International Brotherhood of T v. CBF Trucking Inc.

USDC for the District of New Jerse

From surface fault traces to a fault growth model: the Vogar fissure swarm of the Reykjanes Peninsula, Southwest Iceland

International audienceThe Vogar Fissure Swarm is one of four en-echelon fracture swarms that connect the Reykjanes Ridge to the South Iceland Seismic Zone and the Western Volcanic Zone. Occurring in an area of flat topography, this fissure swarm is clearly visible at the surface, where it can be seen to affect recent postglacial lavas. Using remote sensing methods to identify and measure all the faults and fractures in the swarm, combined with additional field observations and measurements, we measured 478 individual fractures, 33% of them being faults and 67% being fissures. The fracture lengths show roughly log-normal distributions. Most of the individual fractures belong to 68 main composite fractures, seven of which are longer than 2500 m and correspond to the main fault scarps of the fissure swarm. We showed that these main faults are distributed along five, equally spaced zones, ~500 m apart and a few kilometers long. We drawn 71 across-strike profiles to characterize the shape of the fault scarps, and 5 along-strike profiles to characterize the evolution of vertical throw along the main faults. Each fault consists of a coalescence of individual segments of approximately equal length. Fault throws are never larger than 10 m and are smallest at the junctions between individual segments. Analyses of along-strike throw profiles allowed us to determine the early stages of growth after coalescence. The earliest stage is characterized by an increase in the throw of the central parts of segments. This is followed by a second stage during which the throw increases at the junctions between segments, progressively erasing these small- throw zones

Cenozoic inversion of the Weald-Boulonnais and the Dover Strait: new data

The Boulonnais is a former marine gulf superimposed on a zone of tectonic inversion, which was already excavated at least at the early Middle Eocene. New sedimentalogical and paleopedological data discover within the Boulonnais and fresh seismic sections able now to better understand the process of inversion step by step. The initial breaching probably took place in the late Eocene. The Dover Strait was probably open during the Lutetian, a part of the Oligocene and of the Late Neogene. Oligocene and Pliocene faunal assemblages are identical on both sides of the Strait. It was closed again for tectonic and eustatic reasons in the early Quaternary and reopen lately from Last Interglacial. This reopening is related with the evolution of the Western Channel and of its paleovalley system. This inversion of the Variscan front accommodates most of the shortening induced by the Pyrenean Orogen on the Western border of the European plate. The inversion of the Dover Strait region is almost synchronic with those of other basins of the Channel and North Sea areas. Tectonic, geomorphologic and climatic implications of this dynamic are discussed within the Western European context

Diffuse Primary Angiosarcoma of the Pleura: A Case Report and Review of the Literature

Primary pleural angiosarcoma is an extremely rare tumor. We report the case of a patient who presented with recurrent massive bilateral hemothoraxes. Although thoracoscopy was performed, biopsy samples of the pleura were inconclusive. The delayed onset of skin metastases led to the diagnosis of angiosarcoma, however the patient died from pleuropulmonary progression before treatment could be started. We review the literature of primary pleuropulmonary angiosarcoma and discuss its treatment modalities

Reactive transport modelling of carbonate cementation in a deep saline aquifer, the Middle Jurassic Oolithe Blanche Formation, Paris Basin, France.

10 pagesInternational audienceThe Oolithe Blanche Formation (Bathonian, Middle Jurassic) is one of the deep saline aquifers of the Paris Basin in France. The spatial distribution of its reservoir properties (porosity, permeability, tortuosity, etc.) is now better known with relatively homogeneous properties, except for some levels in the central part of the basin, where permeability exhibits higher values. This spatial distribution has been correlated with diagenetic events (variability of cementation) and palaeo-fluid flow circulation phases leading to variable cementation. In this paper, numerical simulations of reactive transport are performed. They provide a preliminary quantitative analysis of the Oolithe Blanche Formation, the type of fluids involved, the duration of fluid flow, and the time required to reduce the primary porosity of the Bathonian sediments by 10% due to cementation. Our results from the reactive transport simulations along a flow line, and a parameter sensitivity analysis suggest that diagenesis processes driven by meteoric water recharge do not exclusively cause the 10% decrease in porosity. Other geochemical and hydrogeologic processes must be involved

Une tectonique synsedimentaire originale du Miocene moyen des environs de Budapest, marquer de l'extension du bassin pannonien. Middle Miocene synsedimentary tectonic structures near Budapest: evidence for extensional process within the Pannonian Basin.

Synsedimentary tectonics that created remarkable patterns of NE-SW tension gashes have affected the Badenian strata near Budapest. Ridges of oomicrite bind these fissures and correspond to an early cementation that occurred contemporaneously with sedimentation. The creation of these tension gashes is connected with the opening of the Pannonian Basin and, in detail, is interpreted as the earlier stage of an extensional process that leads to the development of larger normal faults

A V530I Mutation in c-KIT Exon 10 Is Associated to Imatinib Response in Extraabdominal Aggressive Fibromatosis

Aggressive fibromatosis (AF) or desmoid tumor is a rare condition, characterized by deep tissue invasion by a monoclonal fibroblastic neoplasm, developed from musculoaponeurotic structures. Surgery is the treatment of choice, but negative margins can hardly been achieved in large tumors, and can lead to major functional disability. AF medical therapy includes nonsteroids anti-inflammatory drugs, tamoxifen, with inconsistent results. Several reports of imatinib efficacy in AF appear in the literature. Here, we describe for the first time a V530I KIT exon 10 mutant that was associated to a dramatic imatinib response in an extraabdominal aggressive fibromatosis. The previously discovered V530I substitution was characterized in the core binding factor AML, but had never been reported in any other condition, so far. In this paper, we discuss the KIT exon 10 mutations or polymorphisms that have been described in a variety of KIT-related conditions, including acute myelogenous leukemia, mastocytosis, and aggressive fibromatosis

Successful Treatment of a Granulocytic Sarcoma of the Uterine Cervix in Complete Remission at Six-Year Follow-Up

Background. Localized granulocytic sarcoma of the uterine cervix in the absence of acute myelogenous leukemia (AML) at presentation is very rare, its diagnosis is often delayed, and its prognosis almost always ominous evolving into refractory AML. Case. We present the case of a 30-year-old woman with vaginal bleeding and a large cervical mass. Further evaluation confirmed the presence of a granulocytic sarcoma but failed to reveal systemic involvement. Results. AML type chemotherapy followed by radiotherapy of the uterus led to a durable complete remission. She remains in complete remission six years after diagnosis. Conclusion. Granulocytic sarcoma of the cervix is a rare entity for which early intensive AML type therapy is effective

Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions

Activation of client proteins by the Hsp90 molecular chaperone is dependent on binding and hydrolysis of ATP, which drives a molecular clamp via transient dimerization of the N-terminal domains. The crystal structure of the middle segment of yeast Hsp90 reveals considerable evolutionary divergence from the equivalent regions of other GHKL protein family members such as MutL and GyrB, including an additional domain of new fold. Using the known structure of the N-terminal nucleotide binding domain, a model for the Hsp90 dimer has been constructed. From this structure, residues implicated in the ATPase-coupled conformational cycle and in interactions with client proteins and the activating cochaperone Aha1 have been identified, and their roles functionally characterized in vitro and in vivo