183 research outputs found
DEVELOPMENT OF METHOD AND CRITERIA FOR EVALUATION OF DRY-WASHING EFFICIENCY WITH RE-CON ZERO EVO
- Publication venue
- Publication date
- 01/01/2022
- Field of study
acceptedVersio
Population-based trends in pregnancy hypertension and pre-eclampsia: an international comparative study
- Author
- Publication venue
- BMJ Group
- Publication date
- 01/01/2011
- Field of study
Objective: The objective of this study was to compare international trends in pre-eclampsia rates and in overall pregnancy hypertension rates (including gestational hypertension, pre-eclampsia and eclampsia). Design: Population data (from birth and/or hospital records) on all women giving birth were available from Australia (two states), Canada (Alberta), Denmark, Norway, Scotland, Sweden and the USA (Massachusetts) for a minimum of 6 years from 1997 to 2007. All countries used the 10th revision of the International Classification of Diseases, except Massachusetts which used the 9th revision. There were no major changes to the diagnostic criteria or methods of data collection in any country during the study period. Population characteristics as well as rates of pregnancy hypertension and pre-eclampsia were compared. Results: Absolute rates varied across the populations as follows: pregnancy hypertension (3.6% to 9.1%), pre-eclampsia (1.4% to 4.0%) and early-onset preeclampsia (0.3% to 0.7%). Pregnancy hypertension and/or pre-eclampsia rates declined over time in most populations. This was unexpected given that factors associated with pregnancy hypertension such as prepregnancy obesity and maternal age are generally increasing. However, there was also a downward shift in gestational age with fewer pregnancies reaching 40 weeks. Conclusion: The rate of pregnancy hypertension and pre-eclampsia decreased in northern Europe and Australia from 1997 to 2007, but increased in Massachusetts. The use of a different International Classification of Diseases coding version in Massachusetts may contribute to the difference in trend. Elective delivery prior to the due date is the most likely explanation for the decrease observed in Europe and Australia. Also, the use of interventions that reduce the risk of pregnancy hypertension and/or progression to pre-eclampsia (low-dose aspirin, calcium supplementation and early delivery for mild hypertension) may have contributed to the decline
Genetic architecture of subcortical brain structures in 38,851 individuals
- Author
- Abramovic Lucija
- Adams Hieab H. H.
- Agartz Ingrid
- Alhusaini Saud
- Ames David
- Amin Najaf
- Amouyel Philippe
- Andersson Micael
- Andreassen Ole A.
- Arfanakis Konstantinos
- Arias-Vasquez Alejandro
- Aribisala Benjamin S.
- Armstrong Nicola J.
- Assareh Amelia A.
- Athanasiu Lavinia
- Axelsson Tomas
- Bastin Mark E.
- Becker Diane M.
- Becker James T.
- Beiser Alexa S.
- Bennett David A.
- Bernard Manon
- Bis Joshua C.
- Bohlken Marc M.
- Boks Marco P.
- Boomsma Dorret
- Bralten Janita
- Brodaty Henry
- Brouwer Rachel M.
- Brunner Han G.
- Buckner Randy L.
- Buitelaar Jan K.
- Bulayeva Kazima B.
- Burkhardt Ralph
- Cahn Wiepke
- Calhoun Vince D.
- Carmichael Owen
- Cavalleri Gianpiero L.
- Chakravarty M. Mallar
- Chauhan Ganesh
- Chen Christopher
- Chen Qiang
- Cheng Ching-Yu
- Cheung Joshua W.
- Ching Christopher R. K.
- Cichon Sven
- Crespo-Facorro Benedicto
- Crivello Fabrice
- Cuellar-Partida Gabriel
- Dale Anders M.
- Davies Gareth E.
- de Geus Eco J. C.
- De Jager Philip L.
- de Zubicaray Greig
- Deary Ian J.
- Debette Stephanie
- DeCarli Charles
- Delanty Norman
- den Braber Anouk
- Depondt Chantal
- Desrivieres Sylvane
- DeStefano Anita L.
- Djurovic Srdjan
- Ehrlich Stefan
- Eicher John D.
- Erk Susanne
- Espeseth Thomas
- Fedko Iryna O.
- Fernandez Guilln
- Filippi Irina
- Fisher Simon E.
- Fleischman Debra A.
- Fletcher Evan
- Fornage Myriam
- Foroud Tatiana M.
- Francks Clyde
- Franke Barbara
- Giddaluru Sudheer
- Goldman Aaron L.
- Gollub Randy L.
- Grabe Hans J.
- Green Robert C.
- Greve Douglas N.
- Grimm Oliver
- Groenewold Nynke A.
- Gruber Oliver
- Guadalupe Tulio
- Gudnason Vilmundur
- Haberg Asta K.
- Hagenaars Saskia P.
- Hansell Narelle K.
- Harris Tamara B.
- Hartman Catharina A.
- Haukvik Unn K.
- Hegenscheid Katrin
- Heinz Andreas
- Hernandez Maria C. Valdes
- Heslenfeld Dirk J.
- Hibar Derrek P.
- Hilal Saima
- Himali Jayandra J.
- Ho Beng-Choon
- Hoehn David
- Hoekstra Pieter J.
- Hofer Edith
- Hoffmann Wolfgang
- Hofman Albert
- Holmes Avram J.
- Holsboer Florian
- Homuth Georg
- Hoogman Martine
- Hosten Norbert
- Hottenga Jouke-Jan
- Hu Yanhui
- Huentelman Matthew
- Ikram M. Arfan
- Ikram M. Kamran
- Ipser Jonathan C.
- Jack Clifford R. Jr.
- Jahanshad Neda
- Janowitz Deborah
- Jia Tianye
- Jian Xueqiu
- Johnson Andrew D.
- Jones Hannah J.
- Jonsson Erik G.
- Kahn Rene S.
- Kanai Ryota
- Kasperaviciute Dalia
- Kim Sungeun
- Klein Marieke
- Kloszewska Iwona
- Knol Maria J.
- Koen Nastassja
- Koh Jia Yu
- Kraemer Bernd
- Kwok John B. J.
- Launer Lenore J.
- Lawrie Stephen M.
- Le Hellard Stephanie
- Lee Phil H.
- Lee Tom
- Lemaitre Herve
- Li Shuo
- Liewald David C. M.
- Lin Honghuang
- Loeffler Markus
- Longstreth William T. Jr.
- Loohuis Loes M. Olde
- Lopez Oscar L.
- Lovestone Simon
- Luciano Michelle
- Macare Christine
- Maillard Pauline
- Marquand Andre F.
- Martin Nicholas G.
- Martinot Jean-Luc
- Masouleh Shahrzad Kharabian
- Matarin Mar
- Mather Karen A.
- Mattay Venkata S.
- Mattheisen Manuel
- Mazoyer Bernard
- McIntosh Andrew M.
- McMahon Katie L.
- Mecocci Patrizia
- Medland Sarah E.
- Melle Ingrid
- Meyer-Lindenberg Andreas
- Milaneschi Yuri
- Mirza-Schreiber Nazanin
- Mohnke Sebastian
- Montgomery Grant W.
- Mosley Thomas H.
- Muehleisen Thomas W.
- Mueller-Myhsok Bertram
- Nauck Matthias
- Nhat Trung Doan
- Nho Kwangsik
- Niessen Wiro J.
- Noethen Markus M.
- Nyberg Lars
- Nyquist Paul A.
- Oosterlaan Jaap
- Ophoff Roel A.
- Pandolfo Massimo
- Papmeyer Martina
- Paus Tomas
- Pausova Zdenka
- Penninx Brenda W. J. H.
- Pike G. Bruce
- Pol Hilleke E. Hulshoff
- Potkin Steven G.
- Psaty Bruce M.
- Puetz Benno
- Rentera Miguel E.
- Reppermund Simone
- Richards Jennifer S.
- Rietschel Marcella
- Risacher Shannon L.
- Roffman Joshua L.
- Roiz-Santianez Roberto
- Romanczuk-Seiferth Nina
- Rommelse Nanda
- Roshchupkin Gennady
- Rotter Jerome
- Saba Yasaman
- Sachdev Perminder S.
- Saemann Philipp G.
- Saremi Arvin
- Sargurupremraj Muralidharan
- Satizabal Claudia L.
- Saykin Andrew J.
- Schmaal Lianne
- Schmidt Helena
- Schmidt Reinhold
- Schofield Peter R.
- Scholz Markus
- Schork Andrew J.
- Schroeter Matthias L.
- Schumann Gunter
- Seshadri Sudha
- Shen Li
- Shin Jean
- Shulman Joshua M.
- Shumskaya Elena
- Simmons Andrew
- Singh Baljeet
- Sisodiya Sanjay M.
- Smith Albert
- Smith George Davey
- Smoller Jordan W.
- Soininen Hilkka
- Steen Vidar M.
- Stein Dan J.
- Stein Jason L.
- Stevens Allison
- Strike Lachlan T.
- Sussmann Jessika E.
- Teumer Alexander
- Thalamuthu Anbupalam
- Thompson Paul M.
- Toga Arthur W.
- Tordesillas-Gutierrez Diana
- Toro Roberto
- Tsolaki Magda
- Turner Jessica A.
- Tzourio Christophe
- Uitterlinden Andre G.
- van Bokhoven Hans
- van der Lee Sven J.
- van der Meer Dennis
- van der Wee Nic J. A.
- van Donkelaar Marjolein M. J.
- van Duijn Cornelia M.
- van Eijk Kristel R.
- van Erp Theo G. M.
- van Haren Neeltje E. M.
- van Rooij Daan
- van Tol Marie-Jose
- van't Ent Dennis
- Vellas Bruno
- Veltman Dick J.
- Vernooij Meike W.
- Villringer Arno
- Vinke Louis N.
- Voelzke Henry
- Walter Henrik
- Walton Esther
- Wardlaw Joanna M.
- Wassink Thomas H.
- Weinberger Daniel R.
- Weiner Michael W.
- Wen Wei
- Westlye Lars T.
- Westman Eric
- Whelan Christopher D.
- White Charles C.
- White Tonya
- Witte A. Veronica
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wong Tien Yin
- Wright Margaret J.
- Yanek Lisa R.
- Yang Jingyun
- Yang Qiong
- Zwiers Marcel P.
- Publication venue
- Ludwig-Maximilians-Universität München
- Publication date
- 01/01/2019
- Field of study
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease
Genetic architecture of subcortical brain structures in 38,851 individuals
- Author
- Abramovic Lucija
- Adams Hieab H. H.
- Agartz Ingrid
- Alhusaini Saud
- Ames David
- Amin Najaf
- Amouyel Philippe
- Andersson Micael
- Andreassen Ole A.
- Arfanakis Konstantinos
- Arias-Vasquez Alejandro
- Aribisala Benjamin S.
- Armstrong Nicola J.
- Assareh Amelia A.
- Athanasiu Lavinia
- Axelsson Tomas
- Bastin Mark E.
- Becker Diane M.
- Becker James T.
- Beiser Alexa S.
- Bennett David A.
- Bernard Manon
- Bis Joshua C.
- Bohlken Marc M.
- Boks Marco P.
- Boomsma Dorret I.
- Bralten Janita
- Brodaty Henry
- Brouwer Rachel M.
- Brunner Han G.
- Buckner Randy L.
- Buitelaar Jan K.
- Bulayeva Kazima B.
- Burkhardt Ralph
- Cahn Wiepke
- Calhoun Vince D.
- Carmichael Owen
- Cavalleri Gianpiero L.
- Chakravarty M. Mallar
- Chauhan Ganesh
- Chen Christopher
- Chen Qiang
- Cheng Ching-Yu
- Cheung Joshua W.
- Ching Christopher R. K.
- Cichon Sven
- Crespo-Facorro Benedicto
- Crivello Fabrice
- Cuellar-Partida Gabriel
- Dale Anders M.
- Davey Smith George
- Davies Gareth E.
- de Geus Eco J. C.
- De Jager Philip L.
- De Zubicaray Greig I.
- Deary Ian J.
- Debette Stéphanie
- Decarli Charles
- Delanty Norman
- Den Braber Anouk
- Depondt Chantal
- Desrivières Sylvane
- Destefano Anita L.
- Djurovic Srdjan
- Doan Nhat Trung
- Ehrlich Stefan
- Eicher John D.
- Erk Susanne
- Espeseth Thomas
- Fedko Iryna O.
- Fernández Guillén
- Filippi Irina
- Fisher Simon E.
- Fleischman Debra A.
- Fletcher Evan
- Fornage Myriam
- Foroud Tatiana M.
- Francks Clyde
- Franke Barbara
- Giddaluru Sudheer
- Goldman Aaron L.
- Gollub Randy L.
- Grabe Hans J.
- Green Robert C
- Greve Douglas N.
- Grimm Oliver
- Groenewold Nynke A.
- Gruber Oliver
- Guadalupe Tulio
- Gudnason Vilmundur
- Hagenaars Saskia P.
- Hansell Narelle K.
- Harris Tamara B.
- Hartman Catharina A.
- Haukvik Unn K.
- Hegenscheid Katrin
- Heinz Andreas
- Heslenfeld Dirk J.
- Hibar Derrek P.
- Hilal Saima
- Himali Jayandra J.
- Ho Beng-Choon
- Hoehn David
- Hoekstra Pieter J.
- Hofer Edith
- Hoffmann Wolfgang
- Hofman Albert
- Holmes Avram J.
- Holsboer Florian
- Homuth Georg
- Hoogman Martine
- Hosten Norbert
- Hottenga Jouke-Jan
- Hu Yanhui
- Huentelman Matthew
- Hulshoff Pol Hilleke E.
- Håberg Asta K.
- Ikram M. Arfan
- Ikram M. Kamran
- Ipser Jonathan C.
- Jack Clifford R.
- Jahanshad Neda
- Janowitz Deborah
- Jia Tianye
- Jian Xueqiu
- Johnson Andrew D.
- Jones Hannah J.
- Jönsson Erik G.
- Kahn René S.
- Kanai Ryota
- Kasperaviciute Dalia
- Kharabian Masouleh Shahrzad
- Kim Sungeun
- Klein Marieke
- Kloszewska Iwona
- Knol Maria J.
- Koen Nastassja
- Koh Jia Yu
- Kraemer Bernd
- Kwok John B. J.
- Launer Lenore J.
- Lawrie Stephen M.
- Le Hellard Stephanie
- Lee Phil H.
- Lee Tom V.
- Lemaître Hervé
- Li Shuo
- Liewald David C. M.
- Lin Honghuang
- Loeffler Markus
- Longstreth William T.
- Lopez Oscar L.
- Lovestone Simon
- Luciano Michelle
- Macare Christine
- Maillard Pauline
- Marquand Andre F.
- Martin Nicholas G.
- Martinot Jean-Luc
- Matarin Mar
- Mather Karen A.
- Mattay Venkata S.
- Mattheisen Manuel
- Mazoyer Bernard
- McIntosh Andrew M.
- McMahon Katie L.
- Mecocci Patrizia
- Medland Sarah E.
- Melle Ingrid
- Meyer-Lindenberg Andreas
- Milaneschi Yuri
- Mirza-Schreiber Nazanin
- Mohnke Sebastian
- Montgomery Grant W.
- Mosley Thomas H.
- Mühleisen Thomas W.
- Müller-Myhsok Bertram
- Nauck Matthias
- Nho Kwangsik
- Niessen Wiro J.
- Nyberg Lars
- Nyquist Paul A.
- Nöthen Markus M.
- Olde Loohuis Loes M.
- Oosterlaan Jaap
- Ophoff Roel A.
- Pandolfo Massimo
- Papmeyer Martina
- Paus Tomas
- Pausova Zdenka
- Penninx Brenda W. J. H.
- Pike G. Bruce
- Potkin Steven G.
- Psaty Bruce M.
- Pütz Benno
- Rentería Miguel E.
- Reppermund Simone
- Richards Jennifer S.
- Rietschel Marcella
- Risacher Shannon L.
- Roffman Joshua L.
- Roiz-Santiañez Roberto
- Romanczuk-Seiferth Nina
- Rommelse Nanda
- Roshchupkin Gennady V.
- Rotter Jerome I.
- Saba Yasaman
- Sachdev Perminder S.
- Saremi Arvin
- Sargurupremraj Muralidharan
- Satizabal Claudia L.
- Saykin Andrew J.
- Schmaal Lianne
- Schmidt Helena
- Schmidt Reinhold
- Schofield Peter R.
- Scholz Markus
- Schork Andrew J.
- Schroeter Matthias L.
- Schumann Gunter
- Seshadri Sudha
- Shen Li
- Shin Jean
- Shulman Joshua M.
- Shumskaya Elena
- Simmons Andrew
- Singh Baljeet
- Sisodiya Sanjay M.
- Smith Albert V.
- Smoller Jordan W.
- Soininen Hilkka
- Steen Vidar M.
- Stein Dan J.
- Stein Jason L.
- Stevens Allison
- Strike Lachlan T.
- Sussmann Jessika E.
- Sämann Philipp G.
- Teumer Alexander
- Thalamuthu Anbupalam
- Thompson Paul M.
- Toga Arthur W.
- Tordesillas-Gutierrez Diana
- Toro Roberto
- Tsolaki Magda
- Turner Jessica A.
- Tzourio Christophe
- Uitterlinden André G.
- Valdés Hernández Maria C.
- Van Bokhoven Hans
- Van Der Lee Sven J.
- van der Meer Dennis
- Van Der Wee Nic J. A.
- Van Donkelaar Marjolein M. J.
- Van Duijn Cornelia M.
- Van Eijk Kristel R.
- Van Erp Theo G. M.
- Van Haren Neeltje E. M.
- Van Rooij Daan
- Van Tol Marie-Jose
- van ‘t Ent Dennis
- Vellas Bruno
- Veltman Dick J.
- Vernooij Meike W.
- Villringer Arno
- Vinke Louis N.
- Völzke Henry
- Walter Henrik
- Walton Esther
- Wardlaw Joanna M.
- Wassink Thomas H.
- Weinberger Daniel R.
- Weiner Michael W.
- Wen Wei
- Westlye Lars T.
- Westman Eric
- Whelan Christopher D.
- White Charles C.
- White Tonya
- Witte A. Veronica
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wong Tien Yin
- Wright Margaret J.
- Yanek Lisa R.
- Yang Jingyun
- Yang Qiong
- Zwiers Marcel P.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease
Novel genetic loci underlying human intracranial volume identified through genome-wide association
- Author
- Abramovic Lucija
- Adams Hieab H H
- Agartz Ingrid
- Aggarwal Neelum T
- Alhusaini Saud
- Almasy Laura
- Ames David
- Amin Najaf
- Amouyel Philippe
- Andersson Micael
- Andreassen Ole A
- Arepalli Sampath
- Arfanakis Konstantinos
- Arias-Vasquez Alejandro
- Aribisala Benjamin S
- Armstrong Nicola J
- Assareh Amelia A
- Athanasiu Lavinia
- Axelsson Tomas
- Barral Sandra
- Bastin Mark E
- Becker Diane M
- Becker James T
- Beecham Ashley H
- Beiser Alexa
- Bennett David A
- Bernard Manon
- Bis Joshua C
- Blangero John
- Blanken Laura M E
- Blanton Susan H
- Bohlken Marc M
- Boks Marco P
- Boomsma Dorret I
- Braber Anouk Den
- Bralten Janita
- Brickman Adam M
- Brodaty Henry
- Brouwer Rachel M
- Brunner Han G
- Buckner Randy L
- Buitelaar Jan K
- Bulayeva Kazima B
- Cahn Wiepke
- Calhoun Vince D
- Cannon Dara M
- Carmichael Owen
- Cavalleri Gianpiero L
- Chakravarty M Mallar
- Chauhan Ganesh
- Chen Christopher
- Chen Qiang
- Cheng Ching-Yu
- Ching Christopher R K
- Chouraki Vincent
- Cichon Sven
- Cookson Mark R
- Corvin Aiden
- Crespo-Facorro Benedicto
- Cuellar-Partida Gabriel
- Curran Joanne E
- Czisch Michael
- Dale Anders M
- Davies Gareth E
- De Craen Anton J M
- De Geus Eco J C
- De Jager Philip L
- De Zubicaray Greig I
- Deary Ian J
- Debette Stéphanie
- Decarli Charles
- Delanty Norman
- Depondt Chantal
- Desrivières Sylvane
- Destefano Anita L
- Dillman Allissa
- Djurovic Srdjan
- Doan Nhat Trung
- Donohoe Gary
- Drevets Wayne C
- Duggirala Ravi
- Dyer Thomas D
- Ehrlich Stefan
- Erk Susanne
- Espeseth Thomas
- Evans Denis A
- Fedko Iryna O
- Fernández Guillén
- Ferrucci Luigi
- Filippi Irina
- Fisher Simon E
- Fleischman Debra A
- Ford Ian
- Fornage Myriam
- Foroud Tatiana M
- Fox Peter T
- Francks Clyde
- Franke Barbara
- Fukunaga Masaki
- Ge Tian
- Gibbs J Raphael
- Giddaluru Sudheer
- Glahn David C
- Goldman Aaron L
- Gollub Randy L
- Gottesman Rebecca F
- Grabe Hans J
- Green Robert C
- Greven Corina U
- Grimm Oliver
- Griswold Michael E
- Gruber Oliver
- Guadalupe Tulio
- Gudnason Vilmundur
- Guelfi Sebastian
- Göring Harald H H
- Hansell Narelle K
- Hardy John
- Hartman Catharina A
- Hashimoto Ryota
- Hass Johanna
- Haukvik Unn K
- Hegenscheid Katrin
- Heinz Andreas
- Hernandez Dena G
- Hernández Maria C Valdés
- Heslenfeld Dirk J
- Hibar Derrek P
- Hilal Saima
- Ho Beng-Choon
- Hoehn David
- Hoekstra Pieter J
- Hofer Edith
- Hoffmann Wolfgang
- Hofman Albert
- Holmes Avram J
- Holsboer Florian
- Homuth Georg
- Hoogman Martine
- Hosten Norbert
- Hottenga Jouke-Jan
- Ikeda Masashi
- Ikram M Arfan
- Ikram M Kamran
- Jack Clifford R
- Jahanshad Neda
- Janowitz Deborah
- Jenkinson Mark
- Jia Tianye
- Johnson Robert
- Jukema J Wouter
- Jönsson Erik G
- Kahn René S
- Kanai Ryota
- Kasperaviciute Dalia
- Kim Sungeun
- Klein Marieke
- Kloszewska Iwona
- Knopman David S
- Kochunov Peter
- Kraemer Bernd
- Kwok John B
- Launer Lenore J
- Lawrie Stephen M
- Le Hellard Stephanie
- Lee Phil H
- Lemaître Hervé
- Liao Jiemin
- Liewald David C M
- Liu Xinmin
- Longo Dan L
- Longstreth
- Loohuis Loes M Olde
- Lopez Lorna M
- Lopez Oscar L
- Lovestone Simon
- Luciano Michelle
- Macare Christine
- Maniega Susana Muñoz
- Marquand Andre
- Martin Nicholas G
- Martinez Oliver
- Martinot Jean-Luc
- Matarin Mar
- Mather Karen A
- Mattay Venkata S
- Mattheisen Manuel
- Mazoyer Bernard
- McDonald Colm
- McIntosh Andrew M
- McKay David R
- McMahon Francis J
- McMahon Katie L
- McWhirter Rebekah
- Mecocci Patrizia
- Medland Sarah E
- Melle Ingrid
- Meyer-Lindenberg Andreas
- Milaneschi Yuri
- Mirza-Schreiber Nazanin
- Mohnke Sebastian
- Montgomery Grant W
- Morris Derek W
- Mosley Thomas H
- Muetzel Ryan L
- Mühleisen Thomas W
- Müller-Myhsok Bertram
- Nalls Michael A
- Nauck Matthias
- Nho Kwangsik
- Nichols Thomas E
- Niessen Wiro J
- Nugent Allison C
- Nyberg Lars
- Nyquist Paul A
- Nöthen Markus M
- Ohi Kazutaka
- Olvera Rene L
- Oosterlaan Jaap
- Ophoff Roel A
- Pandolfo Massimo
- Papmeyer Martina
- Pappa Irene
- Paus Tomas
- Pausova Zdenka
- Penninx Brenda W J H
- Pike G Bruce
- Pirpamer Lukas
- Pol Hilleke E Hulshoff
- Potkin Steven G
- Psaty Bruce M
- Pudas Sara
- Pütz Benno
- Rajan Kumar B
- Ramasamy Adaikalavan
- Rentería Miguel E
- Reppermund Simone
- Richards Jennifer S
- Rietschel Marcella
- Risacher Shannon L
- Roffman Joshua L
- Roiz-Santiañez Roberto
- Romanczuk-Seiferth Nina
- Rommelse Nanda
- Rose Emma J
- Rotter Jerome I
- Royle Natalie A
- Rundek Tatjana
- Ryten Mina
- Sacco Ralph L
- Sachdev Perminder S
- Satizabal Claudia L
- Saykin Andrew J
- Schmaal Lianne
- Schmidt Helena
- Schmidt Reinhold
- Schofield Peter R
- Schork Andrew J
- Schumann Gunter
- Seshadri Sudha
- Shen Li
- Shin Jean
- Shumskaya Elena
- Sigurdsson Sigurdur
- Simmons Andy
- Singleton Andrew
- Sisodiya Sanjay M
- Smith Albert V
- Smith Colin
- Smoller Jordan W
- Soininen Hilkka
- Sprooten Emma
- Srikanth Velandai
- Steen Vidar M
- Stein Jason L
- Stott David J
- Strike Lachlan T
- Sussmann Jessika E
- Sämann Philipp G
- Teumer Alexander
- Thalamuthu Anbupalam
- Thompson Paul M.
- Thomson Russell
- Tiemeier Henning
- Toga Arthur W
- Tordesillas-Gutierrez Diana
- Toro Roberto
- Trabzuni Daniah
- Traynor Bryan J
- Trompet Stella
- Troncoso Juan
- Turner Jessica A
- Tzourio Christophe
- Uitterlinden Andre G
- Vaidya Dhananjay
- Van Bokhoven Hans
- Van Der Brug Marcel
- Van Der Grond Jeroen
- Van Der Lee Sven J
- Van Der Lugt Aad
- Van Der Meer Dennis
- Van Der Wee Nic J A
- Van Donkelaar Marjolein M J
- Van Duijn Cornelia M
- Van Eijk Kristel R
- Van Erp Theo G M
- Van Haren Neeltje E M
- Van Rooij Daan
- Van Tol Marie-Jose
- Van't Ent Dennis
- Vardarajan Badri N
- Veltman Dick J
- Vernooij Meike W
- Völzke Henry
- Walter Henrik
- Walton Esther
- Wardlaw Joanna M
- Wassink Thomas H
- Weale Michael E
- Weinberger Daniel R
- Weiner Michael W
- Wen Wei
- Westlye Lars T
- Westman Eric
- Whelan Christopher D
- White Tonya
- Windham Beverly G
- Winkler Anderson M
- Wittfeld Katharina
- Woldehawariat Girma
- Wolf Christiane
- Wolfers Thomas
- Wong Tien Y
- Wright Clinton B
- Wright Margaret J
- Xu Bing
- Yanek Lisa R
- Yang Jingyun
- Zielke H Ronald
- Zijdenbos Alex
- Zonderman Alan B
- Zwiers Marcel P
- Publication venue
- Publication date
- 01/01/2016
- Field of study
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five novel loci for intracranial volume and confirmed two known signals. Four of the loci are also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (ρgenetic=0.748), which indicated a similar genetic background and allowed for the identification of four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, Parkinson’s disease, and enriched near genes involved in growth pathways including PI3K–AKT signaling. These findings identify biological underpinnings of intracranial volume and provide genetic support for theories on brain reserve and brain overgrowth
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H. H.
- Agartz Ingrid
- Alhusaini Saud
- Almeida Marcio A. A.
- Alnaes Dag
- Alvim Marina K. M.
- Ames David
- Amlien Inge K.
- Anderson Tim J.
- Andersson Micael
- Andreassen Ole A.
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J.
- Artiges Eric
- Ashley-Koch Allison
- Assareh Amelia A.
- Atkins Joshua R.
- Ayesa-Arriola Rosa
- Bastin Mark E.
- Baune Bernhard T.
- Beckham Jean C.
- Belger Aysenil
- Bernard Manon
- Bis Joshua C.
- Blangero John
- Boomsma Dorret I.
- Bralten Janita
- Brandt Christine L.
- Brodaty Henry
- Brouwer Rachel M.
- Brown Gregory G.
- Brunner Han G.
- Buckner Randy L.
- Buimer Elizabeth E. L.
- Buitelaar Jan K.
- Bulow Robin
- Burger Christian
- Bustillo Juan R.
- Cahn Wiepke
- Cairns Murray J.
- Calhoun Vince
- Cannon Dara M.
- Carr Vaughan J.
- Caseras Xavier
- Caspers Svenja
- Cavalleri Gianpiero L.
- Cendes Fernando
- Chakravarty Mallar
- Chen Qiang
- Cheung Joshua W.
- Ching Christopher R. K.
- Cichon Sven
- Colodro-Conde Lucia
- Corvin Aiden
- Couvy-Duchesne Baptiste
- Crespo-Facorro Benedicto
- Curran Joanne E.
- Dale Anders M.
- Dalrymple-Alford John C.
- Dalvie Shareefa
- Dannlowski Udo
- Davies Gareth E.
- de Araujo Tania K.
- de Geus Eco J. C.
- de Zubicaray Greig I.
- de Zwarte Sonja M. C.
- Deary Ian J.
- Debette Stephanie
- Decarli Charles
- Degenhardt Franziska
- Delanty Norman
- den Braber Anouk
- Dennis Michelle F.
- Depondt Chantal
- Desrivieres Sylvane
- Dietsche Bruno
- Djurovic Srdjan
- Doherty Colin P.
- Dohm Katharina
- Donohoe Gary
- Ehrlich Stefan
- Engelbrecht Hannah-Ruth
- Erk Susanne
- Espeseth Thomas
- Espiritu Ryan
- Fan Chun Chieh
- Fedko Iryna O.
- Fernandez Guillen
- Fisher Simon E.
- Flor Herta
- Foley Sonya F.
- Ford Judith M.
- Fornage Myriam
- Forstner Andreas J.
- Francks Clyde
- Franke Barbara
- Fukunaga Masaki
- Garijo Daniel
- Garrett Melanie E.
- Ge Tian
- Giddaluru Sudheer
- Gil Yolanda
- Glahn David C.
- Goldman Aaron L.
- Gollub Randy L.
- Gowland Penny A.
- Grabe Hans J.
- Grasby Katrina L.
- Green Melissa J.
- Green Robert C.
- Groenewold Nynke A.
- Grotegerd Dominik
- Gruber Oliver
- Gudnason Vilmundur
- Gurholt Tiril P.
- Gutman Boris A.
- Haberg Asta K.
- Hansell Narelle K.
- Hariri Ahmad R.
- Harris Mathew A.
- Harrison Marc B.
- Hartman Catharina A.
- Hashimoto Ryota
- Haswell Courtney C.
- Hauser Michael
- Hausler Alexander N.
- Heindel Walter
- Heinz Andreas
- Henskens Frans A.
- Herms Stefan
- Heslenfeld Dirk J.
- Hibar Derrek P.
- Hillegers Manon H. J.
- Ho Beng-Choon
- Ho New Fei
- Hoehn David
- Hoekstra Pieter J.
- Hofer Edith
- Hoffmann Per
- Hoffmann Wolfgang U.
- Holleran Laurena
- Holmes Avram J.
- Holsboer Florian
- Homuth Georg
- Hong L. Elliot
- Hoogman Martine
- Hopkins William D.
- Hosten Norbert
- Hottenga Jouke-Jan
- Ikeda Masashi
- Ikram M. Arfan
- Jack Clifford R.
- Jahanshad Neda
- Jang MiHyun
- Janowitz Deborah
- Jansen Andreas
- Jansen Iris E.
- Jernigan Terry L.
- Jia Tianye
- Jockwitz Christiane
- Jonsson Erik G.
- Kahn Rene S.
- Kanai Ryota
- Karama Sherif
- Kasperaviciute Dalia
- Kaufmann Tobias
- Kelly Sinead
- Kennedy Martin A.
- Kikuchi Masataka
- Kimbrel Nathan A.
- Kircher Tilo T. J.
- Klein Marieke
- Knapp Michael
- Knodt Annchen R.
- Kochunov Peter
- Kolskar Knut
- Koops Sanne
- Kramer Bernd
- Krug Axel
- Kwok John B. J.
- Lam Max
- Lancaster Thomas M.
- Launer Lenore
- Le Hellard Stephanie
- Lee Phil H.
- Lett Tristram A.
- Lewis Lindsay B.
- Lim Kelvin O.
- Lind Penelope A.
- Longstreth W. T.
- Loohuis Loes M. Olde
- Lopes-Cendes Iscia
- Lopez Oscar L.
- Loughland Carmel M.
- Luciano Michelle
- Luykx Jurjen J.
- Macciardi Fabio
- Marquand Andre F.
- Martin Nicholas G.
- Martinot Jean-Luc
- Martinot Marie-Laure Paillere
- Mathalon Daniel H.
- Mather Karen A.
- Mathias Samuel R.
- Mattay Venkata S.
- Matthews Sarah
- Mazoyer Bernard
- McDonald Colm
- McEwen Sarah C.
- McMahon Katie L.
- McMahon Mary Agnes B.
- Medland Sarah E.
- Melle Ingrid
- Melzer Tracy R.
- Meyer-Lindenberg Andreas
- Michie Patricia T.
- Milaneschi Yuri
- Mirza-Schreiber Nazanin
- Moreira Jose C. V.
- Morey Rajendra A.
- Morris Derek W.
- Mosley Thomas H.
- Mota Nina R.
- Mowry Bryan
- Mueller Bryon A.
- Mueller-Myhsok Bertram
- Muhleisen Thomas W.
- Najt Pablo
- Nakahara Soichiro
- Nauck Matthias
- Nhat Trung Doan
- Nho Kwangsik
- Noethen Markus M.
- Nordvik Jan E.
- Nyberg Lars
- O'Leary Daniel S.
- Oosterlaan Jaap
- Opel Nils
- Ophoff Roel A.
- Orfanos Dimitri Papadopoulos
- Painter Jodie N.
- Pantelis Christos
- Paus Tomas
- Pausova Zdenka
- Pearson John F.
- Penninx Brenda W. J. H.
- Pike G. Bruce
- Pitcher Toni L.
- Pizzagalli Fabrizio
- Pol Hilleke E. Hulshoff
- Polderman Tinca J. C.
- Posthuma Danielle
- Preda Adrian
- Putz Benno
- Quide Yann
- Quinlan Erin B.
- Ragothaman Anjanibhargavi
- Rashid Faisal M.
- Rasser Paul E.
- Ratnakar Varun
- Reay William R.
- Redlich Ronny
- Reinbold Celine S.
- Reppermund Simone
- Repple Jonathan
- Richard Genevieve
- Riedel Brandalyn C.
- Rietschel Marcella
- Risacher Shannon L.
- Rocha Cristiane S.
- Roffman Joshua L.
- Roshchupkin Gennady V.
- Rowland Laura M.
- Sachdev Perminder S.
- Salminen Lauren
- Samann Philipp G.
- Saremi Arvin
- Satizabal Claudia L.
- Saykin Andrew J.
- Schall Ulrich
- Schlag Fenja
- Schmaal Lianne
- Schmidt Reinhold
- Schofield Peter R.
- Schumann Gunter
- Scott Rodney J.
- Secolin Rodrigo
- Seshadri Sudha
- Shapland Chin Yang
- Shatokhina Natalia
- Shen Li
- Shin Jean
- Shumskaya Elena
- Sim Kang
- Sisodiya Sanjay M.
- Smoller Jordan W.
- Sommer Iris E.
- Sonderby Ida E.
- Sprooten Emma
- St Pourcain Beate
- Steen Vidar M.
- Stein Dan J.
- Stein Jason L.
- Strike Lachlan T.
- Tansey Katherine E.
- Teumer Alexander
- Thalamuthu Anbupalam
- Thomopoulos Sophia I.
- Thompson Paul M.
- Toga Arthur W.
- Tooney Paul A.
- Tordesillas-Gutierrez Diana
- Torres Fabio R.
- Trollor Julian N.
- Turner Jessica A.
- Uhlmann Anne
- Vallerga Costanza L.
- van der Meer Dennis
- Van der Wee Nic J. A.
- van Donkelaar Marjolein M. J.
- van Eijk Liza
- van Erp Theo G. M.
- van Haren Neeltje E. M.
- van Rooij Daan
- Van Son Jaqueline Mayoral
- van Tol Marie-Jose
- van't Ent Dennis
- Veldink Jan H.
- Veltman Dick J.
- Verhoef Ellen
- Volzke Henry
- Voyvodic James T.
- Walter Henrik
- Walton Esther
- Wang Mingyuan
- Wang Yunpeng
- Wardlaw Joanna M.
- Weber Bernd
- Weinberger Daniel R.
- Wen Wei
- Westlye Lars T.
- Whelan Christopher D.
- Whelan Robert
- White Tonya
- Witt Stephanie H.
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wright Margaret J.
- Wu Jing Qin
- Yamamori Hidenaga
- Yang Qiong
- Yasuda Clarissa L.
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H.
- Zsembik Leo C. P.
- Zwiers Marcel P.
- Publication venue
- Ludwig-Maximilians-Universität München
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
- Ciullo Marina
- Clark Graeme R
- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
- Cochran Barbara
- Cole Shelley
- Colhoun Helen
- Colhoun Helen M
- Collins Francis S
- Collins Rory
- Connell John M
- Cooper Cyrus
- Cooper Jackie A
- Cooper Matthew N
- Cooper Richard S
- Coresh Josef
- Cornelis Marilyn C
- Corre Tanguy
- Corsi Anna Maria
- Couper David
- Cousminer Diana L
- Coviello Andrea D
- Cox David
- Crawford Dana
- Crisponi Laura
- Croteau-Chonka Damien C
- Cucca Francesco
- Cummings Steven R
- Cupples Adrienne L
- Cupples L Adrienne
- Curhan Gary
- d'Adamo Pio
- Dahgam Santosh
- Dailiana Zoe
- Danesh John
- Danoy Patrick
- Dastani Zari
- Davies Gail
- Daw E Warwick
- Day Felix R
- Day Ian N M
- de Andrade Mariza
- de Boer Ian H
- de Boer Rudolf A
- de Faire Ulf
- de Geus Eco J C
- Deary Ian J
- Dedoussis George
- Dedoussis George V
- Dedoussis George V Z
- Deelen Joris
- Deelman Ewa
- Dehghan Abbas
- Delgado Graciela
- Deloukas Panagiotis
- Deloukas Panos
- Demerath Ellen W
- Demirkan Ayse
- Demirkan Ayşe
- Den Hertog Heleen M
- Denniff Matthew
- Dennison Elaine M
- Dermitzakis Emmanouil T
- Deshmukh Harshal
- Deshmukh Harshal A
- Devuyst Olivier
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S
- Dimitriou Maria
- Ding Jingzhong
- Do Ron
- Dominiczak Anna F
- Doney Alex
- Dong Yanbin
- Donnelly Louise A
- Doumatey Ayo
- Dreisbach Albert W
- Drong Alexander W
- Duggan David
- Dumitrescu Logan
- Duncan Bruce B
- Duncan Emma L
- Dupuis Josee
- Dupuis Josée
- Durbin Richard
- Durda Peter
- Döring Angela
- Dörr Marcus
- Eastell Richard
- Easton Douglas F
- Ebrahim Shah
- Econs Michael J
- Edkins Sarah
- Egan Josephine
- Ehret Georg
- Eiriksdottir Gudny
- Eisman John A
- Eklund Niina
- El Mokhtari NourEddine
- Elks Cathy E
- Ellinghaus David
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Endlich Karlhans
- Epstein Stephen E
- Erbel Raimund
- Erdmann Jeanette
- Erdos Michael R
- Eriksson Joel
- Eriksson Johan
- Eriksson Niclas
- Eriksson Per
- Ernst Florian
- Esko Tonu
- Esko Tõnu
- Esko Tönu
- Estrada Karol
- Eury Elodie
- Evangelou Evangelos
- Evans Alun
- Evans David M
- Eyheramendy Susana
- Eyjolfsson Gudmundur Ingi
- Fagerholm Emma
- Falhammar Henrik
- Fall Tove
- Farrall Martin
- Fauser Bart C J M
- Fava Cristiano
- Feenstra Bjarke
- Fehrmann Rudolf
- Feitosa Mary
- Feranil Alan B
- Ferrannini Ele
- Ferrario Marco M
- Ferreira Teresa
- Ferreli Liana
- Ferrières Jean
- Ferrucci Luigi
- Fischer Krista
- Florez Jose C
- Folkersen Lasse
- Folsom Aaron R
- Fontanillas Pierre
- Ford Ian
- Fornage Myriam
- Foroud Tatiana
- Forouhi Nita G
- Forrester Terrence
- Forsblom Carol
- Foster Meredith C
- Fowke Jay
- Fowkes F Gerald R
- Fowkes Gerard R
- Fox Caroline S
- Fox Ervin R
- Franceschini Nora
- Franco Oscar H
- Franco-Cereceda Anders
- Franke Andre
- Franke Lude
- Franks Paul W
- Frants Rune
- Fraser Ross M
- Frayling Timothy M
- Freedman Barry I
- Freimer Nelson B
- Freitag Daniel F
- Friedrich Nele
- Froguel Philippe
- Frost Morten
- Fuchsberger Christian
- Galan Pilar
- Ganesh Santhi K
- Ganna Andrea
- Gansevoort Ron T
- Gao Xiaoyi
- Garcia Melissa
- Garcia-Giralt Natàlia
- Garnaas Maija
- Gasparini Paolo
- Gauguier Dominique
- Gaunt Tom R
- Gautvik Kaare M
- Geller Frank
- Gharavi Ali G
- Giedraitis Vilmantas
- Gieger Christian
- Gierman Hinco J
- Gigante Bruna
- Gill Geoffrey V
- Giroux Sylvie
- Giulianini Franco
- Glass Daniel
- Glazer Nicole
- Glazer Nicole L
- Glenn Kim
- Glorioso Nicola
- Go Alan S
- Go Min Jin
- Godson Catherine
- Goel Anuj
- Goessling Wolfram
- Golay Alain
- Goldstein Benjamin A
- Goltzman David
- Gong Jian
- González-Macías Jesús
- Goodall Alison H
- Goodarzi Mark O
- Goodloe Robert
- Gordin Daniel
- Gordon Scott D
- Gorski Mathias
- Grabe Hans-Jörgen
- Graff Misa
- Grallert Harald
- Grammer Tanja B
- Gravito Martha L
- Greenwood Celia M T
- Grewal Jagvir
- Grimsby Jonna
- Grobbee Diederick E
- Groop Leif
- Groop Per-Henrik
- Gross Myron
- Groves Christopher J
- Grundberg Elin
- Grässler Jürgen
- Gräßler Jürgen
- Gu Harvest F
- Gu Tianwei
- Guarrera Simonetta
- Gudbjartsson Daniel F
- Gudnason Villi
- Gudnason Vilmundur
- Guiducci Candace
- Guo Qun
- Guo Xiuqing
- Gurdasani Deepti
- Gustafsson Stefan
- Gyllensten Ulf
- Gyllensten Ulf B
- Hadjadj Samy
- Hadley David
- Haessler Jeff
- Hager Jörg
- Haiman Christopher
- Haines Jonathan
- Hall Alistair S
- Hall Per
- Hallan Stein
- Haller Toomas
- Hallmans Goran
- Hallmans Göran
- Hamsten Anders
- Han Bok-Ghee
- Hankinson Susan E
- Hanson Robert L
- Hardy Rebecca
- Haritunians Talin
- Harjutsalo Valma
- Harris Tamara
- Hartikainen Anna-Liisa
- Hartman Catharina A
- Hass Merli
- Hassanali Neelam
- Hassinen Maija
- Hastie Nicholas D
- Hastie Nick
- Hattersley Andrew T
- Haun Margot
- Havulinna Aki S
- Hayward Caroline
- Hazen Stanley L
- He Bing
- He Chunyan
- Heard-Costa Nancy L
- Heath Andrew C
- Heath Simon
- Heckbert Susan R
- Hedblad Bo
- Hedman Åsa K
- Heid Iris M
- Heikkilä Kauko
- Heikkilä Outi
- Heiss Gerardo
- Heliövaara Markku
- Helmer Catherine
- Helmer Quinta
- Henders Anjali K
- Henderson Brian
- Hengstenberg Christian
- Henneman Peter
- Hercberg Serge
- Herder Christian
- Hernandez Dena
- Hernandez Dena G
- Herrera Lizbeth
- Herzig Karl-Heinz
- Hicks Andrew A
- Hietala Kustaa
- Higashio Julia
- Hillege Hans L
- Hilton Gina
- Hindorff Lucia
- Hingorani Aroon
- Hirschhorn Joel N
- Hivert Marie-France
- Ho Weang K
- Hocking Lynne J
- Hoffmann Wolfgang
- Hofman Albert
- Holliday Elizabeth G
- Holm Hilma
- Holmen Oddgeir
- Homuth Georg
- Hopewell Jemma C
- Horikoshi Momoko
- Hosseini Mohsen
- Hottenga Jouke-Jan
- Hovingh G Kees
- Howard Philip
- Hsiung Chao Agnes
- Hsu Yi-Hsiang
- Hu Frank B
- Huang Huateng
- Huang Jinyan
- Hui Jennie
- Humphries Steve E
- Hundertmark Claudia
- Hung Yi-Jen
- Hunt Sarah E
- Hunt Steven C
- Hunter David J
- Husted Lise Bjerre
- Hveem Kristian
- Hwang Shih-Jen
- Hyppönen Elina
- Igl Wilmar
- Ikram M Arfan
- Illig Thomas
- Imboden Medea
- Ingelsson Erik
- Ingle Catherine
- Ingvarsson Thorvaldur
- Ioannidis John P A
- Iribarren Carlos
- Isaacs Aaron
- Isakova Tamara
- Islam Muhammad
- Ittermann Till
- Iwai Naoharu
- Jackson Anne U
- Jackson Rebecca
- Jacobs Gunnar
- Jafar Tazeen H
- James Alan L
- Jameson Karen A
- Jang Yangsoo
- Janipalli Charles S
- Jansen Hanneke
- Janssens A Cecile J W
- Jarvelin Marjo-Riitta
- Jeff Janina
- Jenny Nancy
- Johannsdottir Hrefna
- Johansen Berit
- Johansson Ingegerd
- Johansson Åsa
- Johnson Andrew
- Johnson Louise
- Johnson Paul C D
- Johnson Toby
- Jones Graeme
- Jones Michelle R
- Jousilahti Pekka
- Ju Sung Yun
- Jukema J Wouter
- Jula Antti
- Juliusdottir Thorhildur
- Justice Anne E
- Järvelin Marjo-Riitta
- Jöckel Karl-Heinz
- Kaakinen Marika
- Kahali Bratati
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- Witteman Jacqueline C M
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- Wolffenbuttel Bruce H R
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- Wong Tien Y
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- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
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- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- Alnæs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
- Artiges Eric
- Artiges Eric
- Ashley-Koch Allison
- Assaly Michele
- Assareh Amelia A
- Asthana Sanjay
- Atkins Joshua R
- Aydin Semiha
- Ayesa-Arriola Rosa
- Baca Marne
- Bachman David
- Banaschewski Tobias
- Barbot Alexis
- Barker Gareth
- Barone Paolo
- Bartha Rob
- Bartzokis George
- Bastin Mark E
- Bastin Mark E
- Bates Vernice
- Baune Bernhard T
- Becerra Mauricio
- Becker Andreas
- Becker James T
- Beckett Laurel
- Beckham Jean C
- Beiser Alexa S
- Belden Christine M
- Belger Aysenil
- Bell Karen L
- Berg Daniela
- Bergman Howard
- Bernard Manon
- Bernard Manon
- Bernick Charles
- Bernstein Matthew
- Beyer Frauke
- Bezivin-Frere Pauline
- Biondo Francesca
- Bis Joshua C
- Bis Joshua C
- Bishop Courtney
- Black Sandra
- Blangero John
- Blank Karen
- Bodge Courtney
- Bokde Arun
- Bonakdarpour Borna
- Boomsma Dorret I
- Borges-Neto Salvador
- Borowski Bret
- Borrie Michael
- Bralten Janita
- Brand Connie
- Brandabur Melanie
- Brandt Christine L
- Brewer James
- Brockington John
- Brodaty Henry
- Brodaty Henry
- Bromberg Uli
- Brooks David
- Brooks William M
- Brosch Jared R
- Brouwer Rachel M
- Brown Gregory G
- Bruehl Ruediger
- Brunner Han G
- Buckholtz Neil
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- Sämann Philipp G
- Sønderby Ida E
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- Tarawneh Rawan
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- Teumer Alexander
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- Thomas Cathi-Ann
- Thomopoulos Sophia I
- Thompson Paul
- Thompson Paul M
- Tingus Kathleen
- Tinklenberg Jared
- Todd Gretchen
- Toga Arthur
- Toga Arthur W
- Toga Arthur W
- Tolosa Eduardo
- Tooney Paul A
- Tordesillas-Gutiérrez Diana
- Torres Fábio R
- Tran Baochan
- Tremont Geoffrey
- Trncic Nadira
- Trojanowki John Q
- Trollor Julian
- Trollor Julian N
- Turner Jessica A
- Turner Raymond Scott
- Tzourio Christophe
- Uhlmann Anne
- Uitterlinden André G
- Ulysse Anaztasia
- Umek Robert
- Uribe Liz
- Vaishnavi Sanjeev
- Vallerga Costanza Ludovica
- van 't Ent Dennis
- van der Brug Marcel
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- van der Meer Dennis
- Van der Wee Nic J A
- van Donkelaar Marjolein M J
- van Duijn Cornelia M
- van Dyck Christopher H
- van Eijk Liza
- van Erp Theo G M
- van Haren Neeltje E M
- van Noort Betteke
- van Rooij Daan
- van Tol Marie-José
- Vanderswag Helen
- Varma Pradeep
- Veillette Suzanne
- Veldink Jan H
- Veltman Dick J
- Vemuri Prashanthi
- Venkov Heli
- Verhoef Ellen
- Vernooij Meike W
- Villena Teresa
- Villringer Arno
- Voyvodic James T
- Völker Uwe
- Völzke Henry
- Walter Henrik
- Walter Henrik
- Walter Sarah
- Walton Esther
- Wang Mingyuan
- Wang Yunpeng
- Ward Chad
- Wardlaw Joanna M
- Wardlaw Joanna M
- Weber Bernd
- Weinberger Daniel R
- Weiner Michael
- Weiner Michael W
- Weintraub Sandra
- Wen Wei
- Wen Wei
- Westlye Lars T
- Whelan Christopher D
- Whelan Robert
- Whelan Robert
- White Tonya
- Willeke Diana
- Williams Karen
- Williams Steve
- Wilson Renee
- Winkfield David
- Witbracht Megan
- Witt Stephanie H
- Witte A Veronica
- Wittfeld Katharina
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wolk David A
- Womack Kyle
- Wong Terence Z
- Woo Ellen
- Wright Margaret J
- Wright Margaret J
- Wu Chuang-Kuo
- Wu Jing Qin
- Wurster Isabel
- Xia Rui
- Yamamori Hidenaga
- Yanez Beatriz
- Yang Mia
- Yang Qiong
- Yang Qiong
- Yankey Jon
- Yasuda Clarissa L
- Yeh Randy
- Yesavage Jerome
- Zamrini Edward
- Zare Habil
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H
- Zimmerman Earl A
- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud Morad
- Aad Georges
- Abbott Brad
- Abdinov Ovsat
- Abeloos Baptiste
- Abidi Syed
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby
- Adachi Shunsuke
- Adamczyk Leszek
- Adelman Jahred
- Adersberger Michael
- Adye Tim
- Affolder Tony
- Afik Yoav
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akatsuka Shunichi
- Akerstedt Henrik
- Akilli Ece
- Akimov Andrei
- Alberghi Gian
- Albert Justin
- Albicocco Pietro
- Alconada Verzini Maria
- Alderweireldt Sara
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
- Aliev Malik
- Alimonti Gianluca
- Alison John
- Alkire Steven
- Allbrooke Benedict
- Allen Benjamin
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alshehri Azzah
- Alstaty Mahmoud
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazia
- Amadio Brian
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana
- Amoroso Simone
- Anastopoulos Christos
- Ancu Lucian
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders John
- Anderson Kelby
- Andreazza Attilio
- Andrei George
- Angelidakis Stylianos
- Angelozzi Ivan
- Angerami Aaron
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antel Claire
- Antonelli Mario
- Antonov Alexey
- Antrim Daniel
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan
- Araujo Ferraz Victor
- Arce Ayana
- Ardell Rose
- Arduh Francisco
- Arguin Jean-Francois
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron
- Armitage Lewis
- Arnaez Olivier
- Arnold Hannah
- Arratia Miguel
- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Artz Sebastian
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- Atlay Naim
- Augsten Kamil
- Avolio Giuseppe
- Axen Bradley
- Ayoub Mohamad
- Azuelos Georges
- Baas Alessandra
- Baca Matthew
- Bachacou Henri
- Bachas Konstantinos
- Backes Moritz
- Bagnaia Paolo
- Bahmani Marzieh
- Bahrasemani Sina
- Baines John
- Bajic Milena
- Baker Oliver
- Bakker Pepijn
- Baldin Evgenii
- Balek Petr
- Balli Fabrice
- Balunas William
- Banas Elzbieta
- Bandyopadhyay Anjishnu
- Banerjee Swagato
- Bannoura Arwa
- Barak Liron
- Barberio Elisabetta
- Barberis Dario
- Barbero Marlon
- Barillari Teresa
- Barisits Martin-Stefan
- Barkeloo Jason
- Barklow Timothy
- Barlow Nick
- Barnes Sarah
- Barnett Bruce
- Barnett Michael
- Barnovska-Blenessy Zuzana
- Baroncelli Antonio
- Barone Gaetano
- Barr Alan
- Barranco Navarro Laura
- Barreiro Guimarães da Costa João
- Barreiro Fernando
- Barros Vale Maria
- Bartoldus Rainer
- Barton Adam
- Bartos Pavol
- Basalaev Artem
- Bassalat Ahmed
- Bates Richard
- Batista Santiago
- Batley Richard
- Battaglia Marco
- Bauce Matteo
- Bauer Florian
- Bawa Harinder
- Beacham James
- Beattie Michael
- Beau Tristan
- Beauchemin Pierre-Hugues
- Bechtle Philip
- Beck Hans~Peter
- Beck Helge
- Becker Kathrin
- Becker Maurice
- Becot Cyril
- Beddall Andrew
- Beddall Ayda
- Bednyakov Vadim
- Bedognetti Matteo
- Bee Christopher
- Beermann Thomas
- Begalli Marcia
- Begel Michael
- Behr Janna
- Bell Andrew
- Bella Gideon
- Bellagamba Lorenzo
- Bellerive Alain
- Bellomo Massimiliano
- Belotskiy Konstantin
- Beltramello Olga
- Belyaev Nikita
- Benary Odette
- Benchekroun Driss
- Bender Michael
- Benekos Nektarios
- Benhammou Yan
- Benhar Noccioli Eleonora
- Benitez Jose
- Benjamin Douglas
- Benoit Mathieu
- Bensinger James
- Bentvelsen Stan
- Beresford Lydia
- Beretta Matteo
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- Dabrowski Wladyslaw
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- Dale Orjan
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- de Asmundis Riccardo
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- De Vasconcelos Corga Kevin
- De Vivie De Regie Jean-Baptiste
- De Kaushik
- Debbe Ramiro
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- Dehghanian Nooshin
- Deigaard Ingrid
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- Delgove David
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- della Volpe Domenico
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- Di Donato Camilla
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- Di Girolamo Beniamino
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- Drechsler Eric
- Dris Manolis
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- Duvnjak Damir
- Dyndal Mateusz
- Dziedzic Bartosz
- Díez Cornell Sergio
- Dührssen Michael
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- Eckardt Christoph
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- Ellajosyula Venugopal
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- Flowerdew Michael
- Forcolin Giulio
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- Forti Alessandra
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- Franchini Matteo
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- Fressard-Batraneanu Silvia
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- Gan Kk
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- Gingrich Douglas
- Giordani MarioPaolo
- Giorgi Filippo
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- Giromini Paolo
- Giugliarelli Gilberto
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- Gjelsten Børge
- Gkaitatzis Stamatios
- Gkialas Ioannis
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- Gladilin Leonid
- Glasman Claudia
- Glatzer Julian
- Glaysher Paul
- Glazov Alexandre
- Goblirsch-Kolb Maximilian
- Godlewski Jan
- Goldfarb Steven
- Golling Tobias
- Golubkov Dmitry
- Gomes Agostinho
- Goncalves Gama Rafael
- Goncalves Pinto Firmino Da Costa Joao
- Gonella Giulia
- Gonella Laura
- Gongadze Alexi
- Gonnella Francesco
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- Gonzalez-Sevilla Sergio
- González de la Hoz Santiago
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- Goossens Luc
- Gorbounov Petr
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- Gorini Benedetto
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- Gorišek Andrej
- Goshaw Alfred
- Gostkin Mikhail
- Gottardo Carlo
- Goudet Christophe
- Goujdami Driss
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- Govender Nicolin
- Gozani Eitan
- Grabowska-Bold Iwona
- Gradin Per
- Gramling Johanna
- Gramstad Eirik
- Grancagnolo Sergio
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- Gravila Paul
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- Gray Heather
- Greenwood Zeno
- Grefe Christian
- Gregersen Kristian
- Gregor Ingrid-Maria
- Grenier Philippe
- Grevtsov Kirill
- Griffiths Justin
- Grillo Alexander
- Grimm Kathryn
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- Gris Philippe
- Grivaz Jean-Francois
- Groh Sabrina
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- Grout Zara
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- Gueta Orel
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- Guido Elisa
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- Guindon Stefan
- Gul Umar
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- Guo Jun
- Guo Wen
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- Gupta Ruchi
- Gurbuz Saime
- Gustavino Giuliano
- Gutelman Benjamin
- Gutierrez Ortiz Nicolas
- Gutierrez Phillip
- Gutschow Christian
- Guyot Claude
- Guzik Marcin
- Gwenlan Claire
- Gwilliam Carl
- Gössling Claus
- Haas Andy
- Haber Carl
- Hadavand Haleh
- Haddad Nacim
- Hadef Asma
- Hageböck Stephan
- Hagihara Mutsuto
- Hakobyan Hrachya
- Haleem Mahsana
- Haley Joseph
- Halladjian Garabed
- Hallewell Gregory
- Hamacher Klaus
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- Hamity Guillermo
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- Hanawa Keita
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- Hawkings Richard
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- Hobbs John
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- Hodgkinson Mark
- Hodgson Paul
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- Hoeferkamp Martin
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- Hooberman Benjamin
- Hopkins Walter
- Horii Yasuyuki
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- Hostiuc Alexandru
- Hou Suen
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- Howarth James
- Hoya Joaquin
- Hrabovsky Miroslav
- Hrdinka Julia
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- Hrivnac Julius
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- Hrynevich Aliaksei
- Hsu Pai-hsien
- Hsu Shih-Chieh
- Hu Qipeng
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- Huang Yanping
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- Hubaut Fabrice
- Huegging Fabian
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- Huhtinen Mika
- HUNTER Robert
- Huo Peng
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- Huston Joey
- Huth John
- Hyneman Rachel
- Iacobucci Giuseppe
- Iakovidis Georgios
- Ibragimov Iskander
- Iconomidou-Fayard Lydia
- Idrissi Zineb
- Iengo Paolo
- Igonkina Olga
- Iizawa Tomoya
- Ikegami Yoichi
- Ikeno Masahiro
- Ilchenko Yuriy
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- Iordanidou Kalliopi
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- Ishitsuka Masaki
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- Istin Serhat
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- Iturbe Ponce Julia
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- Izen Joseph
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- Jarlskog Göran
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- Ji Haoshuang
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- Jinnouchi Osamu
- Jivan Harshna
- Johansson Per
- Johns Kenneth
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- Jones Roger
- Jones Samuel
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- Jones Tim
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- Jézéquel Stéphane
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- Kaluza Adam
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- Kaplan Benjamin
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- Kasahara Kota
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- Kawamoto Tatsuo
- Kawamura Gen
- Kay Ellis
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- Kendrick James
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- Khubua Jemal
- Kido Shogo
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- Kim Hee
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- Kind Oliver
- King Barry
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- Weingarten Jens
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- Yamatani Masahiro
- Yamazaki Tomohiro
- Yamazaki Yuji
- Yan Zhen
- Yang Haijun
- Yang Hongtao
- Yang Yi
- Yang Zongchang
- Yao Weiming
- Yap Yee
- Yasu Yoshiji
- Yatsenko Elena
- Yau Wong Kaven
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- Ye Shuwei
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- Yu Jie
- Yuen Stephanie
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- Zaidan Remi
- Zaitsev Alexander
- Zakharchuk Nataliia
- Zalieckas Justas
- Zaman Aungshuman
- Zambito Stefano
- Zanzi Daniele
- Zeitnitz Christian
- Zemaityte Gabija
- Zemla Andrzej
- Zeng Jian
- Zeng Qi
- Zenin Oleg
- Zerwas Dirk
- Zhang Dengfeng
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Guangyi
- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Liqing
- Zhang Matt
- Zhang Peng
- Zhang Rui
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Yu
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhou You
- Zhu Cheng
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Åkesson Torsten
- Šfiligoj Tina
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
- Author
- Abecasis Goncalo
- Abecasis Gonçalo R.
- Aben Katja K.
- Absher Devin
- Aherrahrou Zouhair
- Ahlqvist Emma
- Ahmadi Kourosh
- Ahmed Nabeel
- Alavere Helene
- Alibrandi Maria T S
- Allayee Hooman
- Almgren Peter
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Ardissino Diego
- Ardlie Kristin
- Armitage Jane
- Arnold Alice M.
- Aspelund Thor
- Assimes Themistocles L.
- Assmann Gerd
- Atwood Larry D.
- Aulchenko Yurii S.
- Azhar Muhammad
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Barbalic Maja
- Barker Adam
- Barker David J P
- Barlassina Christina
- Barlera Simona
- Barnes Daniel
- Barnes Timothy A.
- Barrett Amy
- Barroso H
- Barroso Inês
- Bataille Veronique
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Beilby John P.
- Ben-Shlomo Yoav
- Benediktsson Rafn
- Bennett Amanda J.
- Berger Klaus
- Bergman Richard N.
- Bergmann Sven
- Bernd Sonja I.
- Berndt Sonja I
- Biebermann Heike
- Bis Joshua C.
- Blagieva Roza
- Blakemore Alexandra I F
- Blankenberg Stefan
- Boehm Bernhard O.
- Boehnke Michael
- Boehnke Mike
- Boeing Heiner
- Boekholdt S. Matthijs
- Boerwinkle Eric
- Boes Tanja
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borecki Ingrid B.
- Bornstein Stefan R.
- Boström Kristina Bengtsson
- Bouatia-Naji Nabila
- Bowman Louise
- Bragi Walters G.
- Braund Peter S.
- Bravenboer Bert
- Brown Morris J.
- Buchanan Thomas A.
- Bumpstead Suzannah
- Burnett Mary Susan
- Burtt Noisël P.
- Busonero Fabio
- Buysschaert Ian
- Cambien Francois
- Campbell Harry
- Cappuccio Francesco P.
- Cardiogenics [Unknown]
- Carlquist John F.
- Cauchi Stephane
- Caulfield Mark
- Cavalcanti-Proença Christine
- Chambers John C.
- Chanock Stephen J.
- Charpentier Guillaume
- Chasman Daniel I.
- Chatterjee Nilanjan
- Chen Chih Mei
- Chen Han
- Chen Li
- Chines Peter S.
- Cichon Sven
- Clarke Robert
- Codd Veryan
- Coin Lachlan
- Collins Francis S.
- Collins Rory
- Connell John
- Cooper Cyrus C.
- Cooper Matthew N.
- Cornelis Marilyn
- Couper David J.
- Crawford Gabe
- Cupples L. Adrienne
- Daly Mark J.
- Danesh John
- Davies Robert W.
- Day Ian N M
- de Faire Ulf
- Dedoussis George
- Dehghan Abbas
- Deloukas Panos
- Demissie Serkalem
- den Heijer Martin
- Dennison Elaine M.
- Dermitzakis Emmanouil T.
- Devaney Joseph M.
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S.
- Dina Christian
- Dixon Anna L.
- Do Ron
- Doering Angela
- Doney Alex S F
- Donnelly Peter
- Dorret I Boomsma
- Duan Jubao
- Dupuis Josée
- Durbin Richard
- Ebrahim Shah
- Eifert Sandra
- Eiriksdottir Gudny
- El Mokhtari Nour Eddine
- Elliott Amanda L.
- Elliott Katherine S.
- Elliott Paul
- Ellis Stephen G.
- Elosua Roberto
- Engert James C.
- Epstein Stephen E.
- Erdmann Jeanette
- Erdos Michael R.
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- Eriksson Johan G.
- Eriksson Per
- Esko Tõnu
- Estrad Karol
- Estrada Karol
- Eury Elodie
- Facheris Maurizio F.
- Farooqi I. Sadaf
- Farrall Martin
- Feitosa Mary F.
- Felix Stephan B.
- Ferrannini Ele
- Ferreir Teresa
- Ferreira Teresa
- Fischer Marcus
- Fischer-Posovszky Pamela
- Fisher Eva
- Florez Jose C.
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- Forsen Tom J.
- Fox Caroline S.
- Franklin Christopher S.
- Franzosi Maria Grazia
- Frayling Timothy M.
- Freimer Nelson B.
- Freyer Jennifer
- Friedrich Nele
- Froguel Philippe
- Frossard Philippe
- Fu Mao
- Gaget Stefan
- Ganser Martha
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- Gieger Christian
- Gigante Bruna
- Girelli Domenico
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- Glass Daniel
- Glazer Nicole L.
- Gloyn Anna L.
- Goddard Michael E.
- Goel Anuj
- Goodall Alison H.
- Goyette Philippe
- Grallert Harald
- Grarup Niels
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- Green Todd
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- Gretarsdottir Solveig
- Griffin Simon
- Groop Leif
- Groop Leif C.
- Groves Christopher J.
- Grundberg Elin
- Gräßler Jürgen
- Grönberg Henrik
- Gu Harvest
- Gudnason Vilmundur
- Guiducci Candace
- Gulcher Jeffrey R.
- Gustafsso Stefan
- Gustafsson Stefan
- Gyllensten Ulf
- Hadjadj Samy
- Hall Alistair S.
- Hall Per
- Halperin Eran
- Hammond Christopher J.
- Hammond Naomi
- Hamsten Anders
- Han Chen
- Hansen Torben
- Haritunians Talin
- Harris Tamara B.
- Hartikainen Anna Liisa
- Hassanali Neelam
- Hattersley Andrew T.
- Havulinna Aki S.
- Hayes Richard B.
- Hayward Caroline
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- Heath Andrew C.
- Hebebrand Johannes
- Hedman Åsa K.
- Hei Iris M.
- Heid Iris M
- Heinrich Joachim
- Hellénius Mai Lis
- Hengstenberg Christian
- Herder Christian
- Hicks Andrew A.
- Hide Winston A.
- Hinney Anke
- Hirschhorn Joel N.
- Hitman Graham A.
- Hoesel Volker
- Hofman Albert
- Hofmann Oliver M.
- Holm Hilma
- Homuth Georg
- Hopewell Jemma C.
- Horikoshi Momoko
- Horne Benjamin D.
- Hottenga Jouke Jan
- Hu Frank B.
- Hui Jennie
- Huikuri Heikki V.
- Hunter David J.
- Huth Cornelia
- Hveem Kristian
- Ida Chen Yii Der
- Igl Wilmar
- Illig Thomas
- Ingelsson Erik
- Ingle Catherine
- Iribarren Carlos
- Ishaq Muhammad
- Isomaa Bo
- Jackso Anne U.
- Jackson Anne U.
- Jacobs Kevin B.
- James Alan L.
- Jameson Karen A.
- Jansson John Olov
- Jarick Ivonne
- Jarvelin Marjo Riitta
- Jewell Elizabeth
- Johansson Åsa
- John Ulrich
- Johnson Paul
- Johnson Paul R V
- Johnson Toby
- Jones Gregory T.
- Jousilahti Pekka
- Jukema J. Wouter
- Jula Antti
- Jørgensen Torben
- Kaakinen Marika
- Kaiser Michael A.
- Kajantie Eero
- Kanoni Stavroula
- Kao Wen H L
- Kaplan Lee M.
- Kaplan Robert C.
- Kaprio Jaakko
- Karpe Fredrik
- Kastelein John J P
- Kathiresan Sekar
- Kerr-Conte Julie
- Ketkar Shamika
- Kettunen Johannes
- Khaw Kay Tee
- Kiemeney Lambertus A.
- Kilpeläine Tuomas O.
- Kilpeläinen Tuomas O
- Kinnunen Leena
- Klopp Norman
- Knowles Joshua W.
- Kolcic Ivana
- Kolovou Genovefa
- Kong Augustine
- Kooner Angad S.
- Kooner Jaspal S.
- Koskinen Seppo
- Kovacs Peter
- Kraft Peter
- Krude Heiko
- Kutalik Zoltán
- Kuulasmaa Teemu
- Kuusisto Johanna
- Kvaløy Kirsti
- Kyriakou Theodosios
- Kähönen Mika
- König Inke R.
- Laakso Markku
- Laaksonen Reijo
- Laitinen Jaana
- Lambrechts Diether
- Lamina Claudia
- Langenberg Claudia
- Lango Allen Hana
- Lantieri Olivier
- Lanzani Chiara
- Launer Lenore J.
- Lauritzen Torsten
- Lawlor Debbie A.
- Lawrence Robert W.
- Leander Karin
- Lecoeur Cecile
- Lehtimäki Terho
- Lettre Guillaume
- Levinson Douglas F.
- Li Man
- Li Mingyao
- Li Shengxu
- Lian Liming
- Liang Liming
- Lieb Wolfgang
- Lieverse Aloysius
- Lind Lars
- Lindgre Cecilia M.
- Lindgren Cecilia M.
- Linksted Pamela
- Liu Jianjun
- Lokki Marja Liisa
- Loley Christina
- Loos Ruth J F
- Lorentzon Mattias
- Lotery Andrew J.
- Lua Jian'an
- Luan Jian'an
- Luben Robert N.
- Ludwig Barbara
- Lyssenko Valeriya
- Macciardi Fabio
- MAGIC [Unknown]
- Makrilakis Konstantinos
- Mallick Nadeem
- Mangino Massimo
- Mannila Maria Nastase
- Manning Alisa K.
- Mannucci Pier M.
- Manunta Paolo
- Maouche Seraya
- Marek Diana
- Marre Michel
- Martin Nicholas G.
- Martinelli Nicola
- Martínez-Larrad María Teresa
- McArdle Wendy L.
- McCarroll Steve A.
- McCarroll Steven A.
- McCarthy Anne
- McCarthy Mark
- McCulloch Laura J.
- McKeown Pascal P.
- McKnight Barbara
- McPherson Ruth
- Meigs James B.
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Memon Fazal ur Rehman
- Merlini Pier Angelica
- Metspalu Andres
- Meyre David
- Midthjell Kristian
- Min Josine L.
- Moffatt Miriam F.
- Mohlke Karen L.
- Mond Keri L.
- Monda Keri L
- Montgomery Grant W.
- Montgomery Stephen B.
- Mooser Vincent
- Morgan Thomas
- Morken Mario A.
- Morris Andrew D.
- Morris Andrew P.
- Muhlestein Joseph B.
- Mulic Rosanda
- Munroe Patricia B.
- Musunuru Kiran
- Myers Richard H.
- Mäg Reedik
- Mägi Reedik
- Mälarstig Anders
- März Winfried
- Mühleisen Thomas W.
- Münzel Thomas
- Nahrstaedt Janja
- Narisu Narisu
- Navarro Pau
- Nelis Mari
- Nelson Christopher P.
- Nemes James
- Nemesh James
- Nestle Frank O.
- Neville Matt J.
- Ngwa Julius S.
- Nica Alexandra C.
- Nieminen Markku S.
- Nilesh J Samani
- Nilsson Peter
- Nisbet James
- North Kari E.
- Nyholt Dale R.
- Nöthen Markus M.
- O'Connell Jeffrey R.
- O'Donnel Christopher J.
- O'Donnell Christopher J.
- O'Rahilly Stephen
- O'Rahilly Steve
- Offer Alison
- Ohlsson Claes
- Ohrvik John
- Olivieri Oliviero
- Olsson Gunnar
- Ong Ken K.
- Ongen Halit
- Oostra Ben
- Osmond Clive
- Ostenson Claes-Göran
- Ouwehand Willem H.
- Owen Katharine R.
- Palmer Colin N A
- Palmer Lyle J.
- Pankow James S.
- Par Ju Hyun
- Parish Sarah
- Park Ju-Hyun
- Parker Alex N.
- Parts Leopold
- Paré Guillaume
- Pascoe Laura
- Patel Riyaz S.
- Patterson Chris C.
- Pattou François
- Payne Felicity
- Peden John F.
- Pedersen Oluf
- Pellikka Niina
- Peltonen Leena
- Penninx Brenda W.
- Perola Markus
- Perry John R B
- Peter M Visscher
- Peters Annette
- Peters Marjolein J.
- Petersen Ann Kristin
- Peto Richard
- Petrie John R.
- Peyvandi Flora
- Pichler Irene
- Pietiläinen Kirsi H.
- Platou Carl
- Platou Carl G P
- Polasek Ozren
- Potter Simon
- Pouta Anneli
- Pramstaller Peter P.
- Preuss Michael
- Proença Christine
- Prokopenko Inga
- Purcell Shaun
- Qi Lu
- Qu Liming
- Quertermous Thomas
- Quyyumi Arshed A.
- Rader Daniel J.
- Rafelt Suzanne
- Raitakari Olli
- Rallidis Loukianos S.
- Randal Joshua C.
- Randall Joshua C
- Rasheed Asif
- Rathmann Wolfgang
- Raychaudhuri Soumya
- Rayner N. William
- Rayner Nigel W.
- Reilly Muredach P.
- Reinehr Thomas
- Rice Catherine
- Ridderstråel Martin
- Ridderstråle Martin
- Ridker Paul M.
- Rief Winfried
- Ripatti Samuli
- Rissanen Aila
- Rivadeneira Fernando
- Roberts Robert
- Robertson Neil R.
- Rocheleau Ghislain
- Roden Michael
- Rosendaal Frits R.
- Rubin Diana
- Rudan Igor
- Ruokonen Aimo
- Rust Stephan
- Rybin Denis
- Rzehak Peter
- Ríos Manuel Serrano
- Sabater-Lleal Maria
- Saleheen Danish
- Salomaa Veikko
- Samad Adbus
- Samani Nilesh
- Sampietro M. Lourdes
- Sampson Michael J.
- Samuel Maria
- Sanders Alan R.
- Sandholt Camilla
- Sandhu Manj S.
- Sandhu Manjinder S.
- Sanna Serena
- Saramies Jouko
- Savolainen Markku J.
- Saxena Richa
- Sayer Avan A.
- Schadt Eric
- Scherag Andre
- Scherag Susann
- Schillert Arne
- Schipf Sabine
- Schlessinger David
- Schreiber Stefan
- Schrezenmeir Jürgen
- Schunkert Heribert
- Schwartz Stephen M.
- Schwarz Peter E H
- Schäfer Arne
- Scott James
- Scott Laura J.
- Seedorf Udo
- Segrè Ayellet V.
- Sehmi Joban
- Sekowska Magdalena
- Sennblad Bengt
- Shah Nabi
- Shaun Purcell
- Shi Jianxin
- Shields Beverley M.
- Shrader Peter
- Shuldiner Alan R.
- Sigurdsson Gunnar
- Sijbrands Eric
- Silander Kaisa
- Silveira Angela
- Sinisalo Juha
- Siscovick David S.
- Sivananthan Mohan
- Sivapalaratnam Suthesh
- Sladek Rob
- Sleight Peter
- Small Kerrin
- Smit Jan H.
- Smith Albert
- Smith George Davey
- Smith Tamara B.
- Snoep Jaapjan D.
- Soranzo Nicole
- Sovio Ulla
- Sparsø Thomas
- Spector Timothy D.
- Speliote Elizabeth K.
- Speliotes Elizabeth K
- Spertus John A.
- Stancakova Alena
- Stark Klaus
- Stefansson Kari
- Stein Lincoln D.
- Steinthorsdotti Valgerdur
- Steinthorsdottir Valgerdur
- Stephens Jonathan
- Stewart Alexandre F R
- Stirrups Kathy
- Stoll Monika
- Strachan David P.
- Strassburger Klaus
- Strawbridge Rona
- Stringha Heather M.
- Stringham Heather M.
- Stumvoll Michael
- Sun Qi
- Surakka Ida
- Surdulescu Gabriela
- Swift Amy J.
- Syvänen Ann Christine
- Tammesoo Mari Liis
- Taneera Jalal
- Tang W. H Wilson
- Tardif Jean Claude
- Teder-Laving Maris
- Tennstedt Stephanie
- Terho Lehtimäki
- Teslovich Tanya M.
- Thiering Elisabeth
- Thompson John R.
- Thomson Brian
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsso Gudmar
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tichet Jean
- Timpson Nicholas J.
- Tognoni Gianni
- Tomaszewski Maciej
- Travers Mary
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turrini Fabiola
- Tyrer Jonathan P.
- Tzenova Bell Jordana
- Tönjes Anke
- Uda Manuela
- Uitterlinden Andre
- Uitterlinden Andre G.
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- Valle Timo T.
- van Dam Rob M.
- van Duijn Cornelia M.
- van Haeften Timon W.
- van Herpt Thijs
- van Hoek Mandy
- van Meurs Joyce B.
- van Ommen Gert Jan
- van Rij Andre M.
- van Vliet Jana V
- van Vliet-Ostaptchouk Jana V.
- van Wingerden Sophie
- van't Hooft Ferdinand
- Vatin Vincent
- Vedanta Sailaja
- Vedantam Sailaja
- Viikari Jorma
- Visscher Peter M.
- Visvikis-Siest Sophie
- Vitart Veronique
- Vogel Carla I G
- Voight Benjamin F.
- Wabitsch Martin
- Waeber Gérard
- Waite Lindsay L.
- Walker Mark
- Wallaschofski Henri
- Walter G. Bragi
- Wareham Nicholas J.
- Wareham Nick J.
- Watanabe Richard M.
- Watkins Hugh
- Weedo Michael N.
- Weedon Michael N.
- Welch Ryan
- Wells George A.
- Weyan Robert J.
- Weyant Robert J
- Wheele Eleanor
- Wheeler Eleanor
- White Charles C.
- Wichmann H. Erich
- Widen Elisabeth
- Wiegand Susanna
- Wijmenga Cisca
- Wiklund Fredrik
- Wild Philipp S.
- Wild Sarah H.
- Wilk Alicja
- Wille Cristen J.
- Willemsen Gonneke
- Willenborg Christina
- Willer Cristen J.
- Wilson James F.
- Winkle Thomas W.
- Winkler Thomas W
- Witte Daniel R.
- Witteman Jacqueline
- Witteman Jacqueline C.
- Witteman Jaqueline C M
- Woo Andrew R.
- Wood Andrew R
- Workalemah Tsegaselassie
- Workalemahu Tsegaselassie
- Wright Alan F.
- Wright Benjamin J.
- Wu Guanming
- Xie Weijia
- Xu Jianfeng
- Yang Jian
- Yang Tsun Po
- Ye Shu
- Zabena Carina
- Zaidi Moazzam
- Zaman Khan Shah
- Zeggini Eleftheria
- Zeller Tanja
- Zethelius Björn
- Zgaga Lina
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Ziegler Andreas
- Zillikens M. Carola
- Zitting Paavo
- Zondervan Krina T.
- Öhrvik John
- Östenson Claes Göran
- Publication venue
- Diabetes
- Publication date
- 01/01/2011
- Field of study
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
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