11 research outputs found
Molecular Recognition of Small Molecules by Rho-associated Kinase.
- Author
- Publication venue
- Publication date
- 01/01/2013
- Field of study
Rho-associated coiled-coil containing protein kinase (or ROCK) is the first known effector of the Rho GTPase family of proteins, which are responsible for processes such as adhesion, motility, proliferation, differentiation, and apoptosis. ROCK is one of the six clinically-validated kinase drug targets and its inhibition has been suggested as a potential therapeutic mode of action to treat a diverse array of diseases including cancer and autoimmunity. BZD-29 is a 1,4-benzodiazepine-2,5-dione with demonstrated attenuation of disease in the Schistosoma mansoni model of pulmonary inflammation and no general toxicity in rodents. Target identification and validation along with mechanism of action studies have demonstrated that BZD-29 is an ATP-competitive inhibitor of ROCKII. Although high resolution crystal structures exist for both of the two known ROCK isoforms, the molecular contacts necessary for potency and selectivity among the ROCK enzymes remain a topic of research and debate. This thesis describes the design, synthesis, and analysis of a series of analogs of BZD-29, designed to probe and optimize the structural features important for potent inhibition and selectivity for ROCKII. These efforts have resulted in the development of a highly stereoselective synthetic route for the production of chiral 1,4-benzodiazepine-2,5-diones, the design of inhibitors with 110-fold potency over BZD-29 and 10-fold potency over Fasudil, and the establishment of highly successful structure activity relationship models and computational models for use in future analog design.PHDMedicinal ChemistryUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/102462/1/laurenkd_1.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/102462/2/laurenkd_2.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/102462/3/laurenkd_3.pd
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
- Author
- Aanei Carmen M.
- Abid Muhammad B.
- Abramowitz Matthew K.
- Abu-Zaid Ahmed
- Adamo Vincenzo
- Adeyemo Adebolajo A.
- Afnan Masoud
- Agarabi Cyrus
- Aggelidou Maria
- Ahmad Haroon
- Ahmad Rafi
- Aizat Wan M.
- Ajani Penelope A.
- Akinwumi Sayo A.
- Al-Farha Abd A.
- Al-Lawama Manar
- Al-Owaifeer Adi M.
- Al-Riyami Arwa Z.
- Alanio Alexandre
- Alaux Cedric
- Albery Gregory F.
- Albiol Joan
- Albrecht Dirk R.
- Albuquerque Lucia G.
- Alhowimel Ahmed
- Ali Junaid
- Alimba C.G.
- Allardyce Judith
- Almeida Gabriel M.F.
- Alonso-Caneiro David
- Alper Ozgul M.
- Alshehri Mansour
- Alsuhaibani Mohammed
- Alzghari Saeed K.
- Amer Said E.D.R.
- Amir Shimon
- Amiya Eisuke
- Ammerman Brooke A.
- Amorim Rogerio M.
- An Qianli
- Anazodo Udunna C.
- Andersen Stig U.
- Andersen Vibeke
- Angus Kathryn
- Anikin Andrey
- Aplin John D.
- Argyropoulos Christos
- Armitage Charles
- Asaduzzaman Muhammad
- Asady Hadi
- Ascher David B.
- Ashry Mohamed
- Asmann Yan W.
- Assaeed Abdulaziz M.
- Atack John M.
- Atanasov Atanas G.
- Atchison David A.
- Atkins Gerald J.
- Atlas Lauren
- Ato Dai
- Avery Simon V.
- Avillach Paul
- Azubuike Samuel O.
- Baade Peter D.
- Bach-Mortensen Anders
- Backman Lars
- Badie Christophe
- Bae Taeok
- Bagloee Saeed Asadi
- Bai Xiaoyong
- Baier Dirk
- Bail Kasia
- Baines Rebecca L.
- Baker Chris I.
- Bakkach Joaira
- Baldi Alfonso
- Ball Elizabeth
- Ballantyne Maghan
- Baltiansky Lior
- Ban Bo
- Bannon Ross
- Bansal Abhisheka
- Bar Ido
- Bardot Olivier
- Barnett Adrian G.
- Barraud Pierre
- Bartas Martin
- Basharat Zarrin
- Basner Mathias
- Bathelt Joe
- Batra Jyotsna
- Baumert Philipp
- Bazanova O.M.
- Beale Andrew
- Beck Charles R.
- Beck Jill
- Becker Daniel
- Beddoe Travis
- Belachew Kiflemariam Y.
- Bell Melanie L.
- Ben-Nafa Walid
- Benezeth Yannick
- Bengtsson-Palme Johan
- Benkeser David
- Berbesque Colette
- Berezikov Eugene
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- Berners-Price Sue
- Bernhardt Peter
- Bernier Meghan L.
- Berrevoet Frederik
- Berry Edward
- Berthold Maximilian
- Bessa Theolis B.
- Beyene Tariku J.
- Bhardwaj Vivek
- Biedermann Peter H.W.
- Bijleveld Erik
- Billington Craig
- Binder Karin
- Birch John
- Bittner Florian
- Bitzer Michael
- Black Emma
- Blakely Randy D.
- Blanchard Adam M.
- Blancher Antoine
- Blanck Oliver
- Bland Nicholas S.
- Blankstein Ron
- Blaskovich Mark A.T.
- Bleackley Mark
- Blombach Fabian
- Blum Robert
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- Bodagh Neil
- Boehme Karen A.
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- Bonatsos Vasileios
- Bonvin A.M.J.J.
- Boon Michele H.
- Borges Paulo
- Bosch Carles
- Bosch Oliver
- Bouboulis George
- Boudreau Shellie A.
- Bourgoin Thierry
- Bourke Emer
- Bouvard Daniel
- Boykin Laura M.
- Br\ufchl Albert
- Bradley Graeme
- Bradshaw William
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- Brand Thomas
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- Braun Daniel
- Braun R. J.
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- Bromfield Elizabeth
- Brooks Anastasia
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- Brunetti Arturo
- Bukowy-Bieryllo Zuzanna
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- Bull James A.
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- Bush Stephen J.
- Butkowski Eugene G.
- Butler Lisa M.
- Byrareddy Siddappa N.
- Byrne Hugh J.
- Cabantous Stephanie
- Cai Yufeng
- Calabr\uf2 Giovanna E.
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- Cavalli Giacomo
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- Ch\ue1vez-Fumagalli Miguel A.
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- Chakraborty Sayan
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- Chan Sherwin S.
- Chandrasekaran Arun R.
- Chang Shun C.
- Chang Wei
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- Chen Branson
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- Chhatriwalla Adnan K.
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- Christensen Martin R.
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- Chwalibog Andre
- Ciresi A.
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- Cockcroft Shamshad
- Coelho Luis P.
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- Cooper Jeffrey
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- Covington Natalie V.
- Crawford Stephanie Y.
- Cruz Aparecido D.
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- Day David A.
- de Keersmaecker Kim
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- Ebell Mark H.
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- El-Esawi Mohamed A.
- El-Said Mohammed
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- Elkum Naser
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- Engel Nadja
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- Eskelinen Eeva-Liisa
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- Friebe Michael
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- Galluzzi Luca
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- Garcia-Rivera Enid J.
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- Gleeson Paul A.
- Gloyn Liz
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- Goodin Amie
- Goodyear Carl S.
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- Gr\ufcneberg Patrick
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- Graham Emily B.
- Graham Kathryn E.
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- Graves Patricia M.
- Greene Garrett
- Greenwald Noah F.
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- Gridneva Zoya
- Grimm Dominik G.
- Groen Ewout J.N.
- Grothe Michel J.
- Gruber Jens
- Grunau Christoph
- Grundle D.S.
- Grybos Malgorzata
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- Guerrero Fabricio
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- Guisado J.L.
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- Gurney-Champion Oliver J.
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- Heers Marcel
- Heffler Enrico
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- Hew Khe F.
- Higginbottom Daniel B.
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- Hilaire Cynthia St.
- Hilton Rachel
- Hiroi Noboru
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- Huirne Judith
- Hulse-Kemp Amanda M.
- Hunter Kylie E.
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- Ijzerman Adriaan P.
- Ikeo Kazuho
- Ikonomopoulou Maria P.
- Ingley Evan
- Iskander-Rizk Sophinese
- Iyer Lavanya M.
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- James Ameh S.
- Janga Sarath C.
- Janzen Thijs
- Jayaraman Jayakumar
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- Jeon Sang-Min
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- Jiang Xingyu
- Jibb Lindsay A.
- Jin Yi
- Jo Daehyun
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- Johnson Daniel M.
- Johnston Marie
- Jongen Stefan
- Jonscher Karen R.
- Jorens Philippe G.
- Jorgensen Jens O.L.
- Josse Claire
- Joubert Johan W.
- Jung Sin-Ho
- Junior Antonio M.
- Jurman Giuseppe
- Jutzeler Catherine
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- Kamagata Koji
- Kamboj Sunjeev K.
- Kambondo George
- Kamiya Haruyuki
- Kane Nolan C.
- Kang Yong-Kook
- Kanj Souha S.
- Karamanos Yannis
- Karim Masud
- Karmakar Chandan
- Karnati Priyanka
- Karp Natasha A.
- Karsay Kathrin
- Kasian Olga
- Kauppila Joonas H.
- Kaur Harsheen
- Kaya Cihan
- Kaye Linda K.
- Ke An
- Keitel Anne
- Kelly Daniel
- Kelly Ryan
- Kelly Sarah
- Kelly Shona
- Kempe Andreas
- Kenna Ralph
- Kennedy Jonathan
- Keown Jeremy R.
- Kersten Birgit
- Khalaf Roy A.
- Khalid Javaria M.
- Khan Murad M.
- Khatlani T.
- Kheir Fayez
- Khider Tarig
- Khoo Chin M.
- Khwaja Nyil
- Kichatova V.S.
- Kickert Rob
- Kidibule Peter E.
- Kieselmann Jennifer P.
- Kievit Rogier A.
- Kijanka Gregor S.
- Kim Hyeon J.
- Kim Yong-Min
- King Sarah R.B.
- Kinyanjui Timothy
- Kiraǧ N\ufckhet
- Kish J.K.
- Kitazawa Takeshi
- Kiyani Musa
- Klein Reinhild
- Klempnauer Karl-Heinz
- Kleppe Andreas
- Klump Hannes
- Kluz Tomasz
- Knox Paul
- Kobayashi Tatsuya
- Kobold Sebastian
- Koch Karl-Wilhelm
- Kohanbash Gary
- Kohls Gregor
- Kohonen-Corish Maija R.J.
- Koleva-Kolarova Rositsa G.
- Kong Xiangpeng
- Konkle-Parker Deborah
- Korpela Kalevi M.
- Kosanic Sasha
- Kostrikis Leondios G.
- Koutoukidis Dimitrios A.
- Kovesi Tom
- Kraiczy Peter
- Kramer Paul
- Kraschnewski Jennifer L.
- Kratz Harald
- Krause G\ufcnter
- Krebsbach Paul H.
- Kristensen S\uf8ren R.
- Kristiansson Erik
- Kueberuwa Gray
- Kugler Jan-Michael
- Kulkarni Ameya
- Kumar Addanki P.
- Kumar Dilip
- Kumar Gyanendra
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- Kurgan Lukasz
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- Kwon Young D.
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- Latif Asam
- Lau Colleen L.
- Lauschke Volker M.
- Laverman Gozewijn D.
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- Le Thuc D.
- Leclair Elizabeth E.
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- Lee Ming-Yih
- Lee Moon-Soo
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- Liao Zheng-Yin
- Lidbury Brett A.
- Lieb Klaus
- Liehr Thomas
- Liew Alan W.C.
- Lim Chinten J.
- Lim Renly
- Lim Yau Y.
- Lima Luiz R.A.
- Lin Jessica
- Lin Li
- Lin Michael Z.
- Lindsey Merry L.
- Line Paul-Dag
- Ling Tong
- Linn Sabrina N.
- Litfin Thomas
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- Liu Enwu
- Liu Fang
- Liu Fengbin
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- Liu Hongde
- Liu Siqi
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- Liu Yu-Peng
- Liu Yuchen
- Liu Zhonghua
- Liusuo Wang
- Lizer J.
- Lloyd Vett K.
- Lo Te-Wen
- Lobreglio Giambattista
- Locci Emanuela
- Loft Nikolai D.
- Loidl Josef
- Lopez-Escamez Jose A.
- Lopez-Ruiz Francisco J.
- Lorenzen Johan
- Lorkowski Stefan
- Lovell Nigel H.
- Lowies Cher
- Lu Cheng
- Lu Hua
- Lu Jin-Jian
- Lu Qiang
- Lu Wei
- Lu Yao
- Lu Zhiyong
- Luengo Gustavo S.
- Lum Fok M.
- Lund Bjarte A.
- Lundh Lars-Gunnar
- Luo Hang
- Lussier Alexandre A.
- Luu Andreas M.
- Lygirou Vasiliki
- Lynch Iseult
- Lysy Philippe A.
- Lyu Ran
- Ma Chuang
- Ma Lan
- Ma Liping
- Ma Lisong
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- Ma Wujun
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- Machhi Jatin
- Mack Heather G.
- Mackey David A.
- Macleod Angus
- Macwan Isaac
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- Madani Nima
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- Maher Pamela
- Maher Toby
- Mai Zhi-Ming
- Maibach Edward W.
- Maity Sankar N.
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- Major Rupert W.
- Makowiecki Kalina
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- Mallinson Daniel J.
- Mallis Panagiotis
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- Mangoni Arduino A.
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- Manstead Antony S.R.
- Mantalaris Athanasios
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- Margelyte Ruta
- Maria Caracausi
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- Markonis Y.
- Marsal Jan
- Marschalek Rolf
- Marschall H. U.
- Marsili Luca
- Mart\uedn Carmen S.
- Martin Adam
- Martin Francis L.
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- Martinez-Salas Encarnacion
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- Marvin-Dowle Katie
- Marzocchi Ugo
- Mason Leanda D.
- Mather Diane E.
- Mathieu Daniel
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- Maza Elie
- McCrum Christopher
- McCutcheon James E.
- McGarrigle Christine A.
- McKay Gareth J.
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- McMillan Nigel
- McWilliams Lorna
- Meads Catherine
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- Meresh Edwin
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- Merlaen Britt
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- Meule Adrian
- Meunier Frederic A.
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- Middelveen Marianne
- Miele Adriana E.
- Mier Pablo
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- Miller Jack J.
- Min Rogier
- Minde David-Paul M.
- Minges Alexander
- Mintz Eric M.
- Miotla Pawel
- Mishra Anand K.
- Mishra Eleanor
- Mishra Virendra R.
- Mitchell Kate M.
- Mizukami Takuo
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- Moores Carly
- Moran John V.
- Morcillo Esteban
- Morozov Sergey Y.
- Morrice Nicola
- Mort Matthew
- Moskalensky Alexander E.
- Moss W.N.
- Mota Jorge
- Moultos Othonas A.
- Moyer Robert
- Mozaheb Zahra
- Muhammad Junaid
- Mukherjee Maheswari
- Murai Noriyuki
- Murphy Denis J.
- Murphy Susan K.
- Murray Shauna A.
- Musinguzi Conrad
- Muth Thilo
- Muyaya Ley
- Naganawa Shinji
- Nagler Katja
- Nakayama Kazuhiko
- Nammi Srinivas
- Nandakumar Kutty S.
- Nandhakumar Amar
- Nanou Afroditi
- Naqash Amreen
- Narayan Edward
- Nasios Grigorios
- Natoli Roman M.
- Navaratnarajah [NO FIRST NAME IN SCOPUS]
- Navarin Nicol\uf2
- Negera Edessa
- Neumann Philipp-Alexander
- Ng Grace
- Ng Sheryl H.X.
- Nguyen Frederique
- Nguyen Joe T.
- Nguyen Thi T.H.
- Ni Duan
- Nicol Christine
- Nicoletti Rosario
- Nida [NO FIRST NAME IN SCOPUS]
- Nie Jiyun
- Nie Yingjiu
- Niehof Monika
- Niemeyer Frank
- Nilsen Erlend B.
- Nilsson Henrik
- Nixon Brett
- Nobile Clarissa J.
- Nolan Fiona
- Nolet Philippe
- Nord\ue9n Rickard
- Nordberg Ana
- Norris Adam D.
- Notcovich Shirli
- Nowicki Jessica P.
- Nwaiwu Ogueri
- O\u27Mahony Margaret
- O\u27Toole Ronan
- Obeidat Monther
- Ogami Koichi
- Oh Deog-Hwan
- Ohgami Robert S.
- Ohlsson Sophie
- Ohst Barnabas
- Ohtomo Toshihiko
- Olatunbosun Oluremi
- Oldenmenger Wendy H.
- Ollivier Quinn R.
- Olofsson Per
- Olova Nelly
- Olszewski Pawel
- Olumayede Emmanuel
- Onzima Robert
- Orme Mark W.
- Ortiz Alberto
- Osses Dani\uebl F.
- Oster Henrik
- Ostrikov Kostya
- Otto Siegmar
- Ou Jianhong
- Outeiro Tiago F.
- Ouyang Songying
- Owais Mohammed
- Pace-Asciak Pia
- Paganoni Sabrina
- Page Andrew
- Pallebage-Gamarallage Menuka
- Palm Christoph
- Palma Jose-Alberto
- Pan Chih-Long
- Pan Zihang
- Panthee Suresh
- Panwar Ajay
- Paradies Yin
- Parchi Piero
- Park Caroline
- Park Charny
- Park Dong I.
- Park Seyoung
- Parsons Jerod R.
- Parsons Michael H.
- Parsons Nick
- Pascal Pigny
- Paterson Russell
- Patil Chandrashekhar D.
- Patterson Chris
- Paul Elisabeth
- Pearce Simon P.
- Pearson James A.
- Peckham Michelle
- Pedemonte Nicoletta
- Pedro Sansoa A.
- Peifer Mark
- Pelkonen Tuula
- Pelleri Maria C.
- Pellizzon Michael A.
- Penagos-Tabaree Felipe
- Peng Xiangda
- Peng Yousong
- Perco Paul
- Pereira Joana L.
- Peres Marco A.
- Perry Samuel R.
- Peter Jessica
- Peterson Brent M.
- Petrelli M.
- Pezzuolo Andrea
- Pheko Mpho
- Pianosi Paolo T.
- Pichugin Alexander
- Pinto Carlos J.C.
- Pinto Ines M.
- Pinto Karina A.
- Pinzi Valentina
- Piotrowski Marcin
- Piovesan Allison
- Plantinga Arnoud
- Plevris John N.
- Pluess Michael
- Podolsky Illya M.
- Pollesello Piero
- Polz Martin
- Ponti Giovanna
- Popoola Segun I.
- Porcelli Piero
- Portilla Maribel
- Portillo M.C.
- Pourret Olivier
- Pozdnyakov Ilya
- Prajapati Anilkumar S.
- Pranata Raymond
- Prescott Julie
- Pridans Clare
- Prieto Daniel
- Prince Martin
- Pritchard Antonia L.
- Psaroulaki Anna
- Pujala Ravi K.
- Pulia Michael
- Pulido-Arjona Leonardo
- Pullan Wayne
- Pusch Stefan
- Qi Dongchen
- Qi Peng-Fei
- Qi Xingshun
- Qian Siyu
- Qin Lei
- Quinn Gwendolyn P.
- Quinn Terence J.
- Rafe Ali
- Rafiq Muhammad
- Raghava Gajendra P.S.
- Rahimi Farid
- Rahman Proton
- Rahman Shaifur
- Rai Nayanjot K.
- Raikou Vaia D.
- Raman Ayush
- Ramula Satu
- Ranft Andreas
- Raote Ishier
- Rappsilber Juri
- Rassaf Tienush
- Raucher-Ch\ue9n\ue9 [NO FIRST NAME IN SCOPUS]
- Rawski Rafal
- Ray Asit
- Raza Ali
- Razak Lubna A.
- Rebl Henrike
- Reddan Tristan
- Refai Osama
- Refardt Julie
- Regan Tim
- Rehfeldt Florian
- Reiling Jan H.
- Remacle Claire
- Reschke Cristina R.
- Rezaei Mohsen
- Rhodes Johanna
- Ricciardi Walter
- Richa Tambi
- Richardson Mark F.
- Riddick Eric W.
- Riess Olaf
- Ritter Uwe
- Riva Giuseppe
- Roach Neil W.
- Roberts David D.
- Roberts Nicola J.
- Robinson K.R.
- Robles Guillermo
- Rodrigues Tiago
- Rodriguez Cesar
- Roislien Jo
- Roobol Monique J.
- Ross Kehinde
- Ross Stephanie A.
- Rossoni Luca
- Rotge Jean-Yves
- Rouet Romain
- Rovas Alexandros
- Rowe Alexandra
- Rowe Anna D.
- Rudolf Kevin
- Ruepp Andreas
- Rusch Peter
- Rust Petra
- S\uf6relius Karl
- Saad Sonia
- Sabnis Sandeep C.
- Sack George H.
- Sacks Frank M.
- Sadoine Margaux L.
- Safaei Soroush
- Saggar Manish
- Saito Yu
- Salama Mohamed F.
- Saleh Sherif
- Sallmon Hannes
- Sampson Christopher
- Santos Manuela
- Saudemont Aurore
- Sava Gianni
- Schmidt Axel
- Schmutz Axel
- Schneeberger Pierre H.H.
- Schrading Simone
- Schramm Alexander
- Schreiber Martin
- Schuele Birgitt
- Schuler Sidney
- Schulte Leon N.
- Schuon Robert A.
- Schurr Roey
- Schwotzer Daniela
- Schymkowitz Joost
- Sczyrba Alexander
- Searles Stephen
- Sebastian Agata
- Seib Kate L.
- Selinski Jennifer
- Seltmann Stefanie
- Senghore Thomas
- Seow Esmond
- Sepanski Robert
- Sergeant Kjell
- Sha Feng
- Shabalin Ivan G.
- Shahid Shaouli
- Shalchyan Vahid
- Shalev Nir
- Shang Jin-Long
- Sharma Neeraj
- Sharma Saurab
- Sheehan Barry
- Shen Jun
- Shi Chunhu
- Shi Han-Ping
- Shimada Tomohiro
- Shin Jeon-Soo
- Shirvalkar Prasad
- Shiryayev Oleg
- Shohayeb Belal
- Shortt Colette
- Siebers Robert
- Sillanp\ue4\ue4 Elina
- Silveyra Patricia
- Singer Josef
- Singh Jugpreet
- Singh Mandeep
- Singh Manisha
- Skinner Debra
- Small Ian
- Smeets Paul A.M.
- Smith Simon S.
- Smith Taylor
- Smout Michael J.
- So Po-Wah
- Soares Ant\uf3nio
- Solano Francisco
- Solomon-Moore Emma
- Sommerlad Andrew
- Sonenshine Daniel E.
- Song Chunjiao
- Song Haijun
- Song Jiangning
- Song Lijuan
- Soraggi Samuele
- Sorzano Carlos O.
- Southall Tony
- Speakman John R.
- Spearman Paul
- Srinivasan Mandyam V.
- Srivastava Kshitij
- Srivastava Rupesh K.
- Stabile Laura P.
- Staege Martin S.
- Stanley Ryan
- Stasiak A.
- Steadman Kathryn J.
- Steckhan Nico
- Stein Nils
- Stella Alessandro
- Stephens Andrew W.
- Stevanovic Dejan
- Stewart Christopher J.
- Stewart Douglas I.
- Stine Keith
- Storlazzi Curt
- Stoynova Nataliya V.
- Strehlow Jan
- Strobl Frederic
- Strzalka Wojciech
- Suarez Oscar M.
- Subhash Santhilal
- Subissi Lorenzo
- Subramaniapillai Mehala
- Sukocheva Olga
- Sultana Taranum
- Sumant Anirudha V.
- Summers Mathew J.
- Sun Gang
- Sun Jim
- Sun Xianbao
- Sundar Raghav
- Supriyanto Irwan
- Surve Chinmay R.
- Suzuki Tomo
- Swali Ritu
- Sydes Matthew
- Syme Caitlin
- Szabo Attila
- Szymanski Wiktor
- Tacon Paul
- Taherzadeh Ghazaleh
- Tahir Nur D.M.
- Tai Chan N.P.
- Takeuchi Hisashi
- Tamaian Radu
- Tan Aik-Choon
- Tan Cher M.
- Tan Ene-Choo
- Tan Kok H.
- Tanadini-Lang S.
- Tanaka Kozo
- Tang Fei
- Tang Haixu
- Tang Jun
- Tang Young
- Tanino Y.
- Tantawy Marwa
- Tao Wanyin
- Targett-Adams Paul
- Tayebi Mourad
- Tayyem Reema
- Tebbe Christoph C.
- Telfer Evelyn E.
- Tellechea Juan I.
- Tempel Wolfram
- Tennakoon Sumudu
- Teodorczyk-Injeyan Julita A.
- Terrier Olivier
- Teseo Serafino
- Testa Jean
- Testoni Ines
- Theron G.
- Thijs Gert
- Thomas Lisa-Marie
- Thorne Sally
- Thrift Amanda G.
- Tian Chang F.
- Tian Yu-Shi
- Tian Zhiqi
- Tiffon Celine
- Tingting Qian
- Tinnefeld Philip
- Tjahjono Daryono H.
- Toelzer Christine
- Tofani Marco
- Tolle Fabrice
- Tomov Nikola
- Tong Xin
- Torga Gonzalo
- Toth Ervin
- Tovar Miguel
- Tr\uf6der Simon E.
- Tran Linh
- Tressoldi Patrizio
- Tripathi Sushil
- Tsapas Apostolos
- Tsirigotis Konstantinos
- Tuladhar Anil M.
- Turak Ayse
- Tuttle Lisa M.
- Tuttle Neil
- Tzotzos George
- Uchendu Florence
- Udo Edet E.
- Uhle Florian
- Ukubuiwe Azubuike C.
- Ung Carolina O.L.
- Utsumi Toshiaki
- Uversky Vladimir N.
- Vaidyanathan Subramanian
- Vaillant Michel
- Valenti Anna
- Valgepea Kaspar
- Valsesia Armand
- van de Mortel Thea
- van den Bos Wouter
- van Dessel Pieter
- van Meerten Tom
- van Nieuwerburgh Filip
- van Raaij Mark J.
- van Ruitenbeek Jan
- Vandenbroucke Roosmarijn E.
- Vanneste Sven
- Vatanparast Hamid
- Vavvas Demetrios G.
- Veiga Feliciano H.
- Vendrell Marc
- Verheijen Geert P.
- Verloh Niklas
- Verlot Pierre
- Vesk Peter A.
- Veys Ralf
- Vickers Paul
- Vickstrom Casey
- Victor Victor M.
- Vidal Arnau
- Villemur Richard
- Villet Martin H.
- Vindin Howard
- Vitriol Veronica
- Viveiros Miguel
- Vohl Marie-Claude
- Voolstra Christian R.
- Vorholt Julia A.
- Voskarides Konstantinos
- Voutchkova Denitza D.
- Vuillemin Anne
- Wakelin Steven
- Waldron Levi
- Walker Mirella
- Walsh Laurence J.
- Wang Amanda Y.
- Wang Fang
- Wang Fuan
- Wang Horng-Dar
- Wang Jinhui
- Wang Jiucun
- Wang Jun
- Wang Qing
- Wang Teng
- Wang Xiaomin
- Wang Yun
- Wang Zhenxing
- Watanabe Yoichi
- Watari Ricky
- Waugh Jason
- Webb S.A.
- Webster Rebecca
- Webster Ruth
- Wei Junnian
- Wei Pan
- Weigert Andreas
- Weinstock Christof
- Welter Danielle
- Wen Jet-Chau
- Werner Gijsbert D.A.
- Werten Sebastiaan
- Westermair Anna L.
- Wham Carol
- White Ethan P.
- Wibowo David
- Widera Darius
- Wiener Jan
- Wilharm Gottfried
- Wilkinson Simon
- Williams Brendan A.
- Williams Richard
- Willmann Raffaella
- Wilson Alex
- Wilson Coralie
- Wingenbach Tanja S.H.
- Winslade Matthew
- Wirth Brunhilde
- Wojan Timothy R.
- Woldesemayat Adugna A.
- Wolff Mathieu
- Wong Alvin
- Wong Bryan M.
- Workman Alan D.
- Wu Dalei
- Wu Tzu-Wei
- Wu Yi-Rui
- Wuerbel Hanno
- Wyart [NO FIRST NAME IN SCOPUS]
- Xavier Rose M.
- Xia Wenfeng
- Xiang Tingxiu
- Xiao Han
- Xiao Shumin
- Xiao Xiangshu
- Xie Li-Xin
- Xiong Peng
- Xu Beisi
- Xu Dong
- Xu Haotian
- Xu J.W.
- Xu Jialin
- Xu Jianping
- Xu Juan
- Xu Jun
- Xu Shicai
- Xu Shilin
- Xu Taosheng
- Xu Ziyue
- Xue Bin
- Xue Yu
- Yadollahpour Ali
- Yalcin Suayib
- Yamato Masayuki
- Yan Hong
- Yang Chongjun
- Yang Dongdong
- Yang En-Cheng
- Yang Hui
- Yang Long
- Yang Mingjun
- Yang Shiqi
- Yang Sunny Y.
- Yang Wei
- Yang Yongliang
- Yankilevich Patricio
- Yao Ruifeng
- Yao Wen
- Yassine Abdul-Amir
- Ye Yuzhen
- Ye Zhi-Qiang
- Yeung Andy W.K.
- Yin Cong-Cong
- Yin Qinan
- Yli-Kauhaluoma Jari
- Yoneyama Hiroshi
- Yoon Jihoon G.
- You Yuyi
- Yousefzadeh Abbas
- Yu Chenglong
- Yu Ying
- Yu Yongbo
- Yuan Christina M.
- Yuan Guo-Cheng
- Yuh Chiou-Hwa
- Zabetakis Ioannis
- Zaccolo Manuela
- Zaitsu Masayoshi
- Zare Asma
- Zaritsky Arno
- Zaucha Jan
- Zeineb Zian
- Zeng Chen
- Zeng Erliang
- Zeng Zhen
- Zevnik Branko
- Zhan Jian
- Zhan Xiao-Yong
- Zhang Chengrong
- Zhang Chi
- Zhang Chongxing
- Zhang Gong
- Zhang Haowen
- Zhang Jilei
- Zhang Junpeng
- Zhang Kai
- Zhang Li
- Zhang Linxing
- Zhang Rongqiang
- Zhang Tongchuan
- Zhang Tuo
- Zhang Wei
- Zhang Weijia
- Zhang Xianglilan
- Zhang Xiaolei
- Zhang Yao
- Zhang Yi
- Zhang Yingkai
- Zhang Yusen
- Zhang Zhe
- Zhang Zhiyong
- Zhang Zhong-Yin
- Zhang Zhongheng
- Zhao Guoyan
- Zhao Haochen
- Zhao Jing
- Zhao Xin
- Zhao Yuan
- Zheng Shan
- Zhou Bailing
- Zhou Jianyu
- Zhou Kai
- Zhou Min
- Zhou Xiaofan
- Zhou Xiaoyan
- Zhou Yaoqi
- Zhu Dongjie
- Zhu Shu
- Zhu Zhenxing
- Ziegler Andreas
- Zinke Katharina
- Zuberbier Torsten
- Zuckerman Hannah
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe
QCM virtual multisensor array for fuel discrimination and detection of gasoline adulteration
- Author
- Agarwal
- Albert
- Aleme
- Ayad
- Bachar
- Balabin
- Barbeira
- Bello
- Bourgeois
- Current
- Dahl
- Dahl
- de Oliveira
- Di Natale
- Ding
- Dixon
- Fernandes
- Flumignan
- Gaião
- Galpothdeniya
- Garg
- Gentry
- Goubaidoulline
- Hagleitner
- Hierlemann
- Isiah M. Warner
- Janzen
- Jin
- Kaiser
- Kalligeros
- Koo
- Koshets
- Kwon
- Lauren N. Speller
- Lee
- Liang
- Makino
- McConnell
- Mendes
- Mishra
- Monteiro
- Nicholas C. Speller
- Noureen Siraj
- Obeidat
- Obeidat
- Pereira
- Regmi
- Regmi
- Rehman
- Speller
- Speller
- Stephanie Vaughan
- Suslick
- Tan
- Teixeira
- Toniolo
- Umali
- Xu
- Xu
- Yamaguchi
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
© 2017 Elsevier Ltd Herein, a simplistic quartz crystal microbalance (QCM) approach for discrimination of petroleum based fuels is presented. In this regard, a quartz crystal microbalance (QCM) virtual multisensor array (V-MSA) was employed to discriminate between different petroleum based fuels and to detect gasoline adulteration with high accuracy. First, an ionic liquid based V-MSA was used to discriminate between four fuel types (petroleum ether, gasoline, kerosene, and diesel). Subsequently, the system was used to successfully discriminate between three gasoline grades as a precursor for studies of gasoline adulteration. Finally, the system was used to detect and determine the nature of several gasoline adulterants at different v/v ratios (1%, 10%, 20% and 40%). Excellent accuracy (100%) was achieved for each study extolling the potential of this approach. This report represents the first example of a QCM sensor array utilized for detection of gasoline adulteration
Gene Polymorphisms of Micrornas in Helicobacter pylori-Induced High Risk Atrophic Gastritis and Gastric Cancer
- Author
- A Hishida
- A Jemal
- A Link
- AJ Huang
- Alexander Link
- Audrius Ivanauskas
- BM Ryan
- BM Ryan
- DH Ahn
- F Wang
- GA Calin
- Guntis Ancans
- H Zhang
- HC Lee
- Indre Bruzaite
- J Bornschein
- J Gaedcke
- J Kupcinskas
- J von Frowein
- J Wang
- Juozas Kupcinskas
- Jurgita Skieceviciene
- K Jazdzewski
- K Srivastava
- KA Yoon
- L Kupcinskas
- Limas Kupcinskas
- M Lin
- M Okubo
- Marcis Leja
- Masaru Katoh
- MF Dixon
- MY Song
- N Uemura
- P Correa
- P Lauren
- P Malfertheiner
- Peter Malfertheiner
- PJ Mishra
- Q Sun
- Q Xu
- Ruta Steponaitiene
- S Peng
- S Purcell
- S Wang
- Simonas Juzenas
- T Liu
- Thomas Wex
- Ugne Gyvyte
- Vitalija Petrenkiene
- Y Zhou
- Z Liu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
A New Polymorphism Biomarker rs629367 Associated with Increased Risk and Poor Survival of Gastric Cancer in Chinese by Up-Regulated miRNA-let-7a Expression
- Author
- A Schuldt
- AE Pasquinelli
- AJ Brookes
- AL Sarver
- Bengang Wang
- BM Ryan
- BS Shastry
- Caiyun He
- Chengzhong Xing
- DM Parkin
- DW Salzman
- F Wang
- F Zhou
- GA Calin
- H Brenner
- I Tramacere
- I Tramacere
- J Krol
- J Wang
- J Yang
- J Zhou
- Jingwei Liu
- JT Bensen
- K Srivastava
- L Xu
- Liping Sun
- M Fabbri
- M Fabbri
- M Stolte
- MF Dixon
- MS Kumar
- N Long
- N Wang
- P Lao-Sirieix
- P Lauren
- P Wang
- PJ Mishra
- PS Chen
- Q Xu
- Q Xu
- Q Xu
- Qian Xu
- Qiguan Dong
- Qing-Yi Wei
- R Duan
- R Liu
- T Arisawa
- T Hansen
- V Ambros
- Wenjing Liu
- WK Leung
- WN Wang
- Xiaohang Li
- XJ Wu
- Y Xu
- YG Zhang
- YH Gong
- YM Zhu
- YP Mu
- Yuan Yuan
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Idiosyncratic responding during movie-watching predicted by age differences in attentional control
- Author
- Adarsh Grewal
- Aldabra Stoddart
- Alison McMinn
- Allen
- Amanda Castle
- Andrew Calder
- Andrew Gadie
- Andrew Hilton
- Anna Goulding
- Anna McCarrey
- Anne Barcroft
- Ashburner
- Ashburner
- Baddeley
- Bailey
- Beckmann
- Beth Parkin
- Beth Stevens
- Betti
- Campbell
- Carol Brayne
- Carstensen
- Cattell
- Cheryl Dias
- Cheryl Stone
- Claire Hanley
- Cole
- Craddock
- Damoiseaux
- Damoiseaux
- Dan Barnes
- Darren Price
- David Troy
- Diane Rowland
- Dmochowski
- Dmochowski
- Dorr
- Duncan
- Ed Bullmore
- Engle
- Filippini
- Fiona Matthews
- Fiona Roby
- Folk
- Folstein
- Frances Johnson
- Geoff Hale
- Gillian Amery
- Greicius
- Hale
- Hartley
- Hasher
- Hasher
- Hasson
- Hasson
- Hasson
- Hasson
- Hasson
- Haxby
- Hayley Fisher
- Healey
- Horn
- Hultsch
- James Rowe
- Jason Taylor
- Jaya Hillman
- Jenkinson
- Jessica Penrose
- Joanne Mitchell
- Jodie Allen
- John Duncan
- John Sargeant
- Jonathan Dowrick
- Kamen A. Tsvetanov
- Kamen Tsvetanov
- Kane
- Karen Campbell
- Karen L. Campbell
- Kemper
- Kim Norman
- Laura Villis
- Lauren Bates
- Liana Amunts
- Linda Geerligs
- Linda Geerligs
- Lorraine K. Tyler
- Lorraine K. Tyler
- MacDonald
- Magdalena Kwasniewska
- Maggie Squire
- Marie Dixon
- May
- Melissa Fair
- Meredith A. Shafto
- Meredith Shafto
- Mishra
- Mowinckel
- Naci
- Nitin Williams
- Ozlem Yazlik
- Patel
- Patricia Johnston
- Paul Wright
- Persson
- Power
- Pratt
- Rahhal
- Raz
- Rhodri Cusack
- Rhodri Cusack
- Rik Henson
- Rogier Kievit
- Sambataro
- Sargent
- Satterthwaite
- Shafto
- Sharon Erzinçlioglu
- Shirer
- Simon Davis
- Smith
- Smith
- Smith
- Sofia Gerbase
- Stanimira Georgieva
- Stevens
- Stuss
- Teresa Cheung
- Thea Kavanagh-Williamson
- Tim Dalgleish
- Tina Emery
- Tracy Thompson
- Van Dijk
- William Marslen-Wilson
- Zacks
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
- Author
- Aanei Carmen M.
- Abid Muhammad Bilal
- Abramowitz Matthew K.
- Abu-Zaid Ahmed
- Adamo Vincenzo
- Adeyemo Adebolajo A.
- Afnan Masoud
- Agarabi Cyrus
- Aggelidou Maria
- Ahmad Haroon
- Ahmad Rafi
- Aizat Wan M.
- Ajani Penelope A.
- Akinwumi Sayo A.
- Al-Farha Abd A.
- Al-Lawama Manar
- Al-Owaifeer Adi M.
- Al-Riyami Arwa Z.
- Alanio Alexandre
- Alaux Cedric
- Albery Gregory F.
- Albiol Joan
- Albrecht Dirk R.
- Albuquerque Lucia G.
- Alhowimel Ahmed
- Ali Junaid
- Alimba C. G.
- Allardyce Judith
- Almeida Gabriel M. F.
- Alonso-Caneiro David
- Alper Ozgul M.
- Alshehri Mansour
- Alsuhaibani Mohammed
- Alzghari Saeed K.
- Amer Said E. D. R.
- Amiya Eisuke
- Ammerman Brooke A.
- Amorim Rogerio M.
- An Qianli
- Anazodo Udunna C.
- Andersen Stig U.
- Andersen Vibeke
- Angus Kathryn
- Anikin Andrey
- Aplin John D.
- Argyropoulos Christos
- Armitage Charles
- Asaduzzaman Muhammad
- Asady Hadi
- Ascher David B.
- Asefa N. G.
- Ashry Mohamed
- Asmann Yan W.
- Assaeed Abdulaziz M.
- Atack John M.
- Atanasov Atanas G.
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- Zhan Xiao-Yong
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- Zhou Min
- Zhou Xiaofan
- Zhou Xiaoyan
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- Zinke Katharina
- Zuberbier Torsten
- Zuckerman Hannah
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
- Author
- Aanei Carmen M
- Abid Muhammad Bilal
- Abramowitz Matthew K
- Abu-Zaid Ahmed
- Adamo Vincenzo
- Adeyemo Adebolajo A
- Afnan Masoud
- Agarabi Cyrus
- Aggelidou Maria
- Ahmad Haroon
- Ahmad Rafi
- Aizat Wan M
- Ajani Penelope A
- Akinwumi Sayo A
- Al-Farha Abd A
- Al-Lawama Manar
- Al-Owaifeer Adi M
- Al-Riyami Arwa Z
- Alanio Alexandre
- Alaux Cedric
- Albery Gregory F
- Albiol Joan
- Albrecht Dirk R
- Albuquerque Lucia G
- Alhowimel Ahmed
- Ali Junaid
- Alimba C G
- Allardyce Judith
- Almeida Gabriel M F
- Alonso-Caneiro David
- Alper Ozgul M
- Alshehri Mansour
- Alsuhaibani Mohammed
- Alzghari Saeed K
- Amer Said E D R
- Amiya Eisuke
- Ammerman Brooke A
- Amorim Rogerio M
- An Qianli
- Anazodo Udunna C
- Andersen Stig U
- Andersen Vibeke
- Angus Kathryn
- Anikin Andrey
- Aplin John D
- Argyropoulos Christos
- Armitage Charles
- Asaduzzaman Muhammad
- Asady Hadi
- Ascher David B
- Asefa N G
- Ashry Mohamed
- Asmann Yan W
- Assaeed Abdulaziz M
- Atack John M
- Atanasov Atanas G
- Atchison David A
- Atkins Gerald J
- Atlas Lauren
- Ato Dai
- Avery Simon V
- Avillach Paul
- Azubuike Samuel O
- Baade Peter D
- Bach-Mortensen Anders
- Backman Lars
- Badie Christophe
- Bae Taeok
- Bagloee Saeed A
- Bai Xiaoyong
- Baier Dirk
- Bail Kasia
- Baines Rebecca L
- Baker Chris I
- Bakkach Joaira
- Baldi Alfonso
- Ball Elizabeth
- Ballantyne Maghan
- Baltiansky Lior
- Ban Bo
- Bannon Ross
- Bansal Abhisheka
- Bar Ido
- Bardot Olivier
- Barnett Adrian G
- Barraud Pierre
- Bartas Martin
- Basharat Zarrin
- Basner Mathias
- Bathelt Joe
- Batra Jyotsna
- Baumert Philipp
- Bazanova O M
- Beale Andrew
- Beck Charles R
- Beck Jill
- Becker Daniel
- Beddoe Travis
- Belachew Kiflemariam Y
- Bell Melanie L
- Ben-Nafa Walid
- Benezeth Yannick
- Bengtsson-Palme Johan
- Benkeser David
- Berbesque Colette
- Berezikov Eugene
- Bergsland Niels
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- Berrevoet Frederik
- Berry Edward
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- Bessa Theolis B
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- Chatterjee Pranab
- Chatzitheochari Stella
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- Chen Jui-Tung
- Chen Xiaoyin
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- Chen Yi-Chun
- Chen Yinglong
- Chen Youning
- Chen Yu-Chih
- Chen Zhao
- Cheng Changxiu
- Cheng Jianlin
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- Chenguang
- Cheung Johnny T K
- Chhatriwalla Adnan K
- Chikowe Ibrahim
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- Chowdhury Debashish
- Chowdhury Mohiuddin A K
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- Chuang Trees-Juen
- Chung Hee-Jung
- Chwalibog Andre
- Chávez-Fumagalli Miguel A
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- Yin Qinan
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- Yoneyama Hiroshi
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- Yousefzadeh Abbas
- Yu Chenglong
- Yu Ying
- Yu Yongbo
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- Yuan Guo-Cheng
- Yuh Chiou-Hwa
- Zabetakis Ioannis
- Zaccolo Manuela
- Zaitsu Masayoshi
- Zare Asma
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- Zaucha Jan
- Zeineb Zian
- Zeng Chen
- Zeng Erliang
- Zeng Zhen
- Zevnik Branko
- Zhan Jian
- Zhan Xiao-Yong
- Zhang Chengrong
- Zhang Chi
- Zhang Chongxing
- Zhang Gong
- Zhang Haowen
- Zhang Jilei
- Zhang Junpeng
- Zhang Kai
- Zhang Li
- Zhang Linxing
- Zhang Rongqiang
- Zhang Tongchuan
- Zhang Tuo
- Zhang Wei
- Zhang Weijia
- Zhang Xianglilan
- Zhang Xiaolei
- Zhang Yao
- Zhang Yi
- Zhang Yingkai
- Zhang Yusen
- Zhang Zhe
- Zhang Zhiyong
- Zhang Zhong-Yin
- Zhang Zhongheng
- Zhao Guoyan
- Zhao Haochen
- Zhao Jing
- Zhao Xin
- Zhao Yuan
- Zheng Shan
- Zhou Bailing
- Zhou Jianyu
- Zhou Kai
- Zhou Min
- Zhou Xiaofan
- Zhou Xiaoyan
- Zhou Yaoqi
- Zhu Dongjie
- Zhu Shu
- Zhu Zhenxing
- Ziegler Andreas
- Zinke Katharina
- Zuberbier Torsten
- Zuckerman Hannah
- Publication venue
- Oxford University Press
- Publication date
- 11/06/2020
- Field of study
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical science. © The Author(s) 2019. Published by Oxford University Press
Prospective observational cohort study on grading the severity of postoperative complications in global surgery research
- Author
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams George
- Adamson Michael
- Adekola Oyebola
- Adelaja Yemi
- Ademola Adeyinka
- Adenekan Anthony
- Adenike Odewabi
- Adeolu Augustine A
- Adetoye Adedapo
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- Chetty Rubendraj R
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- De Bruyne Ann
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- De Kegel Dirk
- De Meyer Jenine N
- De Oliveira Mirella Cristine
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- Deblaere Isabel
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- Deepak Shantal
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- Deja Maria
- Del Valle Santiago Garcia
- Delgado García David R
- Demartines Nicolas
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- Denham Samuel
- Dent Kathy
- Dermitzaki Despina
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- Dragoescu Nicoleta Alice
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- Du Fang
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- Dudgeon Lucy
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- Egan Thomas
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- Eichwalder Andreas
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- Ekelund Kim
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- Elferink-Vonk Renske
- Ellis Jessica
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- Fleisher Lee
- Fleisher Lee
- Fleisher Lee A.
- Flores Armando Adolfo Alvarez
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- Foord Denise
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- Freeman David
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- Funk Bonita
- Funk Duane
- Furrer Markus
- Futier E.
- Futier Emmanuel
- Futier Emmanuel
- Gaitanakis Stylianos
- Gall Lewis
- Gallacher Pete
- Gallard Sian
- Gallego Laura
- Gama N Sibusiso
- Gambhir Rajiv
- Ganter Donna Louise
- Ganter Michael T
- Gao Hong
- Garcia Carolina Soledad Romero
- Garcia Juliana
- Garcia-Saiz Irene
- García-Pérez Maria Luisa
- Gardikou Varvara Vanessa
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- Garg Atul
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- Gbolahan Olalere
- Ge Xiaodong
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- Ghushe Neil
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- Gibson-Lapsley Hannah
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- Glasbey James
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- Glover Lyn
- Goad Ehab Helmy Abdel
- Goebel Ulrich
- Goga Ismail E
- Goga Riaz
- Goldberg Olivia
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- Gondo Prisca
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- Granum Simon Nørgaard
- Graterol Juan
- Gratrix Karen
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- Gray Carol
- Gray Catherine
- Gray Sophie
- Greaves K. E.
- Greaves Rosanna
- Green Garyth M
- Green-Thompson Randolph
- Greene Michael
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- Grey Ben
- Griffiths Ewen
- Grigoras Ioana
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- Grintescu Ioana
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- Habicher Marit
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- Haddow J.
- Haddow James
- Hadebe Bernard
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- Hamzah Zulkarnain
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- Hare Gregory
- Hariharan Vimal
- Harrichandparsad R
- Harries Rhiannon
- Harris Benjamin
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- Hennings Charles
- Hering Jens Peter
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- Hernandez Miguel
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- Hinther Ashley
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- Hitchcock Rachael
- Hoare Siobhan
- Hobrok Maria
- Hodgkiss Tracey
- Hodgson Richard E
- Hodzovic Emil
- Hoedt Marielle
- Hoeft Andreas
- Hoeft Andreas
- Hofer Christoph
- Hofer Christoph
- Hoffer Franz
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- Hu Liu
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- Hulme Jonathan
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- Hutchings Melanie
- Hutchins David
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- Huynh Wilson Binh Quan
- Hwan Haifang
- Härtl Christine
- Hübner Martin
- Hüppe Michael
- Iasonidou Christina
- Idowu Olusola
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- Indra Imai
- Ioannidis Orestis
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- Ionita Victor
- Iosep Gabriel Florin
- Ip Peter
- Irshad Mariam
- Ischaki Eleni
- Ishimaru Alexander
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- Jacobs Tom
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- Jammer Ib
- Jansen Tracy-Lee
- Janssen Bruno
- Januszewska Marta
- Januszewska Marta
- Jaquet Yves
- Jardim Jaquelline
- Jawad Monir
- Jee Chiun Chen
- Jeeraz Mohammud A
- Jeffery Holly
- Jeffs Carol
- Jehosua Brillyan
- Jelschen Florian
- Jemmett Kim
- Jemna Ramona
- Jenkins Nia
- Jenkins Nicole
- Jensen-Gadegaard Peter
- Jesus Joana Sofia Teixeira
- Jeyanthan Somasundaram
- Ji Binbin
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- Jones Timothy
- Joory Kavita
- Jordaan J
- Joseph James
- Jowitt Tom
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- Julian Howes
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- Júnior La Hore Correa Rodrigues
- Kabagenyi Fiona
- Kafkalaki Kalliopi
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- Kakembo Nasser
- Kalafatis Nicky
- Kalaitzopoulos Ioannis
- Kalashetty Gunasheela
- Kalles Vasileios
- Kalliafa Elli
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- Karadia Sunny
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- Karelov Alexey
- Karen Markwell
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- Wijeysundera Duminda
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- Xiong Xiapei
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- Xu Guan-Jie
- Xu Lin
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- Xu Qiong
- Xu Shixia
- Xue Rui
- Yagnik Anmol
- Yan Yixiu
- Yang Jian
- Yang Lu
- Yang Qiuhong
- Yang Shuangjia
- Yang Tianqin
- Yang Yang
- Yao Shanglong
- Yao Yurui
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- Yeh Erlinda
- Yin Ning
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- Yuliana Annika
- Yun Bai
- Zaane Bas
- Zaimi Donika
- Zakynthinos Spyros
- Zamudio Diana
- Zangrillo Alberto
- Zapata Darcy Danitza Mari
- Zbitnew Geoff
- Zeggeren Laura
- Zeidan Lisa
- Zeng Qiuting
- Zettergren Jan
- Zhang Baoling
- Zhang Enman
- Zhang Huaigen
- Zhang Huan
- Zhang Jie
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- Zhang Mingxiao
- Zhang Qin
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- Zhang Shihai
- Zhang Weiwei
- Zhang Xiaoguang
- Zhang Xiaolin
- Zhang Xiaoyan
- Zhang Yan
- Zhang Yapping
- Zhang Ye
- Zhang Yuan
- Zhao Bing
- Zhao Bo
- Zhao Chong
- Zhao Jiashi
- Zhao Jinning
- Zhao Lei
- Zhao Shuna
- Zhao Ting
- Zhao Weihong
- Zhao Weilu
- Zhao Xiaoying
- Zhen Jungang
- Zheng Kang
- Zheng Lina
- Zheng Tianzhao
- Zhong Yi
- Zhou Ce
- Zhou Dachun
- Zhou Haidong
- Zhou Haiyan
- Zhou Jiali
- Zhou Jialong
- Zhou Jing
- Zhou Xian-jin
- Zhu Xiaomao
- Zhu Yi
- Zhu Zhipeng
- Zhuang Xiuxiu
- Zilis Georgios
- Zin Nor Hafizah Mohd
- Zingerle Nicolette
- Zingg Urs
- Zoerner Frank
- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Zundert Tom
- Zyl Rebekka
- åkring Irene
- Ögren Katrin
- Publication venue
- 'Wiley'
- Publication date
- 22/10/2018
- Field of study
Background
The Clavien–Dindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the Clavien–Dindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs).
Methods
This was a secondary analysis of the International Surgical Outcomes Study (ISOS), a prospective observational cohort study of elective surgery in adults. Data collection occurred over a 7-day period. Severity of complications was graded using Clavien–Dindo and the simpler ISOS grading (mild, moderate or severe, based on guided investigator judgement). Severity grading was compared using the intraclass correlation coefficient (ICC). Data are presented as frequencies and ICC values (with 95 per cent c.i.). The analysis was stratified by income status of the country, comparing HICs with LMICs.
Results
A total of 44 814 patients were recruited from 474 hospitals in 27 countries (19 HICs and 8 LMICs). Some 7508 patients (16·8 per cent) experienced at least one postoperative complication, equivalent to 11 664 complications in total. Using the ISOS classification, 5504 of 11 664 complications (47·2 per cent) were graded as mild, 4244 (36·4 per cent) as moderate and 1916 (16·4 per cent) as severe. Using Clavien–Dindo, 6781 of 11 664 complications (58·1 per cent) were graded as I or II, 1740 (14·9 per cent) as III, 2408 (20·6 per cent) as IV and 735 (6·3 per cent) as V. Agreement between classification systems was poor overall (ICC 0·41, 95 per cent c.i. 0·20 to 0·55), and in LMICs (ICC 0·23, 0·05 to 0·38) and HICs (ICC 0·46, 0·25 to 0·59).
Conclusion
Caution is recommended when using a treatment approach to grade complications in global surgery studies, as this may introduce bias unintentionally
The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis
- Author
- Ab Majid Mohd Azuan
- Ab Rahman Ahmad Sufian
- Ab Rahman Rusnah
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abd Ghafar Fara Nur Idayu
- Abd Hadi Husni Zaeem
- Abdel Goad Ehab Helmy
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams David
- Adams George
- Adamson Michael
- Adekola Oyebola
- Adelaja Yemi
- Ademola Adeyinka
- Adenekan Anthony
- Adenike Odewabi
- Adeolu Augustine A.
- Adetoye Adedapo
- Adewale Badru
- Adigun Tinuola
- Adolfsson Anne
- Africander Cucu
- Afshari Arash
- Agarwal Vandana
- Agodirin Olayide
- Aguzzoli Crisitiano
- Ahamed khader null
- Ahmad Azam Ummi Azmira
- Ahmad Abdurrahman
- Ahmad Norfaizan
- Ahmad T.
- Ahmad Tahania
- Ahmad Yousra
- Ahmed Ahmed
- Ahmed Jamil
- Ahmed Tahania
- Ai Yanqiu
- Aignatoaie Mariana
- Aimoniotou-Georgiou Eleni
- Akanmu Olanrewaju
- Akerman Nik
- Akinwale Mukaila
- Al Anizi Mashel
- Al hussaini Sabah
- Al'Amri Khalid
- Al-Soudaine Yassr
- Aladin Hafiz
- Alagbe-Briggs Olubusola
- Albaj Safauldeensalem
- Alberto Lisi Zaheer Moolla
- AlbertoVolta Carlo
- Alcock David
- Alcock Liam
- Aldecoa Cesar
- Aleixo Fábia Berganton
- Alexander Hazel
- Alexander Maini
- Alexander-Sefre Farhad
- Alherz Fadhel
- Ali Hani
- Ali Marlynn
- Ali Sarah
- Alias Abdul Hafiz
- Alias Anita
- Alit Mahaalit Aribawa
- Allen Samantha
- Allen Sara Jane
- Allison Joanna
- Alloj Chiara
- Allorto Nikki Leigh
- Allsop Joanne
- Almeida William
- Alonso Eduardo
- Alonso José Ignacio
- Alphonsus Christella
- Alvares Danielle
- Alves Maria Joao
- Amador Juan Carlos Bravo
- Ameer Yusuf
- Amendola Cristina Prata
- Ami Noam
- Amstrup-Hansen Louise
- Anagnou Athina
- Andersen Cheme
- Anderson Charlotte
- Anderson Colette
- Anderson Frank
- Anderson Philip
- Andreadaki Evangelia
- Andreou Alexandros
- Andreou Prematie
- Andrew Alyson
- Andrews Emma
- Angermair Stefan
- Angus Kirsty
- Anillo Victor
- Antal Oana
- Antill Philip
- Antoniadou Eleni
- Antonina Webombesa
- Apagaki Eymorfia
- Apostolou Konstantinos
- Applewhaite Christopher
- Aquino Laura Patricia González
- Ar Praburaj
- Arawwawala Dilshan
- Ardern Diane
- Argue Ruth
- Arkalaki Eleni
- Arlo whitehouse null
- Armaganidis Apostolos
- Armstrong John
- Armstrong Richard
- Arnaoutoglou Christina
- Arnaoutoglou Elena
- Arnold Glenn
- Arrandale Lindsay
- Arrich James
- Arrigo Mario
- Arshad Homa
- Arshad Mohammed Asif
- Artiles Tania Socorro
- Arumugam Swarna
- Arustei Mirela
- Arvaniti Kostoula
- Arya Aryabiantara
- Arya Shobhit
- Asimakos Andreas
- Aslam F Noorbhai M.
- Asudo Felicia
- Athanasakis Elias
- Atiku Mamuda
- Attrill Elizabeth
- Attwood Clare
- Auer Patrick
- Avidan Michael
- Avila Erendira Jocelin Dominguez
- Avis Joanne
- Awad Hadi
- Axioti Elena
- Azambuja Pedro
- Azevedo Caroline
- Aziz Faizal Zuhri
- Baas Peter
- Baghirzada Leyla
- Bai Hui-Ping
- Bai Yun
- Baillie Shelley
- Baines Duncan
- Baio Thalissa Hermínia
- Bairaktari Aggeliki
- Baker Gerard
- Baker Katie-Anne
- Baker Paul
- Balain Birender
- Balaji Packianathaswamy
- Balajonda Naraida
- Balanescu Andreea
- Balasubramaniam Madhu
- Baldisserotto Sérgio
- Baldwin Jacqueline
- Baldwin Matthew
- Balfoussia Danai
- Bali Christina
- Bandeira Maria Expedito
- Banerjee Robin
- Bankewitz Carla
- Banner-Goodspeed Valerie
- Bao Qi
- Barcraft-Barnes Helena
- Barneto Lisa
- Barnett Andrew
- Baroselli Antonio
- Barraclough James
- Barras Jean-Pierre
- Barrett Stephen
- Barrett Wendy Joan
- Basanth Sujith
- Batchelor Nick
- Bateman Brian
- Bates Alexander
- Bates Sarah
- Batista Hugo Dias
- Bauchmuller Kris
- Bauer Marlene
- Baumgarten Georg
- Baxter Linden
- Beaton Ceri
- Beattie Scott
- Beavis Vanessa
- Beavis Vanessa
- Bechan Sudha
- Bejia Tarek
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- Belda Margarita Tormo
- Bell Gillian
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- Bello Jibril
- Beloeil Helene
- Belskiy Vladislav
- Beltran Anna Valle
- Ben-Menachem Erez
- Benavent Pau
- Benedikt Preckel Osne Kirzner
- Benevento Angelo
- Bengeri Sheshagiri
- Bennett Cambell
- Bennett Michael
- Bennett Rachael
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- Beretta Luigi
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- Bernard Andre
- Bernat Maria Jose
- Berntsen Emer
- Bertram Wendy
- Bester Delia
- Bester Marlet
- Bettega Fernanda
- Bettinelli Alessandra
- Bhardwaj Neeraj
- Bhatia Kailash
- Bhula Chettan
- Bi Yanbing
- Biais Matthieu
- Biccard B. M.
- Biccard Bruce
- Biccard Bruce M.
- Bidd Heena
- Bidgoli Jawad
- Biffen Andrew
- Bignami Elena
- Bilolikar Anjali
- Bin Mustapha Mohd Tarmimi
- Birch Julie
- Bishop David Gray
- Biyase Thuli
- Bizios Christol
- Blackwell Clare
- Blackwood Douglas
- Blaj Mihaela
- Blakemore Stephen P.
- Bland Martin
- Blunt Mark
- Blyth Katharine
- Bocchino Speranza
- Bodansky Daniella
- Bodger Phoebe
- Boer Christa
- Boereboom Catherine
- Boggiano Victoria
- Bogner Gerhard
- Bokkel-Andela Janneke ten
- Bolaji Benjamin
- Bolton David
- Boone Myles
- Boschi Luca
- Boshier Piers
- Botes Marisa
- Botis Ioannis
- Bottini Corrado
- Bottrill Fiona
- Bouchez Stefaan
- Boulton Kerenza
- Bouris Vasilios
- Bourner Lynsey
- Boutsikos Georgios
- Bouwman Arthur
- Bowrey Sarah
- Boxall Leigh
- Boyd Christine
- Bradburn Mike
- Bradley Jacqueline
- Branagan Graham
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- Brenner Laura
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- Briscoe Richard
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- Brown Richard
- Brown Robyn
- Browning Julie
- Bruma Dana
- Brunete Tamara
- Brunswicker Annemarie
- Bryant Helen
- Bua Emmanuel
- Buccimazza Ines
- Buckley Sarah
- Buerkle Christian
- Buhre Wolfgang
- Builu Pierre Monji
- Buise Marc
- Bullock Clare
- Bunwarie Bimalshakth
- Burns Karen
- Burrows Lorna
- Burrows Tom
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- Chandler Ben
- Chandra Susilo
- Chandrasekharan Shardha
- Chang Yuan Hsuan
- Chaniotaki Fotini
- Charitos Efthimios
- Charlalampidoy Alexandra
- Charles Rob
- Chatterjee Devnandan
- Chatterjee Jayanta
- Chatzimichali Chatzimichali Aikaterini
- Chau Simon
- Chazova Elena
- Cheah Clarissa
- Cheah Seleen
- Cheeseman Michelle
- Cheing Yushio
- Chen Chao
- Chen Chen
- Chen Feifei
- Chen Fumei
- Chen Hong
- Chen James
- Chen Junping
- Chen Lee-lynn
- Chen Linbi
- Chen Liyong
- Chen Pushan
- Chen Qiang
- Chen Rong
- Chen Shasha
- Chen Shiyu
- Chen Sijia
- Chen Yaqiu
- Chen Yijiao
- Chen Yijun
- Chen Yongjie
- Chen Zhang
- Cheng Baoli
- Cheng Ka Ho
- Cheng Zhonggui
- Cheong Edward
- Cherian Ritchie
- Cherrett Veronica
- Chetty Rubendraj R.
- Chew M. S.
- Chew Michelle
- Chhabra Ashok
- Chicken Dennis-Wayne
- Chilinciuc Ion
- Chin Im Im
- Chirkut Subash
- Chlorou Dimitra
- Choi Hyun-min David
- Choi Stephen
- Chow Lorraine
- Christian Rachel
- Christiansen Ida Cecilie
- Christmas Natasha
- Christodoulidis Gregory
- Christodoulopoulou Theodora
- Christofaki Maria
- Christoforidis Dimitri
- Chronis Christos
- Chu Hiu Man
- Chu Susanna
- Chua Pandora
- Chukkambotla Srikanth
- Chung Chun Kwong Eric
- Cifra Elna
- Ciobanu Cristina
- Ciobotaru Oana Roxana
- Cirstea Emanuel
- Clark Richard
- Clarkson Aisling
- Clarkson Rachel
- Clavien Pierre-Alain
- Claxton Andrew
- Clemmons Karen
- Cloro Luigi Maria
- Clyde Antony
- Cobzaru Isabelle
- Codita Anisoara
- Colangelo Antonio
- Colangelo Chiara
- Colling Kerry
- Collins Hannah
- Collins Michelle
- Collins Nwokoro
- Colvin Carolyn
- Commey Thelma
- Comptaer Nicolas
- Conde Carlos
- Conradie Alae
- Constantin Kathryn
- Cook Tim
- Cooper Lauren
- Cooper Lucy
- Cooper Mariese
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- Cooper Sarah
- Copaciu Elena
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- Copotoiu Sanda Maria
- Coppens Marc
- Corneci Dan
- Cornell Jonathan
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- Correia da Silva Rui Freitas Mendonça
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- Costanzo Eleonora
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- Coulter Suzanne
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- Cronje Larissa
- Cruickshank Ross
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- Cunha Pedro
- Curley Gerard
- Currow Helen
- Czepanski Carolyn
- Czeslick Elke
- D'Andrea Rocco
- Dafnios Nikolaos
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- Nanda Rajesh
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- Nascimento Junior Paulo do
- Nascimento Vinícius
- Nastasi Mauro
- Nau Carla
- Navarro Carlos Delgado
- Nawaz Khan Raja Basit
- Naylor Charde
- Ncomanzi Dumisani
- Neckebroek Martine
- Needleman Joseph
- Neela Fiona Mc
- Neely Julia
- Neonaki Maria
- Nesbitt Vanessa
- Netke Bhagyashree
- Neto Calim Neder
- Netto Thiago Motta
- Neves Matheus
- Newton Maria
- Ney Jacqueline
- Nicklin Philippa
- Nico Zin
- Nicol Scott
- Nicola Delany
- Niebrzegowska Edyta
- Niforopoulou Panagiota
- Nightingale Jeremy
- Nikolaidis Edouardos
- Nilakant Jayashree
- Nilsson Annette
- Niman Sumara
- Nimje Ganesh
- Nishiyama Katia
- Nofal Emma
- Nolan Tracey
- Nolasco Marcos Farias
- Noordzij Peter
- Norddin Muhamad Faiz
- Northey Martin
- Norton Tracy
- Novelli Maria Teresa
- Ntloko Sindiswa
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- Numan Sandra
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- O'Brien Peter
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- O'connor Laura
- O'Connor Patrick
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- Resendes Hernâni Oliveira
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- Ritchie Charlotte
- Roach Richard
- Roasio Agostino
- Robbins James
- Robert Axe
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- Rodrigues Júnior La Hore Correa
- Rodrigues Carla Maria
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- Saad Hesham
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- Saiz Cristina
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- Salmond Timothy
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- Salvana Abegail
- Samoilenko Aleksandr
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- Savarkar Sukhada
- Sayeed Ahmed
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- Serra Sofia
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- Sewpersad Selina
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- Sfyras Dimitrios
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- Shah Bhagyesh
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- Shen Jing
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- Shenoy Ravikiran
- Sherwood Nicholas
- Shi Pengcai
- Shi Xiaoyun
- Shi Yiyi
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- Shida Asako
- Shikanda Anne Wesonga
- Short Tim
- Shrivastava Aditi
- Shulman Mark
- Sibilio Andrea
- Siddiqui Faisal
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- Siegel Hanna
- Sigcu Noluyolo
- Silva Joao
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- Simon Davies
- Simons Henry
- Simpson James
- Sinclair Rhona
- Sineus Marlene
- Singh Avesh
- Singh Bhagwan
- Sinha Vivek
- Siouti Ioanna
- Sirha Ravneet
- Sivasakthi Datin
- Skinner Ben
- Skinner David L.
- Skoufi Anthi
- Slankamenac Ksenija
- Slawson Nicola
- Slepova Tatiana
- Slim Karem
- Smit-Fun Valerie
- Smith Andrew
- Smith Annie
- Smith Christopher
- Smith Coral
- Smith Emma-Jane
- Smith Frances
- Smith Kate
- Smith Kirsty
- Smith Murray J.
- Smith Neil
- Smith Nicola
- Smith Søren Hübertz
- Smith Thomas
- Smith Tony
- Smitz Carine
- Smolen Susan
- Soares Maria da Conceição
- Sobol Julia
- Sofjan Iwan
- Sojod Ghassan
- Sokhi Jagdish
- Sola Sotannde
- Solanki Shalil
- Soll Christopher
- Somanath Sameer
- Somascanthan Priya
- Song Xiumei
- Song Zhiping
- Sonnemann Susanne
- Soon Wai Cheong
- Soro Marina
- Soto Maria Teresa Tebar
- Sottosanti Vicari
- Souri Flora
- Sousana Anisoglou
- Souvatzis Xenia
- Souza Daniela
- Spadaro Savino
- Spagnesi Lorenzo
- Spanjersberg Rob
- Spartinou Anastasia
- Spencer-Jones Richard
- Sperber Jesper
- Spickett Helen
- Spowart Emma
- Sprakel Joost
- Spring Anna
- Spurdle Katie
- Squire Rosalyn
- Ssettabi Eden Michael
- Stafylaraki Maria
- Stamatiou Konstantinos
- Stamoulis Konstantinos
- Stancombe Lucia
- Stanescu Dorin
- Stanworth Helen
- Stapelberg Francois
- Steele Niall
- Steen Julie
- Stefan Andreea
- Stefan Mihai
- Stefanidou Nefeli
- Steindl Johannes
- Steingrímsdóttir Guðný Erla
- Stella Ogunmuyiwa
- Stephens Robert
- Stephenson Lorraine
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- Stevens Amy
- Stewart Kirsten
- Stewart Marcelle
- Steyaert Arnaud
- Steynor Martin
- Stocker Andrea
- Stoica Radu
- Stoltz Deon
- Stone Lucy
- Streanga Lavinea
- Struck Rafael
- Strydom Magdel
- Stundner Ottokar
- Su Lin
- Suarez Luis
- Suarez-de-la-Rica Alejandro
- Subramaniam Kathirvel
- Suen Andrew
- Sukawi Ismawaty
- Sulaiman Hetty Ayuni
- Sule Umar Musa
- Sumner Matthew
- Sun Chuanyu
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- Sun Yongtao
- Sun Yu
- Sundayi Saul
- Sung Weilin
- Susanti Ade
- Swain Andrew
- Swarbrick Gemma
- Swift Diane
- Sybil Shah Mohammad Hafizshah
- Sylvan Axel
- Synekidou Eirini
- Syrogianni Paulina
- Szabo Christian
- Szafranski Jan
- Szakmany Tamas
- Sá Malbouisson Luiz Marcelo
- Tabajara Fernanda Beck
- Taddeo Daiana
- Taffurelli Mario
- Tai Joyce
- Takemoto Steven
- Talabi Ademola
- Tambellini Joanne
- Tameem Alifia
- Tan Jessica
- Tan Mark
- Tan Michael
- Tan Siew Ching
- Tan Tse Siang
- Tang Jing
- Tang Na
- Tang Yongzhong
- Tank Ghanshyambhai
- Tantri Aida
- Tao Fan
- Tao Jing
- Tardelli Maria Angela
- Tayeh Salim
- Taylor Jenna L.
- Tayo Adeoluwa
- Tbaily Lee
- Tchekulaev Aleksandr
- Templer Paul
- Terblanche Nico
- Tesniere Antoine
- Tessera Gaetano
- Testa Valentina
- Theodorakopoulou Maria
- Theodosopoulos Theodosios
- Thiessen Barton
- Thilen Stephan
- Thomas Anna
- Thomas Charlotte
- Thomas Christopher
- Thomas Martin
- Thomas Megan
- Thomas Richard
- Thomas Sian
- Thompson Jonathan
- Thorpe Kevin
- Thunder Joanne
- Tincu Eugen
- Tinti Carla
- Tinuoye Elizabeth
- Tolenaar Noortje
- Tolmasov Alexander
- Tom Charles Otim
- Tomescu Dana
- Tomé Miguel
- Tong Youliang
- Too Lingxi
- Topliffe Joanne
- Torborg Alexandra
- Toretti Ilaria
- Tormo Sergi
- Toro Nancy
- Torrance Andrew
- Torrance Hew
- Tosa Flaviu
- Toth-Tarsoly Piroska
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- Tou Samson
- Towse Kayley
- Trampitsch Ernst
- Tran Diem
- Tranca Sebastian
- Travi Maria Eduarda
- Treggiari Miriam
- Tregonning Julie
- Trembath Lisa
- Tripathi Shiva
- Trodd Dawn
- Troko Jtroko
- Trybus Christoph
- Tsagkaraki Angeliki
- Tsagkaraki Georgia
- Tsakiridou Isaia-sissy
- Tsakok Maria
- Tsampalas Stavros
- Tsang Man Shing
- Tsang Man Shing Caleb
- Tsaousi Georgia
- Tsigou Evdoxia
- Tsigris Christos
- Tsiligiannis Sophia
- Tsimpoukas Fotios
- Tsioka Agoritsa
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- Tsui Albert
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- Utara Utara Hartawan
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- van Zundert Tom
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- Vandenheuvel Michael
- Vanluchene Ann
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- Varley Simon
- Varma Sandeep
- Varsani Nimu
- Vartic Mihaela
- Vasian Horatiu
- Vasileiou Maria
- Veerakumaran Jeyaganesh
- Veevaete Laurent
- Veit Siegfried
- Vele Liana
- Venara Aurélien
- Venner Nicola
- Venugopal Suneetha
- Vera Martin Agüero
- Vercauteren Marcel
- Verdoodt Hans
- Veroniki Fotini
- Verroiotou Maria
- Ververidou Ourania
- Vesely Martin
- Vetsiou Evangelia
- Vicente Bárbara Vázquez
- Vilela dos Santos Ana Maria
- Villagrán María José
- Virdi Pardeep
- Visser Linda
- Visvalingam Sheshendrasurian
- Vivian Mark
- Vivo Jose Tatay
- Vlachogianni Glyceria
- Vohra Akbar
- Vohra Ravinder
- Voldaeva Olga
- Voloudakis Nikolaos
- Von Heymann Christian
- von Rhaden Richard
- Voruz François
- Wadams Beverley
- Waggett Helena
- Walder Bernhard
- Walkden Graham
- Walker Alycon
- Walker Elaine
- Walker Rachel
- Walker Robert
- Walker Tara
- Wallace Art
- Wallace Karin
- Wallet Florent
- Walsgrove Joseph
- Walsh Dean
- Wan Xianwen
- Wang Difei
- Wang Dong
- Wang Fei
- Wang Guoxiang
- Wang Haiying
- Wang Hongfa
- Wang Jiaxing
- Wang Jin
- Wang Jun
- Wang Junkai
- Wang Junlu
- Wang Kenru
- Wang Leilei
- Wang Li
- Wang Lijun
- Wang Sheng
- Wang Shenhui
- Wang Shun
- Wang Tianlong
- Wang Weixing
- Wang Xiu-Li
- Wang Yuelan
- Wang Yuting
- Wang Zhen
- Wang Zhi
- Wang Zhipeng
- Ward Jackie
- Wasmund Christina
- Wassall Richard
- Watanabe Oliveira Henri Roger
- Watson Anthony
- Watson Nicholas
- Watt Philip
- Waugh Darren
- Waweru Peter
- Waworuntu Neil
- Waymouth Ellen
- Weatherall Lucie
- Weatherill J.
- Webb Stephen
- Weber Eric
- Wei Jianfeng
- Weimann Joerg
- Weller Debbie
- Welsh Sarah
- Wen Xiao Hong
- Wen Yazhou
- Wen Zhiting
- Wendling Paulo Rafael
- Wessels Joseph D.
- Wetzel Peter
- Weyland Andreas
- White Steve
- White Stuart
- Whitman Zoe
- Whittle Nicola
- Whitworth Helen
- Whysall Karen
- Wiborg Lange Kai Henrik
- Wibrandt Ida
- Wickboldt Nadine
- Wickenhauser Reinhart
- Wid Widnyana Made
- Widmark Carl
- Wiegand-Loehnert Carola
- Wighton Elinor
- Wigmore Geoffrey
- Wijeysundera Duminda
- Wikner Matthew
- WilberforceTurton Edwin
- Wild Jonathan
- Wildes Troy
- Wildi Stefan
- Williams Alexandra
- Williams Maya
- Williams Sarah
- Wilscott-Davids Candice
- Wilson Alison
- Wilson Debbie
- Wilson Leona
- Wilson Matt
- Wilson Natalie
- Wima Semarawima
- Winch Denyse
- Winstone Ulrika
- Winterton Dario
- Wir Wiryana Made
- Wise Robert
- Wittmann Maria
- Wolfer Alexandra
- Wolfer Alexandra
- Wollaston Julie
- Wong Cheng Weng
- Wong Christopher
- Wong Juan Yong
- Wong Kate
- Wong Kin Wai Kevin
- Wong Sze Meng
- Wong Tony
- Wong Wing Lam
- Woodgate Andrew
- Woolsey Adrianna
- Woon Yuan Liang
- Worreth Marc
- Wouters Patrick
- Wrench Ian
- Wright Sally
- Wu Chao
- Wu Chi
- Wu Jie
- Wu Qiong
- Wu Shuijing
- Wyffels Piet
- Wylie Katharine
- Xia Jiangyan
- Xia Yanfei
- Xia Zhong-yuan
- Xiao Wangpin
- Xiao Wei
- Xie Guohao
- Xie Jue
- Xie Junjie
- Xie Keliang
- Xifara Archontoula
- Xiong Xiapei
- Xiong Yingfen
- Xouplidis Kyriakos
- Xu Guan-Jie
- Xu Lin
- Xu Liyuan
- Xu Qiong
- Xu Shixia
- Xue Rui
- Yagnik Anmol
- Yan Yixiu
- Yang Jian
- Yang Lu
- Yang Qiuhong
- Yang Shuangjia
- Yang Tianqin
- Yang Yang
- Yao Shanglong
- Yao Yurui
- Yap Huey Ling
- Yarwood Jamie
- Yassaee Arrash
- Ye Haiwang
- Ye Hui
- Yegnaram Shashikant
- Yeh Erlinda
- Yin Ning
- Yip Chi Pang
- Yong Johnny
- Yu Hai Chuan
- Yu Shuchun
- Yu Tian
- Yu Yonghao
- Yuan Dajiang
- Yuan Fang
- Yuan Jiaqi
- Yuan Jing
- Yuan Yazhuo
- Yuliana Annika
- Zaimi Donika
- Zakynthinos Spyros
- Zamudio Diana
- Zangrillo Alberto
- Zapata Darcy Danitza Mari
- Zbitnew Geoff
- Zeidan Lisa
- Zeng Qiuting
- Zerman Luiza
- Zettergren Jan
- Zhang Baoling
- Zhang Enman
- Zhang Hongyan
- Zhang Huaigen
- Zhang Huan
- Zhang Jie
- Zhang Kai
- Zhang Lina
- Zhang Min
- Zhang Mingxiao
- Zhang Qin
- Zhang Ruilin
- Zhang Shihai
- Zhang Weiwei
- Zhang Xiaoguang
- Zhang Xiaolin
- Zhang Xiaoyan
- Zhang Xuekang
- Zhang Yan
- Zhang Yapping
- Zhang Ye
- Zhang Yuan
- Zhao Bing
- Zhao Bo
- Zhao Chong
- Zhao Jiashi
- Zhao Jinning
- Zhao Lei
- Zhao Lili
- Zhao Shuna
- Zhao Ting
- Zhao Weihong
- Zhao Weilu
- Zhao Xiaoying
- Zhen Jungang
- Zheng Kang
- Zheng Lina
- Zheng Tianzhao
- Zhong Yi
- Zhou Ce
- Zhou Dachun
- Zhou Haidong
- Zhou Haiyan
- Zhou Jiali
- Zhou Jialong
- Zhou Jing
- Zhou Xian-jin
- Zhu Xiaomao
- Zhu Xiaoping
- Zhu Yi
- Zhu Zhipeng
- Zhuang Xiuxiu
- Zilis Georgios
- Zingerle Nicolette
- Zingg Urs
- Zoerner Frank
- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Åkring Irene
- Ögren Katrin
- Publication venue
- Health Sciences Research Commons
- Publication date
- 30/10/2017
- Field of study
© 2017 British Journal of Anaesthesia Background: The surgical safety checklist is widely used to improve the quality of perioperative care. However, clinicians continue to debate the clinical effectiveness of this tool. Methods: Prospective analysis of data from the International Surgical Outcomes Study (ISOS), an international observational study of elective in-patient surgery, accompanied by a systematic review and meta-analysis of published literature. The exposure was surgical safety checklist use. The primary outcome was in-hospital mortality and the secondary outcome was postoperative complications. In the ISOS cohort, a multivariable multi-level generalized linear model was used to test associations. To further contextualise these findings, we included the results from the ISOS cohort in a meta-analysis. Results are reported as odds ratios (OR) with 95% confidence intervals. Results: We included 44 814 patients from 497 hospitals in 27 countries in the ISOS analysis. There were 40 245 (89.8%) patients exposed to the checklist, whilst 7508 (16.8%) sustained ≥1 postoperative complications and 207 (0.5%) died before hospital discharge. Checklist exposure was associated with reduced mortality [odds ratio (OR) 0.49 (0.32–0.77); P\u3c0.01], but no difference in complication rates [OR 1.02 (0.88–1.19); P=0.75]. In a systematic review, we screened 3732 records and identified 11 eligible studies of 453 292 patients including the ISOS cohort. Checklist exposure was associated with both reduced postoperative mortality [OR 0.75 (0.62–0.92); P\u3c0.01; I2=87%] and reduced complication rates [OR 0.73 (0.61–0.88); P\u3c0.01; I2=89%). Conclusions: Patients exposed to a surgical safety checklist experience better postoperative outcomes, but this could simply reflect wider quality of care in hospitals where checklist use is routine