11 research outputs found

    Art and Feminism

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    Authoritative publication focusing on the role of theory in the evolution of feminist art. Phelan's essay surveying American and British feminist art produced between 1960-2000 traces the "shifting geographies of feminism" by situating diverse formal strategies used by feminist artists within the contexts of abstract expressionim, minimalism, conceptual art, performance art and photographic performance. Her analysis of the ideological forces within representational systems is informed by postructuralism and psychoanalytic theories of sexual difference. Issues of identity, race, sexuality, class, gender and age are considered in relation to the marginalization of women, the objectification of the female body, and essentialism. Includes documentation of numerous artworks and texts by artists and authors working in disciplines of feminist philosophy, psychoanalysis, art history, film theory and literary criticism. Biographical notes. Index of names. Bibliography. Circa 675 bibl. ref

    Capillary electrophoresis for the analysis of small-molecule pharmaceuticals

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    Gap Junctions

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    Gap junctions are essential to the function of multicellular animals, which require a high degree of coordination between cells. In vertebrates, gap junctions comprise connexins and currently 21 connexins are known in humans. The functions of gap junctions are highly diverse and include exchange of metabolites and electrical signals between cells, as well as functions, which are apparently unrelated to intercellular communication. Given the diversity of gap junction physiology, regulation of gap junction activity is complex. The structure of the various connexins is known to some extent; and structural rearrangements and intramolecular interactions are important for regulation of channel function. Intercellular coupling is further regulated by the number and activity of channels present in gap junctional plaques. The number of connexins in cell-cell channels is regulated by controlling transcription, translation, trafficking, and degradation; and all of these processes are under strict control. Once in the membrane, channel activity is determined by the conductive properties of the connexin involved, which can be regulated by voltage and chemical gating, as well as a large number of posttranslational modifications. The aim of the present article is to review our current knowledge on the structure, regulation, function, and pharmacology of gap junctions. This will be supported by examples of how different connexins and their regulation act in concert to achieve appropriate physiological control, and how disturbances of connexin function can lead to disease. © 2012 American Physiological Society. Compr Physiol 2:1981-2035, 2012
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