Designing multifunctional pigments for an improved energy efficiency in buildings

Materials science offers solutions that when are combined can offer important energy savings in the building sector. In this study, high reflectance coating and thermal storage capacity are combined with the aim of improving energy efficiency in buildings. For this issue a multifunctional pigment having a phase change material adsorbed on its surface and a high total solar reflectance has been manufactured. The total solar reflectance of the pigment will make the paint to reflect the sunlight radiation in the infrared part of the spectrum reducing the amount of absorbed radiation. This high reflection provides a surface level effect as is a passive stimulus-responsive solution that acts with sunlight radiation. On the other hand, the thermal storage capability provides a bulk level effect as is passive stimulus-responsive solution acting by temperature changes, making it possible to use constructive materials as a thermal energy storage media. The preparation process is described and the pigment is characterized conveniently. The thermal performance of corresponding pigmented coatings was evaluated by an experiment simulation in which different boxes were covered with the coating containing the multifunctional pigment and traditional pigmented coating on their tops. The indoor air temperature and the interior temperature of the substrate were measured obtaining differences of 4–5°C.European Union Seventh Framework Programme, FP7-NMP-2010-Small-5 (under grant agreement no 280393) Dpto. Educación, Política Lingüística y Cultura of the Basque Goverment, IT-630-13 Ministerio de Ciencia e Innovación, MAT2013-42092-R Engineering and Physical Sciences Research Council, EP/I00393

Color i Pigments

[CAT] En primer lloc, es descriu la llum, es defineix el color i les seves propietats, com són ara el matís, la lluminositat i la saturació. Després es defineixen les mescles additives i les mescles subtractives per comprendre les bases de color i les pastes, formulades mitjançant els pigments, tant inorgànics com orgànics. Es destaca, també, la química d'aquests productes. [ENG] Firstly light is described, and colour and its propieties, such as shade, luminosity and saturation, are then defined. Additive and subtractive mixtures are defined to understand basis of colour and pastes, made from pigments, both inorganic and organic. The chemistry of these products is highlighted

Preclinical evaluation of PHH-1V vaccine candidate against SARS-CoV-2 in non-human primates

SARS-CoV-2 emerged in December 2019 and quickly spread worldwide, continuously striking with an unpredictable evolution. Despite the success in vaccine production and mass vaccination programs, the situation is not still completely controlled, and therefore accessible second-generation vaccines are required to mitigate the pandemic. We previously developed an adjuvanted vaccine candidate coded PHH-1V, based on a heterodimer fusion protein comprising the RBD domain of two SARS-CoV-2 variants. Here, we report data on the efficacy, safety, and immunogenicity of PHH-1V in cynomolgus macaques. PHH-1V prime-boost vaccination induces high levels of RBD-specific IgG binding and neutralizing antibodies against several SARS-CoV-2 variants, as well as a balanced Th1/Th2 cellular immune response. Remarkably, PHH-1V vaccination prevents SARS-CoV-2 replication in the lower respiratory tract and significantly reduces viral load in the upper respiratory tract after an experimental infection. These results highlight the potential use of the PHH-1V vaccine in humans, currently undergoing Phase III clinical trials.Anna Moya and Mireia Muntada for the ELISA analysis; Clara Panosa and Ester Puigvert for her assistance in the production of the vaccine antigen; Glòria Pujol and Eduard Fossas for their assistance in review of the manuscript; and Adrián Lázaro-Frías from Evidenze Health España S.L. for providing medical writing support during the preparation of this paper funded by Hipra Scientific, S.L.U. This project was partially funded by the Centre for the Development of Industrial Technology (CDTI, IDI20210115), a public organization answering to the Spanish Ministry of Science and Innovation.info:eu-repo/semantics/publishedVersio

The Influence of Manga on the Graphic Novel

This material has been published in The Cambridge History of the Graphic Novel edited by Jan Baetens, Hugo Frey, Stephen E. Tabachnick. This version is free to view and download for personal use only. Not for re-distribution, re-sale or use in derivative works. © Cambridge University PressProviding a range of cogent examples, this chapter describes the influences of the Manga genre of comics strip on the Graphic Novel genre, over the last 35 years, considering the functions of domestication, foreignisation and transmedia on readers, markets and forms

Quimica de coordinacio dels acids picolinic i 6-metilpicolinic, i els seus esters, envers Zn(II), Cd(II), Hg(II) i Co(II). Estudi teoric de la flexibilitat coordinativa del Zn i propietats magnetiques dels complexos de Co(II)

Centro de Informacion y Documentacion Cientifica (CINDOC). C/Joaquin Costa, 22. 28002 Madrid. SPAIN / CINDOC - Centro de Informaciòn y Documentaciòn CientìficaSIGLEESSpai

Color i Pigments

[CAT] En primer lloc, es descriu la llum, es defineix el color i les seves propietats, com són ara el matís, la lluminositat i la saturació. Després es defineixen les mescles additives i les mescles subtractives per comprendre les bases de color i les pastes, formulades mitjançant els pigments, tant inorgànics com orgànics. Es destaca, també, la química d'aquests productes. [ENG] Firstly light is described, and colour and its propieties, such as shade, luminosity and saturation, are then defined. Additive and subtractive mixtures are defined to understand basis of colour and pastes, made from pigments, both inorganic and organic. The chemistry of these products is highlighted

Immune response after an experimental intramammary challenge with killed Staphylococcus aureus in cows and heifers vaccinated and not vaccinated with Startvac, a polyvalent mastitis vaccine

An experimental trial was conducted to explore the effect of vaccination with a polyvalent vaccine against mastitis (Startvac) on the early immune response after experimental intramammary challenge with a heterologous killed Staphylococcus aureus strain. The effect of vaccination on milk production, clinical signs, quarter milk somatic cell count, milk polymorphonuclear neutrophilic leukocyte (PMN) concentration and viability, the concentration of antigen-specific antibodies [slime associated antigenic complex (SAAC) and J5] and their IgG1 and IgG2 subtypes in both serum and whey, and the antigen-specific IFN-gamma, IL-4, and IL-17 production by blood lymphocytes after in vitro stimulation with S. aureus and Escherichia coli extracts were determined. A cohort of 8 clinically healthy end-term cows and heifers were conveniently selected, of which half was vaccinated with Startvac at 45 and 10 d before the expected calving date and half served as nonvaccinated control animals. At 15 d in milk, 2 contralateral quarters of each of the 8 animals were challenged with 2 x 10(9) cfu/mL of the formaldehyde-killed S. aureus C195 strain. The 2 other quarters were infused with phosphate-buffered saline and served as control quarters. The increase in both quarter milk somatic cell count and PMN concentration and the drop in milk production after S. aureus inoculation was less pronounced in the vaccinates than in the nonvaccinates, reflecting a less severe inflammatory response. No significant differences in PMN viability between vaccinates and nonvaccinates could be demonstrated. The serum SAAC- and J5-specific antibody concentration significantly increased across the dry period in the vaccinated animals only. The whey concentration of SAAC-specific antibodies was significantly higher in vaccinates than in nonvaccinates at both 15 and 17 d in milk, independent from the challenge status of the quarters. No significant differences in the whey J5-specific antibody concentration were observed. Vaccination with Startvac seems to primarily evoke a Th2 response for S. aureus characterized by a shift toward the IgG1 antibody subtype and accompanied by a less pronounced Th1 response. The type of response against E. coli was less clear, though a weak but significant shift toward the IgG2 antibody subtype after vaccination and high IFN--y levels after in vitro stimulation suggest a Thl response. The increased SAAC-specific antibody concentration in whey in vaccinates compared with nonvaccinates most probably triggers the opsonization of the inoculated S. aureus bacteria, resulting in a more efficient elimination of the bacteria from the mammary gland