Contribution to the study on chemical constituents of Hedyotis auricularia L., (Rubiaceae)

From the whole plant of Hedyotis auricularia L., a new glycoside, 1’-deoxy-6’-O-(1-hydroxymethyl-2-hydroxy-1-methoxy)ethylglucopyranoside (1) was isolated along with 1’-O-ethyl-β-D-galactopyranoside (2), 2-formyl-5-hydroxymethylfuran (3), stigmasta-5,22-diene-3-O-β-D-glucopyranoside (4), ursolic acid (5) and oleanolic acid (6). Among them (1), (2), (3), (4)were the first time known to be present in this plant

Coderivatives at infinity of set-valued mappings

In this paper, the concept of coderivatives at infinity of set-valued mappings is introduced. Well-posedness properties at infinity of set-valued mappings as well as Mordukhovich's criterion at infinity are established. Fermat's rule at infinity in set-valued optimization is also provided. The obtained results, which give new information even in the classical cases of smooth single-valued mappings, provide complete characterizations of the properties under consideration in the setting at infinity of set-valued mappings

Some triterpenoids and steroids from Bruguiera cylindrica leaves collected from Can Gio mangrove forest

Bruguiera cylindrica (Rhizophoracea), distributed in the Southeast Asia, has been used as a traditional medicine in the treatment of diarrhea and healing of wounds. Some triterpenoids and steroids were isolated from the dried leaves of Bruguiera cylindrica, collected at Can Gio mangrove forest, Ho Chi Minh City, including lupeol (1), 3β-hydroxyoleana-9(11),12-diene (2), a mixture of stigmasterol (3a) and b-sitosterol (3b), cholesta-4-ene-3-one (4) and 3β-hydroxycholesta-5-ene-7-one (5). Their chemical structures were elucidated by spectroscopic analysis as well as comparing their data with the ones in the literature. Although these compounds were known in other plants this is the first time they are reported in this species. Keywords. Bruguiera cylindrica, triterpenoids, steroids

OVERVIEW OF ARSENIC CONTAMINATION IN GROUNDWATER AND HUMAN HEALTH RISK IN VIETNAM

Joint Research on Environmental Science and Technology for the Eart

Using metagenomics tool to evaluate the enrichment efficiency of methanogens in marine sediment in Truong Sa archipelage, Khanh Hoa province, Vietnam

Methanogens (archaea bacteria that produce methan) play an important role in the anaerobic digestion of organic waste, however, in marine environment, the low density of methanogens makes anaerobic digestion very slow. In this study, we used methagenomics tool to evaluate the enrichment efficiency of methanogens communities in marine sediments as a basis for building a anaerobic microbial formulation to treat organic waste in marine environment. The results of determination of methanogen density by MPN method have shown that methanogen has been accumulated with higher density (up to 3.2.107 MNP/ml) through 2 times of enrichment in artificial seawater with CH3COONa 10 mM substrate. In addition, metagenomics data have also shown a decrease in the number of archaea species through each enrichment, indicating that methanogenic species have gradually dominated the microbial community. This is the first study on using metagnenomics tools to evaluate the enrichment of methanogens in marine sediment samples in Truong Sa archipelago, Vietnam. Metagenomics data help provide more reliable evidence in microbial studies, especially in obligate anaerobes such as methanogens

UV Light Induced Thermoluminescence of Rare Earth doped Nanomaterials Y2_2O3_3:Eu3+^{3+}, Gd2_2O3_3:Eu3+^{3+} and Gd2_2O3_3:Er3+^{3+}

Thermoluminescence  properties of ultraviolet irradiated Y2O3:Eu3+, Gd2O3:Eu3+ and Gd2O3:Er3+ nanophosphors have been reported. The materials were synthesized by gel- combustion method with EDTA- Na2 as organic agent. This method allows production of very fine white powder at low temperature with very high efficiency. XRD has been studied to determine the structure of the prepared nano powders. The obtained materials exhibit sufficient sensibility to UV radiation and may be useful in UV light measurements

Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Background Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine for 6 months after stroke improves functional outcome in an ethnically diverse population. Methods AFFINITY was a randomised, parallel-group, double-blind, placebo-controlled trial done in 43 hospital stroke units in Australia (n=29), New Zealand (four), and Vietnam (ten). Eligible patients were adults (aged ≥18 years) with a clinical diagnosis of acute stroke in the previous 2–15 days, brain imaging consistent with ischaemic or haemorrhagic stroke, and a persisting neurological deficit that produced a modified Rankin Scale (mRS) score of 1 or more. Patients were randomly assigned 1:1 via a web-based system using a minimisation algorithm to once daily, oral fluoxetine 20 mg capsules or matching placebo for 6 months. Patients, carers, investigators, and outcome assessors were masked to the treatment allocation. The primary outcome was functional status, measured by the mRS, at 6 months. The primary analysis was an ordinal logistic regression of the mRS at 6 months, adjusted for minimisation variables. Primary and safety analyses were done according to the patient's treatment allocation. The trial is registered with the Australian New Zealand Clinical Trials Registry, ACTRN12611000774921. Findings Between Jan 11, 2013, and June 30, 2019, 1280 patients were recruited in Australia (n=532), New Zealand (n=42), and Vietnam (n=706), of whom 642 were randomly assigned to fluoxetine and 638 were randomly assigned to placebo. Mean duration of trial treatment was 167 days (SD 48·1). At 6 months, mRS data were available in 624 (97%) patients in the fluoxetine group and 632 (99%) in the placebo group. The distribution of mRS categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio 0·94, 95% CI 0·76–1·15; p=0·53). Compared with patients in the placebo group, patients in the fluoxetine group had more falls (20 [3%] vs seven [1%]; p=0·018), bone fractures (19 [3%] vs six [1%]; p=0·014), and epileptic seizures (ten [2%] vs two [<1%]; p=0·038) at 6 months. Interpretation Oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and epileptic seizures. These results do not support the use of fluoxetine to improve functional outcome after stroke

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.Peer reviewe