Lactato y base exceso como predictores de mortalidad en los pacientes atendidos en la Unidad de Cuidados Intensivos Pediátricos del Hospital Alemán Nicaragüense de Abril- Septiembre 2018

El lactato y el exceso de base son marcadores de hipoxia tisular, los cuales han servido como predictores de mortalidad en pacientes críticos. Objetivo General. Evaluar el lactato y base exceso como predictor de mortalidad en pacientes de UCIP. Material y Método: Estudio descriptivo, retrospectivo, corte transversal. Se incluyeron a los pacientes ingresados en UCIP de abril a septiembre del 2018, que cumplieron criterios de inclusión. Los niveles de lactato y exceso de base se tomaron en las primeras 24 horas de ingreso, tomando el peor valor. Resultados: El 58%% fueron del sexo femenino, el 58.1% era menor de un año. El tiempo promedio de estancia intrahospitalaria de 8.7 días, (DE± 4.5) El 77% ameritó ventilación mecánica con tiempo promedio de 6.9 días. El 83.8% de los ingresos fueron patologías respiratorias. Falleció el 22.6%, de los cuales el 71% eran hombres y el 86% menor de un año. Los niveles de lactato encontrados en pacientes fallecidos son más altos en relación con los pacientes vivos (Media 6 vs media 2.7), y la base exceso es relativamente más negativa en pacientes fallecidos. (Media -12 vs media -8). Encontramos una adecuada discriminación para el lactato y el exceso de base como predictor de mortalidad, con un área bajo la curva de ROC de 0.94 y 0.97, respectivamente.Conclusión: Tanto el exceso de base como el lactato, o la combinación de ambos, se pueden usar para predecir el resultado en pacientes ingresados en la unidad de cuidados intensivos

Quantified HI Morphology I: Multi-Wavelengths Analysis of the THINGS Galaxies

Galaxy evolution is driven to a large extent by interactions and mergers with other galaxies and the gas in galaxies is extremely sensitive to the interactions. One method to measure such interactions uses the quantified morphology of galaxy images. Well-established parameters are Concentration, Asymmetry, Smoothness, Gini, and M20 of a galaxy image. Thus far, the application of this technique has mostly been restricted to restframe ultra-violet and optical images. However, with the new radio observatories being commissioned (MeerKAT, ASKAP, EVLA, WSRT/APERTIF, and ultimately SKA), a new window on the neutral atomic hydrogen gas (HI) morphology of a large numbers of galaxies will open up. The quantified morphology of gas disks of spirals can be an alternative indicator of the level and frequency of interaction. The HI in galaxies is typically spatially more extended and more sensitive to low-mass or weak interactions. In this paper, we explore six morphological parameters calculated over the extent of the stellar (optical) disk and the extent of the gas disk for a range of wavelengths spanning UV, Optical, Near- and Far-Infrared and 21 cm (HI) of 28 galaxies from The HI Nearby Galaxy Survey (THINGS). Though the THINGS sample is small and contains only a single ongoing interaction, it spans both non-interacting and post-interacting galaxies with a wealth of multi-wavelength data. We find that the choice of area for the computation of the morphological parameters is less of an issue than the wavelength at which they are measured. The signal of interaction is as good in the HI as in any of the other wavelengths in which morphology has been used to trace the interaction rate to date, mostly star-formation dominated ones (near- and far-ultraviolet). The Asymmetry and M20 parameters are the ones which show the most promise as tracers of interaction in 21 cm line observations.Comment: 16 pages, 11 figure, table 1, accepted by MNRAS, appendix not include

Illuminating hydrological processes at the soil-vegetation-atmosphere interface with water stable isotopes

Funded by DFG research project “From Catchments as Organised Systems to Models based on Functional Units” (FOR 1Peer reviewedPublisher PDFPublisher PD

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected

Electrode substrate innovation for electrochemical detection in microchip electrophoresis.

Microchip Electrophoresis (ME) represents the next generation of miniaturised electrophoretic devices and carry benefits such as significant improvement in analysis times, lower consumption of reagents and samples, flexibility, and procedural simplicity. The devices provide a separation method for complex sample matrices and an on-board detection method for the analytical determination of a target compound. The detection part of ME is increasingly leaning towards electrochemical methods, thus the selectivity and sensitivity of detection in ME is dependent upon the chosen working electrode composition in addition to operating conditions of the chip such as separation voltage. Given the current plethora of electrode materials that are available, there exists a possibility to creatively integrate electrodes into ME. This review will overview the application of several electrode materials, from the old through to the new. A particular recent focus has been the selectivity element of MEs overcome with the use of enzymes, carbon composites, and screen-printed technologies. This article is protected by copyright. All rights reserved

Mutations, Genes, and Phenotypes Related to Movement Disorders and Ataxias

26 páginas, 4 figuras, 3 tablasOur clinical series comprises 124 patients with movement disorders (MDs) and/or ataxia with cerebellar atrophy (CA), many of them showing signs of neurodegeneration with brain iron accumulation (NBIA). Ten NBIA genes are accepted, although isolated cases compatible with abnormal brain iron deposits are known. The patients were evaluated using standardised clinical assessments of ataxia and MDs. First, NBIA genes were analysed by Sanger sequencing and 59 patients achieved a diagnosis, including the detection of the founder mutation PANK2 p.T528M in Romani people. Then, we used a custom panel MovDisord and/or exome sequencing; 29 cases were solved with a great genetic heterogeneity (34 different mutations in 23 genes). Three patients presented brain iron deposits with Fe-sensitive MRI sequences and mutations in FBXO7, GLB1, and KIF1A, suggesting an NBIA-like phenotype. Eleven patients showed very early-onset ataxia and CA with cortical hyperintensities caused by mutations in ITPR1, KIF1A, SPTBN2, PLA2G6, PMPCA, and PRDX3. The novel variants were investigated by structural modelling, luciferase analysis, transcript/minigenes studies, or immunofluorescence assays. Our findings expand the phenotypes and the genetics of MDs and ataxias with early-onset CA and cortical hyperintensities and highlight that the abnormal brain iron accumulation or early cerebellar gliosis may resembling an NBIA phenotype.This work was supported by the Instituto de Salud Carlos III (ISCIII)—Subdirección General de Evaluación y Fomento de la Investigación within the framework of the National R + D+I Plan co-funded with European Regional Development Funds (ERDF) [Grants PI18/00147 and PI21/00103 to CE]; the Fundació La Marató TV3 [Grants 20143130 and 20143131 to BPD and CE]; and by the Generalitat Valenciana [Grant PROMETEO/2018/135 to CE]. Part of the equipment employed in this work was funded by Generalitat Valenciana and co-financed with ERDF (OP ERDF of Comunitat Valenciana 2014–2020). PS had an FPU-PhD fellowship funded by the Spanish Ministry of Education, Culture and Sport [FPU15/00964]. IH has a PFIS-PhD fellowship [FI19/00072]. ASM has a contract funded by the Spanish Foundation Per Amor a l’Art (FPAA)Peer reviewe

The 16th Data Release of the Sloan Digital Sky Surveys: First Release from the APOGEE-2 Southern Survey and Full Release of eBOSS Spectra

This paper documents the 16th data release (DR16) from the Sloan Digital Sky Surveys (SDSS), the fourth and penultimate from the fourth phase (SDSS-IV). This is the first release of data from the Southern Hemisphere survey of the Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2); new data from APOGEE-2 North are also included. DR16 is also notable as the final data release for the main cosmological program of the Extended Baryon Oscillation Spectroscopic Survey (eBOSS), and all raw and reduced spectra from that project are released here. DR16 also includes all the data from the Time Domain Spectroscopic Survey and new data from the SPectroscopic IDentification of ERosita Survey programs, both of which were co-observed on eBOSS plates. DR16 has no new data from the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey (or the MaNGA Stellar Library "MaStar"). We also preview future SDSS-V operations (due to start in 2020), and summarize plans for the final SDSS-IV data release (DR17)

The 16th Data Release of the Sloan Digital Sky Surveys: First Release from the APOGEE-2 Southern Survey and Full Release of eBOSS Spectra

This paper documents the 16th data release (DR16) from the Sloan Digital Sky Surveys (SDSS), the fourth and penultimate from the fourth phase (SDSS-IV). This is the first release of data from the Southern Hemisphere survey of the Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2); new data from APOGEE-2 North are also included. DR16 is also notable as the final data release for the main cosmological program of the Extended Baryon Oscillation Spectroscopic Survey (eBOSS), and all raw and reduced spectra from that project are released here. DR16 also includes all the data from the Time Domain Spectroscopic Survey and new data from the SPectroscopic IDentification of ERosita Survey programs, both of which were co-observed on eBOSS plates. DR16 has no new data from the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey (or the MaNGA Stellar Library "MaStar"). We also preview future SDSS-V operations (due to start in 2020), and summarize plans for the final SDSS-IV data release (DR17)