MS Erskine
- MS Erskine
- MT Smith
- N Honda
- N Kang
- P Peretto
- P Peretto
- PJ Bernier
- PM Lledo
- R Guevara-Guzman
- Raúl G. Paredes
- Rebeca Corona
- RG Paredes
- RG Paredes
- RG Paredes
- RJ Mullen
- SP Garcia-Horsman
- T Shingo
- W Portillo
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
The continuous production and addition of new neurons during life in the olfactory bulb is well accepted and has been extensively studied in rodents. This process could allow the animals to adapt to a changing environment. Olfactory neurogenesis begins in the subventricular zone where stem cells proliferate and give rise to young undifferentiated neuroblasts that migrate along the rostral migratory stream to the olfactory bulb (OB). Olfaction is crucial for the expression of sexual behavior in rodents. In female rats, the ability to control the rate of sexual interactions (pacing) has important physiological and behavioral consequences. In the present experiment we evaluated if pacing behavior modifies the rate of new cells that reach the main and accessory olfactory bulb. The BrdU marker was injected before and after different behavioral tests which included: females placed in a mating cage (control), females allowed to pace the sexual interaction, females that mated but were not able to control the rate of the sexual interaction and females exposed to a sexually active male. Subjects were sacrificed fifteen days after the behavioral test. We observed a significant increase in the density of BrdU positive cells in the internal cellular layer of the accessory olfactory bulb when females paced the sexual interaction in comparison to the other 3 groups. No differences in the cell density in the main olfactory bulb were found. These results suggest that pacing behavior promotes an increase in density of the new cells in the accessory olfactory bulb
Two-particle transverse momentum correlations in pp and p-Pb collisions at energies available at the CERN Large Hadron Collider
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- Šafařík K.
- Šerkšnytė L.
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Two-particle transverse momentum differential correlators, recently measured in Pb-Pb collisions at energies available at the CERN Large Hadron Collider (LHC), provide an additional tool to gain insights into particle production mechanisms and infer transport properties, such as the ratio of shear viscosity to entropy density, of the medium created in Pb-Pb collisions. The longitudinal long-range correlations and the large azimuthal anisotropy measured at low transverse momenta in small collision systems, namely pp and p-Pb, at LHC energies resemble manifestations of collective behavior. This suggests that locally equilibrated matter may be produced in these small collision systems, similar to what is observed in Pb-Pb collisions. In this work, the same two-particle transverse momentum differential correlators are exploited in pp and p-Pb collisions at √s=7TeV and √sNN=5.02TeV, respectively, to seek evidence for viscous effects. Specifically, the strength and shape of the correlators are studied as a function of the produced particle multiplicity to identify evidence for longitudinal broadening that might reveal the presence of viscous effects in these smaller systems. The measured correlators and their evolution from pp and p-Pb to Pb-Pb collisions are additionally compared to predictions from Monte Carlo event generators, and the potential presence of viscous effects is discussed
J/Psi suppression at forward rapidity in Pb-Pb collisions at root s(NN)=5.02 TeV
- Author
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- Adamovã¡ D.
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- Publication venue
- Publication date
- 20/06/2016
- Field of study
The inclusive J/Psi production has been studied in Pb-Pb and pp collisions at the centre-of-mass energy per nucleon pair root sNN= 5.02TeV, using the ALICE detector at the CERN LHC. The J/Psi meson is reconstructed, in the centre-of-mass rapidity interval 2.5 <y <4and in the transverse- momentum range p(T)<12GeV/c, via its decay to a muon pair. In this Letter, we present results on the inclusive J/Psi cross section in pp collisions at root s= 5.02TeV and on the nuclear modification factor R-AA. The latter is presented as a function of the centrality of the collision and, for central collisions, as a function of the transverse momentum p(T) of the J/Psi. The measured R-AA values indicate a suppression of the J/Psi in nuclear collisions and are then compared to our previous results obtained in Pb-Pb collisions at root sNN= 2.76TeV. The ratio of the R-AA values at the two energies is also computed and compared to calculations of statistical and dynamical models. The numerical value of the ratio for central events (0-10% centrality) is 1.17 +/- 0.04( stat)+/- 0.20(syst). In central events, as a function of p(T), a slight increase of R-AA with collision energy is visible in the region 2 <p(T)<6GeV/c. Theoretical calculations qualitatively describe the measurements, within uncertainties. (C) 2017 The Author. Published by Elsevier B.V.Peer reviewe
Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.
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- Publication venue
- J Clin Oncol
- Publication date
- 01/01/2020
- Field of study
PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks
Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study
- Author
- Aawsaj Y.
- Abad Gurumeta A.
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- Publication venue
- 'American Society of Clinical Oncology (ASCO)'
- Publication date
- 01/01/2021
- Field of study
PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.
- Author
- Arribas J
- Balmaña J
- Barrett JC
- Baselga J
- Bonache S
- Bruna A
- Cadogan E
- Caldas C
- Caratú G
- Castroviejo-Bermejo M
- Cortés J
- Cruz C
- de Bustos L
- Dougherty B
- Díez O
- Fasani R
- Gris-Oliver A
- Grueso J
- Gutiérrez-Enríquez S
- Guzman M
- Howat WJ
- Ibrahim YH
- Jiménez J
- Jones GN
- Jonkers J
- Kristel P
- Lai Z
- Llop-Guevara A
- Mancuso F
- Montalban G
- Morancho B
- Nuciforo P
- O'Connor MJ
- Oaknin A
- Polanska UM
- Rodríguez O
- Rubio IT
- Rueda OM
- Saura C
- Serra V
- Serres-Créixams X
- Vivancos A
- Publication venue
- Ann Oncol
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: BRCA1 and BRCA2 (BRCA1/2)-deficient tumors display impaired homologous recombination repair (HRR) and enhanced sensitivity to DNA damaging agents or to poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi). Their efficacy in germline BRCA1/2 (gBRCA1/2)-mutated metastatic breast cancers has been recently confirmed in clinical trials. Numerous mechanisms of PARPi resistance have been described, whose clinical relevance in gBRCA-mutated breast cancer is unknown. This highlights the need to identify functional biomarkers to better predict PARPi sensitivity. PATIENTS AND METHODS: We investigated the in vivo mechanisms of PARPi resistance in gBRCA1 patient-derived tumor xenografts (PDXs) exhibiting differential response to PARPi. Analysis included exome sequencing and immunostaining of DNA damage response proteins to functionally evaluate HRR. Findings were validated in a retrospective sample set from gBRCA1/2-cancer patients treated with PARPi. RESULTS: RAD51 nuclear foci, a surrogate marker of HRR functionality, were the only common feature in PDX and patient samples with primary or acquired PARPi resistance. Consistently, low RAD51 was associated with objective response to PARPi. Evaluation of the RAD51 biomarker in untreated tumors was feasible due to endogenous DNA damage. In PARPi-resistant gBRCA1 PDXs, genetic analysis found no in-frame secondary mutations, but BRCA1 hypomorphic proteins in 60% of the models, TP53BP1-loss in 20% and RAD51-amplification in one sample, none mutually exclusive. Conversely, one of three PARPi-resistant gBRCA2 tumors displayed BRCA2 restoration by exome sequencing. In PDXs, PARPi resistance could be reverted upon combination of a PARPi with an ataxia-telangiectasia mutated (ATM) inhibitor. CONCLUSION: Detection of RAD51 foci in gBRCA tumors correlates with PARPi resistance regardless of the underlying mechanism restoring HRR function. This is a promising biomarker to be used in the clinic to better select patients for PARPi therapy. Our study also supports the clinical development of PARPi combinations such as those with ATM inhibitors
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
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- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
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- Abdelmotaleb I
- Abdelraheim M
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- Abdulaziz H
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- Elhusseiny AAE
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- Elzowawi F
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- Espinoza F
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- Muntean L
- Muntean LI
- Muralha N
- Murphy J
- Murray A
- Murutoglu B
- Musa AEK
- Musleh A
- Musowoya J
- Mussad A
- Mustafa M
- Mustafa M
- Mustafa M-A
- Musyoka CK
- Mutabazi A
- Mutabazi AZ
- Mutabazi AZ
- Mutlu D
- Mutlu V
- Muzio E
- Myers J
- Mykoniatis I
- Nabawi A
- Nada F
- Nadeem N
- Nadkarni S
- Naess PA
- Nagy GS
- Nahar SN
- Nair H
- Najjar M
- Nanthakumaran S
- Napolitano L
- Napolitano L
- Naqvi SA
- Naqvi T
- Naranjo Aristizaibal FA
- Narayanan R
- Narayanan R
- Narvestad JK
- Nashaat A
- Nashat M
- Nasher O
- Nashidengo P
- Nasir A
- Nasir AA
- Nasir WNWM
- Nasr A
- Nasr M
- Nasr M
- Nassif D
- Nastri G
- Natalie H
- Nataraja R
- Natili A
- Navarro A
- Nawara C
- Nawawi A
- Nawawi A
- Nayel AR
- Nazir M
- Ndajiwo A
- Ndajiwo A
- Ndegwa W
- Ndlovu SR
- Ndwambi P
- Negida A
- Negoi I
- Nel D
- Nemeth K
- Neo YN
- Neo YT
- Neophytou C
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
- Newton T
- Ng JCK
- Ng S
- Ng YK
- Ng ZH
- Ngayu N
- Ngwa TE
- Niazi AK
- Nicholson L
- Nighat B
- Nigo S
- Nikberg M
- Nikoloudis N
- Nikoloudis N
- Niragire A
- Niranjan N
- Nirumal MK
- Niska K
- Nita GE
- Nita GE
- Niyirera E
- Njokanma I
- Nnajiuba H
- Nocito A
- Nocito A
- Nofal E
- Noor F
- Normile C
- Normile C
- North AS
- Notarnicola M
- Notarnicola M
- Nouh T
- Nouh T
- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana VJP
- Nsengiyumva C
- Ntirenganya F
- Ntirenganya F
- Nurqistan HD
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
- Nymo L
- O'Connor DB
- O'Connor T
- O'Higgins Roche M
- O'neill M
- O'neill S
- O'Neill S
- O'Shea M
- Obute RD
- Occhionorelli S
- Odeyemi B
- Odeyemi B
- Odutola O
- Ofner D
- Ogunsua O
- Ogunyemi A
- Oh J
- Oh J
- Ohene-Yeboah M
- Okenabirhie O
- Olajide TO
- Olaolorun A
- Olivier J
- Olori S
- Olori S
- Oludara M
- Oludara M
- Olugbemi M
- Omar AA
- Omar ME
- Omar MFW
- Omara S
- Omer OA
- Onimowo J
- Onuoha C
- Oosterkamp A
- Opoku-Agyeman R
- Oram S
- Orchard M
- Ortega I
- Ortega I
- Ortega-Vazquez I
- Ortiz N
- Orton P
- Osagie O
- Osei-Nketiah S
- Oshati O
- Oshodi O
- Osinowo A
- Osinowo A
- Osman M
- Osman N
- Osman O
- Osuoji R
- Osuoji R
- Oswald D
- Otero-Diez JL
- Othman M
- Ots R
- Ots R
- Otten K
- Oumer R
- Owen C
- Owusu F
- Owusu F
- Ozben V
- Ozkan BB
- Ozkan BB
- Ozkan BB
- Ozmen BB
- Pabla G
- Padmore G
- Paez Lopez LI
- Pagano G
- Pagnozzi J
- Pagnozzi J
- Pahlsson H-I
- Pai S
- Palayan K
- Palkhi EYA
- Palliyil M
- Palliyil MM
- Palma A
- Palma AF
- Palomino Castillo VD
- Paludi MA
- Paludi MA
- Panait N
- Panieri E
- Panteli C
- Papageorgiou D
- Papailia A
- Papandrea M
- Papaskarlatos I-A
- Pape J
- Parakh J
- Parakh J
- Paramasivan A
- Parasyris S
- Pardo G
- Paredes Decoud H
- Parent V
- Park EHG
- Park J
- Parker J
- Parker R
- Parkinson L
- Parmentier B
- Parpoudi S
- Parseliunas A
- Parthiban S
- Pascale G
- Pascale MM
- Pasini M
- Pasquali S
- Pastora J
- Pata D
- Pata D
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F
- Pata G
- Pata G
- Patel K
- Patel K
- Patel P
- Patel P
- Patel S
- Patel V
- Paterson-Brown S
- Patoulias I
- Paul M
- Paul S
- Paulouski D
- Pazuskis M
- Peck FS
- Pektas AM
- Pellino G
- Peltrini R
- Pena L
- Pereira B
- Perenyei M
- Perera J
- Perera J
- Perez Rojas AD
- Perez Velasquez CI
- Periasammy D
- Perino M
- Peros G
- Perrotta G
- Pertersen Servin GR
- Pesenti G
- Petrikenas S
- Peycelon M
- Peycelon M
- Pezas T
- Pezas T
- Pezelj N
- Phillips N
- Picardo A
- Picciariello A
- Pimenta ML
- Pineno-Flores C
- Pinkney T
- Pinkney T
- Pinnagoda K
- Pino W
- Pitt SK
- Ploski J
- Pluke K
- Podevin G
- Podevin G
- Poh K-S
- Popa M
- Popoola A
- Popoola A
- Porter J
- Poskus T
- Poskus T
- Poskus T
- Poskus T
- Poskus T
- Poskus T
- Post N
- Powell A
- Prabhudesai A
- Pranevicius R
- Prasad SS
- Preckailaite E
- Primavesi F
- Prins M
- Proctor VK
- Pronin S
- Prudhomme T
- Psaila J
- Psarianos K
- Psarianos K
- Pugliesi TB
- Pujol-Cano N
- Punja V
- Purwaningsih NA
- Puttick M
- Puttick M
- Puyana J
- Puyana JC
- Qadir MRM
- Qaissieh A
- Qawasmi I
- Qenawy M
- Quayle J
- Quek R
- Quintero Riaza VM
- Qureshi AU
- Qureshi AU
- Qureshi AU
- Qureshi M
- Qurie K
- Rabie M
- Rackauskas R
- Rackauskas R
- Radic M
- Radkowiak D
- Radojkovic M
- Rahantasoa FCFP
- Rahmah DF
- Rahmawati FN
- Rajan R
- Rajan R
- Rajjoub Y
- Rajmohan S
- Rakauskas R
- Rakha I
- Rakita I
- Ramadan MT
- Ramarez Cabrera CC
- Ramazzini P
- Ramcharn M
- Ramos Perez V
- Ramos-De la Medina A
- Ramos-De la Medina A
- Ramos-De la Medina A
- Ramos-De La Medina A
- Ramzi S
- Rangarajan M
- Raptis D
- Raptis DA
- Raptis DA
- Raptis DA
- Rasendran A
- Rasendran A
- Rashad E
- Rashad M
- Rashed AM
- Rashid A
- Rashid M
- Rashwan H
- Raslan A
- Raslan C
- Rasndran A
- Rasoaherinomenjanahary F
- Rath M
- Rausa E
- Ravishankar R
- Ray S
- Rayne S
- Rayne S
- Rayne S
- Rayne S
- Rayne S
- Rayne S
- Raza A
- Raza A
- Raza I
- Raza I
- Razek T
- Razi SAU
- Razmdjou S
- Razuri C
- Razzaque J
- Reali C
- Recinos G
- Recinos G
- Recinos G
- Recinos G
- Reda A
- Reda A
- Reddy Y
- Redgrave N
- Redota MAP
- Reece-Smith A
- Rees CM
- Refaat A
- Regalado F
- Reinisch K
- Reinisch KB
- Reinsoo A
- Rekhis S
- Renaux-Petel M
- Restrepo IM
- Restrepo J
- Reunis E
- Reza L
- Reza L
- Rezq A
- Riauka R
- Riauka R
- Riaz A
- Riaz MM
- Ribaldi S
- Richards J
- Richardson L
- Rickard J
- Rida AHEF
- Riente F
- Rinaldi A
- Ringressi MN
- Ripa M
- Riswan NZ
- Rivas R
- Rob Z
- Robert E
- Robertson AGN
- Robertson N
- Robledo-Rabanal A
- Rocke A
- Rod J
- Rod J
- Rodicio J
- Rodriguez Castro M
- Rodriguez L
- Rodriguez STT
- Rodriguez X
- Rodriguez-Uria R
- Roman Velasquez AJ
- Romani Pozo DA
- Romani D
- Romani D
- Rommaneh M
- Roncali S
- Roodt L
- Rooney H
- Rosales J
- Rosas Moran AE
- Rosello O
- Rosenberg GS
- Roslani AC
- Roslani AC
- Roslani AC
- Rossi D
- Roszkowski R
- Roth J
- Rotundo A
- Rotunno G
- Rouse T
- Roy C
- Roy S
- Roy S
- Royson H
- Royson H
- Rslan A
- Rubinkiewicz M
- Rudzenskaite A
- Ruiz Panez W
- Ruiz-Tovar J
- Rulie AS
- Runigamugabo E
- Russo AA
- Rutkowski W
- Ruzzenente A
- Saad AG
- Saad H
- Saad HA
- Saad M
- Saad MM
- Saad R
- Saad S
- Saadeh R
- Saami M
- Saar S
- Sabe A
- Sabe AK
- Sabeeh L
- Sabour FA
- Sabry A
- Sacco M
- Sacco R
- Sadek A
- Sadig N
- Saeed AM
- Saeed H
- Saeed M
- Saeed M
- Saeed M
- Safa H
- Sahbaz NA
- Sahel S
- Saidbadr A
- Sakr A
- Sakr A
- Sakr R
- Salah A
- Salah M
- Salah M
- Salah O
- Salah OM
- Salama M
- Salama M
- Salama Y
- Salama Y
- Salamone G
- Salcedo J
- Sale D
- Saleh AA
- Saleh O
- Salem HK
- Salem HK
- Salem HK
- Salem M
- Salem MM
- Sallam AE
- Salleh A
- Salleh A
- Sallinen V
- Sallinen V
- Salma M
- Salma M
- Salma U
- Salman A
- Salusso P
- Sam ZH
- Samalavicius NE
- Samaraweera DI
- Samih H
- Samir A
- Samison LH
- Sammarco G
- Sammut K
- Sampson C
- Samson G
- Samuel D
- Samuel SA
- Samy M
- Samy M
- Samy S
- Sanad A
- Sanchez Samaniego C
- Sanchez B
- Sanchez D
- Sander A
- Sandler S
- Sandoval Barrantes AM
- Sanni HA
- Sanz S
- Sapci I
- Saqlain M
- Sarafilovic H
- Saraste D
- Saravia F
- Sarmah P
- Sarsik S
- Sarwary S
- Sasia D
- Satoskar R
- Satoskar S
- Sauvat F
- Sava J
- Saw JE
- Sayed A
- Sayed F
- Sayed M
- Sayma EA
- Scalabre A
- Scalabre A
- Schadde E
- Schadde E
- Schiavone R
- Schivo D
- Schmid R
- Schmid R
- Schmitt F
- Schmitt F
- Schoewe C
- Schuetz T
- Schultz JK
- Scicluna R
- Scott M
- Segovia Lohse HA
- Segovia Lohse HA
- Seif M
- Seifelnasr O
- Seisa M
- Seisay S
- Selvaggi F
- Selvaggi L
- Semeda N
- Semiz A
- Sena-Ruiz F
- Senanayake KJ
- Senanayake WSMKJ
- Setiawan J
- Seto DM
- Seyoum N
- Sfougaris D
- Sgroi G
- Shaalan M
- Shabkah A
- Shachykava T
- Shah A
- Shah J
- Shah R
- Shaharuddin S
- Shahbaz AR
- Shaheen A
- Shahine A
- Shahzad N
- Shaikh N
- Shaikh S
- Shaker H
- Shaker R
- Shaker R
- Shakshouk HAG
- Shalabi A
- Shalaby A
- Shalaby M
- Shalaby M
- Shalhoub J
- Shamasneh A
- Shamsedine AW
- Shamsi G
- Shamsi GS
- Shariffuddin AM
- Sharma A
- Sharpin C
- Shatkar V
- Shatkar V
- Shaw CA
- Shaw CA
- Shawki M
- Shawki M
- Shawky MY
- Shawqi M
- Sheehan J
- Shehata S
- Sherif MA
- Sherman T
- Sheshe A
- Sheshe A
- Sheta A
- Sheth S
- Shibao Miyasato H
- Shillito S
- Shimy G
- Shiwani H
- Shiwani HA
- Sholadoye T
- Shrimanker N
- Shu Yip SB
- Shu S
- Shu S
- Shu S
- Shu S
- Shu S
- Shubianok M
- Shukla J
- Shwky A
- Siaw JY
- Sieda B
- Sierra S
- Sierra S
- Sierra S
- Siguantay M
- Sigurdadottir J
- Sii SSY
- Sileri P
- Silvani P
- Silvestre BP
- Silvestri V
- Simioni A
- Simoes RL
- Simutis G
- Singh P
- Singh S
- Sinha S
- Sinha Y
- Sion M
- Sishuba N
- Sivaganesh S
- Skardziukaite A
- Skehan J
- Skelly B
- Skerritt C
- Slade R
- Slapelyte E
- Sleem AS
- Sleem M
- Smart N
- Smart N
- Smart N
- Smart NJ
- Smedley A
- Smith C
- Smith C
- Smith D
- Snaith AC
- Snyder E
- Soares Miguel GP
- Sobnach S
- Sodde P
- Soeselo DA
- Sokratous A
- Solaini L
- Solar Garcia L
- Solar Garcia L
- Soldevila-Verdeguer C
- Soley R
- Soley R
- Soliman A
- Soliman A
- Soliman AR
- Soliman N
- Soliman NA
- Soliman S
- Soliman Y
- Sollazzo V
- Soltani N
- Som R
- Song J
- Song J
- Soon WC
- Soon WC
- Soreide JA
- Soreide K
- Soreide K
- Soreide K
- Soreide K
- Souaibou YI
- Souaibou YI
- Soulou V
- Spence R
- Spence R
- Spence R
- Spence R
- Spence R
- Spence R
- Spina A
- Sproule L
- Spurr M
- Sreedharan A
- Srinivasan R
- Sriram A
- Sroor F
- Sruogiene EZ
- Staerkle RF
- Starr N
- Stasinou T
- Steccanella F
- Stefanopoulos A
- Stephen A
- Stewart D
- Stock S
- Stock S
- Stoddart M
- Stoddart M
- Stoddart M
- Stourton F
- Strazdas A
- Strupas K
- Strupas K
- Strupas K
- Stuva J
- Styles K
- Suarez A
- Suarez AAB
- Subocius A
- Suleiman SI
- Summerour V
- Sund M
- Sund M
- Sunderland G
- Sundstrom SM
- Suresh S
- Sutandi N
- Sutanto EPR
- Sutton P
- Sutton P
- Suyadi A
- Swann J
- Swaroop M
- Swaroop M
- Syibrah KZ
- Sykes M
- Szczap A
- Szeto CCL
- Szeto KJ-Y
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tackie E
- Taddei A
- Tade A
- Tafazal H
- Taha EMS
- Tahboub H
- Taher AA
- Taher M
- Taher MM
- Taieb C
- Taiwo A
- Taiwo O
- Taiwo O
- Talaat M
- Tale F
- Tale L
- Talukder S
- Talukder S
- Talving P
- Talving P
- Tammam A
- Tan C
- Tan CL
- Tan CY
- Tan JJ
- Tan JK
- Tan KSK
- Tan RCK
- Tan YK
- Tan YW
- Tanase A
- Tanase A
- Tang A
- Tang L
- Tani SI
- Tansoker I
- Tarek A
- Tarek A
- Tarek D
- Targa S
- Tariq S
- Tata MD
- Tatagiba LS
- Tawfik BA
- Tawfik G
- Tawfik G
- Taylor F
- Teasdale E
- Teasdale E
- Teasdale E
- Teasdale E
- Tedeschi U
- Tedjaatmadja C
- Telfah MM
- Tembo T
- Temoche E
- Tennakoon A
- Teo SY
- Ter EZ
- Tessera G
- Teufelberger G
- Tew YY
- Tew YY
- Tewari S
- Th'ng F
- Thabet W
- Thalgaspitiya SPB
- Tham JC
- Thanusan V
- Tharmalingam S
- Theodosopoulos T
- Thollot A
- Thomas E
- Thomas HS
- Thompson B
- Thomson P
- Thorarinsdottir H
- Thorarinsdottir H
- Thorell A
- Thorell A
- Thorsen K
- Thurairaja R
- Tierney G
- Tilston TW
- Timothy OK
- Ting JRS
- To K
- To K
- Todd KO
- Toeema AG
- Tolba H
- Tolg C
- Tolonen M
- Tolotra TEC
- Tomas K
- Tori SA
- Toribio Orbegozo PA
- Torrance HD
- Torrance HD
- Torres Cardozo J
- Toto OF
- Tou S
- Townsend D
- Tracy J
- Trompetto M
- Tselos A
- Tshisola SK
- Tugnoli G
- Tugnoli G
- Tun AK
- Tun M
- Tun M
- Turati L
- Turati L
- Turkustani S
- Turner M
- Turpo Espinoza K
- Turpo Espinoza K
- Tutino R
- Tverskis Z
- Tyler R
- Tyler R
- Tze RGE
- Tze RGE
- Tzikos G
- Ubhi HK
- Ubiali P
- Ugalde P
- Ukwenya Y
- Ulusahin M
- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbina Rojas NM
- Urbonas T
- Urbonas T
- Urniezius Z
- Urniezius Z
- Usaityte A
- Uscinas L
- Utter M
- Uzabumwana N
- Vaicius A
- Valcarcel-Saldana M
- Valente Laufer LA
- Valioulis I
- Van Der Naald N
- Van Duren B
- Van Niekerk M
- Van Straten S
- Varcada M
- Vargas M
- Varkalys K
- Vartanoglu T
- Vartic M
- Vartic M
- Vasquez G
- Vasquez I
- Veen T
- Velasquez R
- Vella-Baldacchino M
- Venclauskas L
- Vendramin E
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venugopal C
- Verbeek A
- Vergara Celis JM
- Vergara Mejia AG
- Verjee A
- Vermaas M
- Veronese E
- Vianna JGP
- Vicario E
- Vicenta Collado M
- Vida LC
- Vida LC
- Vilcinskas M
- Villa R
- Villalobos S
- Vimalachandran D
- Vincent J
- Violi P
- Visinskas P
- Vivekanantham S
- Vlachogiorgos A
- Voulgaris E
- Wael N
- Wagener M
- Wakefield R
- Waledziak M
- Waleed H
- Walker M
- Walker N
- Walls L
- Walsh M
- Walsh U
- Waqar M
- Ward AE
- Ward S
- Warda M
- Warren O
- Warren O
- Warwick AM
- Waterman A
- Watson NF
- Watson NF
- Watts A
- Weber B
- Weber P
- Weber P
- Weinstein MS
- Weiser TG
- Werder G
- Wheeler J
- Whewell H
- Whitaker J
- White R
- White T
- Whitehurst K
- Wiborg J
- Widiastini TA
- Widmer LW
- Wijayarathna LS
- Wild JRL
- Williams E
- Williams G
- Williams O
- Williams O
- Williamson A
- Wilson A
- Wilson L
- Wilson M
- Wilson M
- Wilson MSJ
- Wilson MSJ
- Wimalge PMSN
- Winstanley J
- Witherspoon P
- Wogensen F
- Wogensen F
- Wogensen F
- Woin E
- Wold TB
- Wolf B
- Wolf B
- Wondimu S
- Wondoh P
- Wondoh P
- Wong CS
- Wong CY
- Wong F
- Wong HY
- Wood G
- Woodward H
- Worku M
- Worku M
- Worku T
- Wredberg C
- Wright N
- Wright NJ
- Xerri T
- Xerri T
- Yahaya MT
- Yakubu M
- Yallop L
- Yam SY
- Yang J
- Yap S
- Yaseen T
- Yaseen TM
- Yau JD
- Yavuz MA
- Ye J
- Yeang LJ
- Yee J
- Yeo LS
- Yeung ENW
- Yeung MHA
- Yifieyeh A
- Yildirim R
- Yip C
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong CO
- Yong GL
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif JH
- Yuksek MA
- Yusufali T
- Zaa'treh R
- Zachariades D-C
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia MF
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
- Zanini N
- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
- Zidan M
- Zielinski M
- Ziff O
- Zikry M
- Zil-E-Ali A
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zilinskiene R
- Zimmermann EF
- Ziubryte G
- Zohair A
- Zorrilla CD
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study
- Author
- Aahlin Eirik Kjus
- Aamer Ahmed
- Aaniana Kenneth
- Ababneh Ali
- Abaliksta Tomas
- Abantanga Francis
- Abbas Athar
- Abbasy Jibran
- Abbo Olivier
- Abbott Tom
- Abbouch Meryem
- Abd El-Latif Nadia Khalid
- Abd Elkhalek Esraa
- Abd-Elmawla Manar
- Abdallah Emad
- Abdel-Aty Abdulrahman
- Abdel-Hameed Noran
- Abdel-Kader Sara Mahmoud
- Abdelaal Abdelaziz
- Abdelaty Mohamed
- Abdelazeam Anan Rady
- Abdelazim Galaleldin
- Abdelaziz Mohamed A
- Abdelbadeai Kholoud
- Abdelfatah Afnan
- Abdelhady Samar
- Abdelhamed Rasha
- Abdelhamid Amina
- Abdelhaq Aram
- Abdelkader Mostafa
- Abdelkader Omar
- Abdelkhalek Mohamed
- Abdelmageed Eman
- Abdelmotaleb Ibrahem
- Abdelraouf Ahmed Mahmoud
- Abdelrouf Doaa Maher
- Abdelshakour Mahmoud
- Abdrabou Abdulshafi Khaled
- Abdul-Latif Saiba
- Abdulaziz Hager
- Abdulaziz Mustafa
- Abdulbagi Omar
- Abdulhakeem Eman Mahmoud
- Abdullah Mohamed Abozed
- Abdullah Nik Azim Nik
- Abdullah Noha
- Abdullahi Lawal
- Abdurrazzaaq Abdussemiu
- Abem Owusu Emmanuel
- Abiola Olajide
- Aboelella Majed
- Aboelmagd Omnia
- Aboelsoud Moustafa R
- Aboul-Naga Mariam Saad
- Abouzaid Arwa
- Abu Qumbos Amjad
- Abu-toyour Maram
- Abubakr Marwan
- Abuowda Yousef
- Abuqwaider Eman
- Abusalem Lana
- Abushamleh Soha
- Ackom Eric
- Acquah Emmanuel
- Adam Ali
- Adam Nourhan
- Adamu Ahmed
- Adawi Ihdaa
- Adawi Mohammad
- Adebanjo Ademola
- Adebola Oluwaseyi
- Adedeji Adesina
- Adel Badr Eldin
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- Ahlqvist Sandra
- Ahlqvist Sandra
- Ahmed Asdaq
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- Zuber Markus
- Zuk Grzegorz
- Zulkifli Athirah
- Zumbuhl Lucius
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world.
Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231.
Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001).
Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
- Author
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
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- Adya V. B.
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- Aguiar Odylio D.
- Aiello Lorenzo
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- Ajith Parameswaran
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- Amato Alex
- Anand S.
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- Zevin Michael
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
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- Árpád Gergely László
- 劉 國欽
- 曹周键
- 王谨
- 都丸 隆行
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects
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