Familial aggregation of bladder cancer

Background. Except for smoking and certain occupational exposures, the etiology of bladder cancer is largely unknown. Several case reports have described familial aggregation of transitional cell carcinoma of the bladder. Although the majority of patients with bladder cancer do not have family history of transitional cell carcinoma of the urinary tract, the study of familial transitional cell carcinoma may lead to the knowledge on the pathogenesis of this disease. The purpose of this study was to describe three cases of urinary bladder cancer in a single three-member family, i.e. in two generations (mother and son) and a family member related by marriage (the patient's wife). Case report. Three cases of urinary bladder cancer occurred in a three-member family within the interval of 5 years. The following common characteristics were detected in our patients: old age (over 60), working as farmers for more than 50 years, negative personal medical history on relevant health disorders, place of birth - village, place of residence - village, the same water supply, similar nutrition, positive family history on urinary bladder cancer or other malignant tumors, the first sign of illness was macroscopic hematuria in all the patients and the same pathohistological type of cancer - carcinoma papillare transitiocellulare. Conclusion. The stated common characteristics in our cases indicate, above all, the impact of exposure to external surrounding factors on the occurrence of urinary bladder cancer

Critical Success Factors in IT Project Management. Case study on IT Banking Front-end IT System Project in Serbia

The success of project management in organizations depends on the context, that is, on type of organization, type of projects they implement, the environment and the conditions for the realization of projects. What matters to the textual issues of project success is due to a number of factors - type of project, importance for organization, resources, and the like. Insufficient number of organizations successfully managed to implement project manager procedures, while others met with a large number of problems, the resistance of employees first of all, ignorance, lack of resources, bad time management and other issues. Organizations must have an incremental approach to the development and implementation of their project management methodologies, especially when it comes to implementing information technology project, that involve a great deal of human-work, innovation and usually cost a lot, development takes a long time, they are based on the knowledge of new technologies, and their success depends on the people who develop them, and those who will use those IT products and services. This is a great challenge for management in terms of use of information technology, budget and planning, involvement of the project team and establishment of support from the environment. Many IT projects are not implemented successfully because of poor application of project management procedures, lack of stakeholder support, absence of project sponsor etc.

Research of possibilities for use domestic kaolin clays for production of metakaolin

U oblasti građevinarstva, u svetu se intenzivno istražuju mogućnosti primene novih materijala kojima se može supstituisati deo klinkera u Portland cementu ili deo cementa u betonskim mešavinama. Novi materijali treba da zadovolje zahteve u pogledu održivog razvoja, a njihova primena ne sme negativno da utiče na karakteristike materijala. U ovom radu se govoriti o jednom takvom materijalu metakolinu (MK). Osnovna i najčešće korišćena sirovina za proizvodnju MK je kaolinska glina iz koje se MK proizvodi kalcinacijom ili 'termičkom aktivacijom'. Od karakteristika polazne gline zavise mogućnosti njene primene za dobijanje MK. U radu su dati rezultati ispitivanja hemijskog i mineraloškog sastava, kao i termičkih karakteristika uzoraka gline uzetih iz fabrika Kaolin a.d, Valjevo i Keramika, Mladenovac.Environmental concerns coming from the high energy consumption and CO2 emission associated with cement production have brought about pressures to reduce cement consumption through the use of new materials which can be applied for substitution of a part of clinker in Portland cement or a part of cement in concrete. One of the materials that satisfy requirements of sustainable development and, when added in appropriate shares, improves the properties of cement, mortars and concrete, is metakaolin (MK), a processed pozzolana. The main and widely used raw material for production of metakaolin is kaolin clay. MK is produced by calcination or 'thermal activation' of kaolin clay. The possibilities for metakaolin production are strongly related to the characteristics of the used kaolin clay. The samples of domestic kaolin clay used in this study were provided by factories Kaolin, Valjevo, and Keramika, Mladenovac. Chemical composition, mineralogical composition and thermal properties of these samples were determined. Thermal analysis (simultaneous recording of TG, DTG and DTA signals) was carried out at the temperature range from 20 to 1200 °C. For both clays the results show that the loss of mass occurred in two stages. The dehydroxillation of kaolinite and formation of metakaolin occurred in the second stage. Minerals quartz and kaolinite are dominant in the clay Kaolin, Valjevo. Dehydroxillation of kaolinite and formation of metakaolin took place in the temperature range 350-800 °C. This clay does not have clearly distinct exothermic and endothermic peaks. Clay from Keramika, Mladenovac, has a higher content of the kaolinite mineral, i.e. 81.51%. The dehydroxillation of kaolinite and formation of metakaolin occurred in the temperature range 400-700 °C. This clay has two distinct endothermic peaks at 60 and 490 °C. All these results show that both clays can be used for production of metakaolin

Diarylheptanoids from Alnus viridis ssp viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa

Diarylheptanoids from the barks of Alnus viridis ssp. viridis (green alder) and Alnus glutinosa (black alder) were explored for anti-quorum sensing activity. Chemicals with anti-quorum sensing activity have recently been examined for antimicrobial applications. The anti-quorum sensing activity of the selected diarylheptanoids was determined using two biosensors, namely Pseudomonas aeruginosa PAO1 and Chromobacterium violaceum CV026. Although all of the investigated compounds negatively influenced the motility of P. aeruginosa PAO1, four were able to inhibit biofilm formation of this human opportunistic pathogen for 40-70%. Three of the diarylheptanoids (3, 4, and 5) negatively influenced the biosynthesis of pyocyanin, which is under the control of quorum sensing. Platyphyllenone (7) and hirsutenone (5) were able to inhibit the biosynthesis of violacein in C. violaceum CV026, with 5 being able to inhibit the synthesis of both biopigments. Only one of the tested diarylheptanoids (1) was shown to significantly decrease the production of acyl homoserine lactones (AHL) in P. aeruginosa PAO1, more specifically, production of the long chain N-(3-oxododecanoyl)- l-HSL. On the other side, four diarylheptanoids (2-5) significantly reduced the synthesis of 2-alkyl-4-quinolones, part of the P. aeruginosa quinolone-mediated signaling system. To properly assess therapeutic potential of these compounds, their in vitro antiproliferative effect on normal human lung fibroblasts was determined, with doses affecting cell proliferation between 10 and 100 mu g/mL. This study confirms that the barks of green and black alders are rich source of phytochemicals with a wide range of biological activities that could further be exploited as natural agents against bacterial contaminations and infections.Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3034

Potential connections of cockpit floor - seat on passive vibration reduction at a piston propelled airplane

Povećanje udobnosti pilota zrakoplova zahtijeva kontinuiran rad na smanjivanju vibracija koje djeluju na sjedište pilota. U cilju određivanja pogodnosti i potencijala veze pod kabine - sjedište pilota za pasivno prigušenje vibracija, proveden je eksperiment s mjerenjem i analizom vibracija na sjedištu. Parametri vibracija su izmjereni za režime leta zrakoplova s maksimalnim brojem okretaja motora i elise. Ova analiza ukazuje da kvaliteta pasivnog prigušenja vibracija, odnosno funkcionalnost veze pod kabine - sjedište, ovisi o režimu leta zrakoplova i frekvenciji vibracija. Na pojedinim analiziranim režimima leta veza pod - sjedište ponaša se kao multiplikator vibracija na 3. i 4. harmoniku, kao i na 3,5 poluharmoniku osnovne frekvencije okretaja elise, dok se na ostalim analiziranim frekvencijama ova veza ponaša kao prigušivač vibracija. Analiza ovog eksperimenta pokazala je da je opravdano započeti razvoj vlastitog prilagodljivog uređaja za aktivno prigušenje vibracija na sjedištu pilota.Improving aircraft pilot comfort requires continuous work in decreasing vibrations in the seat. In order to determine the suitability and potential of cockpit floor - seat connections we conducted an experiment where measurements were taken and seat vibration analysis conducted. Vibrations parameters were measured for maximum engine and propeller speed. This analysis indicates that passive vibrations damping or cockpit floor - seat connections functionality depends on flights profile and vibrations frequency. The connection in question was behaving like a vibration multiplier on the 3rd and 4th harmonic as well as on the 3,5 sub-harmonic in individual flight modes on basic propeller rotation frequency, however, it behaved as a vibration silencer on all other frequencies. Analysis of the experimental data has shown that it would be justified to start improving the self adaptive unit for active vibration reduction for pilot seats

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good