Dynamika modeli biznesu przedsiębiorstw w gospodarce cyfrowej – perspektywa monetyzacji

Digital transformation creates new perspectives for the development of business models. The result of this process is the emergence of new ways of monetizing them. This creates a new dimension in achieving high efficiency for enterprises operating in the digital ecosystem. The changing business logic opens the way to creating new business models and their further evolution. In this context, digital business models are transforming into their higher stage of development becoming cognitive business models. Cognitive business models are based on new learning algorithms supported by multidimensional business analytics and dynamic inference with strong customer involvement. This can be achieved by introducing dynamics to digital business models, accelerating their further exploration and exploitation, including flexible intelligent solutions embedded in services. Then new and intelligent ways of delivering value appear. Monetization is a factor that stimulates the dynamics of business models. Monetization schemes strongly influence the attractiveness of digital business models. The aim of the article is to present the results of bibliographic research used to identify and characterize key determinants responsible for the dynamics of business models functioning in the digital environment. The scope of the article includes the principles of design and implementation of business models embedded in the digital ecosystem in the context of various monetization schemes.Transformacja cyfrowa tworzy nowe perspektywy rozwoju modeli biznesu. Wynikiem tego procesu jest pojawianie się nowych sposobów ich monetyzacji. Kreuje to nowy wymiar osiągania wysokiej efektywności przedsiębiorstw funkcjonujących w ekosystemie cyfrowym. Zmieniająca się logika prowadzenia biznesu otwiera drogę do tworzenia nowych modeli biznesu i ich dalszej ewolucji. W tym kontekście cyfrowe modele biznesu przechodzą do wyższej fazy rozwoju, stając się kognitywnymi modelami biznesu. Kognitywne modele biznesu bazują na nowych algorytmach uczenia się, wspieranych wielowymiarową analityką biznesową, oraz na dynamicznym wnioskowaniu z silnym zaangażowaniem klientów. Może to być osiągnięte poprzez wprowadzenie do cyfrowych modeli biznesu dynamiki przyspieszającej ich dalszą eksplorację i eksploatację, z uwzględnieniem elastycznych, inteligentnych rozwiązań odpowiedzialnych za dostawę wartości zabudowanych w usługach. Wtedy pojawiają się nowe i inteligentne sposoby dostawy wartości. Czynnikiem stymulującym dynamikę modeli biznesu jest monetyzacja. Schematy monetyzacji silnie oddziałują na atrakcyjność cyfrowych modeli biznesu. Celem opracowania jest przedstawienie wyników badań bibliograficznych służących identyfikacji i charakterystyce kluczowych determinant odpowiedzialnych za dynamikę modeli biznesu funkcjonujących w środowisku cyfrowym. Zakres rozdziału obejmuje zasady projektowania i implementacji modeli biznesu osadzonych w ekosystemie cyfrowym w kontekście rożnych schematów monetyzacji

Simultaneous Extreme-Ultraviolet Explorer and Optical Observations of Ad Leonis: Evidence for Large Coronal Loops and the Neupert Effect in Stellar Flares

We report on the first simultaneous Extreme-Ultraviolet Explorer (EUVE) and optical observations of flares on the dMe flare star AD Leonis. The data show the following features: (1) Two flares (one large and one of moderate size) of several hours duration were observed in the EUV wavelength range; (2) Flare emission observed in the optical precedes the emission seen with EUVE; and (3) Several diminutions (DIMs) in the optical continuum were observed during the period of optical flare activity. To interpret these data, we develop a technique for deriving the coronal loop length from the observed rise and decay behavior of the EUV flare. The technique is generally applicable to existing and future coronal observations of stellar flares. We also determine the pressure, column depth, emission measure, loop cross-sectional area, and peak thermal energy during the two EUV flares, and the temperature, area coverage, and energy of the optical continuum emission. When the optical and coronal data are combined, we find convincing evidence of a stellar 'Neupert effect' which is a strong signature of chromospheric evaporation models. We then argue that the known spatial correlation of white-light emission with hard X-ray emission in solar flares, and the identification of the hard X-ray emission with nonthermal bremsstrahlung produced by accelerated electrons, provides evidence that flare heating on dMe stars is produced by the same electron precipitation mechanism that is inferred to occur on the Sun. We provide a thorough picture of the physical processes that are operative during the largest EUV flare, compare and contrast this picture with the canonical solar flare model, and conclude that the coronal loop length may be the most important factor in determining the flare rise time and energetics

The Origin and Initial Rise of Pelagic Cephalopods in the Ordovician

BACKGROUND: During the Ordovician the global diversity increased dramatically at family, genus and species levels. Partially the diversification is explained by an increased nutrient, and phytoplankton availability in the open water. Cephalopods are among the top predators of today's open oceans. Their Ordovician occurrences, diversity evolution and abundance pattern potentially provides information on the evolution of the pelagic food chain. METHODOLOGY/PRINCIPAL FINDINGS: We reconstructed the cephalopod departure from originally exclusively neritic habitats into the pelagic zone by the compilation of occurrence data in offshore paleoenvironments from the Paleobiology Database, and from own data, by evidence of the functional morphology, and the taphonomy of selected cephalopod faunas. The occurrence data show, that cephalopod associations in offshore depositional settings and black shales are characterized by a specific composition, often dominated by orthocerids and lituitids. The siphuncle and conch form of these cephalopods indicate a dominant lifestyle as pelagic, vertical migrants. The frequency distribution of conch sizes and the pattern of epibionts indicate an autochthonous origin of the majority of orthocerid and lituitid shells. The consistent concentration of these cephalopods in deep subtidal sediments, starting from the middle Tremadocian indicates the occupation of the pelagic zone early in the Early Ordovician and a subsequent diversification which peaked during the Darriwilian. CONCLUSIONS/SIGNIFICANCE: The exploitation of the pelagic realm started synchronously in several independent invertebrate clades during the latest Cambrian to Middle Ordovician. The initial rise and diversification of pelagic cephalopods during the Early and Middle Ordovician indicates the establishment of a pelagic food chain sustainable enough for the development of a diverse fauna of large predators. The earliest pelagic cephalopods were slowly swimming vertical migrants. The appearance and early diversification of pelagic cephalopods is interpreted as a consequence of the increased food availability in the open water since the latest Cambrian

Towards a new image processing system at Wendelstein 7-X: From spatial calibration to characterization of thermal events

Wendelstein 7-X (W7-X) is the most advanced fusion experiment in the stellarator line and is aimed at proving that the stellarator concept is suitable for a fusion reactor. One of the most important issues for fusion reactors is the monitoring of plasma facing components when exposed to very high heat loads, through the use of visible and infrared (IR) cameras. In this paper, a new image processing system for the analysis of the strike lines on the inboard limiters from the first W7-X experimental campaign is presented. This system builds a model of the IR cameras through the use of spatial calibration techniques, helping to characterize the strike lines by using the information given by real spatial coordinates of each pixel. The characterization of the strike lines is made in terms of position, size, and shape, after projecting the camera image in a 2D grid which tries to preserve the curvilinear surface distances between points. The description of the strike-line shape is made by means of the Fourier Descriptors

Forward modeling of collective Thomson scattering for Wendelstein 7-X plasmas: Electrostatic approximation

In this paper, we present a method for numerical computation of collective Thomson scattering (CTS). We developed a forward model, eCTS, in the electrostatic approximation and benchmarked it against a full electromagnetic model. Differences between the electrostatic and the electromagnetic models are discussed. The sensitivity of the results to the ion temperature and the plasma composition is demonstrated. We integrated the model into the Bayesian data analysis framework Minerva and used it for the analysis of noisy synthetic data sets produced by a full electromagnetic model. It is shown that eCTS can be used for the inference of the bulk ion temperature. The model has been used to infer the bulk ion temperature from the first CTS measurements on Wendelstein 7-X

LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus

Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune attack or stimulating beta cell regeneration still have limited clinical efficacy. Therefore, it is timely to identify innovative targets to dampen the immune process, while promoting beta cell survival and function. Liver receptor homologue-1 (LRH-1) is a nuclear receptor that represses inflammation in digestive organs, and protects pancreatic islets against apoptosis. Here, we show that BL001, a small LRH-1 agonist, impedes hyperglycemia progression and the immune-dependent inflammation of pancreas in murine models of T1DM, and beta cell apoptosis in islets of type 2 diabetic patients, while increasing beta cell mass and insulin secretion. Thus, we suggest that LRH-1 agonism favors a dialogue between immune and islet cells, which could be druggable to protect against diabetes mellitus.the Juvenile Diabetes Research Foundation (17-2013-372 to B.R.G.), the Consejeria de Salud, Fundacion Publica Andaluza Progreso y Salud, Junta de Andalucia (PI-0727-2010 to B.R.G. and P10CTS6505 to B.S.), Consejeria de Economia, Innovacion y Ciencia (P10.CTS.6359 to B.R.G.), the Ministerio de Economia y Competidividad cofunded by Fondos FEDER (PI10/00871, PI13/00593, and BFU2017-83588-P to B.R.G.; PI14/01015, RD12/0019/0028, and RD16/0011/0034 to B.S.; PI16/00259 to A. H.) and Deutsche Forschungsgemeinschaft (GRK-1789 ´CEMMA´ and DFG SCHI-505/ 6-1 to R.S.). Special thanks to the families of the DiabetesCero Foundation that graciously supported this work (to B.R.G.). A.M.M. is a recipient of a Miguel Servet grant (CP14/ 00105) from the Instituto de Salud Carlos III co-funded by Fondos FEDER whereas E.F. M. is a recipient of a Juan de la Cierva Fellowship. I.G.H.G. is supported by a fellowship from Amarna Therapeutics. In some instances, human islets were procured through the European Consortium for Islet Transplantation funded by Juvenile Diabetes Research Foundation (3-RSC-2016-162-I-X)

Marek Jablonski, piano (Polonia)

Concierto interpretado por Marek Jablonski. Nació en Cracovia, Polonia; entró en el Conservatorio de esa ciudad a los seis años de edad. Desde que la familia Jablonski se estableció en Edluonton (Canadá) en 1949, la educación musical del joven Marek Jablonski estuvo asegurada por numerosas becas, entre las cuajes la beca Dimitri Mitropoulos que le permitió asistir a la Escuela de Música de Aspen, Colorado. Allí fué escuchado por Rosina Lhevine, quien insistió para que siguiera sus estudios en la Escuela Juilliard. Durante sus estudios en Nueva York, ganó diversos premios, entre los cuales la beca de la Fundación Koscivszko y la Joseph Lhevine MeDIorial Scholarship. En este concierto interpretó obras de Haydn, Beethoven, Chopin, Debussy, Albéniz, Rachmaninoff y Liszt.LA BIBIJOTECA J.UIS · ANGEL ABANCO DEL BANCO DE LA BEPUBLICA Presenlo en su SALA DE CONCIERTOS A MARE'K JABLONSKI PIANISTA BOGOTA, D. E., MIERCOLES 26 DE ABRIL DE 1972 Hora: (j :45 P. M. 00235 Digitalizado por la Biblioteca Luis Ángel Arango del Banco de la República, Colombia. .MAREK JABLONSKI BIOGRAFIA Nació en Cracovia, Polonia; entró en el Conservatorio de esa ciudad a los seis años de edad. Desde que la familia Jablonski se estableció en Edluonton (Canadá) en 1949, la educación musical del joven :Marek Jablonski estuvo asegurada por llUluerosas becas, entre las cuajes la beca DiIuitri ~1itropoulos que le permitió asi '­tir a la Escuela de Música de Aspen, Colorado. Allí fué escuchado por Rosina Lhevine, quien insistió para que siguiera sus estudios en la Escuela Juilliard. Durante sus estudios en Nueva York, ganó diversos preInios, entre los cuales la beca de la Fundación Kos­civszko y la Joseph Lhevine MeDIorial Scholarship. A los 21 años, lVIarek J ahlonski volvió al Canadá y obtuvo, por unanin1idad del Jurado, el Gran Premio del prinler conéurso d~ lnúsica organizado por Juventudes ·Musicales del Canadá. J)es­pués de ganar ese premio, Jablonski grabó algunos discos y reali­zó una jira por el Canadá, Europa y Estados Unidos. Actuó en diversos prognunas de radio y televisión de Radio-Canadá. Ha actuado con las orquestas Iuás inlportantes del Canadá y otros países, bajo la batuta de eminentes directores (incluído el gran director fallecido Pien'e Monteux). Debutó en Nueva York, en el Carnegie Hall, con la American Synlphony Orchestra dirigida por Zubin Mehta. .' J" '1- 1.. Posterionnente obtuvo grandes éxitos en una serie de recita­les en Londres y en la U.R.S.S., donde ha realizado ya dos jiras. Ha actuado en casi iodos los países de Europa y de Am~rica del Sur. Digitalizado por la Biblioteca Luis Ángel Arango del Banco de la República, Colombia. PROGRAMA 1 Andante y Variaciones en fa lnenor Sonata en nlÍ mayor, op. 109 Vivace lna non troppo - Adagio espressivo Prestissilno Andante molto cantabile ed espressivo Nocturno en si mayor, op. 9 N9 3 llalada NQ 4 en fa lnenor, op. 52 Dos preludios El Albaicin Preludio INTERMEDIO II Fantasía sobre "Don Juan" de Mozart Haydn BeelllOuen CllOpin Debussy Albéniz Rachmaninoff Liszt Digitalizado por la Biblioteca Luis Ángel Arango del Banco de la República, Colombia. :.t>" PROXIMOS OONCIERTOS MAYO 2 Friedrich Gulda. Pianista con el Wheater Report Group" MAYO 10 "HAUSMUSIK". Música antigua '\ oc al instrumental. Grupo Colombia. Directora: Luisa de Botero. Integrantes: Luisa Botero, Jean Samper, Col'ette Consaín, Marcela Angel, Amalia Samper, Marina Tafur, Lucila Restrepo. MAYO 15 RAVI SHANKAR, el Gran Virtuoso hindú de la "Sitar'". MAYO 18 The Netherlands Chamber Orchestra. Director David Zinman. MAYO 24 Janos Starker. Chelista Húngaro. MAYO 31 La Orquesta de Cámara de los Solistas de Zagreb. L03 conciertos principiarán invariablemente a la hora anunciada y luego de iniciados, no se permitirá el acceso de más público a la Sala. Digitalizado por la Biblioteca Luis Ángel Arango del Banco de la República, Colombia