MANAGING EUROPEAN CORN BORER RESISTANCE TO BT CORN WITH DYNAMIC REFUGES

We develop a dynamic bioeconomic model of temporally optimal dynamic refuge recommendations for resistance management when a backstop technology arrives at a known date. The impact of the characteristics of the backstop on the use of the current technology, and the difference between static and dynamic refuges are examined.Crop Production/Industries,

Bone marrow senescence and the microenvironment of hematological malignancies

Senescence is the irreversible arrest of cell proliferation that has now been shown to play an important role in both health and disease. With increasing age senescent cells accumulate throughout the body, including the bone marrow and this has been associated with a number of age-related pathologies including malignancies. It has been shown that the senescence associated secretory phenotype (SASP) creates a pro-tumoural environment that supports proliferation and survival of malignant cells. Understanding the role of senescent cells in tumor development better may help us to identify new treatment targets to impair tumor survival and reduce treatment resistance. In this review, we will specifically discuss the role of senescence in the aging bone marrow (BM) microenvironment. Many BM disorders are age-related diseases and highly dependent on the BM microenvironment. Despite advances in drug development the prognosis particularly for older patients remains poor and new treatment approaches are needed to improve outcomes for patients. In this review, we will focus on the relationship of senescence and hematological malignancies, how senescence promotes cancer development and how malignant cells induce senescence

MANAGING THE RISK OF EUROPEAN CORN BORER RESISTANCE TO TRANSGENIC CORN: AN ASSESSMENT OF CONTROVERSIAL REFUGE RECOMMENDATIONS

A bioeconomic model is developed to evaluate the tradeoff between the risk of resistance and increased productivity when refuge is planted in conjunction with transgenic pesticidal corn. The model is used to evaluate controversial refuge recommendations when producers are allowed to treat refuge in years of high pest pressure.Productivity Analysis, Research and Development/Tech Change/Emerging Technologies, Risk and Uncertainty,

BIOTECHNOLOGY AND PEST RESISTANCE: AN ECONOMIC ASSESSMENT OF REFUGES

Transgenic crops offer farmers a new and effective pest control option. However, the wide spread adoption of these crops could lead to a resistant pest population. This paper demonstrates how a pest refuge can be used to maximise the value of farm income in a dynamic model with genetic foundations.Crop Production/Industries, Research and Development/Tech Change/Emerging Technologies,

BT CORN AND INSECT RESISTANCE: AN ECONOMIC ASSESSMENT OF REFUGES

Genetically engineered crops offer farmers a new option for controlling pests. The high efficacy of these pesticidal crops, combined with the potential for widespread adoption, has raised concerns that pest resistance may prematurely diminish their value. In response to these concerns, the Environmental Protection Agency requires resistance management plans. Current resistance management plans rely on a high-dose refuge strategy. This analysis extends the current framework for evaluating high-dose refuge strategies to include a measure of agricultural productivity and conventional pesticide use. The economic tradeoff relative to agricultural productivity, conventional pesticide use, and pest resistance is assessed when Bt corn is planted to control the European corn borer.Crop Production/Industries,

Analysing I/O bottlenecks in LHC data analysis on grid storage resources

We describe recent I/O testing frameworks that we have developed and applied within the UK GridPP Collaboration, the ATLAS experiment and the DPM team, for a variety of distinct purposes. These include benchmarking vendor supplied storage products, discovering scaling limits of SRM solutions, tuning of storage systems for experiment data analysis, evaluating file access protocols, and exploring I/O read patterns of experiment software and their underlying event data models. With multiple grid sites now dealing with petabytes of data, such studies are becoming essential. We describe how the tests build, and improve, on previous work and contrast how the use-cases differ. We also detail the results obtained and the implications for storage hardware, middleware and experiment software