The noise-lovers: cultures of speech and sound in second-century Rome

This chapter provides an examination of an ideal of the ‘deliberate speaker’, who aims to reflect time, thought, and study in his speech. In the Roman Empire, words became a vital tool for creating and defending in-groups, and orators and authors in both Latin and Greek alleged, by contrast, that their enemies produced babbling noise rather than articulate speech. In this chapter, the ideal of the deliberate speaker is explored through the works of two very different contemporaries: the African-born Roman orator Fronto and the Syrian Christian apologist Tatian. Despite moving in very different circles, Fronto and Tatian both express their identity and authority through an expertise in words, in strikingly similar ways. The chapter ends with a call for scholars of the Roman Empire to create categories of analysis that move across different cultural and linguistic groups. If we do not, we risk merely replicating the parochialism and insularity of our sources.Accepted manuscrip

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome associated with COVID-19: An Emulated Target Trial Analysis.

RATIONALE: Whether COVID patients may benefit from extracorporeal membrane oxygenation (ECMO) compared with conventional invasive mechanical ventilation (IMV) remains unknown. OBJECTIVES: To estimate the effect of ECMO on 90-Day mortality vs IMV only Methods: Among 4,244 critically ill adult patients with COVID-19 included in a multicenter cohort study, we emulated a target trial comparing the treatment strategies of initiating ECMO vs. no ECMO within 7 days of IMV in patients with severe acute respiratory distress syndrome (PaO2/FiO2 <80 or PaCO2 ≥60 mmHg). We controlled for confounding using a multivariable Cox model based on predefined variables. MAIN RESULTS: 1,235 patients met the full eligibility criteria for the emulated trial, among whom 164 patients initiated ECMO. The ECMO strategy had a higher survival probability at Day-7 from the onset of eligibility criteria (87% vs 83%, risk difference: 4%, 95% CI 0;9%) which decreased during follow-up (survival at Day-90: 63% vs 65%, risk difference: -2%, 95% CI -10;5%). However, ECMO was associated with higher survival when performed in high-volume ECMO centers or in regions where a specific ECMO network organization was set up to handle high demand, and when initiated within the first 4 days of MV and in profoundly hypoxemic patients. CONCLUSIONS: In an emulated trial based on a nationwide COVID-19 cohort, we found differential survival over time of an ECMO compared with a no-ECMO strategy. However, ECMO was consistently associated with better outcomes when performed in high-volume centers and in regions with ECMO capacities specifically organized to handle high demand. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Modelling human choices: MADeM and decision‑making

Research supported by FAPESP 2015/50122-0 and DFG-GRTK 1740/2. RP and AR are also part of the Research, Innovation and Dissemination Center for Neuromathematics FAPESP grant (2013/07699-0). RP is supported by a FAPESP scholarship (2013/25667-8). ACR is partially supported by a CNPq fellowship (grant 306251/2014-0)

Training flexible categorization to improve arithmetic problem solving: A school-based intervention with 5th graders

Because of its importance in academic achievement, especially in mathematics, training cognitive flexibility at school is a major issue. The present research investigates the effectiveness of a school-based intervention to improve proportion arithmetic problem solving. The study was conducted with 5th graders of 10 classes from 5 high-priority education schools in the Paris region. Students of the control and experimental groups took part in 8 learning sessions about proportion problem solving. The experimental group’s training focused on comparing and flexibly categorizing the problems in the hopes to help students achieve a deeper understanding of proportion problems. Results show that training flexible categorization allowed the experimental group to progress more than the control group, in both categorization and solving tasks. The educational implications of our results are discussed

Cognitive Flexibility Or Flexibilities? New Insights From A Classroom Study

The definition of cognitive flexibility remains debated in the literature. Some refer to flexibility as a general shifting ability. Others argue that it is a context-dependent skill. For others, flexibility is a dimensional construct including reactive flexibility and spontaneous flexibility. To help decide between these views, we analyzed the performances of first-graders across four flexibility tasks. Two tasks focused on reactive flexibility (rule-shifting and verbally-cued-shifting), and two targeted spontaneous flexibility (role-shifting and divergent thinking). Three additional executive tasks investigated the contribution of inhibition, working memory, and processing speed. Significant — though moderate — positive correlations emerged between all but one of the pairs of flexibility tasks. Besides, executive functions were not found to systematically correlate with any measure of flexibility. Furthermore, confirmatory factorial analyses failed to identify a unique or bi-dimensional structure of flexibility. Taken together, these results did not provide evidence for a domain-general ability. Implications and future directions are discussed

Cognitive Flexibility Or Flexibilities? Insights From A Classroom Study.

There is an ongoing debate in the scientific community regarding the nature of cognitive flexibility. It is either seen as a general executive process (set shifting), as a dimensional construct composed of reactive flexibility and spontaneous flexibility, or as a task-dependent skill. To help decide between these views, we analyzed the performances of 86 first-graders across four Cognitive Flexibility tasks. Two tasks focused on reactive flexibility (rule-shifting and predicate-shifting), and two tasks targeted spontaneous flexibility (role-shifting and divergent thinking). We also assessed children’s performance on three Executive Functions tasks (cognitive inhibition, verbal working memory, and visuomotor processing speed) to investigate the extent to which they correlate with cognitive flexibility. Significant — though moderate — positive correlations emerged among five out of the six pairs of cognitive flexibility tasks, regardless of whether they involved a reactive or spontaneous use of cognitive flexibility. Besides, none of the executive functions tasks systematically correlated with the four measures of cognitive flexibility. On the other hand, Confirmatory Factorial Analyses did not state whether cognitive flexibility is a unifactorial or bi-factorial construct. Overall, our results suggest that cognitive flexibility performance may reflect the recruitment of several task-dependent transversal processes. Implications with regard to the three postulates as well as future directions are discussed

Zincate‐Mediated Remote Functionalisation of p ‐Iodobenzyl Derivatives Through Metallotropy in 2‐Methyltetrahydrofuran as Key Solvent

International audience2-MeTHF (2-methyltetrahydrofuran) promotes the zincate-mediated remote functionalisation of p-iodobenzyl derivatives through metallotropy with a broad scope. This biosourced solvent remarkably impacted all the key elementary steps involved in the tandem reaction. The method tolerates a wide range of sensitive functionalities within the substrates as well as enolisable and activated or deactivated aromatic aldehydes as reaction partners. A challenging benzyl naphthalene derivative was even reacted through an original dearomatisation/rearomatisation/metallotropy chain

Effectiveness of Seed Traps for Assessing Seed Rain in Periurban Grasslands

Landscape context plays an important role in plant community structuring, with selection pressure affecting dispersal ability. This is particularly true in cities, where land use heterogeneity and habitat fragmentation can affect plant dispersal patterns. Seed rain surveys are often used to study dispersal but involve a wide variety of methods and trap types and rarely address the urban context. This study aimed to (1) compare seed rain, especially of anemochorous seeds, in different spatial contexts in a periurban area in Angers (western France); and (2) compare seed rain captured using different trap types (funnel traps/sticky traps), trap heights, and shapes. Seven sites, each equipped with five replicates of funnel traps, were selected in a periurban area in the western part of Angers. Within one of these sites, ten types of traps (differing in trapping method, height, shape, degree of tilt, and area) were employed and their performance compared. The results show that trap height rather than trap type is responsible for differences in seed density and composition. Furthermore, the composition of collected seeds appears to be associated with surrounding land cover, in particular built areas, which has implications for urban ecology in terms of understanding the influence of landscape factors on plant dispersal

Easy access to heterobimetallic complexes for medical imaging applications via microwave-enhanced cycloaddition

The Cu(I)-catalysed Huisgen cycloaddition, known as “click” reaction, has been applied to the synthesis of a range of triazole-linked porphyrin/corrole to DOTA/NOTA derivatives. Microwave irradiation significantly accelerates the reaction. The synthesis of heterobimetallic complexes was easily achieved in up to 60% isolated yield. Heterobimetallic complexes were easily prepared as potential MRI/PET (SPECT) bimodal contrast agents incorporating one metal (Mn, Gd) for the enhancement of contrast for MRI applications and one “cold” metal (Cu, Ga, In) for future radionuclear imaging applications. Preliminary relaxivity measurements showed that the reported complexes are promising contrast agents (CA) in MRI