804 research outputs found
Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype
- Author
- Publication venue
- The Authors.
- Publication date
- 01/09/2016
- Field of study
SummaryB cell CLL/lymphoma 11A (BCL11A) is a transcription factor and regulator of hemoglobin switching that has emerged as a promising therapeutic target for sickle cell disease and thalassemia. In the hematopoietic system, BCL11A is required for B lymphopoiesis, yet its role in other hematopoietic cells, especially hematopoietic stem cells (HSCs) remains elusive. The extensive expression of BCL11A in hematopoiesis implicates context-dependent roles, highlighting the importance of fully characterizing its function as part of ongoing efforts for stem cell therapy and regenerative medicine. Here, we demonstrate that BCL11A is indispensable for normal HSC function. Bcl11a deficiency results in HSC defects, typically observed in the aging hematopoietic system. We find that downregulation of cyclin-dependent kinase 6 (Cdk6), and the ensuing cell-cycle delay, correlate with HSC dysfunction. Our studies define a mechanism for BCL11A in regulation of HSC function and have important implications for the design of therapeutic approaches to targeting BCL11A
Collaborative genetic mapping of 12 forensic short tandem repeat (STR) loci on the human X chromosome
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2012
- Field of study
Recent Ancestry of Kyasanur Forest Disease Virus
- Author
- Akhilesh C. Mishra
- Baillie
- Bhat
- Bhat
- Bhatt
- Bobbie R. Erickson
- Boshell
- Boshell
- Bryant
- Charrel
- Charrel
- Charrel
- Devendra T. Mourya
- Drummond
- Farris
- Galtier
- Gould
- Gould
- Goverdhan
- Goverdhan
- Grard
- Hou
- Katoh
- Posada
- Pradip V. Barde
- Pragya Yadav
- Prasanna N. Yergolkar
- Qattan
- Rajeev Mehla
- Sandeep R.P. Kumar
- Serena A. Carroll
- Sreenivasan
- Stuart T. Nichol
- Upadhyaya
- Wang
- Zaki
- Zanotto
- Zanotto
- Zhang
- Publication venue
- Centers for Disease Control and Prevention
- Publication date
- 01/09/2009
- Field of study
Clinicians in Asia should consider this disease when diagnosing acute febrile illnesses
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.
- Author
- Ahluwalia T.S. (Tarunveer Singh)
- Akiyama M. (Masato)
- Alizadeh B.Z. (Behrooz)
- Appel E.V.R. (Emil Vincent R.)
- Arking D.E. (Dan)
- Arnold A.M. (Alice)
- Astrup A. (Arne)
- Barbieri C. (Caterina)
- Beekman M. (Marian)
- Beilby J.P. (John)
- Bekaert S. (Sofie)
- Boerwinkle E. (Eric)
- Boezen H.M. (Marike)
- Brown S.J. (Stephen)
- Buyzere M. (Marc) de
- Campbell P.J. (Purdey J.)
- Cappola A.R. (Anne)
- Ceresini G. (Graziano)
- Cerqueira C. (Charlotte)
- Chaker L. (Layal)
- Cucca F. (Francesco)
- Deary I.J. (Ian)
- Deelen J. (Joris)
- Di Munno C. (Celia)
- Eckardt K.-U. (Kai-Uwe)
- Ekici A.B. (Arif B.)
- Ferrrucci L. (Luigi)
- Fiers T. (Tom)
- Fiorillo E. (Edoardo)
- Ford I. (Ian)
- Fox C.S. (Caroline)
- Franke L. (Lude)
- Fuchsberger C. (Christian)
- Galesloot T.E. (Tessel)
- Gieger C. (Christian)
- Grandi A. (Alessandro) de
- Grarup N. (Niels)
- Greiser K.H. (Karin Halina)
- Groeneweg S. (Stefan)
- Gögele M. (Martin)
- Hagen K. (Knut)
- Haljas K. (Kadri)
- Hansen T. (Torben)
- Harris S.E. (Sarah)
- Heemst D. (Diana) van
- Heijer M. (Martin) den
- Hicks A.A. (Andrew A.)
- Hollander W. (Wouter) den
- Homuth G. (Georg)
- Hui J. (Jennie)
- Ikram M.A. (Arfan)
- Ittermann T. (Till)
- Jensen R.A. (Richard A.)
- Jing J. (Jiaojiao)
- Jukema J.W. (Jan Wouter)
- Kajantie E. (Eero)
- Kamatani Y. (Yoichiro)
- Kasbohm E. (Elisa)
- Kaufman J.-M. (Jean-Marc)
- Kiemeney L.A. (Lambertus A.)
- Kloppenburg M. (Margreet)
- Kronenberg F. (Florian)
- Kubo M. (Michiaki)
- Köttgen A. (Anna)
- Lahti J. (Jari)
- Lapauw B. (Bruno)
- Li S. (Shuo)
- Li Y. (Yong)
- Liewald D.C.M. (David C. M.)
- Lim E.M. (Ee Mun)
- Linneberg A. (Allan)
- Marina M. (Michela)
- Mascalzoni D. (Deborah)
- Matsuda K. (Koichi)
- Medenwald D. (Daniel)
- Medici M. (Marco)
- Meisinger C. (Christa)
- Meulenbelt I. (Ingrid)
- Meyer zu Schwabedissen H.E. (Henriette E.)
- Meyer T. (Thorsten)
- Mikolajczyk R. (Rafael)
- Moed H. (Heleen)
- Naitza S. (Silvia)
- Navis G. (Gerjan)
- Netea-Maier R.T. (Romana)
- Nolte I.M. (Ilja)
- Okada Y. (Yukinori)
- Pala M. (Mauro)
- Pedersen O. (Oluf)
- Peeters R.P. (Robin)
- Penninx B.W.J.H.
- Petersmann A. (Astrid)
- Porcu E. (Eleonora)
- Postmus D. (Douwe)
- Pramstaller P.P. (Peter Paul)
- Psaty B.M. (Bruce)
- Ramos Y.F.M. (Yolande F. M.)
- Rawal R. (Rajesh)
- Redmond P. (Paul)
- Richards J.B. (Brent)
- Rietzschel E.R. (Ernst)
- Rivadeneira Ramirez F. (Fernando)
- Roef G.L. (Greet)
- Rots M.G. (M.)
- Rotter J.I. (Jerome I.)
- Sala C. (Cinzia)
- Sanna S. (Serena)
- Schlessinger D. (David)
- Schultheiss U.T. (Ulla T.)
- Selvin E. (Elizabeth)
- Slagboom P.E. (Eline)
- Snieder H. (Harold)
- Soranzo N. (Nicole)
- Spector T.D. (Timothy)
- Starr J.M. (John)
- Stott D.J. (David. J.)
- Swertz M.A. (Morris A.)
- Sørensen T.I.A. (Thorkild)
- Taes Y.E. (Youri)
- Taliun D. (Daniel)
- Tanaka T. (Toshiko)
- Teumer A. (Alexander)
- Thuesen L. (Leif)
- Tiller D. (Daniel)
- Toniolo D. (Daniela)
- Traglia M. (Michela)
- Uitterlinden A.G. (Andre G.)
- van der Harst P. (Pim)
- Visser T.J. (Theo)
- Visser W.E. (Edward)
- Völzke H. (Henry)
- Walsh J.P. (John P.)
- Wijmenga C. (Cisca)
- Wilson S.G. (Scott)
- Wolffenbuttel B.H.R. (Bruce)
- Yang Q. (Qiong Fang)
- Zheng H.-F. (Hou-Feng)
- Publication venue
- Nat Commun
- Publication date
- 01/01/2018
- Field of study
Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only partly been elucidated, including its transport, metabolism, and genetic determinants. Here we report a large meta-analysis of genome-wide association studies for thyroid function and dysfunction, testing 8 million genetic variants in up to 72,167 individuals. One-hundred-and-nine independent genetic variants are associated with these traits. A genetic risk score, calculated to assess their combined effects on clinical end points, shows significant associations with increased risk of both overt (Graves' disease) and subclinical thyroid disease, as well as clinical complications. By functional follow-up on selected signals, we identify a novel thyroid hormone transporter (SLC17A4) and a metabolizing enzyme (AADAT). Together, these results provide new knowledge about thyroid hormone physiology and disease, opening new possibilities for therapeutic targets
Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.
- Author
- Aalto V. (Ville)
- Albagha O.M.E. (Omar M.)
- Alen M. (Markku)
- Alonso N. (Nerea)
- Amin N. (Najaf)
- Andreassen O.A. (Ole)
- Aragaki A.K. (Aaron)
- Aspelund T. (Thor)
- Aulchenko Y.S. (Yurii)
- Balcells S. (Susana)
- Bettella F. (Francesco)
- Brandi M.L.
- Brown M.A. (Matthew)
- Buckley B.M. (Brendan M.)
- Castaño Betancourt M.C. (Martha)
- Cauley J.A. (Jane)
- Center J.R. (Jacqueline)
- Chasman D.I. (Daniel)
- Cheng S. (Sulin)
- Christiansen C.
- Clark G.R. (Graeme)
- Cooper C. (Charles)
- Cummings S.R. (Steven R.)
- Cupples L.A. (Adrienne)
- Dailiana Z. (Zoe)
- Dale A.M. (Anders)
- Danoy P. (Patrick)
- Dedoussis G.V. (George)
- Dennison E.M. (Elaine)
- Desikan R.S. (Rahul S.)
- Djurovic S. (Srdjan)
- Duggan C.
- Duijn C.M. (Cornelia) van
- Duncan E.L. (Emma)
- Eastell R. (Richard)
- Econs M.J. (Michael)
- Eisman J.A. (John)
- Eriksson J. (Joel)
- Estrada Gil K. (Karol)
- Evangelou E. (Evangelos)
- Evans D.M. (David)
- Ford I. (Ian)
- Frost M. (Morten)
- Garcia M. (Melissa)
- Garcia-Giralt N. (Natàlia)
- Gautvik K.M. (Kaare)
- Giroux S. (Sylvie)
- Goltzman D. (David)
- González-Macías J. (Jesús)
- Grundberg E. (Elin)
- Gudnason V. (Vilmundur)
- Hallmans G. (Göran)
- Harris T.B. (Tamara B.)
- Herrera L. (Lizbeth)
- Hocking L.J. (Lynne)
- Hofman A. (Albert)
- Hsu Y.-H. (Yi-Hsiang)
- Husted L.B. (Lise Bjerre)
- Ingvarsson T. (Torvaldur)
- Ioannidis J.P.A. (John P.A.)
- Jackson R.D. (Rebecca)
- Jameson K. (Karen)
- Johannsdottir H. (Hrefna)
- Jones G. (Graeme)
- Jukema J.W. (Jan Wouter)
- Kammerer C.M. (Candace)
- Kaptoge S. (Stephen)
- Karasik D. (David)
- Karlsson M. (Magnus)
- Kemp J.P. (John)
- Khaw K.T.
- Khusainova R. (Rita)
- Khusnutdinova E.K. (Elza)
- Kiel D.P. (Douglas P.)
- Kim G.S. (Ghi Su)
- Koh J.-M. (Jung-Min)
- Koller D.L. (Daniel)
- Kollia P. (Panagoula)
- Kooperberg C. (Charles)
- Koromila T. (Theodora)
- Kruk M. (Marcin)
- Kung A.W.C. (Annie Wai Chee)
- Kwan T. (Tony)
- Kähönen M. (Mika)
- Laaksonen M. (Marika)
- Lacroix A.Z. (Andrea Z.)
- Langdahl B.L. (Bente)
- Leblanc M. (Marissa)
- Lee S.H. (Seung Hun)
- Lehtimäki T. (Terho)
- Leo P.J. (Paul)
- Leslie W.D. (William D.)
- Leung P.C. (Ping C.)
- Lewis J.R. (Joshua)
- Li G. (Guo)
- Li R. (Rui)
- Lips P. (Paul)
- Liu C.-T. (Ching-Ti)
- Liu Y. (YongMei)
- Ljunggren O. (Östen)
- Lorenc R. (Roman)
- Lorentzon M. (Mattias)
- Luben R.N. (Robert)
- Marc J. (Janja)
- Masi L. (Laura)
- McCloskey E.V. (Eugene)
- McEvoy L.K. (Linda K.)
- Medina-Gomez M.C. (Carolina)
- Mellström D. (Dan)
- Mencej-Bedrac S. (Simona)
- Meurs J.B.J. (Joyce) van
- Mills I.G. (Ian G.)
- Minster R.L. (Ryan)
- Mitchell B.D. (Braxton)
- Moayyeri A. (Alireza)
- Nandakumar K. (Kannabiran)
- Nguyen T.V. (Tuan)
- Nicholson G.C. (Geoffrey)
- Nogues X. (Xavier)
- Ntzani E.E. (Evangelia)
- Obermayer-Pietsch B. (Barbara)
- Oei L. (Ling)
- Ohlsson C. (Claes)
- Olmos D. (David)
- Oostra B.A. (Ben)
- Palsson S.T. (Stefan Th)
- Pastinen T. (Tomi)
- Patel M.S. (Millan)
- Peacock M. (Munro)
- Pettersson-Kymmer U. (Ulrika)
- Pols H.A.P. (Huib)
- Prezelj J. (Janez)
- Prince R.L. (Richard)
- Psaty B.M. (Bruce)
- Raitakari O. (Olli)
- Ralston S.H. (Stuart)
- Raychaudhuri S. (Soumya)
- Reeve J. (Jonathan)
- Reid D.M. (David)
- Reid I.R. (Ian)
- Reppe S. (Sjur)
- Riancho J.A. (José)
- Richards J.B. (Brent)
- Ridker P.M. (Paul)
- Rivadeneira Ramirez F. (Fernando)
- Robbins J. (John)
- Rose L.M. (Lynda)
- Rotter J.I. (Jerome I.)
- Rousseau M.F. (Francois)
- Sambrook P.N. (Philip)
- Schoor N.M. (Natasja) van
- Schork N.J. (Nicholas)
- Scollen S. (Serena)
- Sham P.C. (Pak Chung)
- Shuldiner A.R. (Alan)
- Siggeirsdottir K. (Kristin)
- Sigurdsson G. (Gunnar)
- Slagboom P.E. (Eline)
- Smith A.V. (Davey)
- Spector T.D. (Timothy)
- Streeten E.A. (Elizabeth)
- Styrkarsdottir U. (Unnur)
- Svensson O. (Olle)
- Tang N.L.S. (Nelson L.S.)
- Thompson W.K. (Wesley K.)
- Thorleifsson G. (Gudmar)
- Thorsteinsdottir U. (Unnur)
- Trompet S. (Stella)
- Trummer O. (Olivia)
- Tylavsky F.A. (Frances)
- Uitterlinden A.G. (André)
- Urreizti R. (Roser)
- Van Hul W. (Wim)
- Vandenput L. (Liesbeth)
- Verlaan D.J. (Dominique)
- Viikari J. (Jorma)
- Wang Y. (Yunpeng)
- Wareham N.J. (Nicholas J.)
- Williams F.M. (Frances)
- Willner D. (Dana)
- Wilson J.F. (James F)
- Wilson S.G. (Scott)
- Woo J. (Jean)
- Wood A.R. (Andrew)
- Xiao S.-M. (Su-Mei)
- Yerges-Armstrong L.M. (Laura)
- Zarrabeitia M.T. (María)
- Zheng H.-F. (Hou-Feng)
- Zhou Y. (Yanhua)
- Zhu K. (Kun)
- Zillikens M.C. (Carola)
- Zuber V. (Verena)
- Zwart J-A. (John-Anker)
- Publication venue
- PLoS One
- Publication date
- 01/01/2015
- Field of study
Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucleotide polymorphisms (SNPs) associated with BMD by leveraging cardiovascular disease (CVD) associated disorders and metabolic traits. By conditioning on SNPs associated with the CVD-related phenotypes, type 1 diabetes, type 2 diabetes, systolic blood pressure, diastolic blood pressure, high density lipoprotein, low density lipoprotein, triglycerides and waist hip ratio, we identified 65 novel independent BMD loci (26 with femoral neck BMD and 47 with lumbar spine BMD) at conditional FDR < 0.01. Many of the loci were confirmed in genetic expression studies. Genes validated at the mRNA levels were characteristic for the osteoblast/osteocyte lineage, Wnt signaling pathway and bone metabolism. The results provide new insight into genetic mechanisms of variability in BMD, and a better understanding of the genetic underpinnings of clinical comorbidity
Enabling planetary science across light-years. Ariel Definition Study Report
- Author
- Abreu Manuel
- Al-Refaie Ahmed
- Alonso Gustavo
- Amiaux Jerome
- Anisman Lara
- Aret Anna
- Arhancet Axel
- Ateca Jaume
- Baeyens Robin
- Barstow Joanna
- Beaulieu Jean-Philippe
- Bell Taylor
- Benatti Serena
- Berthé Michel
- Biazzo Katia
- Bishop Georgia
- Borsato Luca
- Bosch José
- Bossini Diego
- Boudin Nathalie
- Bourgalais Jeremy
- Bowles Neil
- Brienza Daniele
- Brucalassi Anna
- Bruno Giovanni
- Buchhave Lars
- Błęcka Maria
- Caines Hamish
- Calcutt Simon
- Caldwell Andrew
- Campante Tiago
- Canestrari Rodolfo
- Cann Nick
- Cara Christophe
- Carine Vandaele Ann
- Carlos Morales Juan
- Carmona Manuel
- Carone Ludmila
- Carrasco Nathalie
- Casali Giada
- Casas Albert
- Casewell Sarah
- Cassone Giuseppe
- Cecchi Pestellini Cesare
- Changeat Quentin
- Charnay Benjamin
- Chioetto Paolo
- Christian Jessen Niels
- Ciaravella Angela
- Civiš Svatopluk
- Claret Antonio
- Claudi Riccardo
- Codella Claudio
- Coffey Deirdre
- Colomé Josep
- Cortecchia Fausto
- Coudé du Foresto Vincent
- Coustenis Athena
- Cowan Nicolas
- Cracchiolo Gianluca
- Crook Martin
- Crouzet Pierre-Elie
- Cubillos Patricio
- Czupalla Markus
- Da Peppo Vania
- Danielski Camilla
- Decin Leen
- Dejabrun Clemence
- Del Vecchio Ciro
- Delgado-Mena Elisa
- Demangeon Olivier
- Di Giorgio Anna
- Diolaiti Emiliano
- Dorn Caroline
- Doublier Vanessa
- Doumayrou Eric
- Dransfield Georgina
- Drossart Pierre
- Drummond Rachel
- Dumaye Luc
- Dunford Emma
- Désjonqueres Lucile
- Eccleston Paul
- Encrenaz Therese
- Farina Maria
- Fedele Davide
- Fernández Alejandro
- Ferus Martin
- Fleury Benjamin
- Focardi Mauro
- Fonte Sergio
- Fontignie Jean
- Fossati Luca
- Funke Bernd
- Galy Camille
- Garai Zoltán
- Garcia Comas Maya
- García Muñoz Antonio
- García Andrés
- García-Rigo Alberto
- Garufi Antonio
- Germano Sacco Giuseppe
- Giacobbe Paolo
- Gilli Gabriella
- Giuseppe Guarcello Mario
- Gonzalez Arturo
- Gonzalez-Galindo Francisco
- Goujon Audrey
- Grassi Davide
- Gressier Amélie
- Griffin Matt
- Griffith Caitlin
- Grzegorczyk Aleksandra
- Guedel Manuel
- Guillot Tristan
- Guilluy Gloria
- Gómez Alejandro
- Haag Martin
- Halain Jean-Philippe
- Hargrave Peter
- Hartogh Paul
- Haswell Carole
- Helled Ravit
- Hellin Marie-Laure
- Herrero Enrique
- Hills Matt
- Holmes Warren
- Horeau Benoit
- Hou Yip Gordon
- Hunt Tom
- I. Moses Julianne
- Ikoma Masahiro
- Ito Yuichi
- J. Díaz José
- J. M. Kruijssen Diederik
- Jimenez Escobar Antonio
- Kabath Petr
- Kama Mihkel
- Kawashima Yui
- Kimura Tadahiro
- Kiss Csaba
- Knížek Antonín
- Kohley Ralf
- Kokori Anastasia
- Kovacs Zsolt
- Kreidberg Laura
- Krijger Matthijs
- Kruid Ronald
- Kubelík Petr
- Kálmán Szilárd
- L. Chubb Katy
- Lagage Pierre-Olivier
- Lara Luisa
- Lebonnois Sebastien
- Leconte Jérémy
- Lee David
- Lefevre Maxence
- Lichtenberg Tim
- Locci Daniele
- Lombini Matteo
- Lopez Puertas Manuel
- Lorenzani Andrea
- Lüftinger Theresa
- M. Gómez Jose
- MacDonald Ryan
- Machado Pedro
- Machado Richardo
- Magrini Laura
- Malaguti Giuseppe
- Maldonado Jesus
- Marcq Emmanuel
- Mendonça João
- Micela Giusi
- Migliorini Alessandra
- Miguel Yamila
- Min Michel
- Modirrousta-Galian Darius
- Molaverdikhani Karan
- Molinari Sergio
- Mollière Paul
- Moneti Andrea
- Moreau Vincent
- Morello Giuseppe
- Morgante Gianluca
- Morinaud Gilles
- Morvan Mario
- Mouzali Salima
- Mugnai Lorenzo
- Møller Pedersen Søren
- N. Edwards Billy
- Nakhjiri Nariman
- Naponiello Luca
- Narita Norio
- Nascimbeni Valerio
- Nikolaou Athanasia
- Nikolaou Nikos
- Noce Vladimiro
- Oliva Fabrizio
- Ollivier Marc
- Ottensamer Roland
- P. Waldmann Ingo
- Pace Emanuele
- Pagano Isabella
- Pagano Teresa
- Palladino Pietro
- Pallé Enric
- Panic Olja
- Papageorgiou Andreas
- Parmentier Vivien
- Pascale Enzo
- Pearson Chris
- Peres Giovanni
- Perez Alvarez Javier
- Perez-Hoyos Santiago
- Perger Manuel
- Petralia Antonino
- Philippon Anne
- Piccialli Arianna
- Pignatari Marco
- Pilbratt Göran
- Piotto Giampaolo
- Pniel Moshe
- Podio Linda
- Polenta Gianluca
- Preti Giampaolo
- Pribulla Theodor
- Puig Ludovic
- Pérez Javier
- R. Barnes John
- Rainer Monica
- Rataj Mirek
- Ratti Francesco
- Ray Tom
- Reess Jean-Michel
- Rengel Miriam
- Renk Florian
- Ribas Ignasi
- Rickman Hans
- Rimmer Paul
- Robert Séverine
- Rocchetto Marco
- Roose Stéphane
- Rosa Zapatero Osorio Maria
- Rosich Albert
- Rossi Loic
- Rust Duncan
- Saleh Ayman
- Salvignol Jean-Christophe
- Sanchez Lopez Alejandro
- Sanna Nicoletta
- Sarkar Subhajit
- Savini Giorgio
- Scharmberg Carsten
- Schisano Eugenio
- Schreiber Laura
- Schwartz Victor
- Scippa Antonio
- Seli Bálint
- Selsis Franck
- Shibata Sho
- Shorttle Oliver
- Simpson Caroline
- Skaf N.
- Skup Konrad
- Sobiecki Mateusz
- Sousa Sergio
- Sozzetti Alessandro
- Stamper Richard
- Stefano Bonomo Aldo
- Steiger Lukas
- Swain Mark
- Symonds Kate
- Szabó Gyula
- Szabó Robert
- Szirovicza Peter
- Szoke Janos
- Tackley Paul
- Tan Jonathan
- Tanga Paolo
- Taylor Jake
- Tecza Matthias
- Tennyson Jonathan
- Terenzi Luca
- Testi Leonardo
- Tinetti Giovanna
- Tosh Ian
- Tozzi Andrea
- Tremblin Pascal
- Triaud Amaury
- Trompet Loïc
- Tsai Shang-Min
- Tsantaki Maria
- Tsiaras Angelos
- Turrini Diego
- Valencia Diana
- Van der Swaelmen Mathieu
- Van Eylen Vincent
- Vandenbussche Bart
- Vardan Adibekyan
- Vasisht Gautam
- Vazan Allona
- Venot Olivia
- Vida Krisztián
- Vilardell Francesc
- Waltham Dave
- Wawer Piotr
- Werner Stephanie
- Widemann Thomas
- Wolkenberg Paulina
- Yung Yuk
- Yurchenko Sergey
- Zellem Rob
- Zilinskas Mantas
- Zingales Tiziano
- Zuppella Paola
- Šponer Judit
- Publication venue
- 'European Space Agency'
- Publication date
- 30/11/2020
- Field of study
Ariel, the Atmospheric Remote-sensing Infrared Exoplanet Large-survey, was adopted as the fourth medium-class mission in ESA's Cosmic Vision programme to be launched in 2029. During its 4-year mission, Ariel will study what exoplanets are made of, how they formed and how they evolve, by surveying a diverse sample of about 1000 extrasolar planets, simultaneously in visible and infrared wavelengths. It is the first mission dedicated to measuring the chemical composition and thermal structures of hundreds of transiting exoplanets, enabling planetary science far beyond the boundaries of the Solar System. The payload consists of an off-axis Cassegrain telescope (primary mirror 1100 mm x 730 mm ellipse) and two separate instruments (FGS and AIRS) covering simultaneously 0.5-7.8 micron spectral range. The satellite is best placed into an L2 orbit to maximise the thermal stability and the field of regard. The payload module is passively cooled via a series of V-Groove radiators; the detectors for the AIRS are the only items that require active cooling via an active Ne JT cooler. The Ariel payload is developed by a consortium of more than 50 institutes from 16 ESA countries, which include the UK, France, Italy, Belgium, Poland, Spain, Austria, Denmark, Ireland, Portugal, Czech Republic, Hungary, the Netherlands, Sweden, Norway, Estonia, and a NASA contribution
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
- Ciullo Marina
- Clark Graeme R
- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
- Cochran Barbara
- Cole Shelley
- Colhoun Helen
- Colhoun Helen M
- Collins Francis S
- Collins Rory
- Connell John M
- Cooper Cyrus
- Cooper Jackie A
- Cooper Matthew N
- Cooper Richard S
- Coresh Josef
- Cornelis Marilyn C
- Corre Tanguy
- Corsi Anna Maria
- Couper David
- Cousminer Diana L
- Coviello Andrea D
- Cox David
- Crawford Dana
- Crisponi Laura
- Croteau-Chonka Damien C
- Cucca Francesco
- Cummings Steven R
- Cupples Adrienne L
- Cupples L Adrienne
- Curhan Gary
- d'Adamo Pio
- Dahgam Santosh
- Dailiana Zoe
- Danesh John
- Danoy Patrick
- Dastani Zari
- Davies Gail
- Daw E Warwick
- Day Felix R
- Day Ian N M
- de Andrade Mariza
- de Boer Ian H
- de Boer Rudolf A
- de Faire Ulf
- de Geus Eco J C
- Deary Ian J
- Dedoussis George
- Dedoussis George V
- Dedoussis George V Z
- Deelen Joris
- Deelman Ewa
- Dehghan Abbas
- Delgado Graciela
- Deloukas Panagiotis
- Deloukas Panos
- Demerath Ellen W
- Demirkan Ayse
- Demirkan Ayşe
- Den Hertog Heleen M
- Denniff Matthew
- Dennison Elaine M
- Dermitzakis Emmanouil T
- Deshmukh Harshal
- Deshmukh Harshal A
- Devuyst Olivier
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S
- Dimitriou Maria
- Ding Jingzhong
- Do Ron
- Dominiczak Anna F
- Doney Alex
- Dong Yanbin
- Donnelly Louise A
- Doumatey Ayo
- Dreisbach Albert W
- Drong Alexander W
- Duggan David
- Dumitrescu Logan
- Duncan Bruce B
- Duncan Emma L
- Dupuis Josee
- Dupuis Josée
- Durbin Richard
- Durda Peter
- Döring Angela
- Dörr Marcus
- Eastell Richard
- Easton Douglas F
- Ebrahim Shah
- Econs Michael J
- Edkins Sarah
- Egan Josephine
- Ehret Georg
- Eiriksdottir Gudny
- Eisman John A
- Eklund Niina
- El Mokhtari NourEddine
- Elks Cathy E
- Ellinghaus David
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Endlich Karlhans
- Epstein Stephen E
- Erbel Raimund
- Erdmann Jeanette
- Erdos Michael R
- Eriksson Joel
- Eriksson Johan
- Eriksson Niclas
- Eriksson Per
- Ernst Florian
- Esko Tonu
- Esko Tõnu
- Esko Tönu
- Estrada Karol
- Eury Elodie
- Evangelou Evangelos
- Evans Alun
- Evans David M
- Eyheramendy Susana
- Eyjolfsson Gudmundur Ingi
- Fagerholm Emma
- Falhammar Henrik
- Fall Tove
- Farrall Martin
- Fauser Bart C J M
- Fava Cristiano
- Feenstra Bjarke
- Fehrmann Rudolf
- Feitosa Mary
- Feranil Alan B
- Ferrannini Ele
- Ferrario Marco M
- Ferreira Teresa
- Ferreli Liana
- Ferrières Jean
- Ferrucci Luigi
- Fischer Krista
- Florez Jose C
- Folkersen Lasse
- Folsom Aaron R
- Fontanillas Pierre
- Ford Ian
- Fornage Myriam
- Foroud Tatiana
- Forouhi Nita G
- Forrester Terrence
- Forsblom Carol
- Foster Meredith C
- Fowke Jay
- Fowkes F Gerald R
- Fowkes Gerard R
- Fox Caroline S
- Fox Ervin R
- Franceschini Nora
- Franco Oscar H
- Franco-Cereceda Anders
- Franke Andre
- Franke Lude
- Franks Paul W
- Frants Rune
- Fraser Ross M
- Frayling Timothy M
- Freedman Barry I
- Freimer Nelson B
- Freitag Daniel F
- Friedrich Nele
- Froguel Philippe
- Frost Morten
- Fuchsberger Christian
- Galan Pilar
- Ganesh Santhi K
- Ganna Andrea
- Gansevoort Ron T
- Gao Xiaoyi
- Garcia Melissa
- Garcia-Giralt Natàlia
- Garnaas Maija
- Gasparini Paolo
- Gauguier Dominique
- Gaunt Tom R
- Gautvik Kaare M
- Geller Frank
- Gharavi Ali G
- Giedraitis Vilmantas
- Gieger Christian
- Gierman Hinco J
- Gigante Bruna
- Gill Geoffrey V
- Giroux Sylvie
- Giulianini Franco
- Glass Daniel
- Glazer Nicole
- Glazer Nicole L
- Glenn Kim
- Glorioso Nicola
- Go Alan S
- Go Min Jin
- Godson Catherine
- Goel Anuj
- Goessling Wolfram
- Golay Alain
- Goldstein Benjamin A
- Goltzman David
- Gong Jian
- González-Macías Jesús
- Goodall Alison H
- Goodarzi Mark O
- Goodloe Robert
- Gordin Daniel
- Gordon Scott D
- Gorski Mathias
- Grabe Hans-Jörgen
- Graff Misa
- Grallert Harald
- Grammer Tanja B
- Gravito Martha L
- Greenwood Celia M T
- Grewal Jagvir
- Grimsby Jonna
- Grobbee Diederick E
- Groop Leif
- Groop Per-Henrik
- Gross Myron
- Groves Christopher J
- Grundberg Elin
- Grässler Jürgen
- Gräßler Jürgen
- Gu Harvest F
- Gu Tianwei
- Guarrera Simonetta
- Gudbjartsson Daniel F
- Gudnason Villi
- Gudnason Vilmundur
- Guiducci Candace
- Guo Qun
- Guo Xiuqing
- Gurdasani Deepti
- Gustafsson Stefan
- Gyllensten Ulf
- Gyllensten Ulf B
- Hadjadj Samy
- Hadley David
- Haessler Jeff
- Hager Jörg
- Haiman Christopher
- Haines Jonathan
- Hall Alistair S
- Hall Per
- Hallan Stein
- Haller Toomas
- Hallmans Goran
- Hallmans Göran
- Hamsten Anders
- Han Bok-Ghee
- Hankinson Susan E
- Hanson Robert L
- Hardy Rebecca
- Haritunians Talin
- Harjutsalo Valma
- Harris Tamara
- Hartikainen Anna-Liisa
- Hartman Catharina A
- Hass Merli
- Hassanali Neelam
- Hassinen Maija
- Hastie Nicholas D
- Hastie Nick
- Hattersley Andrew T
- Haun Margot
- Havulinna Aki S
- Hayward Caroline
- Hazen Stanley L
- He Bing
- He Chunyan
- Heard-Costa Nancy L
- Heath Andrew C
- Heath Simon
- Heckbert Susan R
- Hedblad Bo
- Hedman Åsa K
- Heid Iris M
- Heikkilä Kauko
- Heikkilä Outi
- Heiss Gerardo
- Heliövaara Markku
- Helmer Catherine
- Helmer Quinta
- Henders Anjali K
- Henderson Brian
- Hengstenberg Christian
- Henneman Peter
- Hercberg Serge
- Herder Christian
- Hernandez Dena
- Hernandez Dena G
- Herrera Lizbeth
- Herzig Karl-Heinz
- Hicks Andrew A
- Hietala Kustaa
- Higashio Julia
- Hillege Hans L
- Hilton Gina
- Hindorff Lucia
- Hingorani Aroon
- Hirschhorn Joel N
- Hivert Marie-France
- Ho Weang K
- Hocking Lynne J
- Hoffmann Wolfgang
- Hofman Albert
- Holliday Elizabeth G
- Holm Hilma
- Holmen Oddgeir
- Homuth Georg
- Hopewell Jemma C
- Horikoshi Momoko
- Hosseini Mohsen
- Hottenga Jouke-Jan
- Hovingh G Kees
- Howard Philip
- Hsiung Chao Agnes
- Hsu Yi-Hsiang
- Hu Frank B
- Huang Huateng
- Huang Jinyan
- Hui Jennie
- Humphries Steve E
- Hundertmark Claudia
- Hung Yi-Jen
- Hunt Sarah E
- Hunt Steven C
- Hunter David J
- Husted Lise Bjerre
- Hveem Kristian
- Hwang Shih-Jen
- Hyppönen Elina
- Igl Wilmar
- Ikram M Arfan
- Illig Thomas
- Imboden Medea
- Ingelsson Erik
- Ingle Catherine
- Ingvarsson Thorvaldur
- Ioannidis John P A
- Iribarren Carlos
- Isaacs Aaron
- Isakova Tamara
- Islam Muhammad
- Ittermann Till
- Iwai Naoharu
- Jackson Anne U
- Jackson Rebecca
- Jacobs Gunnar
- Jafar Tazeen H
- James Alan L
- Jameson Karen A
- Jang Yangsoo
- Janipalli Charles S
- Jansen Hanneke
- Janssens A Cecile J W
- Jarvelin Marjo-Riitta
- Jeff Janina
- Jenny Nancy
- Johannsdottir Hrefna
- Johansen Berit
- Johansson Ingegerd
- Johansson Åsa
- Johnson Andrew
- Johnson Louise
- Johnson Paul C D
- Johnson Toby
- Jones Graeme
- Jones Michelle R
- Jousilahti Pekka
- Ju Sung Yun
- Jukema J Wouter
- Jula Antti
- Juliusdottir Thorhildur
- Justice Anne E
- Järvelin Marjo-Riitta
- Jöckel Karl-Heinz
- Kaakinen Marika
- Kahali Bratati
- Kalafati Ioanna-Panagiota
- Kaleebu Pontiano
- Kammerer Candace M
- Kanaya Alka
- Kang Hyun M
- Kang Hyun Min
- Kangas Antti J
- Kanoni Stavroula
- Kao Linda
- Kao W H L
- Kao Wen Hong Linda
- Kaplan Robert C
- Kaprio Jaakko
- Kaptoge Stephen K
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- Kardia Sharon L
- Karjalainen Juha
- Karlsson Magnus
- Karpe Fredrik
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- Kennedy Stephen H
- Kessler Thorsten
- Kestenbaum Bryan
- Kesäniemi Antero
- Ketkar Shamika
- Kettunen Johannes
- Keyzer Jules
- Khaw Kay-Tee
- Khusainova Rita
- Khusnutdinova Elza
- Kiel Douglas P
- Kiess Wieland
- Kilpeläinen Tuomas O
- Kim Eric
- Kim Ghi Su
- Kim Hyo-Soo
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- Kinra Sanjay
- Kiryluk Krzysztof
- Kita Yoshikuni
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- Kleber Marcus E
- Klopp Norman
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- Knowles David
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- Koh Jung-Min
- Kolcic Ivana
- Koller Daniel L
- Kollerits Barbara
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- Kwan Tony
- Kytö Janne
- Kyvik Kirsten O
- Kähönen Mika
- König Inke R
- Körner Antje
- Köttgen Anna
- Laakso Markku
- Laaksonen Marika
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- Ladenvall Claes
- Ladouceur Martin
- Lagou Vasiliki
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- Lahti Jari
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- Lakatta Edward G
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- Lindgren Cecilia M
- Lindström Jaana
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- Liu Jianjun
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- Peacock Munro
- Pechlivanis Sonali
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- Peltonen Leena
- Pendergrass Sarah
- Pennell Craig E
- Penninx Brenda W
- Peralta Carmen A
- Perola Markus
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- Peters Ulrike
- Petersen Ann-Kristin
- Pettersson-Kymmer Ulrika
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- Pouta Anneli
- Power Chris
- Prabhakaran Dorairajan
- Pramstaller Peter P
- Prentice Ross
- Prezelj Janez
- Price Jackie F
- Prince Richard L
- Prior Sarah
- Probst-Hensch Nicole M
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- Province Michael
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- Psaty Bruce
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- Quertermous Thomas
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- Raffel Leslie J
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- Randall Joshua C
- Rankinen Tuomo
- Rao D C
- Rao Dabeeru C
- Rao Madhumathi
- Rasheed Asif
- Rasmussen-Torvik Laura J
- Rathmann Wolfgang
- Rauramaa Rainer
- Raychaudhuri Soumya
- Rayner N William
- Rayner Nigel W
- Redline Susan
- Reeve Jonathan
- Rehnberg Emil
- Reid David M
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- Reinmaa Eva
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- Reppe Sjur
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- Rivadeneira Fernando
- Robbins John
- Roberts Robert
- Robertson Neil
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- Roman Tamara S
- Rose Lynda M
- Roseman Fenella
- Rosengren Annika
- Rosengård-Bärlund Milla
- Rosinger Silke
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- Rosse Stephanie
- Rossing Peter
- Rotimi Charles
- Rotter Jerome I
- Rousseau François
- Roussel Ronan
- Rubin Diana
- Rudan Igor
- Rudock Megan E
- Ruggiero Daniela
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- Ruokonen Aimo
- Rybin Denis
- Räikkönen Katri
- Saaristo Timo E
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- Sala Cinzia
- Salako Tunde
- Saleheen Danish
- Salem Rany M
- Salo Perttu
- Salomaa Veikko
- Salumets Andres
- Samani Nilesh
- Sambrook Philip N
- Sandholm Niina
- Sandhu Manjinder S
- Sanghera Dharambir K
- Sanna Serena
- Saraheimo Markku
- Saramies Jouko
- Sarti Cinzia
- Sarzynski Mark A
- Sattar Naveed
- Savage David A
- Saxena Richa
- Schadt Eric
- Scharnagl Hubert
- Scherag André
- Schlessinger David
- Schmidt Ellen M
- Schmidt Helena
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- Scholtens Salome
- Schork Nicholas J
- Schreiber Stefan
- Schumacher Fredrick
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- Schäfer Arne
- Scollen Serena
- Scott James
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- Scuteri Angelo
- Seeley Janet
- Segrè Ayellet V
- Sehmi Joban S
- Seielstad Mark
- Sekowska Magdalena
- Semple Robert
- Sengupta Sebanti
- Sennblad Bengt
- Serafinceanu Cristian
- Service Susan K
- Seshadri Sudha
- Seufferlein Thomas
- Shah Sonia
- Shah Svati H
- Sham Pak Chung
- Sharma Pankaj
- Shaw-Hawkins Sue
- Sheu Wayne H-H
- Shi Gang
- Shin So-Youn
- Shlipak Michael G
- Shohet Ralph
- Shrine Nick R G
- Shriner Daniel
- Shuldiner Alan R
- Shungin Dmitry
- Sidore Carlo
- Siegbahn Agneta
- Siggeirsdottir Kristin
- Sigurdsson Gunnar
- Sijbrands Eric J G
- Silander Kaisa
- Sim Xueling
- Singleton Andrew
- Sinisalo Juha
- Siscovick David S
- Sitlani Colleen M
- Sivananthan Mohan
- Sjögren Marketa
- Skorpen Frank
- Slaets Joris P
- Slagboom P Eline
- Small Kerrin
- Small Kerrin S
- Smit Johannes H
- Smith Albert
- Smith Erin N
- Smith George Davey
- Smith Jennifer A
- Smith Nicholas L
- Snider Harold
- Snieder Harold
- Soininen Pasi
- Song Ci
- Song Kijoung
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- Sovio Ulla
- Spector Tim D
- Spector Timothy D
- Speliotes Elizabeth K
- Spencer Kylee
- Srinivasan Sathanur R
- St Pourcain Beate
- Stacey Simon N
- Staessen Jan A
- Stanèáková Alena
- Stančáková Alena
- Stark Klaus
- Starr John M
- Stathopoulou Maria G
- Stavarachi Monica
- Stefansson Kari
- Steinle Nanette I
- Steinthorsdottir Valgerdur
- Stewart Alexandre F R
- Stirrups Kathleen
- Stolk Lisette
- Stolk Ronald P
- Strachan David P
- Stracke Sylvia
- Stram Daniel
- Strauch Konstantin
- Strawbridge Rona J
- Streeten Elizabeth A
- Stringham Heather M
- Struchalin Maksim
- Stumvoll Michael
- Styrkarsdottir Unnur
- Sulem Patrick
- Sun Yan V
- Sundström Johan
- Surakka Ida
- Surdulescu Gabriela
- Svensson Olle
- Swan Elizabeth J
- Swertz Morris A
- Swift Amy J
- Syreeni Anna
- Syvänen Ann-Christine
- Sõber Siim
- Söderlund Jenny
- Tabara Yasuharu
- Tai E Shyong
- Taliun Daniel
- Talmud Philippa J
- Tammesoo Mar-Liis
- Tan Sian-Tsung
- Tanaka Toshiko
- Tang Nelson L S
- Tarnow Lise
- Taylor Andrew
- Taylor Kira
- Tayo Bamidele
- Tenesa Albert
- Terzic Janos
- Teslovich Tanya M
- Teumer Alexander
- Thelle Dag S
- Thompson John R
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsson Gudmar
- Thorn Lena M
- Thornton-Wells Tricia
- Thorsteinsdottir Unnur
- Thun Gian-Andri
- Tiirikainen Maarit
- Tikkanen Emmi
- Tikkanen Heikki
- Timpson Nicholas
- Timpson Nicholas J
- Tin Adrienne
- Tiret Laurence
- Tobin Martin
- Tobin Martin D
- Toenjes Anke
- Tolonen Nina
- Tomaschitz Andreas
- Tomaszewski Maciej
- Toniolo Daniela
- Townsend Raymond R
- Tracy Russell P
- Travers Mary E
- Tregouet David-Alexandre
- Treloar Susan A
- Tremblay Angelo
- Tremoli Elena
- Tripathy Vikal
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- Trompet Stella
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- Tryggvadottir Laufey
- Tryggvason Karl
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- Tsaprouni Loukia
- Tsoka Sophia
- Tsui Kim
- Tukiainen Taru
- Tuomilehto Jaakko
- Turner Stephen T
- Tylavsky Frances A
- Tyrer Jonathon
- Tzoulaki Ioanna
- Tönjes Anke
- Uda Manuela
- Ueshima Hirotsugu
- Uh Hae-Won
- Uiterwaal Cuno S P M
- Uitterlinden Andre G
- Uitterlinden André G
- Ulivi Sheila
- Ulivi Shelia
- Umans Jason
- Umemura Satoshi
- Urreizti Roser
- Uusitupa Matti
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- Van den Herik Evita G
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- van Wingerden Sophie
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- Van Zuydam Natalie
- Vandenput Liesbeth
- Varga Tibor V
- Vartiainen Erkki
- Vasan Ramachandran S
- Vedantam Sailaja
- Veldre Gudrun
- Verlaan Dominique
- Vernon Smith Albert
- Veronesi Giovanni
- Verweij Niek
- Verwoert Germaine
- Verwoert Germaine C
- Viigimaa Margus
- Viikari Jorma
- Vinay D G
- Vineis Paolo
- Vink Jacqueline M
- Virtamo Jarmo
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- Visser Jenny A
- Vitart Veronique
- Vohl Marie-Claude
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- Völker Uwe
- Völzke Henry
- Wadén Johan
- Waeber Gerard
- Waeber Gérard
- Wagenknecht Lynne E
- Waggott Daryl
- Wagner Peter J
- Wain Louise V
- Wainwright Nicholas
- Waite Lindsay L
- Walker Mark
- Wallace Leanne
- Wallaschofski Henri
- Wallentin Lars
- Wang Hansong
- Wang Jie Jin
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- Wang Xiaoling
- Wareham Nicholas
- Wareham Nick J
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- Watanabe Richard M
- Waterworth Dawn
- Watkins Hugh
- Weder Alan B
- Weedon Michael N
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- Whitfield John B
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- Wichmann H-Erich
- Widen Elisabeth
- Wiggins Kerri L
- Wijmenga Cisca
- Wijnands-van Gent Colette J M
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- Wild Sarah H
- Wilk Alicja
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- Willemsen Gonneke
- Willemsvan-vanDijk Ko
- Willenborg Christina
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- Williams Winfred W
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- Wilsgaard Tom
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- Wilson Scott G
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- Witteman Jacqueline C
- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud Morad
- Aad Georges
- Abbott Brad
- Abdinov Ovsat
- Abeloos Baptiste
- Abidi Syed
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby
- Adachi Shunsuke
- Adamczyk Leszek
- Adelman Jahred
- Adersberger Michael
- Adye Tim
- Affolder Tony
- Afik Yoav
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akatsuka Shunichi
- Akerstedt Henrik
- Akilli Ece
- Akimov Andrei
- Alberghi Gian
- Albert Justin
- Albicocco Pietro
- Alconada Verzini Maria
- Alderweireldt Sara
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
- Aliev Malik
- Alimonti Gianluca
- Alison John
- Alkire Steven
- Allbrooke Benedict
- Allen Benjamin
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alshehri Azzah
- Alstaty Mahmoud
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazia
- Amadio Brian
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana
- Amoroso Simone
- Anastopoulos Christos
- Ancu Lucian
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders John
- Anderson Kelby
- Andreazza Attilio
- Andrei George
- Angelidakis Stylianos
- Angelozzi Ivan
- Angerami Aaron
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antel Claire
- Antonelli Mario
- Antonov Alexey
- Antrim Daniel
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan
- Araujo Ferraz Victor
- Arce Ayana
- Ardell Rose
- Arduh Francisco
- Arguin Jean-Francois
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron
- Armitage Lewis
- Arnaez Olivier
- Arnold Hannah
- Arratia Miguel
- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Artz Sebastian
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- Atlay Naim
- Augsten Kamil
- Avolio Giuseppe
- Axen Bradley
- Ayoub Mohamad
- Azuelos Georges
- Baas Alessandra
- Baca Matthew
- Bachacou Henri
- Bachas Konstantinos
- Backes Moritz
- Bagnaia Paolo
- Bahmani Marzieh
- Bahrasemani Sina
- Baines John
- Bajic Milena
- Baker Oliver
- Bakker Pepijn
- Baldin Evgenii
- Balek Petr
- Balli Fabrice
- Balunas William
- Banas Elzbieta
- Bandyopadhyay Anjishnu
- Banerjee Swagato
- Bannoura Arwa
- Barak Liron
- Barberio Elisabetta
- Barberis Dario
- Barbero Marlon
- Barillari Teresa
- Barisits Martin-Stefan
- Barkeloo Jason
- Barklow Timothy
- Barlow Nick
- Barnes Sarah
- Barnett Bruce
- Barnett Michael
- Barnovska-Blenessy Zuzana
- Baroncelli Antonio
- Barone Gaetano
- Barr Alan
- Barranco Navarro Laura
- Barreiro Guimarães da Costa João
- Barreiro Fernando
- Barros Vale Maria
- Bartoldus Rainer
- Barton Adam
- Bartos Pavol
- Basalaev Artem
- Bassalat Ahmed
- Bates Richard
- Batista Santiago
- Batley Richard
- Battaglia Marco
- Bauce Matteo
- Bauer Florian
- Bawa Harinder
- Beacham James
- Beattie Michael
- Beau Tristan
- Beauchemin Pierre-Hugues
- Bechtle Philip
- Beck Hans~Peter
- Beck Helge
- Becker Kathrin
- Becker Maurice
- Becot Cyril
- Beddall Andrew
- Beddall Ayda
- Bednyakov Vadim
- Bedognetti Matteo
- Bee Christopher
- Beermann Thomas
- Begalli Marcia
- Begel Michael
- Behr Janna
- Bell Andrew
- Bella Gideon
- Bellagamba Lorenzo
- Bellerive Alain
- Bellomo Massimiliano
- Belotskiy Konstantin
- Beltramello Olga
- Belyaev Nikita
- Benary Odette
- Benchekroun Driss
- Bender Michael
- Benekos Nektarios
- Benhammou Yan
- Benhar Noccioli Eleonora
- Benitez Jose
- Benjamin Douglas
- Benoit Mathieu
- Bensinger James
- Bentvelsen Stan
- Beresford Lydia
- Beretta Matteo
- Berge David
- Bergeaas Kuutmann Elin
- Berger Nicolas
- Bergsten Laura
- Beringer Jürg
- Berlendis Simon
- Bernard Nathan
- Bernardi Gregorio
- Bernius Catrin
- Bernlochner Florian
- Berry Tracey
- Berta Peter
- Bertella Claudia
- Bertoli Gabriele
- Bertram Iain
- Bertsche Carolyn
- Besjes Geert-Jan
- Bessidskaia Bylund Olga
- Bessner Martin
- Besson Nathalie
- Bethani Agni
- Bethke Siegfried
- Betti Alessandra
- Bevan Adrian
- Beyer Julien-christopher
- Bianchi Riccardo-Maria
- Biebel Otmar
- Biedermann Dustin
- Bielski Rafal
- Bierwagen Katharina
- Biesuz Nicolo
- Biglietti Michela
- Billoud Thomas
- Bilokon Halina
- Bindi Marcello
- Bingul Ahmet
- Bini Cesare
- Biondi Silvia
- Bisanz Tobias
- Bittrich Carsten
- Bjergaard David
- Black James
- Black Kevin
- Blair Robert
- Blazek Tomas
- Bloch Ingo
- Blocker Craig
- Blue Andrew
- Blumenschein Ulrike
- Blunier Sylvain
- Bobbink Gerjan
- Bobrovnikov Victor
- Bocchetta Simona
- Bocci Andrea
- Bock Christopher
- Boehler Michael
- Boerner Daniela
- Bogavac Danijela
- Bogdanchikov Alexander
- Bohm Christian
- Boisvert Veronique
- Bokan Petar
- Bold Tomasz
- Boldyrev Alexey
- Bolz Arthur
- Bomben Marco
- Bona Marcella
- Boonekamp Maarten
- Borisov Anatoly
- Borissov Guennadi
- Bortfeldt Jonathan
- Bortoletto Daniela
- Bortolotto Valerio
- Boscherini Davide
- Bosman Martine
- Bossio Sola Jonathan
- Boudreau Joseph
- Bouhova-Thacker Evelina
- Boumediene Djamel
- Bourdarios Claire
- Boutle Sarah
- Boveia Antonio
- Boyd James
- Boyko Igor
- Bozson Adam
- Bracinik Juraj
- Brandt Andrew
- Brandt Gerhard
- Brandt Oleg
- Braren Frued
- Bratzler Uwe
- Brau Benjamin
- Brau James
- Breaden Madden William
- Brendlinger Kurt
- Brennan Amelia
- Brenner Lydia
- Brenner Richard
- Bressler Shikma
- Briglin Daniel
- Bristow Timothy
- Britton Dave
- Britzger Daniel
- Brochu Frederic
- Brock Ian
- Brock Raymond
- Brooijmans Gustaaf
- Brooks Timothy
- Brooks William
- Brosamer Jacquelyn
- Brost Elizabeth
- Broughton James
- Bruckman de Renstrom Pawel
- Bruncko Dusan
- Bruni Alessia
- Bruni Graziano
- Bruni Lucrezia
- Bruno Salvatore
- Brunt Benjamin
- Bruschi Marco
- Bruscino Nello
- Bryant Patrick
- Bryngemark Lene
- Buanes Trygve
- Buat Quentin
- Buchholz Peter
- Buckley Andrew
- Budagov Ioulian
- Buehrer Felix
- Bugge Magnar
- Bulekov Oleg
- Bullock Daniel
- Burch Tyler
- Burdin Sergey
- Burgard Carsten
- Burger Angela
- Burghgrave Blake
- Burka Klaudia
- Burke Stephen
- Burmeister Ingo
- Burr Jonathan
- Bussey Peter
- Butler John
- Buttar Craig
- Butterworth Jonathan
- Butti Pierfrancesco
- Buttinger William
- Buzatu Adrian
- Buzykaev Aleksey
- Büscher Daniel
- Büscher Volker
- C-Q Changqiao
- Cabrera Urbán Susana
- Caforio Davide
- Cai Huacheng
- Cairo Valentina
- Cakir Orhan
- Calace Noemi
- Calafiura Paolo
- Calandri Alessandro
- Calderini Giovanni
- Calfayan Philippe
- Callea Giuseppe
- Caloba Luiz
- Calvente Lopez Sergio
- Calvet David
- Calvet Samuel
- Calvet Thomas
- Camacho Toro Reina
- Camarda Stefano
- Camarri Paolo
- Cameron David
- Caminal Armadans Roger
- Camincher Clement
- Campana Simone
- Campanelli Mario
- Camplani Alessandra
- Campoverde Angel
- Canale Vincenzo
- Cano Bret Marc
- Cantero Josu
- Cao Tingting
- Capeans Garrido Maria
- Caprini Irinel
- Caprini Mihai
- Capua Marcella
- Carbone Ryne
- Cardarelli Roberto
- Cardillo Fabio
- Carli Ina
- Carli Tancredi
- Carlino Gianpaolo
- Carlson Benjamin
- Carminati Leonardo
- Carney Rebecca
- Caron Sascha
- Carquin Edson
- Carrillo-Montoya German
- Carrá Sonia
- Casadei Diego
- Casado Maria
- Casha Albert
- Casolino Mirkoantonio
- Casper David
- Castelijn Remco
- Castillo Gimenez Victoria
- Castro Nuno
- Catinaccio Andrea
- Catmore James
- Cattai Ariella
- Caudron Julien
- Cavaliere Viviana
- Cavallaro Emanuele
- Cavalli Donatella
- Cavalli-Sforza Matteo
- Cavasinni Vincenzo
- Celebi Emre
- Ceradini Filippo
- Cerda Alberich Leonor
- Cerri Alessandro
- Cerrito Lucio
- Cerutti Fabio
- Cervelli Alberto
- Cetin Serkant
- Chafaq Aziz
- Chakraborty Dhiman
- Chan Stephen
- Chan Wing
- Chan Yat
- Chang Philip
- Chapman John
- Charlton Dave
- Chau Chav
- Chavez Barajas Carlos
- Che Siinn
- Cheatham Susan
- Chegwidden Andrew
- Chekanov Sergei
- Chekulaev Sergey
- Chelkov Gueorgui
- Chelstowska Magda
- Chen Cheng
- Chen Chunhui
- Chen Hucheng
- Chen Jing
- Chen Shenjian
- Chen Shion
- Chen Xin
- Chen Ye
- Cheng Hok
- Cheng Huajie
- Cheplakov Alexander
- Cheremushkina Evgeniya
- Cherkaoui El Moursli Rajaa
- Cheu Elliott
- Cheung Kingman
- Chevalier Laurent
- Chiarella Vitaliano
- Chiarelli Giorgio
- Chiodini Gabriele
- Chisholm Andrew
- Chitan Adrian
- Chiu Yu
- Chizhov Mihail
- Choi Kyungeon
- Chomont Arthur
- Chouridou Sofia
- Chow Yun
- Christodoulou Valentinos
- Chu Ming
- Chudoba Jiri
- Chuinard Annabelle
- Chwastowski Janusz
- Chytka Ladislav
- Ciftci Abbas
- Cinca Diane
- Cindro Vladimir
- Cioara Irina
- Ciocio Alessandra
- Cirotto Francesco
- Citron Zvi
- Citterio Mauro
- Ciubancan Mihai
- Clark Allan
- Clark Brian
- Clark Michael
- Clark Philip
- Clarke Robert
- Clement Christophe
- Coadou Yann
- Cobal Marina
- Coccaro Andrea
- Cochran James
- Colasurdo Luca
- Cole Brian
- Colijn Auke-Pieter
- Collot Johann
- Colombo Tommaso
- Conde Muiño Patricia
- Coniavitis Elias
- Connell Simon
- Connelly Ian
- Constantinescu Serban
- Conti Geraldine
- Conventi Francesco
- Cooke Mark
- Cooper-Sarkar Amanda
- Cormier Felix
- Cormier Kyle
- Corradi Massimo
- Corriveau Francois
- Cortes-Gonzalez Arely
- Costa Giuseppe
- Costa María
- Costanzo Davide
- Cottin Giovanna
- Cowan Glen
- Cox Brian
- Cranmer Kyle
- Crawley Samuel
- Creager Rachael
- Cree Graham
- Crescioli Francesco
- Cribbs Wayne
- Cristinziani Markus
- Croft Vince
- Crosetti Giovanni
- Crépé-Renaudin Sabine
- Cueto Ana
- Cuhadar Donszelmann Tulay
- Cukierman Aviv
- Cummings Jane
- Curatolo Maria
- Czekierda Sabina
- Czodrowski Patrick
- Cúth Jakub
- D'amen Gabriele
- D'Auria Saverio
- D'Eramo Louis
- D'Onofrio Monica
- Da Cunha Sargedas De Sousa Mario
- Da Via Cinzia
- Dabrowski Wladyslaw
- Dado Tomas
- Dai Tiesheng
- Dale Orjan
- Dallaire Frederick
- Dallapiccola Carlo
- Dam Mogens
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- Yamatani Masahiro
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- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Åkesson Torsten
- Šfiligoj Tina
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy
- Author
- Aawsaj Yousif
- Abayomi Michael
- Acharya Vikas
- Aggarwal Smeer Kumar
- Ahmad Anwar
- Ahmed Irfan
- Ahmed Jamil
- Ahmed Javed
- Ahmed Talat
- Ainley Paul
- Akhtar Mansoor
- Al Amari Khalid
- Al-Abed Yahya A.
- Al-Akash Musallam
- Al-Bahrani Ahmed Z.
- Al-Khyatt Waleed
- Al-Muhktar Ahmed
- Al-Sarireh Bilal
- Al-Taan Omer
- Alagaratnam Swethan
- Alam Imran
- Alberts Justin
- Alderson Derek
- Aldridge Roland C.
- Aleksandrov Danail
- Ali Haythem
- Ali Shahda
- Amin Khalid
- Andrew David R.
- Appleton Shaun
- Arhi Chanpreet
- Aroori Somaiah
- Aryal Kamal
- Asad Mehek
- Aseem Rabiya
- Asprou Fotini M.
- Awan Altaf
- Ayaani Soofiyah
- Aymon null
- Babu Benoy I.
- Bajwa Dalvir S.
- Bajwa Farrukh M.
- Baker Andrew L.
- Balfe Paul
- Ball William R.
- Ballance Laura
- Banwell Victoria
- Barnes James
- Barrie Jenifer
- Bartlett Francis
- Basheer Mohammed
- Bashir Gareth
- Basra Melvinder
- Basu Sanjoy
- Basynat Pradeep
- Batt Jeremy
- Bausbacher Harald
- Bawa Sadiq
- Beasley William D.
- Belding Rowena
- Bellini Maria Irene
- Bennett Stephen P.
- Bhandari Santosh
- Bharamgoudar Reshma
- Bhattacharya Vish
- Blane Christine
- Blazeby Jane M.
- Boal Matthew
- Boddy Alexander
- Boland Michael
- Bond-Smith Giles
- Booth Michael I.
- Borowski David W.
- Bowen Laura
- Boyce Kathryn M.
- Boyd Alan T.
- Bradley Donal
- Bradley Neil
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- Brett Daniel
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- Brooke Eleanor
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- Bunnell Catherine
- Bunting David M.
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- Cheung Melanie
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- Cross Keith S.
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- Ziprin Paul
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations.
Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves.
Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p 90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score.
Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care
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