111 research outputs found
The Parasexual Cycle in Candida albicans Provides an Alternative Pathway to Meiosis for the Formation of Recombinant Strains
- Author
- Alexander D Johnson
- Anderson
- Anja Forche
- Bennett
- Bennett
- Bergerat
- Bishop
- Borner
- Dana Schaefer
- Davis
- Diaz
- Diener
- Dumitru
- Dunham
- Edmond
- Eggimann
- Fonzi
- Forche
- Forche
- Gerstein
- Goddard
- Gorman
- Graser
- Grimberg
- Gudlaugsson
- Guthrie
- Heitman
- Hilton
- Holmes
- Hughes
- Hull
- Janbon
- Janbon
- Joseph Heitman
- Judith Berman
- Kakar
- Kassir
- Keeney
- Keeney
- Keeney
- Kevin Alby
- Kraus
- Kwon-Chung
- Lachke
- Liu
- Magee
- Mata
- Miller
- Mitchell
- Miyazaki
- Nantel
- Nielsen
- Noble
- Odds
- Paoletti
- Perepnikhatka
- Poulter
- Pujol
- Ramesh
- Richard
- Richard J Bennett
- Ruhnke
- Rustchenko
- Sarachek
- Sarachek
- Selmecki
- Selmecki
- Shinohara
- Staib
- Tavanti
- Torres
- Tzung
- Wey
- Whelan
- Whitby
- White
- Whiteway
- Wilson
- Wu
- Wu
- Publication venue
- Public Library of Science
- Publication date
- 01/05/2008
- Field of study
Candida albicans has an elaborate, yet efficient, mating system that promotes conjugation between diploid a and α strains. The product of mating is a tetraploid a/α cell that must undergo a reductional division to return to the diploid state. Despite the presence of several “meiosis-specific” genes in the C. albicans genome, a meiotic program has not been observed. Instead, tetraploid products of mating can be induced to undergo efficient, random chromosome loss, often producing strains that are diploid, or close to diploid, in ploidy. Using SNP and comparative genome hybridization arrays we have now analyzed the genotypes of products from the C. albicans parasexual cycle. We show that the parasexual cycle generates progeny strains with shuffled combinations of the eight C. albicans chromosomes. In addition, several isolates had undergone extensive genetic recombination between homologous chromosomes, including multiple gene conversion events. Progeny strains exhibited altered colony morphologies on laboratory media, demonstrating that the parasexual cycle generates phenotypic variants of C. albicans. In several fungi, including Saccharomyces cerevisiae and Schizosaccharomyces pombe, the conserved Spo11 protein is integral to meiotic recombination, where it is required for the formation of DNA double-strand breaks. We show that deletion of SPO11 prevented genetic recombination between homologous chromosomes during the C. albicans parasexual cycle. These findings suggest that at least one meiosis-specific gene has been re-programmed to mediate genetic recombination during the alternative parasexual life cycle of C. albicans. We discuss, in light of the long association of C. albicans with warm-blooded animals, the potential advantages of a parasexual cycle over a conventional sexual cycle
Efflux in Fungi: La Pièce de Résistance
- Author
- A Andrade
- A Borst
- A Coste
- A Fleissner
- A Selmecki
- AR Holmes
- AT Coste
- B Posteraro
- B Rogers
- B Rognon
- B-N Lee
- B. Brett Finlay
- BJ Howlett
- C Gauthier
- C-G Chen
- CF Higgins
- CG Blackmore
- CN Lyons
- D Calabrese
- D Sanglard
- D Sanglard
- D Sanglard
- DG Smith
- DM Gardiner
- EJ Helmerhorst
- Eleftherios Mylonakis
- F Barchiesi
- G Cheng
- G Sipos
- GN Agrios
- GP Moran
- H Eichhorn
- H Haas
- H Miyazaki
- H Schoonbeek
- H Schoonbeek
- I Stergiopoulos
- J Collemare
- J Morschhäuser
- J Pitkin
- JA Sheps
- JD Walton
- JD Walton
- Jeffrey J. Coleman
- JK Thakur
- K Franke
- K Niimi
- KA Marr
- KS Smriti
- L Johnson
- L-H Zwiers
- LE Cowen
- M Choquer
- M Dean
- M Goldway
- M Klein
- M Liu
- M Nucci
- M Nucci
- M Schrettl
- M Sengupta
- M Urban
- MA de Waard
- MB Edmond
- Md Micheli
- MH Saier
- MI Borges-Walmsley
- N Alexander
- N Dunkel
- N Ramanan
- N Singh
- NP Keller
- P Heymann
- P-K Chang
- PJ Riggle
- Q Ren
- R Manoharlal
- R Pasrija
- R Prasad
- R Pukkila-Worley
- R Torelli
- R Ullan
- RH Proctor
- S Oide
- S Petrovic
- S Saidane
- S Shukla
- S Theiss
- S Wirsching
- S Wirsching
- SK Katiyar
- SS Pao
- TC White
- TC White
- TC White
- TL Friesen
- TM Callahan
- TP Denny
- TP Denny
- TR Cottrell
- V Perepnikhatka
- W Fan
- WH Jung
- X Liu
- X Zhu
- Y Gbelska
- Y Han
- Publication venue
- Public Library of Science
- Publication date
- 01/06/2009
- Field of study
Pathogens must be able to overcome both host defenses and antimicrobial treatment in order to successfully infect and maintain colonization of the host. One way fungi accomplish this feat and overcome intercellular toxin accumulation is efflux pumps, in particular ATP-binding cassette transporters and transporters of the major facilitator superfamily. Members of these two superfamilies remove many toxic compounds by coupling transport with ATP hydrolysis or a proton gradient, respectively. Fungal genomes encode a plethora of members of these families of transporters compared to other organisms. In this review we discuss the role these two fungal superfamilies of transporters play in virulence and resistance to antifungal agents. These efflux transporters are responsible not only for export of compounds involved in pathogenesis such as secondary metabolites, but also export of host-derived antimicrobial compounds. In addition, we examine the current knowledge of these transporters in resistance of pathogens to clinically relevant antifungal agents
Acute periodontal lesions
- Author
- AAP
- AAP
- Abdollahi
- Abrams
- Abrams
- Agner
- Ahl
- Akman
- Akpan
- Al-Hashimi
- Alam
- Albandar
- Aliko
- Alonso Chevitarese
- Amlot
- Anil
- Antico
- Aquilina
- Arduino
- Arendorf
- Armitage
- Armitage
- Asero
- Assier
- Attard
- Attström
- Axell
- Axell
- Ayangco
- Baer
- Bagan
- Baratti-Mayer
- Barnes
- Barrett
- Baruchin
- Becker
- Beckett
- Bermejo-Fenoll
- Black
- Bodhade
- Bolewska
- Bruyne
- Bucher
- Budtz-Jorgensen
- Burke
- Burke
- Burks
- Bystryn
- Bystryn
- Cannon
- Carbone
- Carbone
- Carbone
- Carrozzo
- Caton
- Chace
- Chambrone
- Chan
- Chan
- Chen
- Chen
- Chue
- Cobb
- Cogen
- Contreras
- Contreras
- Contreras
- Corbet
- Coventry
- Creath
- Dello Russo
- DeRossi
- DeWitt
- Dilsiz
- Dodd
- Duffin
- Dunsche
- Edmond
- Eguchi
- Ehrlich
- Eisen
- Elkhoury
- Endo
- Endo
- Enwonwu
- Enwonwu
- Enwonwu
- Enwonwu
- Escobar
- Fabbri
- Farthing
- Femiano
- Ficarra
- Fine
- Fischer
- Flood
- Fonseca
- Fuss
- Gaggl
- Galeone
- Gallagher
- Galle
- Garip
- Garrett
- Gebel
- Giddon
- Gill
- Gillette
- Girdler
- Glick
- Glick
- Godara
- Gonzalez-Moles
- Goose
- Gray
- Grbic
- Greenberg
- Greene
- Groves
- Grupe
- Hafström
- Haney
- Helovuo
- Helovuo
- Hernandez
- Herrera
- Herrera
- Herrera
- Heylings
- Hodge
- Holmes
- Holmstrup
- Holmstrup
- Holmstrup
- Holmstrup
- Holmstrup
- Horning
- Horning
- Horning
- Huang
- Huff
- Hurwitz
- Ibbott
- Ishikawa
- Issa
- Jacobsen
- Jaramillo
- Jimenez
- Jimenez
- Johnson
- Johnson
- Jorgensen
- Kaimenyi
- Kaldahl
- Kara
- Kareha
- Karlis
- Katz
- Kerr
- Kim
- Kirkham
- Koch
- Korstanje
- Krejci
- Krippaehne
- Kumar
- Laeijendecker
- Laskaris
- Leao
- Leao
- Leggat
- Levin
- Levin
- Lewis
- Lewis
- Lewkowicz
- Liccardi
- Lilleker
- Listgarten
- Litonjua
- Littner
- Lo Russo
- Lo Russo
- Lodi
- Loesche
- Lopez
- Lopez-Pintor
- Lozada
- Lozada
- Lozada-Nur
- Lu
- Lucartorto
- Luders
- MacCarthy
- Mani
- Manian
- Markopoulos
- Marques
- Marrelli
- Martin
- Martin
- Mataftsi
- Mathews
- McCartan
- McDerra
- McGivern
- McLeod
- Meng
- Michalowicz
- Mignogna
- Mignogna
- Millar
- Miller
- Miller
- Moore
- Muppa
- Nahlieli
- Nahlieli
- Navarro
- Negroni de Bonvehi
- Nesbit
- Newman
- Nico
- Nisengard
- Novak
- Nowak-Wegrzyn
- Odden
- Ohta
- Olczak-Kowalczyk
- Osterne
- Ostman
- Osuji
- Ozcelik
- Ozcelik
- Panseriya
- Panzarini
- Parisi
- Parra
- Parrish
- Passi
- Paster
- Pattison
- Pearle
- Pezelj-Ribaric
- Phatale
- Pindborg
- Pindborg
- Pini Prato
- Pope
- Porter
- Pradeep
- Preeti
- Rada
- Rajlawat
- Ramirez-Amador
- Rams
- Rawal
- Reed
- Reichart
- Rentier
- Rindum
- Rivera-Hidalgo
- Roberts
- Robinson
- Rodd
- Rodriguez-Diaz
- Rossi
- Rowland
- Ruokonen
- Ryder
- Ryder
- Sabiston
- Sacher
- Samaranayake
- Sapir
- Sarrami
- Schmid
- Scully
- Scully
- Scully
- Scully
- Scully
- Scully
- Scully
- Scully
- Scully
- Scully
- Selden
- Serper
- Shannon
- Sheiham
- Siegel
- Silva
- Silva
- Sirois
- Sirois
- Skaare
- Slots
- Smith
- Smith
- Smukler
- Socransky
- Sontakke
- Sousa
- Spencer
- Stampien
- Stevens
- Stewart
- Stewart
- Stoopler
- Straus
- Straus
- Suresh
- Suryawanshi
- Suzuki
- Taani
- Tabaqchali
- Tappuni
- Thompson
- Toljanic
- Topoll
- Torabinejad
- Torchia
- Usatine
- Vaillant
- Velegraki
- Vilaplana
- Waal
- Waldman
- Weinberg
- Weinstock
- Wennstrom
- Wiesenfeld
- Williams
- Winkelhoff
- Winkler
- Woo
- Yin
- Yusof
- Zambon
- Zunt
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2014
- Field of study
This is a review and update on acute conditions affecting the gingival tissues, including abscesses in the periodontium, necrotizing periodontal diseases, and other acute conditions that cause gingival lesions with acute presentation, such as infectious process not associated with oral bacterial biofilms, muco-cutanenous disorders, and traumatic and allergic lesions. A periodontal abscess is clinically important since it is a relatively frequent dental emergency, it can compromise the periodontal prognosis of the affected tooth, and because bacteria within the abscess have been identified, mainly by the type of etiology, and there are clear diffrences between those affecting a previously existing periodontal pocket ahd those affecting healthy sites. Therapy for this acute condition consists of drainage and tissue debridement, with individual evaluation of the need for systemic antimicrobial therapy. the definitive treatment of the pre-existing condition should be accomplished after the acute phase is controlled. Necrotizing periodontal disease (NPD) present three typical clinical features : papilla necrosis, gingival bleeding, and pain. Although the prevalence of these diseases is not high, their importance is clear, since they represent the most severe conditions associated with dental biofilm, with very rapid tissue destruction. In adittion to bacteria, the etiology of NPD includes numerous factors that alter the host response and predispose to these diseases, including HIV infection, malnutrition, stress, and tobacco smoking. The treatment consists of superficial debridement, careful mechanical oral hygiene, rinsing with chlorhexidine, and daily re-evaluation. Systemic antimicrobials may be used adjunctively in severe cases or in non-responding conditions
and the best option is metronidazole.Once the acute disease is under control, definitive treatment should be provided, including the adequate therapy for the pre-existing gingivitis or periodontitis. Among other acute conditions affecting the periodontal tissues, but not caused by the microorganisms present in oral biofilms , are infectious diseases, muco-cutaneous diseases and traumatic or allergic lesions. In most cases, the gingival envolvement is not severe, though they are common and may prompt a dental emergency visit. These conditions may the direct result of a trauma or the consequence of the breaking of vesicles and bullae. A proper differential diagnosis is important for an adequate management of the case
The COVID-19 pandemic: a letter to G20 leaders
- Author
- Ahearn Bertie
- Ahmed Masood
- Alphandéry Edmond
- Altwaijri HE Dr Abdulaziz Altwaijri
- Amato Giuliano
- Amersi Mohamed
- Arbour Louise
- Aria Óscar
- Aziz Shaukat
- Bajnai Gordon
- Balkenende Jan Peter
- Banda HE Joyce
- Barak Ehud
- Barletta Nicolás Ardito
- Barroso José Manuel
- Basu Kaushik
- Bazira Dr Deus
- Belka Marek
- Berggruen Nicolas
- Berglöf Erik
- Berisha Sali
- Besley Timothy
- Bildt Carl
- Birkavs Valdis
- Blair Tony
- Bolger James Brendan
- Bolton Patrick
- Bondevik Kjell Magne
- Brahimi Lakhdar
- Brown Gordon
- Brundtland Gro Harlem
- Bruton John
- Calderón Felipe
- Calderón Rafael Ángel
- Cardoso Fernando Henrique
- Chinchilla Laura
- Chissano HE Joaquim
- Clark Helen
- Constantinescu Emil
- Cousin Ertharin
- Cristiani Alfredo
- Cvetković Mirko
- Cárdenas Mauricio
- Davies Gavyn
- De Croo Herman
- de Gaulle Nathalie
- de Klerk Frederik Willem
- Derviş Kemal
- di Mauro Beatrice Weder
- Dreifuss Ruth
- Dybul Dr Mark
- Dzau Dr Victor J.
- Dzurinda Mikuláš
- Evans Gareth
- Farrar Professor Sir Jeremy
- Fischer Jan
- Fischer Joschka
- Frattini Franco
- Gaburici Chiril
- Galal Ahmed
- Gaviria César
- Gonzalez Felipe
- Graham Dr Hamish
- Grenfell Bryan
- Gurib-Fakim Ameenah
- Guriev Sergei
- Gusenbauer Alfred
- Gutiérrez Lucio
- Halonen Tarja
- Hausmann Ricardo
- Holmes Edward C.
- Holmström Bengt
- Hurtado Osvaldo
- Ibrahim Mo
- İhsanoğlu Ekmeleddin
- Ilves Toomas Hendrik
- Itzik Dalia
- Ivanić Mladen
- Ivanov Gjorge
- Jilani Hina
- Jomaa Mehdi
- Josipović Ivo
- Karlsson Mats
- Kende-Robb Caroline
- Key John
- Ki-Moon Ban
- Kikwete HE Jakaya
- Kosor Jadranka
- Kufuor HE John
- Kumaratunga Chandrika
- Köhler Horst
- Lacalle Herrera Luis Alberto
- Lagos Ricardo
- Lagumdzija Zlatko
- Lamy Pascal
- Lee Hong-Koo
- Leonard Mark
- Leterme Yves
- Letta Enrico
- Lin Professor Justin Yifu
- Livni Tzipi
- Lucinschi Petru
- Lustig Nora
- Machel Graça
- Macri Mauricio
- Mahuad Jamil
- Major Sir John
- Mara Moussa
- Margvelashvili Giorgi
- Martin Paul
- Martinelli Ricardo
- Mbeki HE Thabo
- Medgyessy Péter
- Meidani Rexhep
- Mesić Stjepan
- Mkapa HE Benjamin
- Monti Mario
- Moussa Amre
- Muscat Joseph
- Nakagawa Dawn
- Natsios Andrew
- Nishani Bujar
- Noboa Gustavo
- O'Neill Lord Jim
- Obasanjo Chief Olusegun
- Okonjo-Iweala Dr Ngozi
- Otorbayev Djoomart
- Otunbayeva Roza
- Pagrotsky Leif
- Palacio Ana
- Palmer Sir Geoffrey
- Papandreou George
- Pastrana Andrés
- Patterson P. J.
- Pissarides Christopher
- Prodi Romano
- Pronk Jan
- Quiroga Jorge
- Raad al Hussein Zeid
- Radičová Iveta
- Ramos Horta Jose
- Ribas Reig Òscar
- Robinson Mary
- Rodrik Dani
- Rodríguez Miguel Ángel
- Roman Petre
- Rudd Kevin
- Sampaio Jorge
- Sanguinetti Julio Maria
- Santos Juan Manuel
- Satyarthi Kailash
- Schüssel Wolfgang
- Serageldin Ismail
- Sexton Professor John
- Shipley Dame Jenny
- Singh Ahluwalia Montek
- Sirleaf HE Ellen Johnson
- Solana Javier
- Soros George
- Spence Michael
- Sridhar Devi
- Stern Nicholas
- Stiglitz Joseph
- Stoyanov Petar
- Straujuma Laimdota
- Sturzenegger Federico
- Suchocka Hanna
- Summers Lawrence
- Tadić Boris
- Thinley Jigme
- Thorning-Schmidt Helle
- Tkeshelashvili Eka
- Trichet Jean-Claude
- Türk Danilo
- Uteem Cassam
- Velasco Andres
- Verhofstadt Guy
- von Thadden Ernst-Ludwig
- Wantchekon Leonard
- Wei Shang-Jin
- Williams Dr Rowan
- Wolfensohn James
- Yeo George
- Yousafzai Malala
- Yushchenko Kateryna
- Yushchenko Viktor
- Zapatero José Luis Rodríguez
- Zatlers Valdis
- Zedillo Ernesto
- Zhu Min
- Çetin Hikmet
- Đelić Božidar
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
- Andersen C
- Anderson C
- Anderson C
- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
- Andrew A
- Andrews E
- Angermair S
- Angus K
- Anillo V
- Antal O
- Antill P
- Antoniadou E
- Antonina W
- Apagaki E
- Apostolou K
- Applewhaite C
- Aquino LPG
- Ar P
- Arawwawala D
- Ardern D
- Argue R
- Arkalaki E
- Armaganidis A
- Armstrong J
- Armstrong R
- Arnaoutoglou C
- Arnaoutoglou E
- Arnold G
- Arrandale L
- Arrich J
- Arrigo M
- Arshad H
- Arshad MA
- Arumugam S
- Arustei M
- Arvaniti K
- Arya A
- Arya S
- Asimakos A
- Asudo F
- Athanasakis E
- Atiku M
- Attrill E
- Attwood C
- Auer P
- Avidan M
- Avila Sanchez FJ
- Avila EJD
- Avis J
- Awad H
- Axioti E
- Ayyaz H
- Azam UAA
- Azambuja P
- Azevedo C
- Aziz FZ
- Baas P
- Baghirzada L
- Bai H-P
- Bai Y
- Baillie S
- Baines D
- Baio TH
- Bairaktari A
- Baker G
- Baker K-A
- Baker P
- Balain B
- Balaji P
- Balajonda N
- Balanescu A
- Balasubramaniam M
- Baldisserotto S
- Baldwin J
- Baldwin M
- Balfoussia D
- Bali C
- Bandeira ME
- Banerjee R
- Bankewitz C
- Banner-Goodspeed V
- Bao Q
- Barcraft-Barnes H
- Barneto L
- Barnett A
- Baroselli A
- Barraclough J
- Barras J-P
- Barrett S
- Barrett WJ
- Basanth S
- Batchelor N
- Bateman B
- Bates A
- Bates S
- Batista HD
- Bauchmuller K
- Bauer M
- Baumgarten G
- Baxter L
- Beaton C
- Beattie S
- Beavis V
- Bechan S
- Bejia T
- Belciu I
- Belda MT
- Bell G
- Bell R
- Bell S
- Bellandi M
- Bello J
- Beloeil H
- Belskiy V
- Ben-Menachem E
- Benavent P
- Benevento A
- Bengeri S
- Bennett C
- Bennett M
- Bennett R
- Bennett V
- Bentley C
- Beretta L
- Berg A
- Bergin C
- Bernard A
- Berntsen E
- Bertram W
- Bester D
- Bester M
- Bettega F
- Bettinelli A
- Bhardwaj N
- Bhatia K
- Bhula C
- Bi Y
- Biais M
- Biccard BM
- Bidd H
- Bidgoli J
- Biffen A
- Bignami E
- Bilolikar A
- Bin Mustapha MT
- Birch J
- Bishop DG
- Biyase T
- Bizios C
- Blackwell C
- Blackwood D
- Blaj M
- Blakemore SP
- Bland M
- Blunt M
- Blyth K
- Bocchino S
- Bodansky D
- Bodger P
- Boer C
- Boereboom C
- Boggiano V
- Bogner G
- Bolaji B
- Bolton D
- Boone M
- Boschi L
- Boshier P
- Botes M
- Botis I
- Bottini C
- Bottrill F
- Bouchez S
- Boulton K
- Bouris V
- Bourner L
- Boutsikos G
- Bouwman A
- Bouwman RA
- Bowrey S
- Boxall L
- Boyd C
- Bradburn M
- Bradley J
- Branagan G
- Branco T
- Brand B
- Brandsborg B
- Breitenstein S
- Brennan A
- Brennan E
- Brenner L
- Brincat M
- Briscoe R
- Bristogiannis S
- Brooke J
- Brookes J
- Brookes M
- Brooks C
- Broomby R
- Brotto AF
- Brown A
- Brown CW
- Brown G
- Brown J
- Brown J
- Brown L
- Brown R
- Brown R
- Browning J
- Bruma D
- Brunete T
- Brunswicker A
- Bryant H
- Bua E
- Buccimazza I
- Buckley S
- Buerkle C
- Buhre W
- Buhre W
- Buhrer T
- Builu PM
- Buise M
- Bullock C
- Bunwarie B
- Burns K
- Burrows L
- Burrows T
- Burston B
- Burtenshaw A
- Burton M
- Busuioc M
- Butryn I
- Butt G
- Byrne K
- Cabezuelo E
- Cabral R
- Cabral TDN
- Cabrini L
- Cacala S
- Cai F
- Cai Y
- Cain H
- Cairns C
- Cakova V
- Calderwood C
- Callaghan M
- Campbell D
- Campbell D
- Campbell D
- Campbell G
- Campbell G
- Campbell K
- Campbell M
- Campbell T
- Campey L
- Camsooksai J
- Cancho D
- Candido K
- Cang J
- Cannavo M
- Cao J
- Cao Y
- Cao Z
- Cardellino S
- Cardosa J
- Cardoso G
- Cardy J
- Carmino L
- Carp CP
- Carr A
- Carrera R
- Carroll C
- Carroll J
- Caser E
- Castano Moreira B
- Castano B
- Castle G
- Cavanagh S
- Cawthorn L
- Cernea DD
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- Zamudio D
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- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- Alnæs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
- Artiges Eric
- Artiges Eric
- Ashley-Koch Allison
- Assaly Michele
- Assareh Amelia A
- Asthana Sanjay
- Atkins Joshua R
- Aydin Semiha
- Ayesa-Arriola Rosa
- Baca Marne
- Bachman David
- Banaschewski Tobias
- Barbot Alexis
- Barker Gareth
- Barone Paolo
- Bartha Rob
- Bartzokis George
- Bastin Mark E
- Bastin Mark E
- Bates Vernice
- Baune Bernhard T
- Becerra Mauricio
- Becker Andreas
- Becker James T
- Beckett Laurel
- Beckham Jean C
- Beiser Alexa S
- Belden Christine M
- Belger Aysenil
- Bell Karen L
- Berg Daniela
- Bergman Howard
- Bernard Manon
- Bernard Manon
- Bernick Charles
- Bernstein Matthew
- Beyer Frauke
- Bezivin-Frere Pauline
- Biondo Francesca
- Bis Joshua C
- Bis Joshua C
- Bishop Courtney
- Black Sandra
- Blangero John
- Blank Karen
- Bodge Courtney
- Bokde Arun
- Bonakdarpour Borna
- Boomsma Dorret I
- Borges-Neto Salvador
- Borowski Bret
- Borrie Michael
- Bralten Janita
- Brand Connie
- Brandabur Melanie
- Brandt Christine L
- Brewer James
- Brockington John
- Brodaty Henry
- Brodaty Henry
- Bromberg Uli
- Brooks David
- Brooks William M
- Brosch Jared R
- Brouwer Rachel M
- Brown Gregory G
- Bruehl Ruediger
- Brunner Han G
- Buckholtz Neil
- Buckner Randy L
- Budson Andrew E
- Buimer Elizabeth E L
- Buitelaar Jan K
- Burke Anna
- Burns Jeffrey M
- Bustillo Juan R
- Bülow Robin
- Bülow Robin
- Bürger Christian
- Bÿchel Christian
- Cabrera Yuliana
- Cahn Wiepke
- Cairns Murray J
- Cairns Nigel J
- Calhoun Vince
- Cannon Dara M
- Capote Horacio
- Carlsson Cynthia M
- Carmichael Owen
- Carr Vaughan J
- Carrillo Maria
- Carroll Maria
- Carson Richard E
- Carter Raina
- Casaceli Cynthia
- Casalin Paola
- Caseras Xavier
- Caspell Chelsea
- Caspers Svenja
- Catafau Ana
- Cavalleri Gianpiero L
- Cedarbaum Jesse
- Cellar Janet S
- Celmins Dzintra
- Cendes Fernando
- Chahine Lama
- Chakravarty Mallar
- Chalker Alison
- Chao Steven
- Chen Kewei
- Chen Qiang
- Chertkow Howard
- Cheung Joshua W
- Chiang Gloria
- Ching Christopher R K
- Chowdhury Munir
- Chowdhury Sohini
- Chu Congying
- Cichon Sven
- Clark Christopher M
- Clark David
- Coffey Christopher
- Coleman Edward
- Colodro-Conde Lucía
- Comery Thomas
- Conrad Gary
- Conrod Patricia
- Consortium CHARGE
- Consortium Enhancing NeuroImaging Genetics through Meta-Analysis
- Consortium EPIGEN
- Consortium IMAGEN
- Consortium SYS
- Correia Stephen
- Corvin Aiden
- Couvy-Duchesne Baptiste
- Crawford Karen
- Creech Mary L
- Crespo-Facorro Benedicto
- Crivello Fabrice
- Curran Joanne E
- D'Agostino Daniel
- Daedelow Laura
- Daiello Lori A
- Dale Anders M
- Dale Anders M
- Dalley Jeffrey
- Dalrymple-Alford John C
- Dalvie Shareefa
- Dang Mimi
- Dannlowski Udo
- Darin Abigail
- Davies Gareth E
- Davies Peter
- de Araujo Tânia K
- de Geus Eco J C
- de Zubicaray Greig I
- de Zwarte Sonja M C
- Deary Ian J
- Deary Ian J
- Debette Stephanie
- Debette Stephanie
- Decarli Charles
- DeCarli Charles
- Deeley Cheryl
- Degenhardt Franziska
- Delanty Norman
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- den Braber Anouk
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- Desrivieres Sylvane
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- Dietsche Bruno
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- El Khouli Riham
- Engelbrecht Hannah-Ruth
- Erk Susanne
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- Espay Kristy
- Espeseth Thomas
- Espiritu Ryan
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- Factor Stewart
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- Feldman Howard
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- Figurski Michal
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- Fukunaga Masaki
- Gaikwad Mrunalini
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- Gauss Katharina
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- Gruber Oliver
- Gudnason Vilmundur
- Gunter Jeff
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- Guthrie Stephanie
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- Hu Shu-Ching
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- Ikeda Masashi
- Ikram M Arfan
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- Ing Alex
- Initiative Alzheimer’s Disease Neuroimaging
- Initiative Parkinson’s Progression Markers
- Iranzo Alex
- Isaacson Stuart
- Isensee Corinna
- Ismail M Saleem
- Ittermann Bernd
- Jack Clifford R
- Jack Clifford R
- Jagust William
- Jahanshad Neda
- James Angela
- James Olga
- James Raymond
- Jang MiHyun
- Jankovic Joseph
- Janowitz Deborah
- Jansen Andreas
- Jansen Iris E
- Jennings Danna
- Jernigan Terry L
- Jia Tianye
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- Jian Xueqiu
- Jiang Jiyang
- Jicha Greg
- Jimenez Gustavo
- Jockwitz Christiane
- Johnson Kathleen
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- Johnson Nancy
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- Johnson Sterling
- Jones David
- Jönsson Erik G
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- Kaye Jeffrey A
- Kelly Sinead
- Keltz Melanie
- Kennedy Martin A
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- Krug Axel
- Krämer Bernd
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- Launer Lenore
- Le Hellard Stephanie
- Leach Christi
- Leary Laura
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- Lee Virginia
- Lemaitre Hervé
- Lenahan Art
- Leonard Gabriel
- Lerner Alan
- Lethbridge Emma
- Lett Tristram A
- Leverenz James
- Levey Allan I
- Lewis Lindsay
- Lewis Lindsay B
- Li Shuo
- Liang Grace
- Lim Kelvin O
- Lin Honghuang
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- Lind Betty
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- Linder Carly
- Lipowski Kristine
- Loeffler Markus
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- Longstreth W. T.
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- Lopes-Cendes Iscia
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- Mason Sara S
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- Mather Karen A
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- Mathis Chet
- Mattay Venkata S
- Matthews Brandy R
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- Mazoyer Bernard
- Mazoyer Bernard
- McCoy Arita
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- Medland Sarah E
- Melle Ingrid
- Melzer Tracy R
- Mendick Susan
- Mesulam M Marcel
- Mesulam Marek-Marsel
- Meyer Javier Villanueva
- Meyer-Lindenberg Andreas
- Michie Patricia T
- Milaneschi Yuri
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- Miller Bruce L
- Miller Delwyn D
- Miller Sarah
- Minton Mark
- Mintun Mark A
- Mintz Akiva
- Mintzer Jacobo
- Miranda Ruben
- Mirza-Schreiber Nazanin
- Mishra Aniket
- Mitsis Effie
- Mollenhauer Brit
- Monahan Nancy
- Montine Tom
- Moreira Jose C V
- Morey Rajendra A
- Morris Derek W
- Morris John
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- Mosley Thomas H
- Mosley Thomas H
- Mota Nina Roth
- Mowry Bryan
- Mudge Benita
- Mueller Bryon A
- Muglia Pierandrea
- Mule Jennifer
- Muni Donna
- Mühleisen Thomas W
- Müller-Myhsok Bertram
- Najt Pablo
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- Ostrowizki Suzanne
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- Oyonumo Ntekim E
- Pacini Nathaniel
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- Papadopoulos Dimitri
- Parfitt Francine
- Pasternak Stephen
- Paul Steven
- Paus Tomas
- Paus Tomáš
- Pausova Zdenka
- Pausova Zdenka
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- Pavlosky William
- Pawluczyk Sonia
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- Poewe Werner
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- Raichle Marc
- Rainka Michelle
- Raj Balebail Ashok
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- Rasser Paul E
- Ratnakar Varun
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- Redlich Ronny
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- Rudolph Alice
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- Teng Edmond
- Teodoro Liberty
- Tetrud James
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- Thai Gaby
- Thal Leon
- Thalamuthu Anbupalam
- Thalamuthu Anbupalam
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- Thomopoulos Sophia I
- Thompson Paul
- Thompson Paul M
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- Todd Gretchen
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- Toga Arthur W
- Toga Arthur W
- Tolosa Eduardo
- Tooney Paul A
- Tordesillas-Gutiérrez Diana
- Torres Fábio R
- Tran Baochan
- Tremont Geoffrey
- Trncic Nadira
- Trojanowki John Q
- Trollor Julian
- Trollor Julian N
- Turner Jessica A
- Turner Raymond Scott
- Tzourio Christophe
- Uhlmann Anne
- Uitterlinden André G
- Ulysse Anaztasia
- Umek Robert
- Uribe Liz
- Vaishnavi Sanjeev
- Vallerga Costanza Ludovica
- van 't Ent Dennis
- van der Brug Marcel
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- Van der Wee Nic J A
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- van Noort Betteke
- van Rooij Daan
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- Vanderswag Helen
- Varma Pradeep
- Veillette Suzanne
- Veldink Jan H
- Veltman Dick J
- Vemuri Prashanthi
- Venkov Heli
- Verhoef Ellen
- Vernooij Meike W
- Villena Teresa
- Villringer Arno
- Voyvodic James T
- Völker Uwe
- Völzke Henry
- Walter Henrik
- Walter Henrik
- Walter Sarah
- Walton Esther
- Wang Mingyuan
- Wang Yunpeng
- Ward Chad
- Wardlaw Joanna M
- Wardlaw Joanna M
- Weber Bernd
- Weinberger Daniel R
- Weiner Michael
- Weiner Michael W
- Weintraub Sandra
- Wen Wei
- Wen Wei
- Westlye Lars T
- Whelan Christopher D
- Whelan Robert
- Whelan Robert
- White Tonya
- Willeke Diana
- Williams Karen
- Williams Steve
- Wilson Renee
- Winkfield David
- Witbracht Megan
- Witt Stephanie H
- Witte A Veronica
- Wittfeld Katharina
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wolk David A
- Womack Kyle
- Wong Terence Z
- Woo Ellen
- Wright Margaret J
- Wright Margaret J
- Wu Chuang-Kuo
- Wu Jing Qin
- Wurster Isabel
- Xia Rui
- Yamamori Hidenaga
- Yanez Beatriz
- Yang Mia
- Yang Qiong
- Yang Qiong
- Yankey Jon
- Yasuda Clarissa L
- Yeh Randy
- Yesavage Jerome
- Zamrini Edward
- Zare Habil
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H
- Zimmerman Earl A
- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Treatment of neonatal infections: a multi-country analysis of health system bottlenecks and potential solutions
- Author
- A de Sousa
- A Haines
- A Tshefu
- AC Seale
- AH Baqui
- AH Baqui
- AK Zaidi
- AK Zaidi
- Aline Simen-Kapeu
- Anna C Seale
- BJ Stoll
- Christabel Enweronu-Laryea
- Christabel Nyange
- CJ Murray
- CM Healy
- D Singh
- D Thaver
- D Waters
- E Hazel
- F Esamai
- Gary L Darmstadt
- Gaurav Sharma
- GL Darmstadt
- GM Musiime
- Grace Liu
- GW Irimu
- H Afnan-Holmes
- H Campbell
- HK Herbert
- I Baelani
- JE Lawn
- JE Lawn
- Joy E Lawn
- K Edmond
- K Mittal
- K Rasanathan
- Kate J Kerber
- KE Dickson
- Kim E Dickson
- Kim E Dickson
- L Plantin
- Mark Young
- N Bhandari
- N Kissoon
- N Olaniran
- P Dawson
- P Mohan
- P Waiswa
- R Bahl
- R Braun
- R Knippenberg
- S Gogia
- S Khanal
- Sarah G Moxon
- Sarah G Moxon
- Sarah G Moxon
- Shamim A Qazi
- ST Jacob
- Steve Wall
- Trial group African Neonatal Sepsis
- UNICEF
- WHO
- WHO
- WHO
- WHO
- Z Maiga
- ZA Bhutta
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Acute periodontal lesions
- Author
- AAP
- AAP
- Abdollahi
- Abrams
- Abrams
- Agner
- Ahl
- Akman
- Akpan
- Al-Hashimi
- Alam
- Albandar
- Aliko
- Alonso Chevitarese
- Amlot
- Anil
- Antico
- Aquilina
- Arduino
- Arendorf
- Armitage
- Armitage
- Asero
- Assier
- Attard
- Attström
- Axell
- Axell
- Ayangco
- Baer
- Bagan
- Baratti-Mayer
- Barnes
- Barrett
- Baruchin
- Becker
- Beckett
- Bermejo-Fenoll
- Black
- Bodhade
- Bolewska
- Bruyne
- Bucher
- Budtz-Jorgensen
- Burke
- Burke
- Burks
- Bystryn
- Bystryn
- Cannon
- Carbone
- Carbone
- Carbone
- Carrozzo
- Caton
- Chace
- Chambrone
- Chan
- Chan
- Chen
- Chen
- Chue
- Cobb
- Cogen
- Contreras
- Contreras
- Contreras
- Corbet
- Coventry
- Creath
- Dello Russo
- DeRossi
- DeWitt
- Dilsiz
- Dodd
- Duffin
- Dunsche
- Edmond
- Eguchi
- Ehrlich
- Eisen
- Elkhoury
- Endo
- Endo
- Enwonwu
- Enwonwu
- Enwonwu
- Enwonwu
- Escobar
- Fabbri
- Farthing
- Femiano
- Ficarra
- Fine
- Fischer
- Flood
- Fonseca
- Fuss
- Gaggl
- Galeone
- Gallagher
- Galle
- Garip
- Garrett
- Gebel
- Giddon
- Gill
- Gillette
- Girdler
- Glick
- Glick
- Godara
- Gonzalez-Moles
- Goose
- Gray
- Grbic
- Greenberg
- Greene
- Groves
- Grupe
- Hafström
- Haney
- Helovuo
- Helovuo
- Hernandez
- Herrera
- Herrera
- Herrera
- Heylings
- Hodge
- Holmes
- Holmstrup
- Holmstrup
- Holmstrup
- Holmstrup
- Holmstrup
- Horning
- Horning
- Horning
- Huang
- Huff
- Hurwitz
- Ibbott
- Ishikawa
- Issa
- Jacobsen
- Jaramillo
- Jimenez
- Jimenez
- Johnson
- Johnson
- Jorgensen
- Kaimenyi
- Kaldahl
- Kara
- Kareha
- Karlis
- Katz
- Kerr
- Kim
- Kirkham
- Koch
- Korstanje
- Krejci
- Krippaehne
- Kumar
- Laeijendecker
- Laskaris
- Leao
- Leao
- Leggat
- Levin
- Levin
- Lewis
- Lewis
- Lewkowicz
- Liccardi
- Lilleker
- Listgarten
- Litonjua
- Littner
- Lo Russo
- Lo Russo
- Lodi
- Loesche
- Lopez
- Lopez-Pintor
- Lozada
- Lozada
- Lozada-Nur
- Lu
- Lucartorto
- Luders
- MacCarthy
- Mani
- Manian
- Markopoulos
- Marques
- Marrelli
- Martin
- Martin
- Mataftsi
- Mathews
- McCartan
- McDerra
- McGivern
- McLeod
- Meng
- Michalowicz
- Mignogna
- Mignogna
- Millar
- Miller
- Miller
- Moore
- Muppa
- Nahlieli
- Nahlieli
- Navarro
- Negroni de Bonvehi
- Nesbit
- Newman
- Nico
- Nisengard
- Novak
- Nowak-Wegrzyn
- Odden
- Ohta
- Olczak-Kowalczyk
- Osterne
- Ostman
- Osuji
- Ozcelik
- Ozcelik
- Panseriya
- Panzarini
- Parisi
- Parra
- Parrish
- Passi
- Paster
- Pattison
- Pearle
- Pezelj-Ribaric
- Phatale
- Pindborg
- Pindborg
- Pini Prato
- Pope
- Porter
- Pradeep
- Preeti
- Rada
- Rajlawat
- Ramirez-Amador
- Rams
- Rawal
- Reed
- Reichart
- Rentier
- Rindum
- Rivera-Hidalgo
- Roberts
- Robinson
- Rodd
- Rodriguez-Diaz
- Rossi
- Rowland
- Ruokonen
- Ryder
- Ryder
- Sabiston
- Sacher
- Samaranayake
- Sapir
- Sarrami
- Schmid
- Scully
- Scully
- Scully
- Scully
- Scully
- Scully
- Scully
- Scully
- Scully
- Scully
- Selden
- Serper
- Shannon
- Sheiham
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- Silva
- Silva
- Sirois
- Sirois
- Skaare
- Slots
- Smith
- Smith
- Smukler
- Socransky
- Sontakke
- Sousa
- Spencer
- Stampien
- Stevens
- Stewart
- Stewart
- Stoopler
- Straus
- Straus
- Suresh
- Suryawanshi
- Suzuki
- Taani
- Tabaqchali
- Tappuni
- Thompson
- Toljanic
- Topoll
- Torabinejad
- Torchia
- Usatine
- Vaillant
- Velegraki
- Vilaplana
- Waal
- Waldman
- Weinberg
- Weinstock
- Wennstrom
- Wiesenfeld
- Williams
- Winkelhoff
- Winkler
- Woo
- Yin
- Yusof
- Zambon
- Zunt
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
- Adam M.
- Adams C.
- Adams C.
- Adams D.
- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
- Ahmad S.
- Ahmed A.
- Ahmed I.
- Ahmed M.
- Ahmed R.
- Ahmed R.
- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
- Alexander A.
- Alexander P.
- Alhabsha O.
- Ali M.
- Ali M.
- Aliberti E.
- Alin J.
- Aliyuda F.
- Alkhudhayri A.
- Allan N.
- Allanson A.
- Allen E.
- Allen L.
- Alshaer I.
- Altaf S.
- Amezaga M.
- Amin A.
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- Anantapatnaikuni S.
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- Anderson M.
- Anderson M.
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- Anguvaa L.
- Aniruddhan K.
- Antonina Z.
- Araujo M.
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- Archer S.
- Arimoto R.
- Arkley C.
- Armah C.
- Armistead J.
- Armstrong C.
- Arnison-Newgass C.
- Arora D.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
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- Abrams J.
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- Acton C.
- Adam F.
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- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
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- Al-Saadi Z.
- Al-Shahi Salman R.
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- Albert P.
- Alegria A.
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- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
- Chakkarapani E.
- Chakraborty A.
- Chamberlain S.
- Chambers E.
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- Chauhan R.
- Chawla V.
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- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
- Christides A.
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- Church E.
- Cianci N.
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- Clifford S.
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- Coker O.
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- Collini Paul
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
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- Elgohary A.
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- Evison L.
- Ezenduka C.
- Fairbairn I.
- Fairclough A.
- Falconer E.
- Faluyi D.
- Fancois V.
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- Farzana S.
- Fatemi A.
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
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- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
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- Nature Publishing Group
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- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
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