1,878 research outputs found
Evolution of the Fundamental Plane of 0.2<z<1.2 Early-type galaxies in the EGS
The Fundamental Plane relates the structural properties of early-type
galaxies such as its surface brightness and effective radius with its dynamics.
The study of its evolution has therefore important implications for models of
galaxy formation and evolution. This work aims to identify signs of evolution
of early-type galaxies through the study of parameter correlations using a
sample of 135 field galaxies extracted from the Extended Groth Strip in the
redshift range 0.2<z<1.2. Using DEEP2 data, we calculate the internal velocity
dispersions by extracting the stellar kinematics from absorption line spectra,
using a maximum penalized likelihood approach. Morphology was determined
through visual classification using the V+I images of ACS. The structural
parameters of these galaxies were obtained by fitting de Vaucouleurs stellar
profiles to the ACS I-band images, using the GALFIT code. S\'ersic and
bulge-to-disc decomposition models were also fitted to our sample of galaxies,
and we found a good agreement in the Fundamental Plane derived from the three
models. Assuming that effective radii and velocity dispersions do not evolve
with redshift, we have found a brightening of 0.68 mag in the B-band and 0.52
mag in the g-band at =0.7. However, the scatter in the FP is reduced by half
when we allow the FP slope to evolve, suggesting a different evolution of
early-type galaxies according to their intrinsic properties. The study of the
Kormendy relation shows the existence of a population of very compact (Re<2
Kpc) and bright galaxies (-21.5>Mg>-22.5), of which there are only a small
fraction (0.4%) at z=0. The evolution of these compact objects is mainly caused
by an increase in size that could be explained by the action of dry minor
mergers, and this population is responsible for the evolution detected in the
Fundamental Plane.Comment: Accepted for publication in A&A. 12 pages, 10 Figures, and 1 online
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ALDH4A1 is an atherosclerosis auto-antigen targeted by protective antibodies
Cardiovascular disease (CVD) is the leading cause of mortality in the world, with most CVD-related deaths resulting from myocardial infarction or stroke. The main underlying cause of thrombosis and cardiovascular events is atherosclerosis, an inflammatory disease that can remain asymptomatic for long periods. There is an urgent need for therapeutic and diagnostic options in this area. Atherosclerotic plaques contain autoantibodies, and there is a connection between atherosclerosis and autoimmunity. However, the immunogenic trigger and the effects of the autoantibody response during atherosclerosis are not well understood. Here we performed high-throughput single-cell analysis of the atherosclerosis-associated antibody repertoire. Antibody gene sequencing of more than 1,700 B cells from atherogenic Ldlr and control mice identified 56 antibodies expressed by in-vivo-expanded clones of B lymphocytes in the context of atherosclerosis. One-third of the expanded antibodies were reactive against atherosclerotic plaques, indicating that various antigens in the lesion can trigger antibody responses. Deep proteomics analysis identified ALDH4A1, a mitochondrial dehydrogenase involved in proline metabolism, as a target antigen of one of these autoantibodies, A12. ALDH4A1 distribution is altered during atherosclerosis, and circulating ALDH4A1 is increased in mice and humans with atherosclerosis, supporting the potential use of ALDH4A1 as a disease biomarker. Infusion of A12 antibodies into Ldlr mice delayed plaque formation and reduced circulating free cholesterol and LDL, suggesting that anti-ALDH4A1 antibodies can protect against atherosclerosis progression and might have therapeutic potential in CVD.Ministerio de Economía y Competitividad (SVP-2014-068289); P.D. was supported by an AECC grant (AIO 2012, Ayudas a Investigadores en Oncología 2012); A.S.-B. is a Juan de la Cierva researcher (IJC2018-035279-I); I.M.-F. was a fellow of the research training program funded by Ministerio de Economía y Competitividad (SVP-2014-068216); and A.R.R. and J.V. are supported by Centro Nacional de Investigaciones Cardiovasculares (CNIC). The project leading to these results has received funding from la Caixa Banking Foundation under the project code HR17-00247 and from SAF2016-75511-R and PID2019-106773RB-I00 grants to A.R.R. (Plan Estatal de Investigación Científica y Técnica y de Innovación 2013–201
The Mice at play in the CALIFA survey: A case study of a gas-rich major merger between first passage and coalescence
We present optical integral field spectroscopy (IFS) observations of the
Mice, a major merger between two massive (>10^11Msol) gas-rich spirals NGC4676A
and B, observed between first passage and final coalescence. The spectra
provide stellar and gas kinematics, ionised gas properties and stellar
population diagnostics, over the full optical extent of both galaxies. The Mice
provide a perfect case study highlighting the importance of IFS data for
improving our understanding of local galaxies. The impact of first passage on
the kinematics of the stars and gas has been significant, with strong bars
likely induced in both galaxies. The barred spiral NGC4676B exhibits a strong
twist in both its stellar and ionised gas disk. On the other hand, the impact
of the merger on the stellar populations has been minimal thus far: star
formation induced by the recent close passage has not contributed significantly
to the global star formation rate or stellar mass of the galaxies. Both
galaxies show bicones of high ionisation gas extending along their minor axes.
In NGC4676A the high gas velocity dispersion and Seyfert-like line ratios at
large scaleheight indicate a powerful outflow. Fast shocks extend to ~6.6kpc
above the disk plane. The measured ram pressure and mass outflow rate
(~8-20Msol/yr) are similar to superwinds from local ULIRGs, although NGC4676A
has only a moderate infrared luminosity of 3x10^10Lsol. Energy beyond that
provided by the mechanical energy of the starburst appears to be required to
drive the outflow. We compare the observations to mock kinematic and stellar
population maps from a merger simulation. The models show little enhancement in
star formation during and following first passage, in agreement with the
observations. We highlight areas where IFS data could help further constrain
the models.Comment: 23 pages, 13 figures, accepted to A&A. A version with a complete set
of high resolution figures is available here:
http://www-star.st-and.ac.uk/~vw8/resources/mice_v8_astroph.pd
Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study
BACKGROUND: The SARS-CoV-2 variant of concern, omicron, appears to be less severe than delta. We aim to quantify the differences in symptom prevalence, risk of hospital admission, and symptom duration among the vaccinated population. METHODS: In this prospective longitudinal observational study, we collected data from participants who were self-reporting test results and symptoms in the ZOE COVID app (previously known as the COVID Symptoms Study App). Eligible participants were aged 16-99 years, based in the UK, with a body-mass index between 15 and 55 kg/m2, had received at least two doses of any SARS-CoV-2 vaccine, were symptomatic, and logged a positive symptomatic PCR or lateral flow result for SARS-CoV-2 during the study period. The primary outcome was the likelihood of developing a given symptom (of the 32 monitored in the app) or hospital admission within 7 days before or after the positive test in participants infected during omicron prevalence compared with those infected during delta prevalence. FINDINGS: Between June 1, 2021, and Jan 17, 2022, we identified 63 002 participants who tested positive for SARS-CoV-2 and reported symptoms in the ZOE app. These patients were matched 1:1 for age, sex, and vaccination dose, across two periods (June 1 to Nov 27, 2021, delta prevalent at >70%; n=4990, and Dec 20, 2021, to Jan 17, 2022, omicron prevalent at >70%; n=4990). Loss of smell was less common in participants infected during omicron prevalence than during delta prevalence (16·7% vs 52·7%, odds ratio [OR] 0·17; 95% CI 0·16-0·19, p<0·001). Sore throat was more common during omicron prevalence than during delta prevalence (70·5% vs 60·8%, 1·55; 1·43-1·69, p<0·001). There was a lower rate of hospital admission during omicron prevalence than during delta prevalence (1·9% vs 2·6%, OR 0·75; 95% CI 0·57-0·98, p=0·03). INTERPRETATION: The prevalence of symptoms that characterise an omicron infection differs from those of the delta SARS-CoV-2 variant, apparently with less involvement of the lower respiratory tract and reduced probability of hospital admission. Our data indicate a shorter period of illness and potentially of infectiousness which should impact work-health policies and public health advice. FUNDING: Wellcome Trust, ZOE, National Institute for Health Research, Chronic Disease Research Foundation, National Institutes of Health, and Medical Research Council
Anisotropy and chemical composition of ultra-high energy cosmic rays using arrival directions measured by the Pierre Auger Observatory
The Pierre Auger Collaboration has reported evidence for anisotropy in the
distribution of arrival directions of the cosmic rays with energies
eV. These show a correlation with the distribution
of nearby extragalactic objects, including an apparent excess around the
direction of Centaurus A. If the particles responsible for these excesses at
are heavy nuclei with charge , the proton component of the
sources should lead to excesses in the same regions at energies . We here
report the lack of anisotropies in these directions at energies above
(for illustrative values of ). If the anisotropies
above are due to nuclei with charge , and under reasonable
assumptions about the acceleration process, these observations imply stringent
constraints on the allowed proton fraction at the lower energies
Measurement of the cross-section and charge asymmetry of bosons produced in proton-proton collisions at TeV with the ATLAS detector
This paper presents measurements of the and cross-sections and the associated charge asymmetry as a
function of the absolute pseudorapidity of the decay muon. The data were
collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with
the ATLAS experiment at the LHC and correspond to a total integrated luminosity
of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements
varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the
1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured
with an uncertainty between 0.002 and 0.003. The results are compared with
predictions based on next-to-next-to-leading-order calculations with various
parton distribution functions and have the sensitivity to discriminate between
them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables,
submitted to EPJC. All figures including auxiliary figures are available at
https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13
Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector
A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13 TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139 fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV
Search for direct stau production in events with two hadronic tau-leptons in root s=13 TeV pp collisions with the ATLAS detector
A search for the direct production of the supersymmetric partners ofτ-leptons (staus) in final stateswith two hadronically decayingτ-leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of139fb−1, recorded with the ATLAS detector at the LargeHadron Collider at a center-of-mass energy of 13 TeV. No significant deviation from the expected StandardModel background is observed. Limits are derived in scenarios of direct production of stau pairs with eachstau decaying into the stable lightest neutralino and oneτ-lepton in simplified models where the two staumass eigenstates are degenerate. Stau masses from 120 GeV to 390 GeV are excluded at 95% confidencelevel for a massless lightest neutralino
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