REVE 2021: 9th International Workshop on Reverse Variability Engineering

Software Product Line (SPL) migration remains a challenging endeavour. From organizational issues to purely technical challenges, there is a wide range of barriers that complicates SPL adoption. This workshop aims to foster research about making the most of the two main inputs for SPL migration: 1) domain knowledge and 2) legacy assets. Domain knowledge, usually implicit and spread across an organization, is key to define the SPL scope and to validate the variability model and its semantics. At the technical level, domain expertise is also needed to create or extract the reusable software components. Legacy assets can be, for instance, similar product variants (e.g., requirements, models, source code, etc.) that were implemented using ad-hoc reuse techniques such as clone-and-own. More generally, the workshop REverse Variability Engineering attracts researchers and practitioners contributing to processes, techniques, tools, or empirical studies related to the automatic, semi-automatic or manual extraction or refinement of SPL assets

Análisis de diseño a partir de la lectura de dos periódicos en línea, El Universal y La Jornada, mediante el empleo de eye tracking

La lectura de periódicos en línea se ha convertido en una práctica común en todo el mundo, y a pesar de que cada vez son más numerosos los estudios que se hacen sobre el comportamiento de las personas durante la lectura de portales de Internet especializados en la difusión de noticias, no son suficientes para entender la complejidad de estos procesos. A pesar de la proliferación de estos medios electrónicos hay muchas preguntas sin respuesta concernientes tanto al desempeño del usuario como a la usabilidad de los periódicos mismos. El registro de los movimientos oculares de un individuo durante la navegación en un diario en línea proporciona información cuantitativa y objetiva sobre el comportamiento durante la lectura. En este estudio se analizan, con la tecnología eye tracking, dos periódicos en línea: La Jornada, pionero del periodismo digital mexicano, que apareció en la Internet el 6 de febrero de 1995, y El Universal, que desde 1996 se convirtió en proveedor de servicios para los usuarios de la red, con una circulación superior a la de La Jornada. Los periódicos en cuestión mantienen una estructura básica tanto en su forma como en su contenido, pero la interfaz de cada diario en línea resulta significativamente distinta. Las pruebas muestran una mayor eficiencia en términos de usabilidad en la página de La Jornada, ya que su interfaz es más amigable, menos compleja y mucho menos cargada de estímulos visuales. Por el contrario, la página de El Universal, a pesar de sus múltiples rediseños, probó ser menos eficiente, en particular en la búsqueda de notas específicas; su página principal, gráficamente más atractiva, está saturada de estímulos visuales que impiden la lectura y dificultan los procesos cognitivos

Effects of different doses of Salix babylonica extract on growth performance and diet in vitro gas production in Pelibuey growing lambs

Twenty Pelibuey 3-4 month old and 23.7±3.3 kg body weight male lambs were used in a randomised design to study the effects of daily oral administration of Salix babylonica (SB) extract on dry matter (DM), water intake, average daily gain (ADG), and feed efficiency for 72 days. Animals were divided into four groups fed the same total mixed ration with different doses of SB: 0 (Control), 20 (SB20), 40 (SB40) and 60 (SB60) mL/lamb/d. In vitro gas production (GP) of the same diet fed to lambs as a substrate was measured with different doses of SB (0, 0.3, 0.7, 1.0 mL/g DM). Daily administration of SB to lambs had no effects (P=0.05) on growth performance and DMI (linear effect, P=0.2805; quadratic effect, P=0.3747). Both low and moderate doses of SB (SB40>SB20) tended to increase (linear effect, P=0.4010; quadratic effect, P=0.9166) ADG. The asymptotic GP quadratically increased (PSB20) tended to increase (linear effect, P=0.4010; quadratic effect, P=0.9166) ADG. The asymptotic GP quadratically increased (PSB20) tended to increase (linear effect, P=0.4010; quadratic effect, P=0.9166) ADG. The asymptotic GP quadratically increased (P<0.001) with decreased GP rate and with increasing SB extract doses. In vitro GP increased (P<0.05) with advancing of incubation time in all SB doses. During the first 24 h of incubation, 0.3 mL SB/g DM had the highest GP, whereas 1.0 mL SB/g DM quadratically increased (P<0.001) GP. The low dose of SB extract increased ME (linear effect, P=0.024) and short chain fatty acids (SCFA) (linear effect, P=0.023). However, the highest dose quadratically decreased (P=0.02) DM degradability. In conclusion, administration of SB extract at 40 mL/lamb/d tended to increase DM intake, improve daily weight gain in growing lambs with increasing asymptotic in vitro ruminal GP and SB dose

Temas selectos de diseño e interacción tecnológica

76 Páginas.El libro en cuestión, presenta avances de tres trabajos de investigación que a su vez reflejan tres miradas distintas a la relación entre el diseño y las tecnologías digitales. El primer trabajo denominado “Diálogo desde las universidades, un punto de partida”, elaborado por la Mtra. Itzel Sainz, es una primera aproximación teórica que contribuye a mejorar el entendimiento sobre las modalidades de aplicación del diseño en los distintos medios de comunicación gráfica que aplican las instituciones públicas de educación superior en los espacios virtuales. Por su parte, el Dr. Marco Ferruzca nos comparte a través de su texto “Inteligencia colectiva y las prácticas del diseño” una breve reseña sobre cómo este fenómeno colectivo está incidiendo en la actividad proyectual del diseño de espacios, objetos, mensajes u otros tipos de diseño. El tercer texto “Análisis de movimientos oculares a partir de la lectura en línea de dos periódicos nacionales desde la perspectiva del diseño: el caso de los periódicos “El Universal” y “La Jornada”, dirigido por la Mtra. Ivonne Murillo y la Mtra. Alejandra Zafra, con la participación de Ramses Román alumno de Diseño Industrial, el profesor invitado Roberto López y un servidor; el trabajo es un ejemplo de ese otro tipo de argumentos más objetivos que los diseñadores pueden emplear para evaluar el objeto de diseño, en este caso los mensajes gráficos

Measurements of Higgs boson production and couplings in diboson final states with the ATLAS detector at the LHC

Measurements are presented of production properties and couplings of the recently discovered Higgs boson using the decays into boson pairs, H →γ γ, H → Z Z∗ →4l and H →W W∗ →lνlν. The results are based on the complete pp collision data sample recorded by the ATLAS experiment at the CERN Large Hadron Collider at centre-of-mass energies of √s = 7 TeV and √s = 8 TeV, corresponding to an integrated luminosity of about 25 fb−1. Evidence for Higgs boson production through vector-boson fusion is reported. Results of combined fits probing Higgs boson couplings to fermions and bosons, as well as anomalous contributions to loop-induced production and decay modes, are presented. All measurements are consistent with expectations for the Standard Model Higgs boson

Standalone vertex finding in the ATLAS muon spectrometer

A dedicated reconstruction algorithm to find decay vertices in the ATLAS muon spectrometer is presented. The algorithm searches the region just upstream of or inside the muon spectrometer volume for multi-particle vertices that originate from the decay of particles with long decay paths. The performance of the algorithm is evaluated using both a sample of simulated Higgs boson events, in which the Higgs boson decays to long-lived neutral particles that in turn decay to bbar b final states, and pp collision data at √s = 7 TeV collected with the ATLAS detector at the LHC during 2011

Hunt for new phenomena using large jet multiplicities and missing transverse momentum with ATLAS in 4.7 fb−1 of √s=7 TeV proton-proton collisions

Results are presented of a search for new particles decaying to large numbers of jets in association with missing transverse momentum, using 4.7 fb−1 of pp collision data at s√=7TeV collected by the ATLAS experiment at the Large Hadron Collider in 2011. The event selection requires missing transverse momentum, no isolated electrons or muons, and from ≥6 to ≥9 jets. No evidence is found for physics beyond the Standard Model. The results are interpreted in the context of a MSUGRA/CMSSM supersymmetric model, where, for large universal scalar mass m 0, gluino masses smaller than 840 GeV are excluded at the 95% confidence level, extending previously published limits. Within a simplified model containing only a gluino octet and a neutralino, gluino masses smaller than 870 GeV are similarly excluded for neutralino masses below 100 GeV

Natural History of MYH7-Related Dilated Cardiomyopathy

BACKGROUND Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described. OBJECTIVES We sought to determine the phenotype and prognosis of MYH7-related DCM. We also evaluated the influence of variant location on phenotypic expression. METHODS We studied clinical data from 147 individuals with DCM-causing MYH7 variants (47.6% female; 35.6 +/- 19.2 years) recruited from 29 international centers. RESULTS At initial evaluation, 106 (72.1%) patients had DCM (left ventricular ejection fraction: 34.5% +/- 11.7%). Median follow-up was 4.5 years (IQR: 1.7-8.0 years), and 23.7% of carriers who were initially phenotype-negative developed DCM. Phenotypic expression by 40 and 60 years was 46% and 88%, respectively, with 18 patients (16%) first diagnosed at <18 years of age. Thirty-six percent of patients with DCM met imaging criteria for LV noncompaction. During follow-up, 28% showed left ventricular reverse remodeling. Incidence of adverse cardiac events among patients with DCM at 5 years was 11.6%, with 5 (4.6%) deaths caused by end-stage heart failure (ESHF) and 5 patients (4.6%) requiring heart transplantation. The major ventricular arrhythmia rate was low (1.0% and 2.1% at 5 years in patients with DCM and in those with LVEF of <= 35%, respectively). ESHF and major ventricular arrhythmia were significantly lower compared with LMNA-related DCM and similar to DCM caused by TTN truncating variants. CONCLUSIONS MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. Heart failure complications predominate over ventricular arrhythmias, which are rare. (C) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation

The European Hematology Association Roadmap for European Hematology Research. A Consensus Document

Abstract The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at Euro 23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine sections in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients. Received December 15, 2015. Accepted January 27, 2016. Copyright © 2016, Ferrata Storti Foundatio

Functional annotation of human long noncoding RNAs via molecular phenotyping

Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression of 285 lncRNAs in human dermal fibroblasts and quantified cellular growth, morphological changes, and transcriptomic responses using Capped Analysis of Gene Expression (CAGE). Antisense oligonucleotides targeting the same lncRNAs exhibited global concordance, and the molecular phenotype, measured by CAGE, recapitulated the observed cellular phenotypes while providing additional insights on the affected genes and pathways. Here, we disseminate the largest-todate lncRNA knockdown data set with molecular phenotyping (over 1000 CAGE deep-sequencing libraries) for further exploration and highlight functional roles for ZNF213-AS1 and lnc-KHDC3L-2.Peer reviewe