119 research outputs found
Kohn anomalies and enhanced superconductivity in simple systems under pressure: Insights from the nearly free electron model
Genetically distinct leukemic stem cells in human CD34− acute myeloid leukemia are arrested at a hemopoietic precursor-like stage
Gertrude M. Yeager: Barros Arana's Historia Jeneral de Chile: Politics, History and National Identity (Fort Worth: Texas Christian University Press, 1982, n.p.s.) Pp. 187.
Cinema and Social Change in Latin America. Conversations with Filmmakers. By Julianne Burton. (Austin: University of Texas Press, 1986. Pp. xvi, 302. Photographs. Notes. Bibliography. Index. 10.95 paper.)
A growth factor antagonist as a targeting agent for sterically stabilized liposomes in human small cell lung cancer
The ability of a growth factor antagonist, [-Arg6,-Trp7,9-NmePhe8]-substance P(6-11), named antagonist G, to selectively target polyethylene glycol-grafted liposomes (known as sterically stabilized liposomes) to a human classical small cell lung cancer (SCLC) cell line, H69, was examined. Our results showed that radiolabeled antagonist G-targeted sterically stabilized liposomes (SLG) bound to H69 cells with higher avidity than free antagonist G and were internalized (reaching a maximum of 13[punctuation space]000 SLG/cell), mainly through a receptor-mediated process, likely involving clathrin-coated pits. This interaction was confirmed by confocal microscopy to be peptide- and cell-specific. Moreover, it was shown that SLG significantly improved the nuclear delivery of encapsulated doxorubicin to the target cells, increasing the cytotoxic activity of the drug over non-targeted liposomes. In mice, [125I]tyraminylinulin-containing SLG were long circulating, with a half-life of 13 h. Use of peptides like antagonist G to promote binding and internalization of sterically stabilized liposomes, with their accompanying drug loads, i.e., anticancer drugs, genes or antisense oligonucleotides, into target cells has the potential to improve therapy of SCLC.http://www.sciencedirect.com/science/article/B6T1T-43XFRH5-G/1/ffb9c3c56ac7b931d285ff452f8c5d7
For God or Country: History Textbooks and the Secularization of Chilean Society, 1840–1890
Short length of stay and rapid recovery to normal function after surgery for metastatic melanoma to abdominal and retroperitoneal viscera
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