Predicting risk of readmission in heart failure patients using electronic health records

This thesis research investigates the prediction of readmission risk in heart failure patients using their electronic health record (EHR) data from previous hospitalizations. We examine three primary questions. First, we study the use of attention mechanism in readmission prediction model based on long short-term memory(LSTM) networks and investigate the interpretability it offers regarding the importance of critical time during the visit in readmission prediction. Second given that, generally dataset is curated by combining data from multiple hospitals we investigate model generalization across multiple sites. Finally since in real life scenario model will be trained on past data and used to predict future readmission events, we further investigate model generalization across time. Along with those things, model performance across different endpoints will be studied

IMPACT OF SYSTEMATIC TRAINING IN EMOTIONAL INTELLIGENCE ON THE SECONDARY SCHOOL TEACHERS’ EQ LEVELS

Introduction: While working with various educational institutes and being a trusty of family school, researcher had to deal with all the issues related with Teachers’ training, recruitment, and teaching learning processes. Researcher was also teaching in the renowned college at Mumbai, and after that, working as Psychological and Emotional Intelligence consultant at a very big Educational Organization in Mumbai. Researcher got an opportunity to have a dialogue with various principals and management trusties and educationists and the people working in human resource departments of Educational Institutes. She found that all are agreed with the fact that all the teachers are Intelligent and some of them are Brilliant to bring the subject to students, given them to teach. But they also mentioned that, the most of the times the whole teaching learning process is becoming very stressful and that is transferred to students as well. Some teachers are trying very hard to make it interesting but that is not enough. That motivated the researcher to discover what must be there beneath the whole process. At the same time, she also had to deal with many cases of the teachers who have come to her to resolve their issues and she found that it’s not their Intelligence but it’s their emotions intervening in the process, they are intelligent but most of them don’t know how to deal with their emotions in their personal life, at work or at social level that is somewhere interfering in the process. So the aim of the research is to find out their Emotional Intelligence levels and also then after training in Emotional Intelligence, with post assessments, finding out whether there is any significant change. Objective: While working on the Ph.D. thesis, one of the aims of the researcher is to discover, “The impact of the systematic training in emotional intelligence on the overall competencies of emotional intelligence levels of teachers.”Methodology: To understand the impact on teachers, the “Social Emotional Intelligence Assessment” was conducted for secondary school teachers teaching in two CBSE (Central Board of School Education) Schools in the periphery of Nasik District, Maharashtra, India.  Research was conducted for the teachers of both the schools. Training in Emotional Intelligence was conducted for the teachers of one school, where as teachers of other school were gaining EQ with the knowledge they had and the knowledge they acquired with the reports of their assessments provided to them. The training modules involved emotional intelligence skills such as, empathy, how the teacher can live with a purpose, navigating emotions and recognizing patterns. All the modules were uniquely designed and developed by the Researcher herself. Findings: The teachers who participated in the training programs showed almost 14% rise in various competencies of Emotional Intelligence. Research Outcomes: The teachers mentioned that the whole process is changing and bringing a lot of positivity, hope and ease and interest among classrooms, students and in their lives as well. Their life is changing at all levels as at personal level, at work, Social and family level.Future Scope: This research has been conducted in two C.B.S.E schools; in future it can be conducted in many other syllabus also for working staff in the organizations, or in the states other than Maharashtra.&nbsp

The Todays Teaching Human Resource Wants to Remember Joyful and Understanding Teachers More than Others of their Childhood

Wh ile conducting the research in Emotional Intelligence about the human resource in educational institutes i e secondary school teachers the researcher was always curious to know about what are those teachers remembered by today s teachers And what can be the reasons for recalling only those particular teachers While conducting EQ awareness programs and S EI Social Emotional Intelligence Assessment the researcher organized various interventions between Pre and Post Training Assessments for Teachers The base of developing and designing the modules was Pre Training Assessments Where the researcher obser ved that teachers are struggling to achieve SEI Compe- tencies namely Navigating Emotions Empathy Recognizing Patterns and Pursue Noble Goal She always wanted to know what is the purpose teachers have for their profession When she asked some questions while interviewing them in groups and also then they were writing individually about their teachers who taught them in their schools when they were learning in their childhood most of the teachers wrote and responded that they remember joyful an d understanding teachers As an EQ researcher especially in the field of HRM Impact of teachers Emotional Intelligence on student s performance this data found very interesting and important to her This research paper will put forth the light upon ho w the teachers recently teaching in the schools when the researcher gave them an option to choose a teacher to follow in their life now they want to remember and choose those who are joyful understanding happy helpful careful smiling giving creating examples and so o

VITAMIN B1PROMOTED GREEN SYNTHESIS OF BENZOFURAN CHALCONES: PROMISING SCAFFOLDS FOR DRUG DEVELOPMENT IN ANTIMICROBIAL

 Objective: To develop metal free and environmentally benign synthetic method for the synthesis of chalcones bearing benzofuran scaffolds. Materials and Methods:Starting material chloroacetone,anhydrous potassium carbonate, different aromatic aldehydes, ethanol and vitamin B1 of AR grade wereused for synthesis.Various chalcones were synthesized byClaisen-Schmidt condensation.The structure of the synthesized compounds was confirmed by elemental analysis, IR,1H NMR and mass spectra.  Results:In this context we have tried new metal free and environmentally benign synthetic method for synthesis of the pharmaceutically important molecule 1-(4-substituted-1-benzofuran-2-yl) substituted chalcones and its derivatives and it was screened for their antimicrobial activity.Most of the compounds exhibited the good to moderate activity. Conclusion:Herein we have tried a highly efficient protocol for the synthesis of chalconesa good result with variety of functionalities, a high yield of products, and the recoverability of this catalyst.Vitamin B1 as a catalyst has been developed using green solvent EtOH

Integrated experimental and computer modeling approach to understand permafrost thaw subsidence induced oil well instability for Alaska North Slope oil wells

Thesis (M.S.) University of Alaska Fairbanks, 2016Hydrocarbon reservoirs in the Arctic region of Alaska have been developed by various oil and gas producers for several years. Most of them are overlain by massive layers of permafrost soils which extend to a thickness of up to 2300 feet. Production and injection wells in such regions have experienced design and operational challenges due to heat loss from the wellbore and subsequent thawing of the permafrost soils. Thawing is a phase change of ice to water resulting in volumetric reduction of the frozen soil due to pore space contraction and segregated ice thaw, causing a major problem of thaw subsidence. Thaw subsidence affects the stability of the well, causing buckling and structural distress along the length of the wellbore within the thaw susceptible permafrost zones, thus damaging the well casing. Two different experimental approaches, one-dimensional consolidation and three-dimensional physical scale test, were employed to study thaw subsidence mechanisms in three different types of soils; namely, clay, silt and sand. The main objective of these experiments was to understand the well-soil system and the changes occurring within it with time, which will further increase knowledge of the interaction between the wellbore and the soil in Arctic regions during progressive thaw. Due to a lack of data and information, several areas were selected for multiple experimental approaches, including lateral pressure development, soil strain and strain within well casing, to study the frictional effects along the wellbore and pore-pressure response within the soil. Along with the experimental work, two different models were built in COMSOL Multiphysics™. The first model focused on thermal analysis of the thawing and refreezing behavior of ice-rich permafrost for drilling and production operations, while the second model focused on mechanical analysis, to study and understand the generation of the vertical and horizontal loads and stress-strain characteristics of the ice-rich permafrost. Simulations focused mainly on obtaining data for lateral pressure development, well stress-strain and temperature.Chapter 1: Introduction -- Permafrost -- Methods of permafrost formation -- Distribution of permafrost -- Factors affecting the presence of permafrost -- Permafrost in Alaska -- Permafrost thaw subsidence -- Chapter 2: Literature review -- Heat transfer -- Basic theory -- Heat capacity and latent heat -- Behavior of permafrost around a wellbore -- Melting of excess ice -- Fluid expulsion along with thaw consolidation -- Pore pressure reduction -- Stiffness reduction -- Factors influential towards permafrost thaw subsidence -- Soil lithology -- Deposition history and freezing and thawing conditions -- Well geometry and spacing -- Thaw discontinuities -- Behavior of permafrost soils upon thaw -- External and internal freezeback -- Thaw subsidence loading -- Summary of mechanisms and factors influencing permafrost thaw subsidence -- Previous work described in the literature -- Chapter 3: Objective of the study -- Chapter 4: Experimental approach to understand thaw subsidence -- Understanding and testing of soil -- Testing of soil part #1: sieve analysis and hydrometer analysis -- Results for sieve analysis and hydrometer analysis -- Testing of soil part #2: atterberg limit tests -- Results for liquid limit test and plastic limit tests -- Testing of soil part #3: soil consolidation and layer test -- Testing of soil part #4: frost heave test -- Preparation of soil sample -- Japanese cell -- Laval cell -- Three-dimensional physical scale test -- One dimensional consolidation test -- Chapter 5: Computer modeling approach to understand thaw subsidence -- Thermal analysis -- Base model for thermal analysis -- Input parameters and assumptions for thermal analysis -- Results and their validation for base model -- Main model for thermal analysis -- Results for main model -- Mechanical analysis -- Base model for mechanical analysis -- Input parameters and assumptions for mechanical analysis -- Results for base model -- Main model for mechanical analysis -- Results for main model -- Chapter 6: Conclusions and recommendations -- Conclusions -- Recommendations -- References -- Appendix

ROLE OF IL-17 AND TH17 CELLS IN HSV INDUCED OCULAR IMMUNOPATHOLOGY

Herpes simplex virus (HSV) infection of the cornea leads to a blinding immuno-inflammatory condition of the eye also called stromal keratitis (SK). SK immunopathology is characterized by the infiltration of CD4+ T cells of Th1 phenotype as well as the development of new blood vessels into the normally avascular cornea. Studies in mouse models of SK have firmly established the role of CD4+ T cells, and particularly of Th1 phenotype, as the principal mediators of SK immunopathology. However, with the recent discovery of IL-17A and Th17 cells, the role of this cytokine as well as Th17 cells remains to be further defined. Recently it was shown that the normal cornea expresses VEGF-A, however its biological activity is impeded by its binding to a soluble form of VEGF-A receptor-1 (sVEGFR-1). Past studies have implicated the role of vascular endothelial growth factor-A (VEGF-A) in HSV induced corneal angiogenesis, however the source of VEGF-A as well as molecular mechanisms, particularly in the context of VEGF-A/sVEGFR-1 balance during HSV infection, are poorly understood. The first part of this dissertation (I) reviews past literature on HSV induced corneal SK immunopathology. It focuses on the understanding of HSV-1 induced events that particularly results in corneal angiogenesis as well as tissue damage mediated by different type of cells as well as their secreted products. The next three parts (II-IV) focus on the mechanisms of HSV induced corneal angiogenesis as well as the relative role of Th1 and Th17 cells in SK immunopathology. Results in part II focuses on the relative role of IFN-γ/IL-17 as well as Th1/Th17 cells in HSV induced corneal immunopathology. The third section evaluate the significance of VEGF-A/sVEGFR-1 balance in HSV induced corneal neovascularization. Results in part IV focus on the role of IL-17A in altering the balance between VEGF-A and sVEGFR-1 post ocular HSV infection and subsequent corneal angiogenesis. Collectively these studies identified novel mechanisms by which HSV infection of the cornea leads to the development of angiogenesis as well as corneal tissue damage and subsequent SK immunopathology, the most common cause of infectious blindness in the Western World

A Survey Paper on Information Leakage in Malicious Environment

Purposeful or unexpected leakage of private information is no doubt an extraordinary problem amongst the most extreme security problems that organizations consider in the computerized era. This system shows a generic data lineage framework LIME for data stream above various elements that take two trademarks, viz., owner and consumer. The system characterizes the correctness of security guarantees required by such an information leakage component towards identifiable proof of a guilty party, and identify the improving non-refusing and genuineness suspicions. System then create and dissect a novel accountable data transfer protocol by extending oblivious transfer, robust watermarking, and signature primitives. It also performs an assessment regarding the coherence of the protocol , application of our framework to the necessary information leakage situations of data outsourcing and social networking organizations. System now consider LIME , lineage framework for information transfer, to be a key tread towards acheiving accountability by design

Periodic Orbit Analytic Construction In The Circular Restricted Three-Body Problem

This thesis investigates an approximate analytic construction of halo-type periodic orbits about the collinear equilibrium points in the circular restricted three-body problem. The research follows a parallel approach to the one used by Ghazy and Newman, but the initial assumptions and utilized functions are unique to this thesis. A suppositional base solution constructed using Jacobi elliptic functions and satisfying Jacobi\u27s integral equation is at the core of the analytic construction framework. The locus of this solution is a circle lying in the plane perpendicular to the line joining the primaries. The base solution elicits a closed-form expression for the period in terms of the elliptic integral of the first kind and a frequency-like parameter. The base solution satisfies a combination of third body equations of motion in the y and z axes, and the equation of motion in the x axis is satisfied in an averaged and bounded sense when the vertical plane is located at one of the collinear Lagrange points. Because the third body cannot traverse this type of path naturally, an analytic correction process is pursued to recover accuracy. An iterated perturbation process is used whereby corrections to the base solution along the axis connecting the primaries is considered first, followed by correction in the other two directions. The iterated approach is followed to exploit the coupling structure inherent in the three-body system to simplify calculations. Linear assumptions are also used in these calculations for simplifying reasons. The non-homogeneous solution excitations for the x and y corrections are in the form of Fourier series expansions of the Jacobi elliptic functions in terms of the nome function. The development assumes the suppositional plane passes through one of the collinear Lagrange points. Only homogeneous correction is needed for the z axis. The modified solution then consists of the base solution plus first order corrections which can be further developed to include second and higher order corrections. The base solution is compared with a L1 halo orbit example and somewhat rough similarity is observed; the period of the base solution being approximately half of the true orbit. An interesting result is obtained when the truncated version of the correction forcing signal is compared with the exact one. When the frequency-like parameter is greater than or equal to unity, the full and truncated forcing signals become almost identical which justifies the use of the truncated forcing function for the L1 halo orbit test case. The initial conditions for the true orbit are substituted in the truncated series solution and a new value of the frequency-like parameter is obtained using numerical computation depending in which axis is sought. For the test case, a unique value of the parameter is obtained from the y axis velocity initial conditions, which when employed in the x, y, and z solutions gives improved motion compared to the base one, and the corrected orbit reaches closer to the true orbit. The error in the period of this corrected orbit is reduced to zero when compared to the true orbit