Systematic study of pentaquark states: qqq−qqˉqqq-q\bar{q} configuration

Group theoretic method for the systematic study of five-quark states with meson-baryon ($q\bar{q}-q^3$) configuration is developed. The calculation of matrix elements of many body Hamiltonian is simplified by transforming the physical bases (meson-baryon quark cluster bases) to symmetry bases (group chain classified bases), where the fractional parentage expansion method can be used. Three quark models, the naive Glashow-Isgur model, Salamanca chiral quark model and quark delocalization color screening model, are used to show the general applicability of the method and general results of constituent quark models for five-quark states are given. The method can also be useful in the calculation of meson-baryon scattering and the study of the five-quark components effect in baryon structure. The physical contents of different model configurations for the same multi-quark system can also be compared through the transformation between different physical bases to the same set of symmetry bases.Comment: 30 pages, 8 figure

Enhanced Catalytic Performance of Pd/HMIL-121 Catalysts with Hierarchical Porosity for Selective Hydrogenation of Phenylacetylene: Mechanistic Insights and Comparative Analysis

Metal–organic frameworks (MOFs) with Al metal nodes, being stable and cost-effective materials, are well-suited for use as catalyst supports. In this study, a hierarchical Pd/HMIL-121 catalyst with adjustable pore sizes was synthesized through heat treatment using MIL-121 as the support. The study reveals that as thermal treatment intensity escalates, the pore volume and specific surface area of HMIL-121 initially rise and then decrease. Concurrently, as the pore volume and BET specific surface area increase, the styrene selectivity improves, and the rate of phenylacetylene conversion accelerates. This is attributed to the larger pore volume significantly enhancing the internal diffusion of phenylacetylene and styrene.The presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author

Defining Global Gene Expression Changes of the Hypothalamic-Pituitary-Gonadal Axis in Female sGnRH-Antisense Transgenic Common Carp (Cyprinus carpio)

BACKGROUND: The hypothalamic-pituitary-gonadal (HPG) axis is critical in the development and regulation of reproduction in fish. The inhibition of neuropeptide gonadotropin-releasing hormone (GnRH) expression may diminish or severely hamper gonadal development due to it being the key regulator of the axis, and then provide a model for the comprehensive study of the expression patterns of genes with respect to the fish reproductive system. METHODOLOGY/PRINCIPAL FINDINGS: In a previous study we injected 342 fertilized eggs from the common carp (Cyprinus carpio) with a gene construct that expressed antisense sGnRH. Four years later, we found a total of 38 transgenic fish with abnormal or missing gonads. From this group we selected the 12 sterile females with abnormal ovaries in which we combined suppression subtractive hybridization (SSH) and cDNA microarray analysis to define changes in gene expression of the HPG axis in the present study. As a result, nine, 28, and 212 genes were separately identified as being differentially expressed in hypothalamus, pituitary, and ovary, of which 87 genes were novel. The number of down- and up-regulated genes was five and four (hypothalamus), 16 and 12 (pituitary), 119 and 93 (ovary), respectively. Functional analyses showed that these genes involved in several biological processes, such as biosynthesis, organogenesis, metabolism pathways, immune systems, transport links, and apoptosis. Within these categories, significant genes for neuropeptides, gonadotropins, metabolic, oogenesis and inflammatory factors were identified. CONCLUSIONS/SIGNIFICANCE: This study indicated the progressive scaling-up effect of hypothalamic sGnRH antisense on the pituitary and ovary receptors of female carp and provided comprehensive data with respect to global changes in gene expression throughout the HPG signaling pathway, contributing towards improving our understanding of the molecular mechanisms and regulative pathways in the reproductive system of teleost fish

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Effect of mulching on labile soil organic matter pools, microbial community functional diversity and nitrogen transformations in two hardwood plantations of subtropical Australia

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