9 research outputs found
Volume 10
Introduction Dr. Roger A. Byrne
An Analysis of Media Framing in Cases of Violence Against Women by Taylor Hogg
Writing in the Discipline of Nursing by Tiffany Carter
Photography by Brandyn Johnson
The Hidden Life of Beef Cattle: A Study of Cattle Welfare on Traditional Ranches and Industrial Farms by Haleigh James
Bloodworth\u27s by Josh Baker and Tyler Cernak
Prosimians: Little Bodies, Big Significance by Kirsten Bauer
Skinformed by Allie Snavely
Coopertition and Gracious Professionalism: The Effects of First Robotics Folklore and Culture on the Stem Community by Mary Zell Galen
Tilt by Eric Powell And Thomas Wise
The Millennial Generation and Protest Politics: How Social Media Affects Civic Engagement by Katie Kinsey
Effects of Intergenerational Daycares: Parents\u27 Perception of Early Childhood Socialization with Elderly Populations by Beth Barbolla, Maeleigh Ferlet, Rebecca Morra
Speech and Intelligence: Does My Use of AAE Label Me Incompetent? By Michala Day
Stimulation of Dendritic Cells with Dimethylfumarate Leads to Cd-4 Th2 T-Cells Immune Responses in Multiple Sclerosis and Psoriasis by Alexandra Evangelista, Max Flores, Harley Hodges, and Clardene Jones
The Hunt by Harrison Samaniego
The Rise of Structural Individualism: Millennial Attitudes Towards Welfare and Poverty by Jamesha Watson
A Rhetorical Analysis of Pope Francis\u27s Address to U.S. Congress on September 24, 2015: A Petition for the Revival of Community and Common Values by Abby Gargiulo
Photomontage Poster by Heather Green
Love You to Death: Repressed Desires in Poe\u27s The Black Cat by Haley Klepatzki
Muhammad Ali by Juan Guevara
No end to it, baby : Pynchon, Communication, and The Crying of Lot 49 by Dani Bondurant
The Sun Has Set on Britain By Michael Joseph Link, Jr.
The Handbettering Campaign by Pamela Dahl
Ceremony Marks FDR\u27s Continuance as Leader as War Goes On: An Analysis Of FDR\u27s Fourth Inauguration and How It Reflected the Effect of the War in American Society by Maeve Losen
How White Is for Witching and Get Out Challenge Western Xenophobia by Charlotte Murphe
Expanding the medicinal chemistry synthetic toolbox
The key objectives of medicinal chemistry are to efficiently design and synthesize bioactive compounds that have the potential to become safe and efficacious drugs. Most medicinal chemistry programmes rely on screening compound collections populated by a range of molecules derived from a set of known and robust chemistry reactions. Analysis of the role of synthetic organic chemistry in subsequent hit and lead optimization efforts suggests that only a few reactions dominate. Thus, the uptake of new synthetic methodologies in drug discovery is limited. Starting from the known limitations of reaction parameters, synthesis design tools, synthetic strategies and innovative chemistries, here we highlight opportunities for the expansion of the medicinal chemists’ synthetic toolbox. More intense crosstalk between synthetic and medicinal chemists in industry and academia should enable enhanced impact of new methodologies in future drug discovery. © 2018 Springer Nature Limited. All rights reserved