158 research outputs found
Identifying Resistance Mechanisms against Five Tyrosine Kinase Inhibitors Targeting the ERBB/RAS Pathway in 45 Cancer Cell Lines
- Author
- A Akcakanat
- A Lutcke
- A Sartore-Bianchi
- A. Marcell Szász
- AJ Cohen
- Attila Szendrői
- B Dave
- B Escudier
- B Gyorffy
- B Gyorffy
- B Gyorffy
- B Gyorffy
- Balázs Győrffy
- BC Widemann
- Bálint Tegze
- C Peraldo-Neia
- CD Coldren
- CE Geyer
- D Cameron
- D Huang
- DM Jackman
- EJ Jung
- F Di Nicolantonio
- F Huang
- HL Gomez
- IB Jeffery
- IB Weinstein
- István Likó
- J Barretina
- JL Marks
- JM Balko
- JM Cheng
- K Suda
- KT Nam
- L Gautier
- L Ruan
- M Miyake
- M Munz
- M Varga
- MH Cohen
- R Breitling
- R Breitling
- R Tibshirani
- Reinhold Schäfer
- RG Amado
- RJ Motzer
- RJ Motzer
- S Cludts
- S Dietmann
- S Lugthart
- Stefan Wölfl
- T Minematsu
- TK Choueiri
- VG Tusher
- VM Delgado
- W Pao
- W Zhou
- X Yan
- Zsófia Pénzváltó
- Zsófia Sztupinszki
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 29/03/2013
- Field of study
Because of the low overall response rates of 10-47% to targeted cancer therapeutics, there is an increasing need for predictive biomarkers. We aimed to identify genes predicting response to five already approved tyrosine kinase inhibitors. We tested 45 cancer cell lines for sensitivity to sunitinib, erlotinib, lapatinib, sorafenib and gefitinib at the clinically administered doses. A resistance matrix was determined, and gene expression profiles of the subsets of resistant vs. sensitive cell lines were compared. Triplicate gene expression signatures were obtained from the caArray project. Significance analysis of microarrays and rank products were applied for feature selection. Ninety-five genes were also measured by RT-PCR. In case of four sunitinib resistance associated genes, the results were validated in clinical samples by immunohistochemistry. A list of 63 top genes associated with resistance against the five tyrosine kinase inhibitors was identified. Quantitative RT-PCR analysis confirmed 45 of 63 genes identified by microarray analysis. Only two genes (ANXA3 and RAB25) were related to sensitivity against more than three inhibitors. The immunohistochemical analysis of sunitinib-treated metastatic renal cell carcinomas confirmed the correlation between RAB17, LGALS8, and EPCAM and overall survival. In summary, we determined predictive biomarkers for five tyrosine kinase inhibitors, and validated sunitinib resistance biomarkers by immunohistochemistry in an independent patient cohort. © 2013 Pénzváltó et al
Sickle cell disease and pregnancy outcomes: a study of the community-based hospital in a tribal block of Gujarat, India
- Author
- Ankit Anand
- BC Kar
- BC Kar
- D Mohanty
- D Poddar
- D Weatherall
- DC Rees
- Dhiren Modi
- DJ Weatherall
- FB Piel
- FB Piel
- FE Al Jama
- G Desai
- Gayatri Desai
- GJ Hofmeyr
- GR Serjeant
- GR Serjeant
- Hardik Bhatt
- JA Pritchard
- JA Smith
- Kapilkumar Dave
- M Hickman
- M Kamble
- M Koshy
- M Thame
- MB Mukherjee
- MS Villers
- N Awasthy
- Pankaj Shah
- PM Sun
- PS Muganyizi
- S Asma
- Shobha Shah
- Shrey Desai
- SL Kate
- StataCorp
- WD Barfield
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Bio-hybrid materials for immunoassay-based sensing of cortisol
- Author
- A Manivannan
- AJ Pesce
- AN Araujo
- AT Borchers
- B Dunn
- B Fleet
- BC Dave
- BC Dave
- Bruce Dunn
- CC Yang
- CI Li
- CJ Brinker
- D Avnir
- D Avnir
- D Avnir
- DC Harris
- DT Nguyen
- E Hund
- EH Lan
- EH Lan
- EL Holthoff
- Esther H. Lan
- FS Ashkar
- G Tortora
- H Li
- J Livage
- J Livage
- J Yperman
- JC Zhou
- JD Brennan
- Jeffrey I. Zink
- JG Lewis
- JI Zink
- Jing C. Zhou
- JM Miller
- Jonathan Fang
- L Klein
- LB Foster
- LM Ellerby
- NM Martyak
- P Basilicata
- R Wang
- RA Doong
- RF Boyer
- RF Masseyeff
- S Braun
- S Kim
- S Kumar
- SA Berson
- SA Yamanaka
- SA Yamanaka
- Y Kobayashi
- Y Kobayashi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Pyruvate: immunonutritional effects on neutrophil intracellular amino or alpha-keto acid profiles and reactive oxygen species production
- Author
- A Kielducka
- A Klein
- A Mahiout
- A Tsung
- AC Brown
- AP Halestrap
- AS Johansson
- B Cai
- B Zingarelli
- BC Burckhardt
- BQ Cheng
- C Dahlgren
- C Haslett
- CC Aires
- D Bakowski
- D. Mathioudakis
- DA Hume
- DC Dooley
- DK Gardner
- E Jolkver
- E Riedel
- EA Wiemer
- F Su
- FQ Zhou
- G Agam
- G. J. Scheffer
- GL Edlund
- H Miwa
- H. Harbach
- HA Krebs
- HA Krebs
- HL Willems
- I Mackenzie
- I. D. Welters
- ID Welters
- IM Rebecchi
- J Frei
- J Lee
- J Mühling
- J Mühling
- J Mühling
- J Mühling
- J Mühling
- J Mühling
- J Mühling
- J Mühling
- J Su
- J Zhao
- J. Engel
- JL Paul
- JM Engel
- JM Engel
- JM Lamers
- JM Matés
- Jörg Mühling
- K. Weismüller
- L Cicalese
- L Cicalese
- LF Huang
- M Berger
- M Board
- M Board
- M Brivet
- M Fuchs
- M Hollenbach
- M. Fuchs
- M. G. Dehne
- M. Henrich
- MA Serrano
- MA Zoelen Van
- MD Taylor
- MP Fink
- MP Fink
- MP Fink
- MP Fink
- N Merezhinskaya
- N Ramakrishnan
- N Venizelos
- NM Kozlova
- P Eggleton
- P Newsholme
- PA Hyslop
- PI Homem de Bittencourt
- PR Di
- Q Wang
- R Curi
- R Curi
- R Gabbianelli
- R Yang
- R. Matejec
- RC Poole
- RC Woodman
- RJ Selvaraj
- RL Stjernholm
- SD Varma
- SH Dave
- T Genovese
- T Kobayashi
- T Matsumoto
- T. Schwandner
- TS Ing
- U Fauth
- U Fauth
- UN Das
- UN Das
- V Witko-Sarsat
- W Krumholz
- W Krumholz
- WE Knox
- WJ Vaartjes
- X Liang
- XZ Chen
- Y Han
- Y Zhang
- YH Chang
- YH Kang
- YT Wu
- YT Wu
- ZH Deng
- Publication venue
- Springer Vienna
- Publication date
- 01/01/2010
- Field of study
For the first time the immunonutritional role of pyruvate on neutrophils (PMN), free α-keto and amino acid profiles, important reactive oxygen species (ROS) produced [superoxide anion (O2−), hydrogen peroxide (H2O2)] as well as released myeloperoxidase (MPO) acitivity has been investigated. Exogenous pyruvate significantly increased PMN pyruvate, α-ketoglutarate, asparagine, glutamine, aspartate, glutamate, arginine, citrulline, alanine, glycine and serine in a dose as well as duration of exposure dependent manner. Moreover, increases in O2− formation, H2O2-generation and MPO acitivity in parallel with intracellular pyruvate changes have also been detected. Regarding the interesting findings presented here we believe, that pyruvate fulfils considerably the criteria for a potent immunonutritional molecule in the regulation of the PMN dynamic α-keto and amino acid pools. Moreover it also plays an important role in parallel modulation of the granulocyte-dependent innate immune regulation. Although further research is necessary to clarify pyruvate’s sole therapeutical role in critically ill patients’ immunonutrition, the first scientific successes seem to be very promising
Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2
- Author
- Au Yeung KHR
- Chadburn A
- Czader MB
- Datta J
- Dave SS
- Davis NS
- Dunson DB
- Gascoyne RD
- Goodlad JR
- Healy JA
- Hsi ED
- Iqbal J
- Kovanen PE
- Kwong YL
- Leppa S
- Levy S
- Love C
- Lugar PL
- Mannisto S
- McKinney M
- Moffittt AB
- Naresh K
- Ondrejka SL
- Palus BC
- Rajagopalan D
- Rempel RE
- Richards KL
- Said J
- Smith EC
- Srivastava G
- Teh CH
- Tse EWC
- Tzeng TJ
- Villa D
- Yu J
- Zhuang Y
- Publication venue
- 'Rockefeller University Press'
- Publication date
- 01/01/2017
- Field of study
published_or_final_versio
Localization and broadband follow-up of the gravitational-wave transient GW150914
- Author
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla FB
- Abe F
- Abernathy MR
- Acernese F
- Ackermann M
- Ackley K
- Adame JA
- Adams C
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Agathos M
- Agatsuma K
- Aggarwal N
- Aguiar OD
- Aiello L
- Ain A
- Ajello M
- Ajith P
- Albert A
- Allam S
- Allen B
- Allen WH
- Allison J
- Allocca A
- Altin PA
- Amati L
- Anderson B
- Anderson JP
- Anderson SB
- Anderson WG
- Annis J
- Antonelli LA
- Aptekar RL
- Arai K
- Araya MC
- Arceneaux CC
- Areeda JS
- Armstrong R
- Arnaud N
- Arun KG
- Ascenzi S
- Ashton G
- Ast M
- Aston SM
- Astone P
- Atwood WB
- Aufmuth P
- Aulbert C
- Axelsson M
- Babak S
- Bacon P
- Bader MKM
- Bai J
- Baiardi LC
- Baker PT
- Balanutsa P
- Baldaccini F
- Baldini L
- Ballardin G
- Ballmer SW
- Baltay C
- Banerji M
- Bannister K
- Barayoga JC
- Barbiellini G
- Barclay SE
- Barish BC
- Barker D
- Barlow T
- Barone F
- Barr B
- Barsotti L
- Barsuglia M
- Barta D
- Barthelmy S
- Bartlett J
- Bartos I
- Bassiri R
- Basti A
- Bastieri D
- Batch JC
- Baune C
- Bavigadda V
- Bazzan M
- Bazzano A
- Behnke B
- Bejger M
- Bell AS
- Bell CJ
- Bell ME
- Bellazzini R
- Bellm E
- Benacquista M
- Benoit-Levy A
- Berger BK
- Berger E
- Bergman J
- Bergmann G
- Bernstein RA
- Beroiz M
- Berry CPL
- Bersanetti D
- Bersier DF
- Bertin E
- Bertolini A
- Betzwieser J
- Bhagwat S
- Bhalerao V
- Bhandare R
- Bhat PN
- Bilenko IA
- Billingsley G
- Birch J
- Birney R
- Biscans S
- Bisht A
- Bissaldi E
- Bissaldi E
- Bitossi M
- Bitossi M
- Biwer C
- Bizouard MA
- Blackburn JK
- Blackburn L
- Blair CD
- Blair DG
- Blair RM
- Blandford RD
- Bloemen S
- Bloom ED
- Bock O
- Bode MF
- Bodiya TP
- Boer M
- Bogaert G
- Bogan C
- Bohe A
- Bojtos P
- Bond C
- Bondu F
- Bonino R
- Bonnand R
- Boom BA
- Bork R
- Boschi V
- Bose S
- Bottacini E
- Botticella MT
- Bouffanais Y
- Bozzi A
- Bozzo E
- Bradaschia C
- Brady PR
- Braginsky VB
- Branchesi M
- Brandt S
- Brandt TJ
- Brandt TJ
- Brau JE
- Briant T
- Briggs MS
- Brillet A
- Brinkmann M
- Brisson V
- Brocato E
- Brockill P
- Broderick JW
- Brooks AF
- Brout D
- Brown DA
- Brown DD
- Brown NM
- Buchanan CC
- Buckley D
- Buckley-Geer E
- Budnev NM
- Buikema A
- Bulik T
- Bulten HJ
- Buonanno A
- Burke DL
- Burns E
- Burrows DN
- Buskulic D
- Buson S
- Bustillo JC
- Buy C
- Byer RL
- Caballero-Garcia MD
- Cabral J
- Cadonati L
- Cagnoli G
- Cahillane C
- Caliandro GA
- Callister T
- Calloni E
- Cameron RA
- Camp JB
- Campana S
- Campbell H
- Cannon KC
- Cano Z
- Cao J
- Cao Y
- Capaccioli M
- Capano CD
- Capocasa E
- Capozzi D
- Cappellaro E
- Caragiulo M
- Caraveo PA
- Carbognani F
- Caride S
- Carretero J
- Casentini C
- Castander FJ
- Castellon A
- Castillo-Carrion S
- Castro JMG
- Castro-Tirado AJ
- Caudill S
- Cavaglia M
- Cavalier F
- Cavalieri R
- Cavazzuti E
- Cella G
- Cenko SB
- Cepeda CB
- Cerretani G
- Cesarini E
- Chakraborty R
- Chalermsongsak T
- Chamberlin SJ
- Chambers KC
- Chan M
- Chao S
- Charles E
- Charlton P
- Chassande-Mottin E
- Chatterjee S
- Chekhtman A
- Chen HY
- Chen T-W
- Chen Y
- Cheng C
- Chiang J
- Chiaro G
- Chincarini A
- Chippendale AP
- Chiummo A
- Cho HS
- Cho M
- Chornock R
- Chow JH
- Christensen N
- Chu Q
- Chua S
- Chung S
- Ciani G
- Ciprini S
- Clara F
- Claret A
- Clark JA
- Cleva F
- Cleveland W
- Cline T
- Coccia E
- Cohadon P-F
- Cohen-Tanugi J
- Colazo C
- Colla A
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- Collette CG
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- Couvares P
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- Cowan EE
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- Cowart MJ
- Cowperthwaite PS
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- Coyne DC
- Coyne R
- Craig K
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- Cripe J
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- Crowder SG
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- Cunningham L
- Cuoco A
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- D'Ammando F
- D'Andrea CB
- D'Antonio S
- D'Avanzo P
- D'Elia V
- da Costa LN
- Dal Canton T
- Danilishin SL
- Danzmann K
- Darman NS
- Darnley MJ
- Dattilo V
- Dave I
- Daveloza HP
- Davier M
- Davies GS
- Daw EJ
- Day R
- De Laurentis M
- de Palma F
- De Rosa R
- DeBra D
- Debreczeni G
- Degallaix J
- Del Pozzo W
- Deleglise S
- Denker T
- Denneau L
- Dennefeld M
- Dent T
- DePoy DL
- Dereli H
- Dergachev V
- DeRosa RT
- Desai S
- DeSalvo R
- Desiante R
- Desiante R
- Dhurandhar S
- Di Fiore L
- Di Giovanni M
- Di Lalla N
- Di Lieto A
- Di Mauro M
- Di Pace S
- Di Palma I
- Di Venere L
- Di Virgilio A
- Diaz JC
- Diaz MC
- Diehl HT
- Dietrich JP
- Doctor Z
- Doi M
- Dojcinoski G
- Dolique V
- Dominguez A
- Dominguez M
- Donovan F
- Dooley KL
- Doravari S
- Douglas R
- Downes TP
- Drago M
- Drell PS
- Drever RWP
- Driggers JC
- Drlica-Wagner A
- Drout MR
- Du Z
- Dubois R
- Ducrot M
- Duggan G
- Dwyer SE
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- Edwards PG
- Effler A
- Eggenstein H-B
- Ehrens P
- Eichholz J
- Eifler TF
- Eikenberry SS
- Elias-Rosa N
- Ellman N
- Engels W
- Essick RC
- Estrada J
- Etzel T
- Evans M
- Evans PA
- Evans TM
- Everett R
- Evrard AE
- Factourovich M
- Fafone V
- Fair H
- Fairhurst S
- Fan X
- Fan Y
- Fang Q
- Farinon S
- Farr B
- Farr WM
- Favata M
- Favuzzi C
- Fays M
- Fehrmann H
- Fejer MM
- Fender RP
- Feng L
- Fernandez CG
- Fernandez E
- Fernandez-Munoz R
- Ferrante I
- Ferrara EC
- Ferreira EC
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- Ferrigno C
- Ferrini F
- Fidecaro F
- Finley DA
- Fiori I
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- Fitzpatrick G
- Flaminio R
- Flaugher B
- Fletcher M
- Flewelling H
- Fong W-F
- Fosalba P
- Fournier J-D
- Fox DB
- Franckowiak A
- Franco S
- Franzen TMO
- Frasca S
- Frasconi F
- Fraser M
- Frederiks DD
- Frei Z
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- Frey V
- Fricke TT
- Frieman J
- Fritschel P
- Frolov VV
- Fryer CL
- Fujisawa K
- Fukazawa Y
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- Fusco P
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- Gaur G
- Gaztanaga E
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- Gemme G
- Gendre B
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- Gennai A
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- Gerdes DW
- Gergely L
- Germain V
- Getman F
- Ghosh A
- Ghosh S
- Giaime JA
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- Giazotto A
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- Giles MM
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- Giommi P
- Giommi P
- Giordano F
- Giroletti M
- Giuffrida G
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- Gutierrez G
- Guziy S
- Hacker JJ
- Hadasch D
- Hall BR
- Hall ED
- Hammond G
- Haney M
- Hanke MM
- Hanks J
- Hanlon L
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- Hanson J
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- Hardwick T
- Haris K
- Harmanen J
- Harms J
- Harry GM
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- Hart MJ
- Hartman MT
- Harvey-Smith L
- Haster C-J
- Haughian K
- Hays E
- Heidmann A
- Heintze MC
- Heitmann H
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- Hemming G
- Hendry M
- Heng IS
- Hennig J
- Heptonstall AW
- Herner K
- Heurs M
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- Hiriart D
- Hjorth J
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- Hofman D
- Hollitt SE
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- Holz DE
- Honscheid K
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- Horesh A
- Hosken DJ
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- Hough J
- Houston EA
- Howell EJ
- Hu Y-D
- Hu YM
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- Huber ME
- Hudec R
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- Huet D
- Hughey B
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- Husa S
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- Ingram DR
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- Irwin M
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- Jang H
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- Jaranowski P
- Jawahar S
- Jelinek M
- Jenke P
- Jeong S
- Jimenez-Forteza F
- Jogler T
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- Johnson AS
- Johnson MD
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- Johnson WW
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- Jones DI
- Jones R
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- Jr CM
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- Kalogera V
- Kandhasamy S
- Kang G
- Kankare E
- Kanner JB
- Kaplan DL
- Karki S
- Karliner I
- Kasen D
- Kasliwal MM
- Kasprzack M
- Katsavounidis E
- Katzman W
- Kaufer S
- Kaur T
- Kawabata KS
- Kawabe K
- Kawazoe F
- Kefelian F
- Kehl MS
- Keitel D
- Kelley DB
- Kells W
- Kendrick R
- Kennea JA
- Kennedy R
- Kensei S
- Kent S
- Kessler R
- Key JS
- Khalaidovski A
- Khalili FY
- Khan I
- Khan S
- Khan Z
- Khazanov EA
- Kijbunchoo N
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- Kim J
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- Kippen RM
- Kissel JS
- Kleybolte L
- Klimenko S
- Klotz A
- Kobayashi S
- Kocevski D
- Koehlenbeck SM
- Kokeyama K
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- Kondrashov V
- Konig S
- Kontos A
- Kornilov V
- Korobko M
- Korth WZ
- Kotak R
- Kowalska I
- Kozak DB
- Krimm H
- Kringel V
- Krolak A
- Krueger C
- Kubanek P
- Kuehn G
- Kuehn K
- Kulkarni SR
- Kumar P
- Kuo L
- Kuo L
- Kupfer T
- Kuropatkin N
- Kuss M
- Kuulkers E
- Kuznetsov A
- La Mura G
- Lackey BD
- Lahav O
- Laher R
- Lambas DG
- Landry M
- Lange J
- Lantz B
- Lares M
- Larsson S
- Lasky PD
- Latronico L
- Laugier R
- Laurent P
- Lazzarini A
- Lazzaro C
- Le Guillou L
- Leaci P
- Leavey S
- Lebigot EO
- Lee CH
- Lee HK
- Lee HM
- Lee K
- Lee WH
- Lenon A
- Leonardi M
- Leong JR
- Leroy N
- Letendre N
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- Publication venue
- Astrophysical Journal Letters
- Publication date
- 01/01/2016
- Field of study
A gravitational-wave (GW) transient was identified in data recorded by the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) detectors on 2015 September 14. The event, initially designated G184098 and later given the name GW150914, is described in detail elsewhere. By prior arrangement, preliminary estimates of the time, significance, and sky location of the event were shared with 63 teams of observers covering radio, optical, near-infrared, X-ray, and gamma-ray wavelengths with ground- and space-based facilities. In this Letter we describe the low-latency analysis of the GW data and present the sky localization of the first observed compact binary merger. We summarize the follow-up observations reported by 25 teams via private Gamma-ray Coordinates Network circulars, giving an overview of the participating facilities, the GW sky localization coverage, the timeline, and depth of the observations. As this event turned out to be a binary black hole merger, there is little expectation of a detectable electromagnetic (EM) signature. Nevertheless, this first broadband campaign to search for a counterpart of an Advanced LIGO source represents a milestone and highlights the broad capabilities of the transient astronomy community and the observing strategies that have been developed to pursue neutron star binary merger events. Detailed investigations of the EM data and results of the EM follow-up campaign are being disseminated in papers by the individual teams
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
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- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
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- Zhou H
- Zidova M
- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
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- Milia Sabrina
- Miller AA
- Miller CJ
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- Moore CJ
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- Moskalenko IV
- Moskvitin AS
- Mostaf M
- Motohara K
- Moulai M
- Moulin E
- Mours B
- Moussa A
- Mow-Lowry CM
- Mrka S
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- Mueller AL
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- Mueller G
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- Mueller MA
- Mueller S
- Muir AW
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- Mukherjee Arunava
- Mukherjee D
- Mukherjee S
- Mukund N
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- Mundell CG
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- Muoz RR
- Murach T
- Murata KL
- Muratore M
- Murguia-Berthier A
- Murphy T
- Murray PG
- Mussa R
- Myers ST
- Nagai H
- Nagashima H
- Nagayama T
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- Nakahira S
- Nakajima M
- Nakamura Y
- Nakaoka T
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- Nang Y
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- Neilsen E
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- Oikonomou F
- Ojha R
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- Ostrowski M
- Ottaway DJ
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- Ozawa S
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- Padilla N
- Padovani M
- Pagani C
- Page J
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- Page MA
- Pai A
- Pai SA
- Pal-Singh A
- Palamos JR
- Palashov O
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- Palatka M
- Palazzi E
- Palczewski T
- Paliya VS
- Palliyaguru N
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- Pallot D
- Pallotta J
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- Paneque D
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- Pankow C
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- Pant BC
- Panter M
- Paoletti F
- Paoletti F
- Paoli A
- Papa MA
- Papenbreer P
- Paragi Z
- Parente G
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- Pele A
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- Pepper JA
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- Perennes C
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- Perlin M
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- Perri LM
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- Perrina C
- Perrodin D
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- Pescalli A
- Pesce-Rollins M
- Peters C
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- Petrera S
- Petrucci P-O
- Peyaud B
- Pfeiffer HP
- Phelps M
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- Pian E
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- Piel Q
- Pieloth D
- Piergiovanni F
- Pierog T
- Pierro V
- Pignata G
- Pike S
- Pilia M
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- Pinard L
- Pinat E
- Pinto IM
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- Piran T
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- Piranomonte S
- Pirello M
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- Piron F
- Pirronello V
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- Pita S
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- Pittori C
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- Podsiadlowski P
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- Poggiani R
- Poh J
- Poireau V
- Pollmann A Obertacke
- Poolakkil S
- Poon H
- Popa V
- Popolizio P
- Poppi S
- Porowski C
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- Possenti A
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- Powell J
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- Poznanski D
- Pradier T
- Prado RR
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- Prochaska JX
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- Puncken O
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- Puppo P
- Qi H
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- Qu JL
- Quataert E
- Quel EJ
- Querchfeld S
- Querel R
- Quetschke V
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- Quinn L
- Quinn S
- Quinones C
- Quintero EA
- Quirrenbach A
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- Raab C
- Raab FJ
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- Rabeling DS
- Rabus M
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- Racusin J
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- Raja S
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- Ramirez KE
- Ramirez-Ruiz E
- Ramos-Buades A
- Ramos-Pollan R
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- Rando R
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- RATIR RIMAS
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- Regimbau T
- Rei L
- Reichart DE
- Reid S
- Reimann R
- Reimer A
- Reimer A
- Reimer O
- Reimer O
- Reitze DH
- Relethford B
- Relich M
- Ren W
- Ren Z
- Renaud M
- Renzi V
- Reposeur T
- Resconi E
- Resmi L
- Rest A
- Reva IV
- Reyes R De Los
- Reyes SD
- Reynolds T
- Rho CD
- Rhode W
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- Ricci R
- Ricciarini S
- Riccobene G
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- Rivera A Ramirez
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- Rizi V
- Rizzo M
- Roberts OJ
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- Robie R
- Robinet F
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- Rojo J Rodriguez
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- Rosenberg M
- Rosetti S
- Rosinska D
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- Rossi A
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- Roth M
- Rott C
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- Rowan S
- Rowell G
- Rowlinson A
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- Roy R
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- Rysewyk D
- Saba A
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- Sai N
- Saito S
- Saito T
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- Sakamaki A
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- Sakellariadou M
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- Salamida F
- Salazar H
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- Saleem M
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- Sanchez B
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- Schroder FG
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- Selsing J
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- Serino M
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- Serra-Ricart M
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- Steinlechner J
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- Taiuti M
- Tajitsu A
- Takahashi I
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- Takahashi T
- Takao Y
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- Tamura T
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- Tan Y
- Tanaka I
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- Tanimoto A
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- Tao C
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- Tasson JD
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- Ter Veen S
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- Terai T
- Terliuk A
- Terreran G
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model
- Author
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- Zimmerman Ab
- Zucker Me
- Zweizig J
- Publication venue
- College Park, MD : American Physical Society
- Publication date
- 01/01/2019
- Field of study
We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO's second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h095%=3.47×10-25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering. © 2019 American Physical Society
Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model
- Author
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2019
- Field of study
We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO’s second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h95%0=3.47×10−25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering
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