32 research outputs found
Heterogeneous response and progression patterns reveal phenotypic heterogeneity of tyrosine kinase inhibitor response in metastatic renal cell carcinoma
SC was funded by fellowships from NIHR and Cancer Research UK. IK was
funded by the UCLH Experimental Cancer Centre and UCLH NIHR Biomedical
Research Centre. TP was funded by grants from Cancer Research UK (the
Experimental Cancer Medicine Centre). MG was funded by grants from
Cancer Research UK, Prostate Cancer UK, the Prostate Cancer Foundation,
the Schottlander Research Charitable Trust, the Royal Marsden NIHR
Biomedical Research Centre for Cancer and the Wellcome Trust (grant
number: 105104/Z/14/Z
Recommended from our members
Assessing the quality of models of the ambient solar wind
In this paper we present an assessment of the status of models of the global Solar Wind in the inner heliosphere. We limit our discussion to the class of models designed to provide solar wind forecasts, excluding those designed for the purpose of testing physical processes in idealized configurations. In addition, we limit our discussion to modeling of the ‘ambient’ wind in the absence of coronal mass ejections. In this assessment we cover use of the models both in forecast mode and as tools for scientific research. We present a brief history of the development of these models, discussing the range of physical approximations in use. We discuss the limitations of the data inputs available to these models and its impact on their quality. We also discuss current model development trends
A systematic review, meta-analysis, and meta-regression of the impact of diurnal intermittent fasting during Ramadan on body weight in healthy subjects aged 16 years and above
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe
Stagnation point flow of viscoelastic nanomaterial over a stretched surface
Present communication aims to discuss magnetohydrodynamic (MHD) stagnation point flow of Jeffrey nanofluid by a stretching cylinder. Modeling is based upon Brownian motion, thermophoresis, thermal radiation and heat generation. Problem is attempted by using (HAM). Residual errors for h-curves are plotted. Convergent solutions for velocity, temperature and concentration are obtained. Skin friction coefficient, local Nusselt number and Sherwood number are studied. It is examined that velocity field decays in the presence of higher estimation of magnetic variable. Furthermore temperature and concentration fields are enhanced for larger magnetic variable. Keywords: Viscoelastic fluid, Nanomaterial, MHD, Brownian motion, Stagnation point, Thermophoresi