82 research outputs found

    Motivations for Food Consumption during Specific Eating Occasions in Turkey

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    Citation: Chambers, D., Phan, U. T. X., Chanadang, S., Maughan, C., Sanchez, K., Di Donfrancesco, B., . . . Esen, E. (2016). Motivations for Food Consumption during Specific Eating Occasions in Turkey. Foods, 5(2), 14. doi:10.3390/foods5020039Several studies in different countries have been conducted to investigate factors affecting food choices. The objective of this study was to understand the motivations of specific food and beverage choices for different eating occasions in a typical diet of the Turkish people. A convenience sample of 141 respondents from seven different geographical regions in Turkey completed an online survey questionnaire that included questions about demographic information and details about their latest eating occasion. Respondents reported all of their motivations for choosing each food/beverage item reported for that specific eating occasion. Results indicated that different motivations played different roles in food choices of people in Turkey. Liking was a key characteristic for all eating occasions, but key natural concerns were even more important at breakfast, and need and hunger were more important for a mid-afternoon snack. Lunch involved additional motivations such as Sociability, Variety Seeking, and Social Norms. In addition to Liking, choices of different food groups were also driven by other motivations such as Habits, Convenience, Need and Hunger, Natural Concerns, and Health. This study helped better understand the current dietary patterns of Turkish people as well as the motives underlying their choices of foods and beverages for different meals and snacks. These findings could be useful for dietary campaigns that aim to improve eating behaviors in Turkey

    Duração do sabor em amostras de goma de mascar elaboradas com erva-mate.

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    Gomas de mascar são consumidas em vários países e são tidas como produtos em expansão, principalmente quando carreiam ingredientes ativos. São apreciadas por ativar a energia e concentração dos consumidores, com redução de estresse. A tendência atual desse segmento alimentício é a busca de produtos alternativos, isentos de açúcar e com apelo sensorial e sustentável. A erva-mate reúne essas características, sendo reconhecida por suas propriedades estimulantes, em decorrência da presença de cafeína. Uma das principais características considerados para a goma de mascar é o tempo que o sabor permanece na boca durante a mastigação. Inicialmente, foram elaboradas nove gomas de mascar com diferentes tipos de erva-mate e aromas. O produto de melhor aceitação foi utilizado no teste tempo-intensidade, no qual avaliou-se o tempo total que o sabor da goma de mascar permaneceu na boca. Participaram 14 avaliadores treinados, que analisaram a amostra em três repetições. Eles foram orientados a provar a amostra e indicar a intensidade do sabor durante a mastigação, com uma escala de 10. O programa utilizado para a coleta de dados foi o Time-Intensity Data Collection System que registrou a intensidade máxima percebida por cada avaliador, tempo máximo em que a intensidade de sabor foi percebida, tempo inicial quando a percepção de sabor começou a ser percebida e tempo total que o estímulo permaneceu. A percepção do sabor teve início em menos de um minuto e o estímulo total durou cinco minutos. Esses dados sugerem que o produto seja reavaliado incluindo melhorias no processo tecnológico.Resumo

    APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL

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    Oncogenic driver mutations are those that provide a proliferative or survival advantage to neoplastic cells, resulting in clonal selection. Although most cancer-causing mutations have been detected in the protein-coding regions of the cancer genome; driver mutations have recently also been discovered within noncoding genomic sequences. Thus, a current challenge is to gain precise understanding of how these unique genomic elements function in cancer pathogenesis, while clarifying mechanisms of gene regulation and identifying new targets for therapeutic intervention. Here we report a C-to-T single nucleotide transition that occurs as a somatic mutation in noncoding sequences 4 kb upstream of the transcriptional start site of the LMO1 oncogene in primary samples from patients with T-cell acute lymphoblastic leukaemia. This single nucleotide alteration conforms to an APOBEC-like cytidine deaminase mutational signature, and generates a new binding site for the MYB transcription factor, leading to the formation of an aberrant transcriptional enhancer complex that drives high levels of expression of the LMO1 oncogene. Since APOBEC-signature mutations are common in a broad spectrum of human cancers, we suggest that noncoding nucleotide transitions such as the one described here may activate potent oncogenic enhancers not only in T-lymphoid cells but in other cell lineages as well

    LIF-Dependent Signaling: New Pieces in the Lego

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    LIF, a member of the IL6 family of cytokine, displays pleiotropic effects on various cell types and organs. Its critical role in stem cell models (e.g.: murine ES, human mesenchymal cells) and its essential non redundant function during the implantation process of embryos, in eutherian mammals, put this cytokine at the core of many studies aiming to understand its mechanisms of action, which could benefit to medical applications. In addition, its conservation upon evolution raised the challenging question concerning the function of LIF in species in which there is no implantation. We present the recent knowledge about the established and potential functions of LIF in different stem cell models, (embryonic, hematopoietic, mesenchymal, muscle, neural stem cells and iPSC). We will also discuss EVO-DEVO aspects of this multifaceted cytokine

    Localization and broadband follow-up of the gravitational-wave transient GW150914

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    A gravitational-wave (GW) transient was identified in data recorded by the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) detectors on 2015 September 14. The event, initially designated G184098 and later given the name GW150914, is described in detail elsewhere. By prior arrangement, preliminary estimates of the time, significance, and sky location of the event were shared with 63 teams of observers covering radio, optical, near-infrared, X-ray, and gamma-ray wavelengths with ground- and space-based facilities. In this Letter we describe the low-latency analysis of the GW data and present the sky localization of the first observed compact binary merger. We summarize the follow-up observations reported by 25 teams via private Gamma-ray Coordinates Network circulars, giving an overview of the participating facilities, the GW sky localization coverage, the timeline, and depth of the observations. As this event turned out to be a binary black hole merger, there is little expectation of a detectable electromagnetic (EM) signature. Nevertheless, this first broadband campaign to search for a counterpart of an Advanced LIGO source represents a milestone and highlights the broad capabilities of the transient astronomy community and the observing strategies that have been developed to pursue neutron star binary merger events. Detailed investigations of the EM data and results of the EM follow-up campaign are being disseminated in papers by the individual teams

    Multi-messenger observations of a binary neutron star merger

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    On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta

    Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo

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    Jaakko Tuomilehto Global BPgen Consortium'n jäsenPeer reviewe

    Localization and broadband follow-up of the gravitational-wave transient GW150914

    Get PDF
    A gravitational-wave transient was identified in data recorded by the Advanced LIGO detectors on 2015 September 14. The event candidate, initially designated G184098 and later given the name GW150914, is described in detail elsewhere. By prior arrangement, preliminary estimates of the time, significance, and sky location of the event were shared with 63 teams of observers covering radio, optical, near-infrared, X-ray, and gamma-ray wavelengths with ground- and space-based facilities. In this Letter we describe the low-latency analysis of the gravitational wave data and present the sky localization of the first observed compact binary merger. We summarize the follow-up observations reported by 25 teams via private Gamma-ray Coordinates Network Circulars, giving an overview of the participating facilities, the gravitational wave sky localization coverage, the timeline and depth of the observations. As this event turned out to be a binary black hole merger, there is little expectation of a detectable electromagnetic signature. Nevertheless, this first broadband campaign to search for a counterpart of an Advanced LIGO source represents a milestone and highlights the broad capabilities of the transient astronomy community and the observing strategies that have been developed to pursue neutron star binary merger events. Detailed investigations of the electromagnetic data and results of the electromagnetic follow-up campaign will be disseminated in the papers of the individual teams

    Effects of post-bleeding vascular infusion of cattle with a solution of sugars, sodium chloride, and phosphates with or without vitamin c on carcass traits, Warner-Bratzler shear forces, and patalability

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    Two groups of grain-finished, crossbred Charolais steers were utilized to determine the effects of post-bleeding vascular infusion on dressing percentages, USDA quality and yield grades, Warner-Bratzler shear force values, and flavor. Nine steers from one group of 18 were infused with a solution containing sugars, sodium chloride, and a phosphate blend (MPSC), and the remaining nine steers served as noninfused controls. Nine in the second slaughter group of 18 were MPSC-infused, and nine were infused with the MPSC solution plus 500 ppm vitamin C (MPSC+C). The MPSC cattle had a 2.9% higher mean dressing percentage (P<.05) than control cattle. Vascular infusion had no effect (P>.05) on Warner-Bratzler shear force or USDA quality and yield grades. Results from a descriptive flavor profile sensory panel showed some significant differences in flavor profile characteristics, but these differences were small and inconsistent. Vascular infusion with MPSC or MPSC+C increased carcass weights, had few effects on USDA quality or yield grades or shear force, and had no consistent effects on flavor profile characteristics of cooked beef
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