Sterol O-acyltransferase阻害は高脂肪食による虚血再灌流障害後の腎臓三次リンパ組織拡大・成熟と線維化の促進を抑制する

京都大学新制・課程博士博士(医学)甲第24795号医博第4987号新制||医||1066(附属図書館)京都大学大学院医学研究科医学専攻(主査)教授 小林 恭, 教授 波多野 悦朗, 教授 羽賀 博典学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDFA

経口固形製剤の溶出性に影響する因子及びメカニズムの分光学的手法を利用した解析

武蔵野大学2017年

Reshaping-induced spatiotemporal chaos in driven, damped sine-Gordon systems

Spatiotemporal chaos arising from the competition between sine-Gordon-breather and kink-antikink-pair solitons by reshaping an ac force is demonstrated. After introducing soliton collective coordinates, Melnikov's method is applied to the resulting effective equation of motion to estimate the parameter-space regions of the ac force where homoclinic bifurcations are induced. The analysis reveals that the chaos-order threshold exhibits sensitivity to small changes in the force shape. Computer simulations of the sine-Gordon system show good agreement with these theoretical predictions.Comment: 11 pages, 3 figure

Ghrelin and Functional Dyspepsia

The majority of patients with dyspepsia have no identifiable cause of their disease, leading to a diagnosis of functional dyspepsia (FD). While a number of different factors affect gut activity, components of the nervous and endocrine systems are essential for normal gut function. Communication between the brain and gut occurs via direct neural connections or endocrine signaling events. Ghrelin, a peptide produced by the stomach, affects gastric motility/emptying and secretion, suggesting it may play a pathophysiological role in FD. It is also possible that the functional abnormalities in FD may affect ghrelin production in the stomach. Plasma ghrelin levels are reported to be altered in FD, correlating with FD symptom score. Furthermore, some patients with FD suffer from anorexia with body-weight loss. As ghrelin increases gastric emptying and promotes feeding, ghrelin therapy may be a new approach to the treatment of FD